Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Hepatitis C virus | Hepatitis C virus NS5B RNA-dependent RNA polymerase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0195 | 0.5169 | 0.5169 |
Echinococcus multilocularis | adenosine deaminase | 0.029 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase 2, putative | 0.0094 | 0 | 0.5 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.029 | 1 | 1 |
Plasmodium falciparum | adenosine deaminase | 0.029 | 1 | 1 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.029 | 1 | 1 |
Schistosoma mansoni | adenosine deaminase-related | 0.029 | 1 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.029 | 1 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0094 | 0 | 0.5 |
Mycobacterium ulcerans | adenosine deaminase | 0.029 | 1 | 0.5 |
Echinococcus granulosus | adenosine deaminase | 0.029 | 1 | 1 |
Leishmania major | adenine aminohydrolase | 0.029 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0094 | 0 | 0.5 |
Trypanosoma brucei | AMP deaminase, putative | 0.0094 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0195 | 0.5169 | 0.5169 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0094 | 0 | 0.5 |
Trypanosoma brucei | AMP deaminase, putative | 0.0094 | 0 | 0.5 |
Entamoeba histolytica | adenosine deaminase, putative | 0.029 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0094 | 0 | 0.5 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.029 | 1 | 1 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.029 | 1 | 0.5 |
Trypanosoma cruzi | adenosine monophosphate deaminase, putative | 0.0094 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0195 | 0.5169 | 0.5169 |
Trypanosoma brucei | AMP deaminase, putative | 0.0094 | 0 | 0.5 |
Entamoeba histolytica | adenosine deaminase, putative | 0.029 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0195 | 0.5169 | 0.5169 |
Loa Loa (eye worm) | hypothetical protein | 0.029 | 1 | 1 |
Trypanosoma brucei | adenosine monophosphate deaminase, putative | 0.0094 | 0 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0094 | 0 | 0.5 |
Plasmodium vivax | adenosine deaminase, putative | 0.029 | 1 | 1 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.029 | 1 | 0.5 |
Schistosoma mansoni | adenosine deaminase | 0.029 | 1 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.029 | 1 | 0.5 |
Treponema pallidum | adenosine deaminase | 0.029 | 1 | 0.5 |
Trypanosoma cruzi | adenosine monophosphate deaminase-like protein, putative | 0.0094 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 8.6 uM | Inhibitory activity against Hepatitis C RNA dependent RNA polymerase Nonstructural protein 5B (NS5B polymerase) expressed from baculovirus-infected Sf9 insect cells | ChEMBL. | 12672227 |
IC50 (binding) | = 8.6 uM | Inhibitory activity against Hepatitis C RNA dependent RNA polymerase Nonstructural protein 5B (NS5B polymerase) expressed from baculovirus-infected Sf9 insect cells | ChEMBL. | 12672227 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.