Detailed information for compound 29698

Basic information

Technical information
  • TDR Targets ID: 29698
  • Name: 6-[(3-chlorophenyl)sulfanylmethyl]-5-methylpy rido[2,3-d]pyrimidine-2,4-diamine
  • MW: 331.823 | Formula: C15H14ClN5S
  • H donors: 2 H acceptors: 3 LogP: 3.11 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cccc(c1)SCc1cnc2c(c1C)c(N)nc(n2)N
  • InChi: 1S/C15H14ClN5S/c1-8-9(7-22-11-4-2-3-10(16)5-11)6-19-14-12(8)13(17)20-15(18)21-14/h2-6H,7H2,1H3,(H4,17,18,19,20,21)
  • InChiKey: JULCQUSZPHPRJL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 6-[(3-chlorophenyl)sulfanylmethyl]-5-methyl-pyrido[2,3-d]pyrimidine-2,4-diamine
  • 6-[[(3-chlorophenyl)thio]methyl]-5-methylpyrido[2,3-d]pyrimidine-2,4-diamine
  • [2-amino-6-[[(3-chlorophenyl)thio]methyl]-5-methyl-pyrido[2,3-d]pyrimidin-4-yl]amine
  • 6-[(3-chlorophenyl)sulfanylmethyl]-5-methylpyrido[3,2-e]pyrimidine-2,4-diamine
  • 6-[(3-chlorophenyl)sulfanylmethyl]-5-methyl-pyrido[3,2-e]pyrimidine-2,4-diamine
  • 6-[[(3-chlorophenyl)thio]methyl]-5-methylpyrido[3,2-e]pyrimidine-2,4-diamine
  • [2-amino-6-[[(3-chlorophenyl)thio]methyl]-5-methyl-pyrido[3,2-e]pyrimidin-4-yl]amine
  • 174654-94-5
  • AIDS-041330
  • AIDS041330
  • SRI 8573
  • 2,4-Diamino-5-methylpyrido(2,3-d)pyrimidine, 6-((3-chlorophenylthio)methyl), 0.9 hydrate
  • 2,4-Diamino-5-methylpyrido[2,3-d]pyrimidine, 6-[(3-chlorophenylthio)methyl], 0.9 hydrate

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens dihydrofolate reductase Starlite/ChEMBL References
Mycobacterium avium Dihydrofolate reductase Starlite/ChEMBL References
Pneumocystis carinii Dihydrofolate reductase Starlite/ChEMBL References
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase Starlite/ChEMBL References
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) Curated by TDR Targets References
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) Curated by TDR Targets References
Rattus norvegicus Dihydrofolate reductase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) Get druggable targets OG5_127385 All targets in OG5_127385
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Loa Loa (eye worm) thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Mycobacterium ulcerans dihydrofolate reductase DfrA Get druggable targets OG5_128410 All targets in OG5_128410
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) Get druggable targets OG5_127385 All targets in OG5_127385
Cryptosporidium hominis chain A, crystal structure of Dhfr Get druggable targets OG5_127385 All targets in OG5_127385
Leishmania mexicana dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Candida albicans dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Echinococcus granulosus dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Brugia malayi thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Plasmodium knowlesi bifunctional dihydrofolate reductase-thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Chlamydia trachomatis dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Candida albicans dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Brugia malayi Dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Trypanosoma brucei gambiense dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Neospora caninum Bifunctional dihydrofolate reductase-thymidylate synthase, related Get druggable targets OG5_127385 All targets in OG5_127385
Candida albicans Thymidylate synthase capable of functional substitution for S. cerevisiae CDC21 (YOR074C) Get druggable targets OG5_127385 All targets in OG5_127385
Echinococcus multilocularis dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Leishmania braziliensis dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Plasmodium berghei bifunctional dihydrofolate reductase-thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Onchocerca volvulus Get druggable targets OG5_127385 All targets in OG5_127385
Schistosoma japonicum ko:K00287 dihydrofolate reductase [EC1.5.1.3], putative Get druggable targets OG5_128410 All targets in OG5_128410
Plasmodium yoelii thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Candida albicans hypothetical protein Get druggable targets OG5_128410 All targets in OG5_128410
Leishmania donovani dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Theileria parva dihydrofolate reductase-thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Cryptosporidium parvum dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) Get druggable targets OG5_128410 All targets in OG5_128410
Leishmania major dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) Get druggable targets OG5_128410 All targets in OG5_128410
Mycobacterium ulcerans thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Schistosoma mansoni dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Loa Loa (eye worm) dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Echinococcus multilocularis thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Echinococcus granulosus thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127385 All targets in OG5_127385
Babesia bovis dihydrofolate reductase/thymidilate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Schistosoma japonicum ko:K00560 thymidylate synthase [EC2.1.1.45], putative Get druggable targets OG5_127385 All targets in OG5_127385
Candida albicans Thymidylate synthase capable of functional substitution for S. cerevisiae CDC21 (YOR074C) Get druggable targets OG5_127385 All targets in OG5_127385
Brugia malayi dihydrofolate reductase family protein Get druggable targets OG5_128410 All targets in OG5_128410
Leishmania infantum dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium knowlesi bifunctional dihydrofolate reductase-thymidylate synthase, putative Dihydrofolate reductase   187 aa 209 aa 29.2 %
Babesia bovis dihydrofolate reductase/thymidilate synthase Dihydrofolate reductase   187 aa 191 aa 31.9 %
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   187 aa 186 aa 37.1 %
Leishmania donovani dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   187 aa 172 aa 36.0 %
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 159 aa 140 aa 37.9 %
Leishmania mexicana dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   187 aa 172 aa 33.7 %
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative Dihydrofolate reductase   187 aa 209 aa 29.2 %
Plasmodium yoelii thymidylate synthase, putative Dihydrofolate reductase   187 aa 212 aa 27.8 %
Theileria parva dihydrofolate reductase-thymidylate synthase, putative Dihydrofolate reductase   187 aa 193 aa 32.1 %
Neospora caninum Bifunctional dihydrofolate reductase-thymidylate synthase, related Dihydrofolate reductase   187 aa 187 aa 35.8 %
Onchocerca volvulus Putative dihydrofolate reductase Dihydrofolate reductase   181 aa 174 aa 31.6 %
Plasmodium berghei bifunctional dihydrofolate reductase-thymidylate synthase, putative Dihydrofolate reductase   187 aa 211 aa 28.4 %
Trypanosoma brucei gambiense dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   187 aa 210 aa 30.0 %
Cryptosporidium parvum dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   187 aa 182 aa 33.5 %
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 165 aa 143 aa 34.3 %
Leishmania braziliensis dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   187 aa 172 aa 34.3 %
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   187 aa 202 aa 29.2 %
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase dihydrofolate reductase 187 aa 202 aa 29.7 %
Leishmania major dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   187 aa 172 aa 36.0 %
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   187 aa 210 aa 30.0 %
Leishmania infantum dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   187 aa 172 aa 36.0 %
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   206 aa 193 aa 29.5 %
Cryptosporidium hominis chain A, crystal structure of Dhfr Dihydrofolate reductase   187 aa 182 aa 34.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi ribonuclease H1, putative 0.0089 0.0315 0.0019
Trypanosoma brucei unspecified product 0.0097 0.0376 0.0069
Brugia malayi DNA polymerase I family protein 0.0205 0.1244 0.0959
Giardia lamblia Thymidine kinase 0.0253 0.163 1
Wolbachia endosymbiont of Brugia malayi thymidylate kinase 0.0221 0.1372 1
Trypanosoma brucei ribonuclease H1 0.0089 0.0315 0.0006
Trypanosoma cruzi thymidine kinase, putative 0.0253 0.163 0.1377
Leishmania major mitochondrial DNA polymerase beta 0.0627 0.4628 0.4473
Schistosoma mansoni hypothetical protein 0.0221 0.1372 0.1309
Leishmania major dihydrofolate reductase-thymidylate synthase 0.1296 0.9979 1
Entamoeba histolytica thymidine kinase, putative 0.0253 0.163 1
Chlamydia trachomatis dihydrofolate reductase 0.1298 1 1
Trypanosoma brucei RNA helicase, putative 0.0334 0.2275 0.2033
Leishmania major ribonuclease H1, putative 0.0089 0.0315 0.0019
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0088 0.0309 0.0013
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.1298 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0365 0.2523 1
Trypanosoma brucei thymidylate kinase, putative 0.0221 0.1372 0.1099
Toxoplasma gondii thymidylate kinase 0.0221 0.1372 0.1093
Trypanosoma cruzi thymidylate kinase, putative 0.0221 0.1372 0.111
Schistosoma mansoni DNA polymerase gamma 0.0205 0.1244 0.118
Mycobacterium tuberculosis Hypothetical protein 0.0365 0.2523 0.1334
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0297 0.1981 0.1729
Trypanosoma brucei hypothetical protein, conserved 0.0097 0.0376 0.0069
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0767 0.5742 0.5065
Schistosoma mansoni thymidylate kinase 0.0221 0.1372 0.1309
Schistosoma mansoni phosphoglucomutase 0.0089 0.0315 0.0245
Trichomonas vaginalis thymidine kinase, putative 0.0253 0.163 0.5955
Trichomonas vaginalis thymidine kinase, putative 0.0253 0.163 0.5955
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0097 0.0376 0.0069
Mycobacterium ulcerans hypothetical protein 0.0331 0.2249 0.1017
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.1298 1 1
Echinococcus multilocularis ribonuclease H1 0.0089 0.0315 0.0245
Onchocerca volvulus 0.0767 0.5742 1
Loa Loa (eye worm) thymidylate kinase 0.0221 0.1372 0.1152
Onchocerca volvulus Putative thymidylate kinase 0.0221 0.1372 0.2046
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0297 0.1981 0.1739
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0767 0.5742 0.5711
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0627 0.4628 0.4466
Echinococcus multilocularis thymidylate kinase 0.0221 0.1372 0.1309
Echinococcus multilocularis thymidylate synthase 0.0767 0.5742 0.5711
Trypanosoma brucei ingi protein (ORF1) 0.0097 0.0376 0.0069
Brugia malayi Dihydrofolate reductase 0.1298 1 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0627 0.4628 0.4473
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.1296 0.9979 1
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.1296 0.9979 1
Treponema pallidum thymidylate kinase (tmk) 0.0221 0.1372 1
Loa Loa (eye worm) dihydrofolate reductase 0.1298 1 1
Trypanosoma cruzi ribonuclease H1, putative 0.0089 0.0315 0.0019
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.1298 1 1
Giardia lamblia CDC8 0.0221 0.1372 0.8416
Schistosoma mansoni phosphoglucomutase 0.0089 0.0315 0.0245
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0108 0.0464 0.0172
Trichomonas vaginalis thymidylate kinase, putative 0.0221 0.1372 0.4786
Leishmania major thymidylate kinase-like protein 0.0221 0.1372 0.111
Trypanosoma cruzi thymidine kinase, putative 0.0253 0.163 0.1377
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0088 0.0309 0.0013
Echinococcus granulosus thymidylate kinase 0.0221 0.1372 0.1309
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.1296 0.9979 1
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0767 0.5742 0.5065
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0088 0.0309 0.0013
Trypanosoma brucei ingi protein (ORF1) 0.0097 0.0376 0.0069
Brugia malayi hypothetical protein 0.0365 0.2523 0.228
Echinococcus multilocularis dihydrofolate reductase 0.1298 1 1
Brugia malayi thymidylate synthase 0.0767 0.5742 0.5603
Mycobacterium tuberculosis Conserved hypothetical protein 0.0331 0.2249 0.1017
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.1296 0.9979 1
Leishmania major thymidine kinase, putative 0.0253 0.163 0.1377
Schistosoma mansoni hypothetical protein 0.0334 0.2275 0.2219
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0627 0.4628 0.4473
Schistosoma mansoni phosphoglucomutase 0.0089 0.0315 0.0245
Mycobacterium ulcerans thymidylate synthase 0.0767 0.5742 0.5065
Trypanosoma cruzi thymidylate kinase, putative 0.0221 0.1372 0.111
Trichomonas vaginalis thymidylate kinase, putative 0.0221 0.1372 0.4786
Brugia malayi thymidylate kinase 0.0221 0.1372 0.1091
Onchocerca volvulus Ribonuclease H1 homolog 0.0089 0.0315 0.0122
Echinococcus granulosus ribonuclease H1 0.0089 0.0315 0.0245
Trypanosoma brucei thymidine kinase 0.0253 0.163 0.1366
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0365 0.2523 0.2299
Loa Loa (eye worm) thymidylate synthase 0.0767 0.5742 0.5633
Giardia lamblia Ribonuclease H 0.0089 0.0315 0.1933
Trichomonas vaginalis thymidine kinase, putative 0.0253 0.163 0.5955
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.1296 0.9979 1
Echinococcus granulosus thymidylate synthase 0.0767 0.5742 0.5711
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0297 0.1981 0.1739
Schistosoma mansoni thymidylate kinase 0.0221 0.1372 0.1309
Loa Loa (eye worm) hypothetical protein 0.0205 0.1244 0.1021
Trypanosoma brucei thymidylate kinase, putative 0.0221 0.1372 0.1099
Echinococcus granulosus DNA polymerase subunit gamma 0.0205 0.1244 0.118
Toxoplasma gondii hypothetical protein 0.0101 0.0413 0.0101
Echinococcus multilocularis hypothetical protein 0.0205 0.1244 0.118
Schistosoma mansoni dihydrofolate reductase 0.1298 1 1
Echinococcus granulosus dihydrofolate reductase 0.1298 1 1

Activities

Activity type Activity value Assay description Source Reference
Activity scale (binding) < 10 nM Antimycobacterial activity scale was evaluated and found to be highly active against MAC Dihydrofolate reductase ChEMBL. 11754578
Activity scale (binding) < 10 nM Antimycobacterial activity scale was evaluated and found to be highly active against MAC Dihydrofolate reductase ChEMBL. 11754578
Activity scale (binding) > 1000 nM Antimycobacterial activity scale was evaluated and found to be moderately active against human Dihydrofolate reductase ranges from 100-1000 ChEMBL. 11754578
Activity scale (binding) > 1000 nM Antimycobacterial activity scale was evaluated and found to be moderately active against human Dihydrofolate reductase ranges from 100-1000 ChEMBL. 11754578
IC50 (binding) = 3.9 nM Antimycobacterial activity against Mycobacterium avium complex diihydrofolate reductase (MAC DHFR) ChEMBL. 11754578
IC50 (binding) = 3.9 nM Antimycobacterial activity against Mycobacterium avium complex diihydrofolate reductase (MAC DHFR) ChEMBL. 11754578
IC50 (binding) = 420 nM Antimycobacterial activity against human dihydrofolate reductase (hDHFR) ChEMBL. 11754578
IC50 (binding) = 420 nM Antimycobacterial activity against human dihydrofolate reductase (hDHFR) ChEMBL. 11754578
IC50 (binding) = 0.068 uM Inhibitory activity against Pneumocystis carinii dihydrofolate reductase ChEMBL. 8632434
IC50 (binding) = 0.068 uM Inhibitory activity against Pneumocystis carinii dihydrofolate reductase ChEMBL. 8632434
IC50 (binding) = 0.09 uM Inhibitory activity against Toxoplasma gondii dihydrofolate reductase ChEMBL. 8632434
IC50 (binding) = 0.09 uM Inhibitory activity against Toxoplasma gondii dihydrofolate reductase ChEMBL. 8632434
IC50 (functional) = 0.15 uM Inhibition of Toxoplasma gondii cell growth ChEMBL. 8632434
IC50 (functional) = 0.15 uM Inhibition of Toxoplasma gondii cell growth ChEMBL. 8632434
IC50 (binding) = 0.19 uM Inhibitory activity of the compound against rat liver dihydrofolate reductase ChEMBL. 8632434
IC50 (binding) = 0.19 uM Inhibitory activity of the compound against rat liver dihydrofolate reductase ChEMBL. 8632434
Selectivity (binding) = 2.1 Ratio of IC50 rat liver DHFR vs IC50 of T. gondii DHFR ChEMBL. 8632434
Selectivity (binding) = 2.8 Ratio of IC50 rat liver DHFR vs IC50 of P. carinii DHFR ChEMBL. 8632434

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Toxoplasma gondii ChEMBL23 8632434

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Targets
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from specific protein inhibition (ECO:0000020) Mycobacterium avium 256134  
Annotator: crowther@u.washington.edu Comment: 2007-12-27 References: 10579848 10991861 11754594 12467708 12699390 12832132 14998335 15026078 15115391 15214795 15974594 17010625 9554874
growth (GO:0040007) decreased (PATO:0000468) inferred from in vitro culture assay (ECO:0000182) Mycobacterium avium 256134  
Annotator: crowther@u.washington.edu Comment: 2007-12-27 References: 10052907 10991861 14998335 7486934 8913480 9835537
growth (GO:0040007) decreased (PATO:0000468) inferred from in vitro culture assay (ECO:0000182) Mycobacterium avium 5868  
Annotator: crowther@u.washington.edu Comment: 2007-12-27 References: 10052907 10991861 14998335 7486934 8913480 9835537
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from specific protein inhibition (ECO:0000020) Mycobacterium avium 5868  
Annotator: crowther@u.washington.edu Comment: 2007-12-27 References: 10579848 10991861 11754594 12467708 12699390 12832132 14998335 15026078 15115391 15214795 15974594 17010625 9554874

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

19 literature references were collected for this gene.

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