Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | tachykinin receptor 1 | Starlite/ChEMBL | References |
Homo sapiens | tachykinin receptor 2 | Starlite/ChEMBL | References |
Homo sapiens | tachykinin receptor 3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | tachykinin peptides receptor 99D | Get druggable targets OG5_131969 | All targets in OG5_131969 |
Schistosoma japonicum | ko:K04224 tachykinin receptor 3, putative | Get druggable targets OG5_137770 | All targets in OG5_137770 |
Echinococcus granulosus | tachykinin peptides receptor 99D | Get druggable targets OG5_131969 | All targets in OG5_131969 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0147 | 0.3252 | 0.3252 |
Schistosoma mansoni | thyroid hormone receptor | 0.0147 | 0.3252 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0137 | 0.2916 | 0.8556 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0137 | 0.2916 | 0.2916 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0072 | 0.0925 | 0.5 |
Echinococcus multilocularis | tachykinin peptides receptor 99D | 0.0367 | 1 | 1 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0137 | 0.2916 | 0.2916 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.026 | 0.6696 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0147 | 0.3252 | 1 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0072 | 0.0925 | 0.0925 |
Brugia malayi | follicle stimulating hormone receptor | 0.026 | 0.6696 | 1 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0072 | 0.0925 | 0.5 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0072 | 0.0925 | 0.5 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0072 | 0.0925 | 0.0925 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0072 | 0.0925 | 0.5 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0072 | 0.0925 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 153 nM | Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P | ChEMBL. | 7513763 |
IC50 (binding) | = 153 nM | Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P | ChEMBL. | 7513763 |
IC50 (binding) | > 5 uM | Binding affinity to the NK2 receptor assayed by displacement of [125I]-Neurokinin A | ChEMBL. | 7513763 |
IC50 (binding) | > 5 uM | Affinity to NK3 receptors assayed by displacement of [125I]-Bolton-Hunter labeled eledoisin radioligand | ChEMBL. | 7513763 |
IC50 (binding) | > 5 uM | Binding affinity to the NK2 receptor assayed by displacement of [125I]-Neurokinin A | ChEMBL. | 7513763 |
IC50 (binding) | > 5 uM | Affinity to NK3 receptors assayed by displacement of [125I]-Bolton-Hunter labeled eledoisin radioligand | ChEMBL. | 7513763 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.