Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0451 | 1 | 0.5 |
Treponema pallidum | flavodoxin | 0.0172 | 0 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0451 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0451 | 1 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0451 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0224 | 0.1841 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0451 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0172 | 0 | 0.5 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0172 | 0 | 0.5 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0451 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0172 | 0 | 0.5 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0227 | 0.1964 | 0.0151 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0451 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.04 | 0.8159 | 0.5 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0451 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0451 | 1 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0451 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0451 | 1 | 1 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0451 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0278 | 0.3805 | 0.3805 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0451 | 1 | 1 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.04 | 0.8159 | 0.5 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0451 | 1 | 1 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0278 | 0.3805 | 0.2407 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0451 | 1 | 1 |
Plasmodium vivax | flavodoxin domain containing protein | 0.04 | 0.8159 | 0.8159 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0172 | 0 | 0.5 |
Trypanosoma cruzi | p450 reductase, putative | 0.0451 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0172 | 0 | 0.5 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0451 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0451 | 1 | 1 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.04 | 0.8159 | 0.8159 |
Leishmania major | p450 reductase, putative | 0.0451 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0451 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0224 | 0.1841 | 0.5 |
Chlamydia trachomatis | sulfite reductase | 0.0278 | 0.3805 | 0.5 |
Leishmania major | cytochrome P450 reductase, putative | 0.04 | 0.8159 | 0.8159 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0451 | 1 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0451 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0278 | 0.3805 | 0.3805 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | 0 nM | In vitro antagonistic activity at the Histamine H1 receptor in guinea pig ileum; No inhibition | ChEMBL. | 10866399 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.