Detailed information for compound 2976

Basic information

Technical information
  • TDR Targets ID: 2976
  • Name: Paclitaxel
  • MW: 853.906 | Formula: C47H51NO14
  • H donors: 4 H acceptors: 9 LogP: 3.31 Rotable bonds: 15 Rule of 5 violations (Lipinski): 2
  • SMILES: CC(=O)O[C@@H]1C(=O)[C@@]2(C)[C@@H](O)C[C@H]3[C@](C2[C@H]([C@@]2(C(C1=C(C)[C@H](OC(=O)[C@H]([C@H](c1ccccc1)NC(=O)c1ccccc1)O)C2)(C)C)O)OC(=O)c1ccccc1)(CO3)OC(=O)C
  • InChi: 1S/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31-,32-,33+,35-,36+,37+,38?,40-,45+,46-,47+/m0/s1
  • InChiKey: RCINICONZNJXQF-VAZQATRQSA-N  

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Synonyms

  • albumin-bound paclitaxel
  • 33069-62-4
  • KBio2_005628
  • Probes2_000350
  • UPCMLD-DP108:002
  • Bio1_000851
  • IDI1_002171
  • KBio3_000903
  • KBio3_000904
  • BSPBio_001152
  • C07394
  • SPBio_000943
  • IDI1_000441
  • SMP1_000228
  • Abraxane (TN)
  • D00491
  • Paclitaxel (JAN/USP/INN)
  • Taxol (TN)
  • Spectrum4_001197
  • BSPBio_002614
  • EU-0101201
  • LMPR01040091
  • Spectrum5_001491
  • Bio1_000362
  • Bio2_000416
  • KBioGR_000492
  • KBioSS_000492
  • Spectrum3_001057
  • Spectrum2_000872
  • KBioSS_002016
  • Spectrum_001536
  • KBioGR_001893
  • Bio1_001340
  • NINDS_000441
  • Bio2_000896
  • DivK1c_000441
  • NCGC00024995-04
  • KBio3_001834
  • SPECTRUM1503908
  • SDCCGMLS-0066823.P001
  • KBio2_002016
  • KBio2_004584
  • KBio2_007152
  • KBio1_000441
  • Lopac0_001201
  • KBio2_000492
  • KBio2_003060
  • UPCMLD-DP108:001

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Leishmania major beta tubulin Curated by TDR Targets References
Leishmania major epsilon tubulin, putative Curated by TDR Targets References
Leishmania major alpha tubulin Curated by TDR Targets References
Leishmania major beta tubulin Curated by TDR Targets References
Leishmania major beta tubulin Curated by TDR Targets References
Leishmania major alpha tubulin Curated by TDR Targets References
Leishmania major alpha tubulin Curated by TDR Targets References
Leishmania major alpha tubulin Curated by TDR Targets References
Leishmania major beta tubulin Curated by TDR Targets References
Leishmania major alpha tubulin Curated by TDR Targets References
Leishmania major beta tubulin Curated by TDR Targets References
Leishmania major alpha tubulin Curated by TDR Targets References
Leishmania major gamma-tubulin Curated by TDR Targets References
Leishmania major zeta tubulin, putative Curated by TDR Targets References
Leishmania major beta tubulin Curated by TDR Targets References
Leishmania major beta tubulin Curated by TDR Targets References
Leishmania major beta tubulin Curated by TDR Targets References
Leishmania major alpha tubulin Curated by TDR Targets References
Leishmania major alpha tubulin Curated by TDR Targets References
Leishmania major beta tubulin Curated by TDR Targets References
Leishmania major alpha tubulin Curated by TDR Targets References
Leishmania major beta tubulin Curated by TDR Targets References
Leishmania major delta tubulin, putative Curated by TDR Targets References
Leishmania major beta tubulin Curated by TDR Targets References
Leishmania major alpha tubulin Curated by TDR Targets References
Leishmania major beta tubulin Curated by TDR Targets References
Leishmania major alpha tubulin Curated by TDR Targets References
Leishmania major beta tubulin Curated by TDR Targets References
Leishmania major alpha tubulin Curated by TDR Targets References
Leishmania major beta tubulin Curated by TDR Targets References
Leishmania major beta tubulin Curated by TDR Targets References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania donovani zeta tubulin, putative Get druggable targets OG5_145938 All targets in OG5_145938
Plasmodium vivax tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin alpha 1C chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium yoelii tubulin gamma chain Get druggable targets OG5_127652 All targets in OG5_127652
Candida albicans cytoskeletal structural protein Get druggable targets OG5_126605 All targets in OG5_126605
Cryptosporidium parvum gamma tubulin Get druggable targets OG5_127652 All targets in OG5_127652
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana epsilon tubulin, putative Get druggable targets OG5_130726 All targets in OG5_130726
Entamoeba histolytica tubulin alpha-1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Entamoeba histolytica tubulin gamma chain Get druggable targets OG5_127652 All targets in OG5_127652
Echinococcus granulosus peroxisome assembly protein 26 Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major gamma-tubulin Get druggable targets OG5_127652 All targets in OG5_127652
Echinococcus multilocularis Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin alpha-1 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin epsilon chain Get druggable targets OG5_130726 All targets in OG5_130726
Leishmania infantum gamma-tubulin Get druggable targets OG5_127652 All targets in OG5_127652
Loa Loa (eye worm) tubulin beta-1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium knowlesi tubulin gamma chain, putative Get druggable targets OG5_127652 All targets in OG5_127652
Leishmania braziliensis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium vivax tubulin gamma chain, putative Get druggable targets OG5_127652 All targets in OG5_127652
Trichomonas vaginalis tubulin alpha-1 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit alpha Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi tubulin alpha-2 chain Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin beta-1 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium berghei tubulin gamma chain, putative Get druggable targets OG5_127652 All targets in OG5_127652
Schistosoma japonicum ko:K07375 tubulin beta, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma cruzi tubulin delta chain Get druggable targets OG5_143817 All targets in OG5_143817
Plasmodium yoelii tubulin beta chain Get druggable targets OG5_130726 All targets in OG5_130726
Echinococcus granulosus tubulin alpha 3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis hypothetical protein Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin gamma chain, putative Get druggable targets OG5_130726 All targets in OG5_130726
Brugia malayi beta-tubulin, identical Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major epsilon tubulin, putative Get druggable targets OG5_130726 All targets in OG5_130726
Leishmania infantum beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania donovani epsilon tubulin, putative Get druggable targets OG5_130726 All targets in OG5_130726
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Neospora caninum tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium knowlesi alpha-tubulin II, putative Get druggable targets OG5_126605 All targets in OG5_126605
Babesia bovis tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin alpha 3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium vivax tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi tubulin alpha chain - mouse Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin beta 4A class IVa Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum ko:K07374 tubulin alpha, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei gambiense epsilon tubulin Get druggable targets OG5_130726 All targets in OG5_130726
Trypanosoma congolense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei gambiense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin gamma 1 chain Get druggable targets OG5_127652 All targets in OG5_127652
Trypanosoma brucei gambiense delta tubulin, putative Get druggable targets OG5_143817 All targets in OG5_143817
Candida albicans gamma tubulin-like protein Get druggable targets OG5_127652 All targets in OG5_127652
Theileria parva tubulin gamma chain, putative Get druggable targets OG5_127652 All targets in OG5_127652
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin beta-1 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania donovani tubulin gamma chain Get druggable targets OG5_127652 All targets in OG5_127652
Plasmodium falciparum tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium yoelii Tubulin/FtsZ family, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin, beta 4A class IVa Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma congolense tubulin gamma chain Get druggable targets OG5_127652 All targets in OG5_127652
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Theileria parva Tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana zeta tubulin, putative Get druggable targets OG5_145938 All targets in OG5_145938
Trypanosoma brucei alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis peroxisome assembly protein 26 Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Brugia malayi Tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania mexicana Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin, putative Get druggable targets OG5_127652 All targets in OG5_127652
Echinococcus multilocularis tubulin beta 1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum ko:K07374 tubulin alpha, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma cruzi epsilon tubulin, putative Get druggable targets OG5_130726 All targets in OG5_130726
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum zeta tubulin, putative Get druggable targets OG5_145938 All targets in OG5_145938
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma cruzi tubulin delta chain Get druggable targets OG5_143817 All targets in OG5_143817
Entamoeba histolytica tubulin family protein Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin alpha-1 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma congolense zeta tubulin Get druggable targets OG5_145938 All targets in OG5_145938
Cryptosporidium parvum alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha 2 Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin beta 1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Neospora caninum Beta-tubulin, related Get druggable targets OG5_127652 All targets in OG5_127652
Trypanosoma cruzi epsilon tubulin, putative Get druggable targets OG5_130726 All targets in OG5_130726
Echinococcus granulosus Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Cryptosporidium parvum tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma congolense epsilon tubulin Get druggable targets OG5_130726 All targets in OG5_130726
Leishmania braziliensis zeta tubulin, putative Get druggable targets OG5_145938 All targets in OG5_145938
Trypanosoma cruzi zeta tubulin, putative Get druggable targets OG5_145938 All targets in OG5_145938
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha 2 Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei gambiense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Theileria parva tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium falciparum alpha tubulin 1 Get druggable targets OG5_126605 All targets in OG5_126605
Neospora caninum tubulin delta chain, putative Get druggable targets OG5_143817 All targets in OG5_143817
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma congolense alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum ko:K10389 tubulin gamma, putative Get druggable targets OG5_127652 All targets in OG5_127652
Echinococcus granulosus tubulin subunit TubB Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania infantum alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis gamma-tubulin Get druggable targets OG5_127652 All targets in OG5_127652
Babesia bovis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei tubulin gamma chain Get druggable targets OG5_127652 All targets in OG5_127652
Leishmania major zeta tubulin, putative Get druggable targets OG5_145938 All targets in OG5_145938
Plasmodium vivax tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin alpha-2/alpha-4 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Candida albicans gamma tubulin-like protein Get druggable targets OG5_127652 All targets in OG5_127652
Schistosoma mansoni tubulin subunit alpha Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium berghei alpha tubulin 2 Get druggable targets OG5_126605 All targets in OG5_126605
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein Get druggable targets OG5_130726 All targets in OG5_130726
Neospora caninum tubulin epsilon chain, putative Get druggable targets OG5_130726 All targets in OG5_130726
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania mexicana alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin alpha-3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit epsilon Get druggable targets OG5_130726 All targets in OG5_130726
Trichomonas vaginalis tubulin gamma chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium vivax tubulin epsilon chain, putative Get druggable targets OG5_130726 All targets in OG5_130726
Loa Loa (eye worm) beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium falciparum tubulin epsilon chain, putative Get druggable targets OG5_130726 All targets in OG5_130726
Loa Loa (eye worm) tubulin gamma chain Get druggable targets OG5_127652 All targets in OG5_127652
Leishmania infantum delta tubulin, putative Get druggable targets OG5_143817 All targets in OG5_143817
Brugia malayi Tubulin alpha-2 chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Cryptosporidium hominis beta-catenin-like repeat protein Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium knowlesi alpha tubulin, putative Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha-2 chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Babesia bovis tubulin gamma chain Get druggable targets OG5_127652 All targets in OG5_127652
Loa Loa (eye worm) tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma cruzi zeta tubulin, putative Get druggable targets OG5_145938 All targets in OG5_145938
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major delta tubulin, putative Get druggable targets OG5_143817 All targets in OG5_143817
Leishmania braziliensis delta tubulin, putative Get druggable targets OG5_143817 All targets in OG5_143817
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Toxoplasma gondii beta-1 tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium falciparum tubulin gamma chain Get druggable targets OG5_127652 All targets in OG5_127652
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium berghei alpha tubulin 1 Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi Tubulin beta-1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin alpha 3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei gambiense alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) alpha-tubulin isotype 2 Get druggable targets OG5_126605 All targets in OG5_126605
Cryptosporidium hominis gamma-tubulin Get druggable targets OG5_127652 All targets in OG5_127652
Brugia malayi Tubulin alpha-2 chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium knowlesi tubulin epsilon chain, putative Get druggable targets OG5_130726 All targets in OG5_130726
Loa Loa (eye worm) BEN-1 protein Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei epsilon tubulin Get druggable targets OG5_130726 All targets in OG5_130726
Echinococcus multilocularis tubulin subunit TubB Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma congolense tubulin delta chain Get druggable targets OG5_143817 All targets in OG5_143817
Plasmodium berghei tubulin epsilon chain, putative Get druggable targets OG5_130726 All targets in OG5_130726
Trypanosoma cruzi tubulin gamma chain Get druggable targets OG5_127652 All targets in OG5_127652
Trypanosoma brucei epsilon tubulin Get druggable targets OG5_130726 All targets in OG5_130726
Giardia lamblia Gamma tubulin Get druggable targets OG5_127652 All targets in OG5_127652
Brugia malayi Tubulin gamma chain Get druggable targets OG5_127652 All targets in OG5_127652
Schistosoma mansoni alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Entamoeba histolytica tubulin family protein Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta-4 chain Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei zeta tubulin Get druggable targets OG5_145938 All targets in OG5_145938
Trypanosoma brucei zeta tubulin, putative Get druggable targets OG5_145938 All targets in OG5_145938
Plasmodium yoelii tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma cruzi beta tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania donovani alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium berghei tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma cruzi alpha tubulin, putative Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) BEN-1 protein Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium falciparum alpha tubulin 2 Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Toxoplasma gondii alpha-tubulin I, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin alpha chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Toxoplasma gondii beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha 1C chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania donovani tubulin delta chain Get druggable targets OG5_143817 All targets in OG5_143817
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha 1C chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium yoelii tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei tubulin delta chain Get druggable targets OG5_143817 All targets in OG5_143817
Echinococcus granulosus Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Giardia lamblia Alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Toxoplasma gondii beta-tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum epsilon tubulin, putative Get druggable targets OG5_130726 All targets in OG5_130726
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Cryptosporidium hominis alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit alpha Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha 3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Giardia lamblia Alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin beta-4 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin alpha-1C chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin beta-7 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Entamoeba histolytica tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin epsilon chain Get druggable targets OG5_130726 All targets in OG5_130726
Toxoplasma gondii alpha tubulin TUBA1 Get druggable targets OG5_126605 All targets in OG5_126605
Babesia bovis tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha 1C chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Toxoplasma gondii tubulin, putative Get druggable targets OG5_130726 All targets in OG5_130726
Echinococcus multilocularis tubulin gamma 1 chain Get druggable targets OG5_127652 All targets in OG5_127652
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei gambiense gamma tubulin Get druggable targets OG5_127652 All targets in OG5_127652
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin beta-2A chain Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin gamma chain, putative Get druggable targets OG5_127652 All targets in OG5_127652
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis epsilon tubulin, putative Get druggable targets OG5_130726 All targets in OG5_130726
Leishmania mexicana gamma-tubulin Get druggable targets OG5_127652 All targets in OG5_127652
Schistosoma japonicum ko:K10391 tubulin epsilon, putative Get druggable targets OG5_130726 All targets in OG5_130726
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha 2 Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Theileria parva tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum ko:K07375 tubulin beta, putative Get druggable targets OG5_126611 All targets in OG5_126611
Giardia lamblia Epsilon tubulin Get druggable targets OG5_130726 All targets in OG5_130726
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit gamma Get druggable targets OG5_127652 All targets in OG5_127652
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein Get druggable targets OG5_143817 All targets in OG5_143817
Trypanosoma brucei gambiense zeta tubulin Get druggable targets OG5_145938 All targets in OG5_145938
Trichomonas vaginalis tubulin alpha-1 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Plasmodium falciparum tubulin gamma chain alpha tubulin 451 aa 457 aa 30.9 %
Trypanosoma brucei epsilon tubulin epsilon tubulin, putative 470 aa 488 aa 68.0 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Plasmodium falciparum tubulin gamma chain alpha tubulin 451 aa 457 aa 30.9 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Plasmodium falciparum tubulin gamma chain alpha tubulin 451 aa 457 aa 30.9 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Plasmodium falciparum tubulin gamma chain alpha tubulin 451 aa 457 aa 30.9 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Plasmodium falciparum tubulin gamma chain alpha tubulin 451 aa 457 aa 30.9 %
Plasmodium falciparum tubulin gamma chain alpha tubulin 451 aa 457 aa 30.9 %
Plasmodium falciparum tubulin gamma chain alpha tubulin 451 aa 457 aa 30.9 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Plasmodium falciparum tubulin gamma chain alpha tubulin 451 aa 457 aa 30.9 %
Plasmodium falciparum tubulin gamma chain alpha tubulin 451 aa 457 aa 30.9 %
Plasmodium falciparum tubulin gamma chain alpha tubulin 451 aa 457 aa 30.9 %
Plasmodium falciparum tubulin gamma chain alpha tubulin 451 aa 457 aa 30.9 %
Plasmodium falciparum tubulin epsilon chain, putative gamma-tubulin 447 aa 479 aa 28.2 %
Plasmodium falciparum tubulin gamma chain alpha tubulin 451 aa 457 aa 30.9 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) 0 Net cell kill in ip dosed mouse implanted with 12 human tumor cell lines ChEMBL. 16913702
Activity (functional) = -23 % Compound was evaluated to determine the stenosis in Rabbit Iliac Arteries value expressed as difference from bare stents ChEMBL. 15084126
Activity (functional) = -11 % Compound was evaluated to determine the stenosis in Rabbit Iliac Arteries value expressed as difference from polymercoatedstents ChEMBL. 15084126
Activity (functional) 11 % Ability of the compound to induce cells in G0/G1 phase ChEMBL. 15369401
Activity (functional) 18 % Ability of the compound to induce cells in S phase ChEMBL. 15369401
Activity (functional) = 57.7 % Antiproliferative activity of the paclitaxel-TPCD complex was tested against K562 erythroleukemia after 72 hr at a concentration of 1E-6 mg/mL using MTT cytotoxicity assay ChEMBL. 14561082
Activity (functional) 71 % Ability of the compound to induce cells in G2/M phase ChEMBL. 15369401
Body weight change (functional) = 7.8 % Percentage change in the body weight on day 20 after intravenous administration (10 mg/kg) against B16 melanoma (implanted subcutaneously in mice). ChEMBL. 12392737
Body weight change (functional) = 16.9 % Percentage change in the body weight on day 20 after intravenous administration (8 mg/Kg) against human breast cancer xenograph Bcap-37 (grown sc in athymic mice) ChEMBL. 12392737
Cytotoxicity (functional) = 3.5 ng ml-1 Cytotoxicity against human colon adenocarcinoma HT-29 cell line ChEMBL. 7739007
Cytotoxicity (functional) = 4.3 ng ml-1 Cytotoxicity against human lung carcinoma A549 cell line ChEMBL. 7739007
Cytotoxicity (functional) = 6.3 ng ml-1 Cytotoxicity against mouse melanoma B16F10 cell line ChEMBL. 7739007
Cytotoxicity (functional) = 11 ng ml-1 Cytotoxicity against mouse lymphocytic leukemia P388 cell line ChEMBL. 7739007
EC50 (functional) = 0.009 uM Cell cycle arrest in A431 cells by accumulation at G2/M phase ChEMBL. 16377187
EC50 (functional) = 0.054 uM Effective concentration required to arrest propidium iodide stained K562 cells in G2/M phase ChEMBL. 12852768
EC50 (functional) > 10 uM Cell cycle arrest in NCI/ADR (MDR) cells by accumulation at G2/M phase ChEMBL. 16377187
ED50 (functional) = 4 nM Cytotoxicity of the compound against MCF-7 cells with reference to taxol ChEMBL. 11334567
ED50 (functional) = 0.001 ug ml-1 Effective dose required for inhibitory activity against KB human tumor cell line. ChEMBL. 12852747
ED50 (functional) = 0.002 ug ml-1 Effective dose required for inhibitory activity against 1A9 human tumor cell line. ChEMBL. 12852747
ED50 (functional) = 0.005 ug ml-1 Effective dose required for inhibitory activity against A549 human tumor cell line. ChEMBL. 12852747
ED50 (functional) = 0.011 ug ml-1 Effective dose required for inhibitory activity against HCT-8 human tumor cell line. ChEMBL. 12852747
ED50 (functional) = 0.041 ug ml-1 Effective dose required for inhibitory activity against PTX10 human tumor cell line ChEMBL. 12852747
ED50 (binding) = 0.4 uM Tubulin binding of the compound with reference to taxol was determined by tubulin assembly assay ChEMBL. 11334567
ED50 (functional) = 0.4 uM Effective dose which causes polymerization of 50% of the tubulin present at 37 degree C in Microtubule assembly assay ChEMBL. 10743961
ED50 (functional) = 0.86 uM Concentration of the compound that induces microtubule assembly (tublin obtained from porcine brain) by 50% in the absence of GTP ChEMBL. 9925441
ED50 (functional) = 0.93 uM Tested for the reduction of the supernatant protein concentration by tubulin assembly assay ChEMBL. 7915328
eLog D (ADMET) = 4.45 HPLC capacity factor (k') ChEMBL. 12061889
fi (ADMET) = 0 Fraction ionized (pH 7.4) ChEMBL. 12061889
FR (functional) = 11 Fold resistance of the compound was calculated as IC50 ratio between retrovirally transformed P388/VMDRC.04 and parental P388/S cells ChEMBL. 10843209
fu (ADMET) = 0.03 Unbound fraction (plasma) ChEMBL. 12061889
fut (ADMET) = 0.005 Unbound fraction (tissues) ChEMBL. 12061889
GI50 (functional) = 0.063 uM Tested for inhibition of cell proliferation activity in human uterus sarcoma MES-SA cell ChEMBL. 12773051
GI50 (functional) > 10 uM Tested for inhibition of cell proliferation activity in doxorubicin resistant human uterus sarcoma MES-SA/DX5 cell ChEMBL. 12773051
IC50 (functional) 0 Inhibition of tubulin polymerization ChEMBL. 16377187
IC50 (binding) 0 Displacement of [3H]colchicine from tubulin at 65 nM ChEMBL. 16377187
IC50 (functional) = 0.09 nM Cytotoxicity of the compound expressed as concentration required to inhibit cell growth by 50% on continuous exposure time of 96h in L1210 cell line by MTT assay. ChEMBL. 12392737
IC50 (functional) = 0.31 nM Cytotoxicity of the compound expressed as concentration required to inhibit cell growth by 50% on continuous exposure time of 96h in PG-49 cell line by MTT assay. ChEMBL. 12392737
IC50 (functional) = 0.5 nM Cytotoxicity of the compound expressed as concentration required to inhibit cell growth by 50% on continuous exposure time of 96h in MCF-7 cell line by MTT assay. ChEMBL. 12392737
IC50 (functional) = 0.58 nM Cytotoxicity of the compound expressed as concentration required to inhibit cell growth by 50% on continuous exposure time of 72 hr in L1210 cell line by MTT assay. ChEMBL. 12392737
IC50 (functional) = 1 nM The compound was tested for inhibition concentration against U-937 cell line ChEMBL. 7907372
IC50 (functional) = 1.6 nM The compound was tested for inhibition concentration against MOLT-4 cell line ChEMBL. 7907372
IC50 (functional) = 1.7 nM Inhibitory activity against the growth of MCF-7 (human breast carcinoma) cell line after 72 hours of drug exposure ChEMBL. 10617084
IC50 (functional) = 1.7 nM In vitro cytotoxicity of compound against human MCF-7 (breast) cancer cell line after 72 hr of drug exposure ChEMBL. 12477344
IC50 (functional) = 1.7 nM In vitro cytotoxycity of the compound against MCF-7 cell line ChEMBL. 14584931
IC50 (functional) = 1.7 nM Cytotoxicity against human mammary tumor cell line MCF7-S ChEMBL. 16298526
IC50 (functional) = 2.14 nM Cytotoxicity of the compound expressed as concentration required to inhibit cell growth by 50% on continuous exposure time of 72 hr in PG-49 cell line by MTT assay. ChEMBL. 12392737
IC50 (functional) = 2.87 nM Cytotoxicity of the compound expressed as concentration required to inhibit cell growth by 50% on continuous exposure time of 72 hr in MCF-7 cell line by MTT assay. ChEMBL. 12392737
IC50 (functional) = 2.92 nM Concentration required to inhibit the growth of paclitaxel-sensitive human epidermoid carcinoma cells KB-31 by 50 percent (72 h exposure) ChEMBL. 11133086
IC50 (functional) = 3 nM In vitro cytotoxicity of compound against human A549 (non small cell lung) cancer cell line after 72 hr of drug exposure ChEMBL. 12477344
IC50 (functional) = 3.1 nM Inhibitory activity against the growth of LCC6-WT (human breast carcinoma) cell line after 72 hours of drug exposure ChEMBL. 10617084
IC50 (functional) = 3.4 nM Concentration of compound to inhibit the growth of human A2780 ovarian carcinoma cells(in vitro) ChEMBL. 9288161
IC50 (functional) = 3.6 nM In vitro cytotoxicity of compound against human A549 (non small cell lung) cancer cell line after 72 hr of drug exposure ChEMBL. 12477344
IC50 (functional) = 3.9 nM Inhibitory concentration of the compound against KB-3-1 cells was evaluated ChEMBL. 15341492
IC50 (functional) = 4 nM Compound was tested for cytotoxicity against human colon tumor cell line (HCT-116) ChEMBL. 11277525
IC50 (functional) = 4 nM Compound was tested for cytotoxicity against human colon tumor cell line (HCT-116) ChEMBL. 11277526
IC50 (functional) = 4.6 nM In vitro cytotoxycity of the compound against A2780CIS cell line ChEMBL. 14584931
IC50 (functional) = 5.3 nM In vitro cytotoxycity of the compound against A2780 cell line ChEMBL. 14584931
IC50 (functional) = 6 nM Compound was tested for the cytotoxicity against KB-3-1 cell line; value ranges from 2-6 nM ChEMBL. 15261296
IC50 (functional) = 8.9 nM Inhibitory concentration of the compound against KM20 cells was evaluated ChEMBL. 15341492
IC50 (functional) = 16 nM The compound was tested for susceptibility to a multidrug resistant(MDR) subline of murine P388/S leukemia cells under continuous exposure conditions for 3-4 days ChEMBL. 10843209
IC50 (functional) = 17.3 nM Inhibitory concentration against Lox melanoma cells ChEMBL. 15341492
IC50 (functional) = 27 nM The compound was tested for cell growth inhibition against DLD-1 human colon cancer cells under continuous exposure conditions for 3-4 days ChEMBL. 10843209
IC50 (functional) = 37.7 nM Inhibitory concentration of the compound against NCI-H1299 cells was evaluated ChEMBL. 15341492
IC50 (functional) = 80 nM Compound was tested for the cytotoxicity against KB-8-5 cell line expressing P-glycoprotein; value ranges from 30-80 nM ChEMBL. 15261296
IC50 (functional) = 92 nM Inhibitory concentration of the compound against S1 cells was evaluated ChEMBL. 15341492
IC50 (functional) = 170 nM The compound was tested for susceptibility to P-glycoprotein(PgP) mediated drug efflux using murine P388/VMDRC.04 cells under continuous exposure conditions for 3-4 days ChEMBL. 10843209
IC50 (functional) = 299 nM In vitro cytotoxicity of compound against human MCF-7-MDR (breast) cancer cell line after 72 hr of drug exposure ChEMBL. 12477344
IC50 (functional) = 299 nM In vitro cytotoxycity of the compound against MCF7-R cell line ChEMBL. 14584931
IC50 (functional) = 300 nM Inhibitory activity against the growth of MCF-7R ( multi drug resistant human breast carcinoma) cell line after 72 hours of drug exposure ChEMBL. 10617084
IC50 (functional) = 346 nM Inhibitory activity against the growth of LCC6-MDR (Multi Drug Resistant 1 transduced line) cell line after 72 hours of drug exposure ChEMBL. 10617084
IC50 (functional) = 438 nM Inhibitory concentration of the compound against HCT-15 cells was evaluated ChEMBL. 15341492
IC50 (functional) = 490 nM Inhibitory concentration against LCC6-MDR human breast cancer cell line ChEMBL. 11549446
IC50 (functional) = 550 nM Cytotoxicity against human mammary tumor cell line MCF7-R ChEMBL. 16298526
IC50 (functional) = 626 nM Concentration required to inhibit the growth of paclitaxel-resistant human epidermoid carcinoma cells KB-8511 by 50 percent (72 h exposure) ChEMBL. 11133086
IC50 (functional) = 2688 nM In vitro cytotoxycity of the compound against A2780ADR cell line ChEMBL. 14584931
IC50 (functional) > 3000 nM Compound was tested for the cytotoxicity against KB-V1 cell line expressing P-glycoprotein ChEMBL. 15261296
IC50 (functional) = 4498 nM In vitro cytotoxycity of the compound against A2780TAX cell line ChEMBL. 14584931
IC50 (functional) = 0.0001 ug ml-1 Invitro cytotoxicity of compound against MCF7, human breast cancer was defined by microculture tetrazolium assay ChEMBL. 12620075
IC50 (functional) = 0.01 ug ml-1 Invitro cytotoxicity of compound against HT-29, human colorectal adenocarcinoma was defined by microculture tetrazolium assay ChEMBL. 12620075
IC50 (functional) = 1.34 ug ml-1 Invitro cytotoxicity of compound against EL4, mouse thymoma was defined by microculture tetrazolium assay ChEMBL. 12620075
IC50 (functional) = 2.27 ug ml-1 Invitro cytotoxicity of compound against P388, mouse fibroblast leukemia was defined by microculture tetrazolium assay ChEMBL. 12620075
IC50 (functional) = 7.39 ug ml-1 Invitro cytotoxicity of compound against Bewo, human choriocarcinoma was defined by microculture tetrazolium assay ChEMBL. 12620075
IC50 (functional) = 0.0003 uM The compound was evaluated for the growth inhibition of Dx5 w/PSC cell lines using MTT assay. ChEMBL. 10698449
IC50 (functional) = 0.0006 uM The compound was evaluated for the growth inhibition of MES-SA uterine tumor cell lines using MTT assay. ChEMBL. 10698449
IC50 (functional) = 0.0008 uM Cytotoxicity against paclitaxel sensitive LCC6-WT-human breast carcinoma cell line ChEMBL. 11549446
IC50 (functional) = 0.0015 uM Concentration required for growth inhibition of human lymphoblastic leukemic cell line (CCRF-CEM) was determined ChEMBL. 15324894
IC50 (functional) > 0.0021 uM Inhibitory concentration of the compound against human KB-3-1 cells ChEMBL. 15863325
IC50 (functional) = 0.0026 uM Concentration required for growth inhibition of human HCT-116 colon tumor cell line (CCRF-CEM) was determined ChEMBL. 15324894
IC50 (functional) = 0.0029 uM Concentration required for growth inhibition of human lung carcinoma cell line (CCRF-CEM) was determined ChEMBL. 15324894
IC50 (functional) = 0.006 uM Antiproliferative activity against LT12 tumor cell line ChEMBL. 12852768
IC50 (functional) = 0.01 uM Cytotoxic activity against cellular metabolic activity of Cervix KB/HeLa tumor cell line using XTT proliferation assay after incubation with the compound for 48 h ChEMBL. 12852768
IC50 (functional) = 0.01 uM Cytotoxic activity against cellular metabolic activity of Ovary SKOV3 tumor cell line using XTT proliferation assay after incubation with the compound for 48 h ChEMBL. 12852768
IC50 (functional) = 0.01 uM Cytotoxic activity against cellular metabolic activity of Glioma SF-268 tumor cell line using XTT proliferation assay after incubation with the compound for 48 h ChEMBL. 12852768
IC50 (functional) = 0.01 uM Cytotoxic activity against cellular metabolic activity of Lung NCI-H460 tumor cell line using XTT proliferation assay after incubation with the compound for 48 h ChEMBL. 12852768
IC50 (functional) = 0.01 uM Cytotoxic activity against human colon adenocarcinoma RKO cells without ectopic inducible expression of cyclin-dependent kinase inhibitor p27kip1 ChEMBL. 12852768
IC50 (functional) = 0.04 uM Antiproliferative activity against P388 tumor cell line ChEMBL. 12852768
IC50 (functional) = 0.06 uM Antiproliferative activity against L1210 tumor cell line ChEMBL. 12852768
IC50 (functional) = 0.14 uM Concentration required for growth inhibition of taxol resistant human lymphoblastic leukemic cell line (CCRF-CEM/taxol) was determined ChEMBL. 15324894
IC50 (functional) = 0.312 uM In vitro anti-cancer activity against the colon cancer cell line SW480 was determined ChEMBL. 12873496
IC50 (functional) = 0.4 uM Antiproliferative activity against LT12 phenotype LT12 MDR tumor cell line ChEMBL. 12852768
IC50 (functional) > 0.6 uM Inhibitory concentration of the compound against KB-G2 cells ChEMBL. 15863325
IC50 (functional) = 0.612 uM Cytotoxicity against paclitaxel resistant LCC6-MDR-MDR1 transfected cell line ChEMBL. 11549446
IC50 (functional) ~~ 1 uM In vitro antiproliferative effect of the compound on cultured human coronary artery smooth muscle cells (hCASMC) ChEMBL. 15084126
IC50 (functional) = 1 uM Concentration required to inhibit 50% of rate of microtubule disassembly ChEMBL. 15537348
IC50 (functional) = 1.62 uM Concentration required for growth inhibition of vinblastine resistant human lymphoblastic leukemic cell line (CCRF-CEM/VBL) was determined ChEMBL. 15324894
IC50 (functional) = 2.7 uM The compound was evaluated for the growth inhibition of Dx5 cell lines using MTT assay. ChEMBL. 10698449
IC50 (functional) > 3 uM Cytotoxic activity against human colon adenocarcinoma RKO cells with ectopic inducible expression of cyclin-dependent kinase inhibitor p27kip1 ChEMBL. 12852768
IC50 (functional) > 5 uM Antiproliferative activity against L1210 phenotype L1210 VCR tumor cell line ChEMBL. 12852768
IC50 (functional) > 5 uM Antiproliferative activity against P388 phenotype P388 ADR tumor cell line ChEMBL. 12852768
IC50 reduction (functional) = 0 % Percent reduction of inhibitory concentration against LCC6-MDR human breast cancer cell line at 5 uM concentration ChEMBL. 11549446
IC99 (functional) = 230 nM The compound was tested for its ability to maintain a irreversible mitotic block 10 h after drug washout using flow cytometric analysis of U937 human histiocytic lymphoma cells ChEMBL. 10843209
ID50 (functional) = 2.3 nM Compound was tested in vitro for cytotoxicity against HCT116, human colon cancer cells (taxol-resistant) at a drug concentration producing 50% inhibition of colony formation ChEMBL. 11965362
ID50 (functional) = 4 nM Compound was tested in vitro for cytotoxicity against PC-3, human prostate cancer cells (taxol-sensitive) at a drug concentration producing 50% inhibition of colony formation ChEMBL. 11965362
ID50 (functional) > 50 nM Compound was tested in vitro for cytotoxicity against VM46 subline of HCT116 (taxol-sensitive) at a drug concentration producing 50% inhibition of colony formation ChEMBL. 11965362
ID50 (functional) > 10000 nM Compound was tested in vitro for cytotoxicity against MCF-7ADR, human breast cancer cells (taxol-resistant) at a drug concentration producing 50% inhibition of colony formation ChEMBL. 11965362
Inhibition (functional) Active 0 Inhibitory activity of the compound in presence of VX-710 inhibitor; successful in clinical trials ChEMBL. 15012986
Inhibition (functional) 0 Drug interaction towards A549 cell line was determined in terms of combination index; Not available ChEMBL. 15012986
Inhibition (functional) = 1.227 Drug interaction towards DLKP cell line was determined in terms of combination index and was found to have antagonistic effect in presence of Indomethacin ChEMBL. 15012986
Inhibition (functional) = 1.233 Drug interaction towards DLKP cell line was determined in terms of combination index and was found to have antagonistic effect in presence of Sulindac ChEMBL. 15012986
Inhibition (functional) = 1.349 Drug interaction towards A549 cell line was determined in terms of combination index and was found to have antagonistic effect in presence of Tolmetin ChEMBL. 15012986
Inhibition (functional) = 1.539 Drug interaction towards A549 cell line was determined in terms of combination index and was found to have antagonistic effect in presence of Sulindac ChEMBL. 15012986
Inhibition (functional) = 2.234 Drug interaction towards A549 cell line was determined in terms of combination index and was found to have antagonistic effect in presence of Indomethacin ChEMBL. 15012986
Inhibition (functional) = 24.8 Relative resistance of the compound is the ratio of IC50 values of drug with JTV-519 to that in absence of the reversing agent ChEMBL. 15012986
Inhibition (functional) 0 % Compound was evaluated for the inhibition of MAP-rich tubulin polymerisation at 0.3 uM; promotes tubulin polymerisation ChEMBL. 15261296
Km (binding) = 0.7 uM Michaelis menton constant for human P-glycoprotein expressed in Sf9 cells ChEMBL. 15863325
Log 1/Km (ADMET) = -1.2553 log (1/Km) value for human liver microsome cytochrome P450 3A4 ChEMBL. 15990295
Log GI50 (functional) = -8.6 Compound was tested for growth inhibitory activity against SR cell line ChEMBL. 9871773
Log GI50 (functional) = -8.6 Compound was tested for growth inhibitory activity against MDA-MB-435 cell line ChEMBL. 9871773
Log GI50 (functional) = -8.5 Compound was tested for growth inhibitory activity against NCI-H522 cell line ChEMBL. 9871773
Log GI50 (functional) = -8.5 Compound was tested for growth inhibitory activity against COLO 205 cell line ChEMBL. 9871773
Log GI50 (functional) = -8.5 Compound was tested for growth inhibitory activity against KM12 cell line ChEMBL. 9871773
Log GI50 (functional) = -8.5 Compound was tested for growth inhibitory activity against SF-539 cell line ChEMBL. 9871773
Log GI50 (functional) = -8.5 Compound was tested for growth inhibitory activity against OVCAR-3 cell line ChEMBL. 9871773
Log GI50 (functional) = -8.5 Compound was tested for growth inhibitory activity against MCF-7 cell line ChEMBL. 9871773
Log GI50 (functional) = -8.5 Compound was tested for growth inhibitory activity against HS 578T cell line ChEMBL. 9871773
Log GI50 (functional) = -8.4 Compound was tested for growth inhibitory activity against MOLT-4 cell line ChEMBL. 9871773
Log GI50 (functional) = -8.4 Compound was tested for growth inhibitory activity against HCC-2998 cell line ChEMBL. 9871773
Log GI50 (functional) = -8.4 Compound was tested for growth inhibitory activity against U251 cell line ChEMBL. 9871773
Log GI50 (functional) = -8.4 Compound was tested for growth inhibitory activity against PC-3 cell line ChEMBL. 9871773
Log GI50 (functional) = -8.4 Compound was tested for growth inhibitory activity against SK-MEL-5 cell line ChEMBL. 9871773
Log GI50 (functional) = -8.4 Compound was tested for growth inhibitory activity against UACC-62 cell line ChEMBL. 9871773
Log GI50 (functional) = -8.3 Compound was tested for growth inhibitory activity against HL-60 cell line ChEMBL. 9871773
Log GI50 (functional) = -8.3 Compound was tested for growth inhibitory activity against SK-MEL-2 cell line ChEMBL. 9871773
Log GI50 (functional) = -8.3 Compound was tested for growth inhibitory activity against OVCAR-8 cell line ChEMBL. 9871773
Log GI50 (functional) = -8.2 Compound was tested for growth inhibitory activity against BT-549 cell line ChEMBL. 9871773
Log GI50 (functional) = -8.1 Compound was tested for growth inhibitory activity against SF-268 cell line ChEMBL. 9871773
Log GI50 (functional) = -8.1 Compound was tested for growth inhibitory activity against RXF 393 cell line ChEMBL. 9871773
Log GI50 (functional) = -8 Compound was tested for growth inhibitory activity against SNB-19 cell line ChEMBL. 9871773
Log GI50 (functional) = -8 Compound was tested for growth inhibitory activity against M14 cell line ChEMBL. 9871773
Log GI50 (functional) = -8 Compound was tested for growth inhibitory activity against SK-OV-3 cell line ChEMBL. 9871773
Log GI50 (functional) = -7.8 Compound was tested for growth inhibitory activity against HOP-62 cell line ChEMBL. 9871773
Log GI50 (functional) = -7.8 Compound was tested for growth inhibitory activity against SF-295 cell line ChEMBL. 9871773
Log GI50 (functional) = -7.7 Compound was tested for growth inhibitory activity against 786-0 cell line ChEMBL. 9871773
Log GI50 (functional) = -7.5 Compound was tested for growth inhibitory activity against NCI-H226 cell line ChEMBL. 9871773
Log GI50 (functional) = -7.1 Compound was tested for growth inhibitory activity against A498 cell line ChEMBL. 9871773
Log GI50 (functional) = -6.7 Compound was tested for growth inhibitory activity against HCT-15 cell line ChEMBL. 9871773
Log GI50 (functional) = -6 Compound was tested for growth inhibitory activity against UO-31 cell line ChEMBL. 9871773
Log GI50 (functional) = -5.5 Compound was tested for growth inhibitory activity against MCF-7/ADR cell line ChEMBL. 9871773
Log GI50 (functional) = 8.6 Compound was tested for growth inhibitory activity against HT-29 cell line ChEMBL. 9871773
Log kill (functional) < 0.7 In vivo activity against transplanted Mam-16/C/Adr tumors of mice ChEMBL. 11356111
Log kill (functional) < 0.7 In vivo activity against transplanted Mam-16/C/ Taxol tumors of mice ChEMBL. 11356111
Log kill (functional) < 0.7 In vivo activity against transplanted Panc-02 tumors of mice ChEMBL. 11356111
Log kill (functional) < 0.7 In vivo activity against transplanted Mam-17/Adr tumors of mice ChEMBL. 11356111
Log kill (functional) = 0.7 In vivo activity against transplanted colon-26 tumors of mice ChEMBL. 11356111
Log kill (functional) = 0.7 In vivo activity against transplanted Mel-B16 tumors of mice ChEMBL. 11356111
Log kill (functional) < 0.7 In vivo activity against transplanted Squam lung-LC12 tumors of mice ChEMBL. 11356111
Log kill (functional) < 0.7 In vivo activity against iv transplanted AML Leukemia 1498 tumors of mice ChEMBL. 11356111
Log kill (functional) < 1 In vivo activity against iv transplanted Leukemia L1210 tumors of mice ChEMBL. 11356111
Log kill (functional) = 1.2 In vivo activity against transplanted colon-51 tumors of mice ChEMBL. 11356111
Log kill (functional) > 2.8 In vivo activity against transplanted colon-38 tumors of mice ChEMBL. 11356111
Log kill (functional) > 2.8 In vivo activity against transplanted Mam-16/C tumors of mice ChEMBL. 11356111
Log kill (functional) > 2.8 In vivo activity against transplanted Panc-03 tumors of mice ChEMBL. 11356111
Log kill (functional) > 2.8 In vivo activity against transplanted Mam-17 tumors of mice ChEMBL. 11356111
MCHC (functional) = 36.5 g dl-1 Mean corpuscular hemoglobin concentration(MCHC) ChEMBL. 10780911
Mitotic index (functional) = 28 nM Concentration inducing 20% mitotic index for mitotic block in murine B16 melanoma cells ChEMBL. 9288161
MTD (functional) = 40.6 mg kg-1 Compound was tested in vivo for antitumor activity, reported as maximum tolerated dose (MTD) in mice injected intravenously with drug ChEMBL. 11965362
ND (functional) 0 Effective dose of the compound required for inhibitory activity against SK-MEL-2 human tumor cell line; Not determined ChEMBL. 12852747
ND (functional) 0 Effective dose of the compound required for inhibitory activity against MCF-7 human tumor cell line; Not determined ChEMBL. 12852747
ND (functional) 0 Effective dose of the compound required for inhibitory activity against PC-3 human tumor cell line; Not determined ChEMBL. 12852747
ND (functional) 0 Effective dose of the compound required for inhibitory activity against HOS human tumor cell line; Not determined ChEMBL. 12852747
ND (functional) 0 Effective dose of the compound required for inhibitory activity against CAKI human tumor cell line; Not determined ChEMBL. 12852747
ND (functional) 0 Effective dose of the compound required for inhibitory activity against KB-VIN human tumor cell line; Not determined ChEMBL. 12852747
Platelet (functional) = 1.04 10e6 ul-1 Hematological effects in female CDF1 mice at the dose of 30mg, in platelets ChEMBL. 10780911
Ratio (functional) = 0.9 Potency differential in resistant to that of sensitive A2780CIS cell line ChEMBL. 14584931
Ratio (functional) = 1 Ratio between ED50 of compound and ED50 of taxol ChEMBL. 7915328
Ratio (functional) = 1 Cytotoxicity ratio of the compound was evaluated against human tumor cell line SKOV3 (Human ovarian cancer) after 72 h incubation ChEMBL. 10743961
Ratio (functional) = 1 Cytotoxicity ratio of the compound was evaluated against human tumor cell line WIDR (Human colon cancer) after 72 h incubation ChEMBL. 10743961
Ratio (functional) = 1 Cytotoxicity ratio of the compound was evaluated against human tumor cell line MCF-7 (Human breast cancer) after 72 h incubation ChEMBL. 10743961
Ratio (functional) = 1 Cytotoxicity ratio of the compound was evaluated against human tumor cell line BEL-7402 (Human liver cancer) after 72 h incubation relative to paclitaxel (ED50 = 1.00) ChEMBL. 10743961
Ratio (functional) = 1 Cytotoxicity ratio of the compound was evaluated against tumor cell line ECa-109 (Human esophagus cancer) after 72 h incubation ChEMBL. 10743961
Ratio (functional) = 1 ED50 compared to that of taxol. ChEMBL. 7739007
Ratio (binding) = 50 Ratio of maximum velocity to that of Km value was determined by P-glycoprotein ChEMBL. 15863325
Ratio (functional) = 112 Ratio of activities, drug resistant (R) to drug sensitive (S) carcinoma cell lines ChEMBL. 10617084
Ratio (functional) = 176 Potency differential in resistant to that of sensitive MCF7-R cell line ChEMBL. 14584931
Ratio (functional) = 177 Ratio of activities, drug resistant (R) to drug sensitive (S) carcinoma cell lines ChEMBL. 10617084
Ratio (functional) = 507 Potency differential in resistant to that of sensitive A2780ADR cell line ChEMBL. 14584931
Ratio (functional) = 849 Potency differential in resistant to that of sensitive A2780TAX cell line ChEMBL. 14584931
RBC (functional) = 8.33 10e3 ul-1 Hematological effects in female CDF1 mice at the dose of 30mg, in red blood cells ChEMBL. 10780911
Solubility = 0.25 ug ml-1 Aqueous solubility of the compound was determined ChEMBL. 12392737
Stenosis (functional) = 22.6 % Compound was evaluated to determine the stenosis in Rabbit Iliac Arteries ChEMBL. 15084126
Survivors (functional) = 0 % Antitumor activity in female CDF1 mice bearing L1210 Leukemia at the dose of 30 ug/kg and survivors(60-day) was expressed ChEMBL. 10780911
T/C (functional) = 150 % The tumor growth value was reported as ratio of surviving days of mice treated with anticancer drug to surviving days of control mice ChEMBL. 11965362
T/C (functional) = 161 % % T/C of the compound was measured in B6D2F1 mice bearing ip-implanted B16 melanoma cells at the dose of 250 ng/kg on the days 1 and 3 ChEMBL. 9288161
T/C (functional) = 215 % Compound was tested in vivo against M109 using Madison murine lung carcinoma (M109) tumor model at 40 mg/kg ChEMBL. 11277525
T/C (functional) = 246 % Compound was tested in vivo against M109 using Madison murine lung carcinoma (M109) tumor model ChEMBL. 11277526
Toxicity (ADMET) = 0 Toxicity expressed in terms of number of toxic deaths after administration (8 mg/Kg) in athymic mice; out of 6 tested ChEMBL. 12392737
Toxicity (ADMET) = 2 Toxicity expressed in terms of number of toxic deaths after administration (10 mg/Kg) in mice; out of 10 tested ChEMBL. 12392737
Tubulin polymerization (functional) = 1 Compound was tested in vitro for inhibition of tubulin polymerization,expressed as ratio to that obtained for paclitaxel ChEMBL. 11277525
Tubulin polymerization (functional) = 1 Compound was tested in vitro for inhibition of tubulin polymerization,expressed as ratio to that obtained for paclitaxel ChEMBL. 11277526
Tubulin polymerization (functional) = 49 % Induction of polymerization of porcine brain-derived microtubule protein by 2 microM epothilone B ChEMBL. 11133086
Tumor inhibition (functional) = 71.4 % Tumor inhibition expressed as (average tumor weight of treated group/average tumor weight of control group)*100 at a dose of 10 mg/kg ChEMBL. 12392737
Tumor inhibition (functional) = 78.02 % Tumor inhibition expressed as (average tumor weight of treated group/average tumor weight of control group)*100 at a dose of (8 mg/kg) ChEMBL. 12392737
Vdss (ADMET) = 2.4 l kg-1 Volume of distribution in man (IV dose) ChEMBL. 12061889
Vmax (binding) = 35 uM Maximum velocity against human P-glycoprotein expressed in Sf9 cells ChEMBL. 15863325
WBC (functional) = 13.4 10e3 ul-1 Hematological effects in female CDF1 mice at the dose of 30mg, in white blood cells ChEMBL. 10780911

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Targets
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 26882  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 26953  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 29919  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 25756  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 29777  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 25113  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 29099  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 28601  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 24472  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 21739  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 28044  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 21309  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 24440  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 20919  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 22594  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 23453  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 21545  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 29554  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 29031  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 23905  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 21179  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 25450  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 22205  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 27459  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 26961  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 22252  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 23996  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 23078  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 20827  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 28024  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) decreased (PATO:0000468) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from specific protein inhibition (ECO:0000020) Leishmania amazonensis 28324  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents prevents mictotubule formation in vitro with purified tubulin and in live cells; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 26882  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 26953  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 29919  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 25756  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 29777  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 25113  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 29099  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 28601  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 24472  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 21739  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 28044  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 21309  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 24440  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 20919  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 22594  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 23453  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 21545  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 29554  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 29031  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 23905  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 21179  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 25450  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 22205  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 27459  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 26961  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 22252  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 23996  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 23078  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 20827  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 28024  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 28324  
Annotator: aaronjr@u.washington.edu Comment: Drug: 16037-91-5. chemical inhibition with antimicrotubule agents leads to slow growth of Leishmania sp. in cell assay; unclear as to which topoisomerase I gene(s)/enzyme(s) was/were studied References: 10029309
microtubule polymerization (GO:0046785) increased (PATO:0000470) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania donovani 26882  
Annotator: aaronjr@u.washington.edu Comment: chemical inhibition with microtubule stabilising agent forces mictotubule formation in live cells and interrupts cell cycle; unclear as to which topoisomerase II gene/enzyme was studied References: 10427726
microtubule polymerization (GO:0046785) increased (PATO:0000470) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania donovani 26953  
Annotator: aaronjr@u.washington.edu Comment: chemical inhibition with microtubule stabilising agent forces mictotubule formation in live cells and interrupts cell cycle; unclear as to which topoisomerase II gene/enzyme was studied References: 10427726
microtubule polymerization (GO:0046785) increased (PATO:0000470) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania donovani 29919  
Annotator: aaronjr@u.washington.edu Comment: chemical inhibition with microtubule stabilising agent forces mictotubule formation in live cells and interrupts cell cycle; unclear as to which topoisomerase II gene/enzyme was studied References: 10427726
microtubule polymerization (GO:0046785) increased (PATO:0000470) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania donovani 25756  
Annotator: aaronjr@u.washington.edu Comment: chemical inhibition with microtubule stabilising agent forces mictotubule formation in live cells and interrupts cell cycle; unclear as to which topoisomerase II gene/enzyme was studied References: 10427726
microtubule polymerization (GO:0046785) increased (PATO:0000470) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania donovani 29777  
Annotator: aaronjr@u.washington.edu Comment: chemical inhibition with microtubule stabilising agent forces mictotubule formation in live cells and interrupts cell cycle; unclear as to which topoisomerase II gene/enzyme was studied References: 10427726
microtubule polymerization (GO:0046785) increased (PATO:0000470) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania donovani 25113  
Annotator: aaronjr@u.washington.edu Comment: chemical inhibition with microtubule stabilising agent forces mictotubule formation in live cells and interrupts cell cycle; unclear as to which topoisomerase II gene/enzyme was studied References: 10427726
microtubule polymerization (GO:0046785) increased (PATO:0000470) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania donovani 29099  
Annotator: aaronjr@u.washington.edu Comment: chemical inhibition with microtubule stabilising agent forces mictotubule formation in live cells and interrupts cell cycle; unclear as to which topoisomerase II gene/enzyme was studied References: 10427726
microtubule polymerization (GO:0046785) increased (PATO:0000470) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania donovani 28601  
Annotator: aaronjr@u.washington.edu Comment: chemical inhibition with microtubule stabilising agent forces mictotubule formation in live cells and interrupts cell cycle; unclear as to which topoisomerase II gene/enzyme was studied References: 10427726
microtubule polymerization (GO:0046785) increased (PATO:0000470) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania donovani 24472  
Annotator: aaronjr@u.washington.edu Comment: chemical inhibition with microtubule stabilising agent forces mictotubule formation in live cells and interrupts cell cycle; unclear as to which topoisomerase II gene/enzyme was studied References: 10427726
microtubule polymerization (GO:0046785) increased (PATO:0000470) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania donovani 21739  
Annotator: aaronjr@u.washington.edu Comment: chemical inhibition with microtubule stabilising agent forces mictotubule formation in live cells and interrupts cell cycle; unclear as to which topoisomerase II gene/enzyme was studied References: 10427726
microtubule polymerization (GO:0046785) increased (PATO:0000470) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania donovani 28044  
Annotator: aaronjr@u.washington.edu Comment: chemical inhibition with microtubule stabilising agent forces mictotubule formation in live cells and interrupts cell cycle; unclear as to which topoisomerase II gene/enzyme was studied References: 10427726
microtubule polymerization (GO:0046785) increased (PATO:0000470) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania donovani 21309  
Annotator: aaronjr@u.washington.edu Comment: chemical inhibition with microtubule stabilising agent forces mictotubule formation in live cells and interrupts cell cycle; unclear as to which topoisomerase II gene/enzyme was studied References: 10427726
microtubule polymerization (GO:0046785) increased (PATO:0000470) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania donovani 24440  
Annotator: aaronjr@u.washington.edu Comment: chemical inhibition with microtubule stabilising agent forces mictotubule formation in live cells and interrupts cell cycle; unclear as to which topoisomerase II gene/enzyme was studied References: 10427726
microtubule polymerization (GO:0046785) increased (PATO:0000470) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania donovani 20919  
Annotator: aaronjr@u.washington.edu Comment: chemical inhibition with microtubule stabilising agent forces mictotubule formation in live cells and interrupts cell cycle; unclear as to which topoisomerase II gene/enzyme was studied References: 10427726
microtubule polymerization (GO:0046785) increased (PATO:0000470) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania donovani 22594  
Annotator: aaronjr@u.washington.edu Comment: chemical inhibition with microtubule stabilising agent forces mictotubule formation in live cells and interrupts cell cycle; unclear as to which topoisomerase II gene/enzyme was studied References: 10427726
microtubule polymerization (GO:0046785) increased (PATO:0000470) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania donovani 23453  
Annotator: aaronjr@u.washington.edu Comment: chemical inhibition with microtubule stabilising agent forces mictotubule formation in live cells and interrupts cell cycle; unclear as to which topoisomerase II gene/enzyme was studied References: 10427726
microtubule polymerization (GO:0046785) increased (PATO:0000470) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania donovani 21545  
Annotator: aaronjr@u.washington.edu Comment: chemical inhibition with microtubule stabilising agent forces mictotubule formation in live cells and interrupts cell cycle; unclear as to which topoisomerase II gene/enzyme was studied References: 10427726
microtubule polymerization (GO:0046785) increased (PATO:0000470) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania donovani 29554  
Annotator: aaronjr@u.washington.edu Comment: chemical inhibition with microtubule stabilising agent forces mictotubule formation in live cells and interrupts cell cycle; unclear as to which topoisomerase II gene/enzyme was studied References: 10427726
microtubule polymerization (GO:0046785) increased (PATO:0000470) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania donovani 29031  
Annotator: aaronjr@u.washington.edu Comment: chemical inhibition with microtubule stabilising agent forces mictotubule formation in live cells and interrupts cell cycle; unclear as to which topoisomerase II gene/enzyme was studied References: 10427726
microtubule polymerization (GO:0046785) increased (PATO:0000470) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania donovani 23905  
Annotator: aaronjr@u.washington.edu Comment: chemical inhibition with microtubule stabilising agent forces mictotubule formation in live cells and interrupts cell cycle; unclear as to which topoisomerase II gene/enzyme was studied References: 10427726
microtubule polymerization (GO:0046785) increased (PATO:0000470) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania donovani 21179  
Annotator: aaronjr@u.washington.edu Comment: chemical inhibition with microtubule stabilising agent forces mictotubule formation in live cells and interrupts cell cycle; unclear as to which topoisomerase II gene/enzyme was studied References: 10427726
microtubule polymerization (GO:0046785) increased (PATO:0000470) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania donovani 25450  
Annotator: aaronjr@u.washington.edu Comment: chemical inhibition with microtubule stabilising agent forces mictotubule formation in live cells and interrupts cell cycle; unclear as to which topoisomerase II gene/enzyme was studied References: 10427726
microtubule polymerization (GO:0046785) increased (PATO:0000470) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania donovani 22205  
Annotator: aaronjr@u.washington.edu Comment: chemical inhibition with microtubule stabilising agent forces mictotubule formation in live cells and interrupts cell cycle; unclear as to which topoisomerase II gene/enzyme was studied References: 10427726
microtubule polymerization (GO:0046785) increased (PATO:0000470) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania donovani 27459  
Annotator: aaronjr@u.washington.edu Comment: chemical inhibition with microtubule stabilising agent forces mictotubule formation in live cells and interrupts cell cycle; unclear as to which topoisomerase II gene/enzyme was studied References: 10427726
microtubule polymerization (GO:0046785) increased (PATO:0000470) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania donovani 26961  
Annotator: aaronjr@u.washington.edu Comment: chemical inhibition with microtubule stabilising agent forces mictotubule formation in live cells and interrupts cell cycle; unclear as to which topoisomerase II gene/enzyme was studied References: 10427726
microtubule polymerization (GO:0046785) increased (PATO:0000470) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania donovani 22252  
Annotator: aaronjr@u.washington.edu Comment: chemical inhibition with microtubule stabilising agent forces mictotubule formation in live cells and interrupts cell cycle; unclear as to which topoisomerase II gene/enzyme was studied References: 10427726
microtubule polymerization (GO:0046785) increased (PATO:0000470) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania donovani 23996  
Annotator: aaronjr@u.washington.edu Comment: chemical inhibition with microtubule stabilising agent forces mictotubule formation in live cells and interrupts cell cycle; unclear as to which topoisomerase II gene/enzyme was studied References: 10427726
microtubule polymerization (GO:0046785) increased (PATO:0000470) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania donovani 23078  
Annotator: aaronjr@u.washington.edu Comment: chemical inhibition with microtubule stabilising agent forces mictotubule formation in live cells and interrupts cell cycle; unclear as to which topoisomerase II gene/enzyme was studied References: 10427726
microtubule polymerization (GO:0046785) increased (PATO:0000470) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania donovani 20827  
Annotator: aaronjr@u.washington.edu Comment: chemical inhibition with microtubule stabilising agent forces mictotubule formation in live cells and interrupts cell cycle; unclear as to which topoisomerase II gene/enzyme was studied References: 10427726
microtubule polymerization (GO:0046785) increased (PATO:0000470) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania donovani 28024  
Annotator: aaronjr@u.washington.edu Comment: chemical inhibition with microtubule stabilising agent forces mictotubule formation in live cells and interrupts cell cycle; unclear as to which topoisomerase II gene/enzyme was studied References: 10427726
microtubule polymerization (GO:0046785) increased (PATO:0000470) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania donovani 28324  
Annotator: aaronjr@u.washington.edu Comment: chemical inhibition with microtubule stabilising agent forces mictotubule formation in live cells and interrupts cell cycle; unclear as to which topoisomerase II gene/enzyme was studied References: 10427726
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania donovani 26882  
Annotator: aaronjr@u.washington.edu Comment: chemical inhibition with microtubule stabilising agent forces mictotubule formation in live cells and interrupts cell cycle; unclear as to which topoisomerase II gene/enzyme was studied References: 10427726
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania donovani 26953  
Annotator: aaronjr@u.washington.edu Comment: chemical inhibition with microtubule stabilising agent forces mictotubule formation in live cells and interrupts cell cycle; unclear as to which topoisomerase II gene/enzyme was studied References: 10427726
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania donovani 29919  
Annotator: aaronjr@u.washington.edu Comment: chemical inhibition with microtubule stabilising agent forces mictotubule formation in live cells and interrupts cell cycle; unclear as to which topoisomerase II gene/enzyme was studied References: 10427726
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania donovani 25756  
Annotator: aaronjr@u.washington.edu Comment: chemical inhibition with microtubule stabilising agent forces mictotubule formation in live cells and interrupts cell cycle; unclear as to which topoisomerase II gene/enzyme was studied References: 10427726
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania donovani 29777  
Annotator: aaronjr@u.washington.edu Comment: chemical inhibition with microtubule stabilising agent forces mictotubule formation in live cells and interrupts cell cycle; unclear as to which topoisomerase II gene/enzyme was studied References: 10427726
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania donovani 25113  
Annotator: aaronjr@u.washington.edu Comment: chemical inhibition with microtubule stabilising agent forces mictotubule formation in live cells and interrupts cell cycle; unclear as to which topoisomerase II gene/enzyme was studied References: 10427726
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania donovani 29099  
Annotator: aaronjr@u.washington.edu Comment: chemical inhibition with microtubule stabilising agent forces mictotubule formation in live cells and interrupts cell cycle; unclear as to which topoisomerase II gene/enzyme was studied References: 10427726
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania donovani 28601  
Annotator: aaronjr@u.washington.edu Comment: chemical inhibition with microtubule stabilising agent forces mictotubule formation in live cells and interrupts cell cycle; unclear as to which topoisomerase II gene/enzyme was studied References: 10427726
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania donovani 24472  
Annotator: aaronjr@u.washington.edu Comment: chemical inhibition with microtubule stabilising agent forces mictotubule formation in live cells and interrupts cell cycle; unclear as to which topoisomerase II gene/enzyme was studied References: 10427726
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania donovani 21739  
Annotator: aaronjr@u.washington.edu Comment: chemical inhibition with microtubule stabilising agent forces mictotubule formation in live cells and interrupts cell cycle; unclear as to which topoisomerase II gene/enzyme was studied References: 10427726
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania donovani 28044  
Annotator: aaronjr@u.washington.edu Comment: chemical inhibition with microtubule stabilising agent forces mictotubule formation in live cells and interrupts cell cycle; unclear as to which topoisomerase II gene/enzyme was studied References: 10427726
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania donovani 21309  
Annotator: aaronjr@u.washington.edu Comment: chemical inhibition with microtubule stabilising agent forces mictotubule formation in live cells and interrupts cell cycle; unclear as to which topoisomerase II gene/enzyme was studied References: 10427726
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania donovani 24440  
Annotator: aaronjr@u.washington.edu Comment: chemical inhibition with microtubule stabilising agent forces mictotubule formation in live cells and interrupts cell cycle; unclear as to which topoisomerase II gene/enzyme was studied References: 10427726
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania donovani 20919  
Annotator: aaronjr@u.washington.edu Comment: chemical inhibition with microtubule stabilising agent forces mictotubule formation in live cells and interrupts cell cycle; unclear as to which topoisomerase II gene/enzyme was studied References: 10427726
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania donovani 22594  
Annotator: aaronjr@u.washington.edu Comment: chemical inhibition with microtubule stabilising agent forces mictotubule formation in live cells and interrupts cell cycle; unclear as to which topoisomerase II gene/enzyme was studied References: 10427726
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania donovani 23453  
Annotator: aaronjr@u.washington.edu Comment: chemical inhibition with microtubule stabilising agent forces mictotubule formation in live cells and interrupts cell cycle; unclear as to which topoisomerase II gene/enzyme was studied References: 10427726
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania donovani 21545  
Annotator: aaronjr@u.washington.edu Comment: chemical inhibition with microtubule stabilising agent forces mictotubule formation in live cells and interrupts cell cycle; unclear as to which topoisomerase II gene/enzyme was studied References: 10427726
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania donovani 29554  
Annotator: aaronjr@u.washington.edu Comment: chemical inhibition with microtubule stabilising agent forces mictotubule formation in live cells and interrupts cell cycle; unclear as to which topoisomerase II gene/enzyme was studied References: 10427726
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania donovani 29031  
Annotator: aaronjr@u.washington.edu Comment: chemical inhibition with microtubule stabilising agent forces mictotubule formation in live cells and interrupts cell cycle; unclear as to which topoisomerase II gene/enzyme was studied References: 10427726
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania donovani 23905  
Annotator: aaronjr@u.washington.edu Comment: chemical inhibition with microtubule stabilising agent forces mictotubule formation in live cells and interrupts cell cycle; unclear as to which topoisomerase II gene/enzyme was studied References: 10427726
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania donovani 21179  
Annotator: aaronjr@u.washington.edu Comment: chemical inhibition with microtubule stabilising agent forces mictotubule formation in live cells and interrupts cell cycle; unclear as to which topoisomerase II gene/enzyme was studied References: 10427726
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania donovani 25450  
Annotator: aaronjr@u.washington.edu Comment: chemical inhibition with microtubule stabilising agent forces mictotubule formation in live cells and interrupts cell cycle; unclear as to which topoisomerase II gene/enzyme was studied References: 10427726
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania donovani 22205  
Annotator: aaronjr@u.washington.edu Comment: chemical inhibition with microtubule stabilising agent forces mictotubule formation in live cells and interrupts cell cycle; unclear as to which topoisomerase II gene/enzyme was studied References: 10427726
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania donovani 27459  
Annotator: aaronjr@u.washington.edu Comment: chemical inhibition with microtubule stabilising agent forces mictotubule formation in live cells and interrupts cell cycle; unclear as to which topoisomerase II gene/enzyme was studied References: 10427726
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094)