Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.2581 | 0.5228 | 0.5 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.4175 | 0.938 | 1 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.2343 | 0.4607 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.2581 | 0.5228 | 1 |
Brugia malayi | nuclear hormone receptor | 0.4175 | 0.938 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity ratio (functional) | = 0.1 | Analgesic activity against phenylquinone induced writhing in mice compared to that of aspirin. | ChEMBL. | 7731014 |
Activity ratio (functional) | = 0.7 | Analgesic activity against acetic acid-induced writhing in the rat compared to that of aspirin. | ChEMBL. | 7731014 |
Inhibition (functional) | = 9 % | Inhibition of phenylquinone induced writhing in mice following 50 mg/kg p.o. | ChEMBL. | 7731014 |
Inhibition (functional) | = 9 % | Inhibition of phenylquinone induced writhing in mice following 50 mg/kg p.o. | ChEMBL. | 7731014 |
Inhibition (functional) | = 50 % | Inhibition of acetic acid induced writhing in rat following 50 mg/kg p.o. | ChEMBL. | 7731014 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.