Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Pneumocystis carinii | Dihydrofolate reductase | Starlite/ChEMBL | References |
Mycobacterium avium | Dihydrofolate reductase | Starlite/ChEMBL | References |
Rattus norvegicus | Dihydrofolate reductase | Starlite/ChEMBL | References |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | Starlite/ChEMBL | References |
Homo sapiens | dihydrofolate reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | dihydrofolate reductase | 0.1298 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.1298 | 1 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.1298 | 1 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.1298 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.1298 | 1 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.1298 | 1 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.1298 | 1 | 1 |
Onchocerca volvulus | 0.0177 | 0 | 0.5 | |
Chlamydia trachomatis | dihydrofolate reductase | 0.1298 | 1 | 0.5 |
Onchocerca volvulus | 0.0177 | 0 | 0.5 | |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0659 | 0.4297 | 0.5 |
Onchocerca volvulus | 0.0177 | 0 | 0.5 | |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0659 | 0.4297 | 0.5 |
Onchocerca volvulus | 0.0177 | 0 | 0.5 | |
Onchocerca volvulus | 0.0177 | 0 | 0.5 | |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0659 | 0.4297 | 0.5 |
Onchocerca volvulus | 0.0177 | 0 | 0.5 | |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0659 | 0.4297 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.1298 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0659 | 0.4297 | 0.5 |
Onchocerca volvulus | 0.0177 | 0 | 0.5 | |
Onchocerca volvulus | 0.0177 | 0 | 0.5 | |
Onchocerca volvulus | 0.0177 | 0 | 0.5 | |
Onchocerca volvulus | 0.0177 | 0 | 0.5 | |
Onchocerca volvulus | 0.0177 | 0 | 0.5 | |
Onchocerca volvulus | 0.0177 | 0 | 0.5 | |
Onchocerca volvulus | 0.0177 | 0 | 0.5 | |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0177 | 0 | 0.5 |
Onchocerca volvulus | 0.0177 | 0 | 0.5 | |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0177 | 0 | 0.5 |
Onchocerca volvulus | 0.0177 | 0 | 0.5 | |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0659 | 0.4297 | 0.5 |
Onchocerca volvulus | 0.0177 | 0 | 0.5 | |
Onchocerca volvulus | 0.0177 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity scale (binding) | < 10 nM | Antimycobacterial activity scale was evaluated and found to be highly active against MAC Dihydrofolate reductase | ChEMBL. | 11754578 |
Activity scale (binding) | < 10 nM | Antimycobacterial activity scale was evaluated and found to be highly active against MAC Dihydrofolate reductase | ChEMBL. | 11754578 |
Activity scale (binding) | < 100 nM | Antimycobacterial activity scale found to be highly active against human dihydrofolate reductase. | ChEMBL. | 11754578 |
Activity scale (binding) | < 100 nM | Antimycobacterial activity scale found to be highly active against human dihydrofolate reductase. | ChEMBL. | 11754578 |
IC50 (binding) | = 1.2 nM | Antimycobacterial activity against Mycobacterium avium complex diihydrofolate reductase (MAC DHFR) | ChEMBL. | 11754578 |
IC50 (binding) | = 1.2 nM | Antimycobacterial activity against Mycobacterium avium complex diihydrofolate reductase (MAC DHFR) | ChEMBL. | 11754578 |
IC50 (binding) | = 36 nM | Antimycobacterial activity against human dihydrofolate reductase (hDHFR) | ChEMBL. | 11754578 |
IC50 (binding) | = 36 nM | Antimycobacterial activity against human dihydrofolate reductase (hDHFR) | ChEMBL. | 11754578 |
IC50 (binding) | = 0.038 uM | Inhibitory activity against Toxoplasma gondii dihydrofolate reductase | ChEMBL. | 8632434 |
IC50 (binding) | = 0.038 uM | Inhibitory activity against Toxoplasma gondii dihydrofolate reductase | ChEMBL. | 8632434 |
IC50 (binding) | = 0.093 uM | Inhibitory activity against Pneumocystis carinii dihydrofolate reductase | ChEMBL. | 8632434 |
IC50 (binding) | = 0.093 uM | Inhibitory activity against Pneumocystis carinii dihydrofolate reductase | ChEMBL. | 8632434 |
IC50 (functional) | = 0.2 uM | Inhibition of Toxoplasma gondii cell growth | ChEMBL. | 8632434 |
IC50 (functional) | = 0.2 uM | Inhibition of Toxoplasma gondii cell growth | ChEMBL. | 8632434 |
IC50 (binding) | = 0.23 uM | Inhibitory activity of the compound against rat liver dihydrofolate reductase | ChEMBL. | 8632434 |
IC50 (binding) | = 0.23 uM | Inhibitory activity of the compound against rat liver dihydrofolate reductase | ChEMBL. | 8632434 |
Selectivity (binding) | = 2.5 | Ratio of IC50 rat liver DHFR vs IC50 of P. carinii DHFR | ChEMBL. | 8632434 |
Selectivity (binding) | = 6.2 | Ratio of IC50 rat liver DHFR vs IC50 of T. gondii DHFR | ChEMBL. | 8632434 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Toxoplasma gondii | ChEMBL23 | 8632434 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.