Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | thymidylate synthase | 0.3183 | 0.9247 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0214 | 0.0195 | 0.0211 |
Schistosoma mansoni | dihydrofolate reductase | 0.0464 | 0.0959 | 0.1037 |
Echinococcus granulosus | thymidylate synthase | 0.3183 | 0.9247 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0464 | 0.0959 | 0.1037 |
Trypanosoma brucei | deoxyuridine triphosphatase, putative | 0.0362 | 0.0647 | 0.0647 |
Leishmania major | thymidine kinase, putative | 0.0249 | 0.0301 | 0.0301 |
Brugia malayi | hypothetical protein | 0.1514 | 0.416 | 0.4498 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.3429 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0464 | 0.0959 | 1 |
Entamoeba histolytica | thymidine kinase, putative | 0.0249 | 0.0301 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 0.0464 | 0.0959 | 0.1037 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0464 | 0.0959 | 0.1037 |
Mycobacterium ulcerans | thymidylate synthase | 0.3183 | 0.9247 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0464 | 0.0959 | 0.1037 |
Trypanosoma cruzi | deoxyuridine triphosphatase, putative | 0.0362 | 0.0647 | 0.0647 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0464 | 0.0959 | 0.1037 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.3429 | 1 | 1 |
Leishmania major | deoxyuridine triphosphatase, putative,dUTP diphosphatase | 0.0362 | 0.0647 | 0.0647 |
Brugia malayi | thymidylate synthase | 0.3183 | 0.9247 | 1 |
Giardia lamblia | Thymidine kinase | 0.0249 | 0.0301 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0464 | 0.0959 | 0.1037 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0249 | 0.0301 | 0.0301 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0249 | 0.0301 | 0.0724 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3429 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0464 | 0.0959 | 0.1037 |
Trypanosoma cruzi | deoxyuridine triphosphatase, putative | 0.0362 | 0.0647 | 0.0647 |
Onchocerca volvulus | 0.3183 | 0.9247 | 1 | |
Mycobacterium tuberculosis | Hypothetical protein | 0.1514 | 0.416 | 0.4498 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.3429 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3429 | 1 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3183 | 0.9247 | 1 |
Treponema pallidum | thymidylate kinase (tmk) | 0.015 | 0 | 0.5 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0249 | 0.0301 | 0.0724 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.3183 | 0.9247 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.1514 | 0.416 | 0.416 |
Wolbachia endosymbiont of Brugia malayi | thymidylate kinase | 0.015 | 0 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.0464 | 0.0959 | 0.1037 |
Trypanosoma brucei | RNA helicase, putative | 0.0214 | 0.0195 | 0.0195 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.3183 | 0.9247 | 1 |
Trypanosoma brucei | thymidine kinase | 0.0249 | 0.0301 | 0.0301 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0249 | 0.0301 | 0.0724 |
Loa Loa (eye worm) | thymidylate synthase | 0.3183 | 0.9247 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1514 | 0.416 | 1 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0249 | 0.0301 | 0.0301 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Cooperativity (binding) | = 0.8 | Subtype selectivity and the cooperativity with N-methyl scopolamine (NMS) at muscarinic acetylcholine receptor M3; Activity range is 0.2-0.8 | ChEMBL. | 11881995 |
Cooperativity (binding) | = 0.8 | Subtype selectivity and the cooperativity with N-methyl scopolamine (NMS) at Muscarinic acetylcholine receptor M1; Activity range is 0.2-0.8 | ChEMBL. | 11881995 |
Cooperativity (binding) | = 1.19 | Subtype selectivity and the cooperativity with N-methyl scopolamine (NMS) at Muscarinic acetylcholine receptor M4; Activity range is 0.81-1.19 | ChEMBL. | 11881995 |
Cooperativity (binding) | = 1.19 | Subtype selectivity and the cooperativity with N-methyl scopolamine (NMS) at Muscarinic acetylcholine receptor M2; Activity range is 0.81-1.19 | ChEMBL. | 11881995 |
Cooperativity (binding) | = 0.8 | Subtype selectivity and the cooperativity with N-methyl scopolamine (NMS) at Muscarinic acetylcholine receptor M1; Activity range is 0.2-0.8 | ChEMBL. | 11881995 |
Cooperativity (binding) | = 0.8 | Subtype selectivity and the cooperativity with N-methyl scopolamine (NMS) at muscarinic acetylcholine receptor M3; Activity range is 0.2-0.8 | ChEMBL. | 11881995 |
Cooperativity (binding) | = 1.19 | Subtype selectivity and the cooperativity with N-methyl scopolamine (NMS) at Muscarinic acetylcholine receptor M2; Activity range is 0.81-1.19 | ChEMBL. | 11881995 |
Cooperativity (binding) | = 1.19 | Subtype selectivity and the cooperativity with N-methyl scopolamine (NMS) at Muscarinic acetylcholine receptor M4; Activity range is 0.81-1.19 | ChEMBL. | 11881995 |
Log 1/M (binding) | = 5.23 | Logarithm of affinity (log 1/M) at the (N-methyl scopolamine) NMS-liganded muscarinic acetylcholine receptor M3 by using semiquantitative equilibrium and off-rate assay | ChEMBL. | 11881995 |
Log 1/M (binding) | = 5.52 | Logarithm of affinity (log 1/M) at the muscarinic acetylcholine receptor M4 by using semiquantitative equilibrium and off-rate assay | ChEMBL. | 11881995 |
Log 1/M (binding) | = 5.6 | Logarithm of affinity (log 1/M) at the muscarinic acetylcholine receptor M3 by using semiquantitative equilibrium and off-rate assay | ChEMBL. | 11881995 |
Log 1/M (binding) | = 5.6 | Logarithm of affinity (log 1/M) at the muscarinic acetylcholine receptor M2 by using semiquantitative equilibrium and off-rate assay | ChEMBL. | 11881995 |
Log 1/M (binding) | = 5.64 | Logarithm of affinity (log 1/M) at the (N-methyl scopolamine) NMS-liganded muscarinic acetylcholine receptor M2 by using semiquantitative equilibrium and off-rate assay | ChEMBL. | 11881995 |
Log 1/M (binding) | = 5.65 | Logarithm of affinity (log 1/M) at the (N-methyl scopolamine) NMS-liganded muscarinic acetylcholine receptor M4 by using semiquantitative equilibrium and off-rate assay | ChEMBL. | 11881995 |
Log 1/M (binding) | = 6.13 | Logarithm of affinity (log 1/M) at the (N-methyl scopolamine) NMS-liganded muscarinic acetylcholine receptor M1 by using semiquantitative equilibrium and off-rate assay | ChEMBL. | 11881995 |
Log 1/M (binding) | = 6.59 | Logarithm of affinity (log 1/M) at the free muscarinic acetylcholine receptor M1 by using semiquantitative equilibrium and off-rate assay | ChEMBL. | 11881995 |
Log 1/M (binding) | = 5.23 | Logarithm of affinity (log 1/M) at the (N-methyl scopolamine) NMS-liganded muscarinic acetylcholine receptor M3 by using semiquantitative equilibrium and off-rate assay | ChEMBL. | 11881995 |
Log 1/M (binding) | = 5.52 | Logarithm of affinity (log 1/M) at the muscarinic acetylcholine receptor M4 by using semiquantitative equilibrium and off-rate assay | ChEMBL. | 11881995 |
Log 1/M (binding) | = 5.6 | Logarithm of affinity (log 1/M) at the muscarinic acetylcholine receptor M2 by using semiquantitative equilibrium and off-rate assay | ChEMBL. | 11881995 |
Log 1/M (binding) | = 5.6 | Logarithm of affinity (log 1/M) at the muscarinic acetylcholine receptor M3 by using semiquantitative equilibrium and off-rate assay | ChEMBL. | 11881995 |
Log 1/M (binding) | = 5.64 | Logarithm of affinity (log 1/M) at the (N-methyl scopolamine) NMS-liganded muscarinic acetylcholine receptor M2 by using semiquantitative equilibrium and off-rate assay | ChEMBL. | 11881995 |
Log 1/M (binding) | = 5.65 | Logarithm of affinity (log 1/M) at the (N-methyl scopolamine) NMS-liganded muscarinic acetylcholine receptor M4 by using semiquantitative equilibrium and off-rate assay | ChEMBL. | 11881995 |
Log 1/M (binding) | = 6.13 | Logarithm of affinity (log 1/M) at the (N-methyl scopolamine) NMS-liganded muscarinic acetylcholine receptor M1 by using semiquantitative equilibrium and off-rate assay | ChEMBL. | 11881995 |
Log 1/M (binding) | = 6.59 | Logarithm of affinity (log 1/M) at the free muscarinic acetylcholine receptor M1 by using semiquantitative equilibrium and off-rate assay | ChEMBL. | 11881995 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.