Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | Starlite/ChEMBL | References |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | Curated by TDR Targets | References |
Pneumocystis carinii | Dihydrofolate reductase | Starlite/ChEMBL | References |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | Curated by TDR Targets | References |
Rattus norvegicus | Dihydrofolate reductase | Starlite/ChEMBL | References |
Mycobacterium avium | Dihydrofolate reductase | Starlite/ChEMBL | References |
Homo sapiens | dihydrofolate reductase | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity scale (binding) | < 10 nM | Antimycobacterial activity scale was evaluated and found to be highly active against MAC Dihydrofolate reductase | ChEMBL. | 11754578 |
Activity scale (binding) | < 10 nM | Antimycobacterial activity scale was evaluated and found to be highly active against MAC Dihydrofolate reductase | ChEMBL. | 11754578 |
Activity scale (binding) | > 1000 nM | Antimycobacterial activity scale was evaluated and found to be moderately active against human Dihydrofolate reductase | ChEMBL. | 11754578 |
Activity scale (binding) | > 1000 nM | Antimycobacterial activity scale was evaluated and found to be moderately active against human Dihydrofolate reductase | ChEMBL. | 11754578 |
IC50 (binding) | = 2.7 nM | Antimycobacterial activity against Mycobacterium avium complex diihydrofolate reductase (MAC DHFR) | ChEMBL. | 11754578 |
IC50 (binding) | = 2.7 nM | Antimycobacterial activity against Mycobacterium avium complex diihydrofolate reductase (MAC DHFR) | ChEMBL. | 11754578 |
IC50 (binding) | = 500 nM | Antimycobacterial activity against human dihydrofolate reductase (hDHFR) | ChEMBL. | 11754578 |
IC50 (binding) | = 500 nM | Antimycobacterial activity against human dihydrofolate reductase (hDHFR) | ChEMBL. | 11754578 |
IC50 (binding) | = 0.11 uM | Inhibitory activity against Toxoplasma gondii dihydrofolate reductase | ChEMBL. | 8632434 |
IC50 (binding) | = 0.11 uM | Inhibitory activity against Toxoplasma gondii dihydrofolate reductase | ChEMBL. | 8632434 |
IC50 (functional) | = 0.2 uM | Inhibition of Toxoplasma gondii cell growth | ChEMBL. | 8632434 |
IC50 (functional) | = 0.2 uM | Inhibition of Toxoplasma gondii cell growth | ChEMBL. | 8632434 |
IC50 (binding) | = 0.34 uM | Inhibitory activity against Pneumocystis carinii dihydrofolate reductase | ChEMBL. | 8632434 |
IC50 (binding) | = 0.34 uM | Inhibitory activity against Pneumocystis carinii dihydrofolate reductase | ChEMBL. | 8632434 |
IC50 (binding) | = 0.6 uM | Inhibitory activity of the compound against rat liver dihydrofolate reductase | ChEMBL. | 8632434 |
IC50 (binding) | = 0.6 uM | Inhibitory activity of the compound against rat liver dihydrofolate reductase | ChEMBL. | 8632434 |
Selectivity (binding) | = 1.8 | Ratio of IC50 rat liver DHFR vs IC50 of P. carinii DHFR | ChEMBL. | 8632434 |
Selectivity (binding) | = 5.3 | Ratio of IC50 rat liver DHFR vs IC50 of T. gondii DHFR | ChEMBL. | 8632434 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Toxoplasma gondii | ChEMBL23 | 8632434 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
19 literature references were collected for this gene.