Detailed information for compound 29792
Basic information
Technical information
- TDR Targets ID: 29792
- Name: 6-(pyridin-4-ylmethyl)-5,6,7,8-tetrahydronaph thalen-2-ol
- MW: 239.312 | Formula: C16H17NO
-
H donors: 1
H acceptors: 2
LogP: 3.55
Rotable bonds: 2
Rule of 5 violations (Lipinski): 1 - SMILES: Oc1ccc2c(c1)CCC(C2)Cc1ccncc1
- InChi: 1S/C16H17NO/c18-16-4-3-14-10-13(1-2-15(14)11-16)9-12-5-7-17-8-6-12/h3-8,11,13,18H,1-2,9-10H2
- InChiKey: HOYYGGIWRKOTDQ-UHFFFAOYSA-N
Network
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Synonyms
- 2-(4-pyridylmethyl)tetralin-6-ol
- 2-(4-pyridylmethyl)-6-tetralinol
Targets
Known targets for this compound
| Species | Target name | Source | Bibliographic reference |
|---|---|---|---|
| Homo sapiens | cytochrome P450, family 19, subfamily A, polypeptide 1 | Starlite/ChEMBL | References |
Predicted pathogen targets for this compound
By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
| Species | Potential target | Known druggable target | Length | Alignment span | Identity |
|---|---|---|---|---|---|
| Trypanosoma cruzi | cytochrome P450, putative | cytochrome P450, family 19, subfamily A, polypeptide 1 | 503 aa | 425 aa | 18.8 % |
Obtained from network model
Ranking Plot
Putative Targets List
| Species | Potential target | Raw | Global | Species |
|---|---|---|---|---|
| Brugia malayi | gonadotropin-releasing hormone receptor 2 | 0.1357 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.1357 | 1 | 1 |
| Echinococcus multilocularis | neuropeptide receptor | 0.1357 | 1 | 1 |
| Schistosoma mansoni | thyrotropin-releasing hormone receptor | 0.1357 | 1 | 1 |
| Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.1357 | 1 | 1 |
| Echinococcus multilocularis | neuropeptide FF receptor 2 | 0.1357 | 1 | 1 |
| Echinococcus multilocularis | fmrfamide receptor | 0.1357 | 1 | 1 |
| Onchocerca volvulus | 0.1357 | 1 | 1 | |
| Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.011 | 0.0063 | 0.0063 |
| Brugia malayi | sulfakinin receptor protein | 0.1357 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.1357 | 1 | 1 |
| Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.1357 | 1 | 1 |
| Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.011 | 0.0063 | 0.0063 |
| Echinococcus multilocularis | g-protein coupled receptor | 0.1357 | 1 | 1 |
| Echinococcus multilocularis | growth hormone secretagogue receptor type 1 | 0.1357 | 1 | 1 |
| Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | 0.1357 | 1 | 1 |
| Schistosoma mansoni | neuropeptide receptor | 0.1357 | 1 | 1 |
| Echinococcus multilocularis | rhodopsin orphan GPCR | 0.1357 | 1 | 1 |
| Schistosoma mansoni | peptide (FMRFamide/neurokinin-3)-like receptor | 0.1357 | 1 | 1 |
| Brugia malayi | G protein-coupled receptor | 0.1357 | 1 | 1 |
| Echinococcus multilocularis | biogenic amine (5HT) receptor | 0.1357 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.1357 | 1 | 1 |
| Schistosoma mansoni | biogenic amine (5HT) receptor | 0.1357 | 1 | 1 |
| Echinococcus granulosus | neuropeptide receptor | 0.1357 | 1 | 1 |
| Schistosoma mansoni | myosin xvIII | 0.1357 | 1 | 1 |
| Echinococcus granulosus | 7tm_1 domain containing protein | 0.1357 | 1 | 1 |
| Echinococcus multilocularis | neuropeptide Y receptor | 0.1357 | 1 | 1 |
| Echinococcus granulosus | alpha 1A adrenergic receptor | 0.1357 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.0063 | 0.0063 |
| Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.0063 | 0.0063 |
| Loa Loa (eye worm) | gonadotropin-releasing hormone receptor 2 | 0.1357 | 1 | 1 |
| Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.011 | 0.0063 | 0.0063 |
| Brugia malayi | G protein-coupled receptor F59B2.13 | 0.1357 | 1 | 1 |
| Echinococcus granulosus | orexin receptor type 2 | 0.1357 | 1 | 1 |
| Brugia malayi | hypothetical protein | 0.1357 | 1 | 1 |
| Echinococcus granulosus | rhodopsin orphan GPCR | 0.1357 | 1 | 1 |
| Brugia malayi | putative neuropeptide receptor | 0.1357 | 1 | 1 |
| Schistosoma mansoni | opsin-like receptor | 0.1357 | 1 | 1 |
| Brugia malayi | Dopamine receptor protein 2 | 0.1357 | 1 | 1 |
| Schistosoma mansoni | biogenic amine receptor | 0.1357 | 1 | 1 |
| Brugia malayi | hypothetical protein | 0.1357 | 1 | 1 |
| Echinococcus multilocularis | somatostatin receptor | 0.1357 | 1 | 1 |
| Brugia malayi | G-protein coupled receptor | 0.1357 | 1 | 1 |
| Echinococcus multilocularis | neuropeptide receptor A26 | 0.1357 | 1 | 1 |
| Echinococcus granulosus | rhodopsin orphan GPCR | 0.1357 | 1 | 1 |
| Echinococcus granulosus | G protein coupled receptor 139 | 0.1357 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.1357 | 1 | 1 |
| Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.1357 | 1 | 1 |
| Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.1357 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.1357 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.0063 | 0.0063 |
| Echinococcus multilocularis | fmrfamide receptor | 0.1357 | 1 | 1 |
| Echinococcus granulosus | biogenic amine 5HT receptor | 0.1357 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.1357 | 1 | 1 |
| Brugia malayi | Serotonin receptor | 0.1357 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.1357 | 1 | 1 |
| Echinococcus multilocularis | neuropeptide receptor | 0.1357 | 1 | 1 |
| Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.1357 | 1 | 1 |
| Echinococcus granulosus | allatostatin A receptor | 0.1357 | 1 | 1 |
| Echinococcus multilocularis | rhodopsin orphan GPCR | 0.1357 | 1 | 1 |
| Echinococcus granulosus | rhodopsin orphan GPCR | 0.1357 | 1 | 1 |
| Schistosoma mansoni | neuropeptide receptor | 0.1357 | 1 | 1 |
| Echinococcus granulosus | neuropeptide FF receptor 2 | 0.1357 | 1 | 1 |
| Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.011 | 0.0063 | 0.0063 |
| Loa Loa (eye worm) | hypothetical protein | 0.1357 | 1 | 1 |
| Echinococcus granulosus | g protein linked acetylcholine receptor gar 2a | 0.1357 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.1357 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.0063 | 0.0063 |
| Schistosoma mansoni | hypothetical protein | 0.1357 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.1357 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.1357 | 1 | 1 |
| Echinococcus multilocularis | rhodopsin orphan GPCR | 0.1357 | 1 | 1 |
| Onchocerca volvulus | 0.1357 | 1 | 1 | |
| Echinococcus multilocularis | neuropeptides capa receptor | 0.1357 | 1 | 1 |
| Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.1357 | 1 | 1 |
| Onchocerca volvulus | 0.1357 | 1 | 1 | |
| Onchocerca volvulus | 0.1357 | 1 | 1 | |
| Echinococcus granulosus | tm gpcr rhodopsin | 0.1357 | 1 | 1 |
| Brugia malayi | hypothetical protein | 0.1357 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.0063 | 0.0063 |
| Echinococcus granulosus | sex peptide receptor | 0.1357 | 1 | 1 |
| Echinococcus multilocularis | 7TM GPCR, rhodopsin | 0.1357 | 1 | 1 |
| Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.1357 | 1 | 1 |
| Echinococcus granulosus | g protein coupled receptor | 0.1357 | 1 | 1 |
| Schistosoma mansoni | amine GPCR | 0.1357 | 1 | 1 |
| Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.1357 | 1 | 1 |
| Onchocerca volvulus | 0.1357 | 1 | 1 | |
| Schistosoma mansoni | hypothetical protein | 0.1357 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.1357 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.1357 | 1 | 1 |
| Schistosoma mansoni | hypothetical protein | 0.1357 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.1357 | 1 | 1 |
| Echinococcus multilocularis | dro:myosuppressin receptor | 0.1357 | 1 | 1 |
| Brugia malayi | Dopamine receptor | 0.1357 | 1 | 1 |
| Schistosoma mansoni | growth hormone secretagogue receptor | 0.1357 | 1 | 1 |
| Schistosoma mansoni | peptide (allatostatin)-like receptor | 0.1357 | 1 | 1 |
| Echinococcus multilocularis | rhodopsin orphan GPCR | 0.1357 | 1 | 1 |
| Brugia malayi | Unidentified vitellogenin-linked transcript protein 6, putative | 0.1357 | 1 | 1 |
| Schistosoma mansoni | histamine-responsive GPCR (AAF21638) | 0.1357 | 1 | 1 |
| Toxoplasma gondii | hypothetical protein | 0.0102 | 0 | 0.5 |
| Brugia malayi | GnHR receptor homolog | 0.1357 | 1 | 1 |
| Schistosoma mansoni | muscarinic acetylcholine (GAR) receptor | 0.1357 | 1 | 1 |
| Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.011 | 0.0063 | 0.0063 |
| Loa Loa (eye worm) | hypothetical protein | 0.1357 | 1 | 1 |
| Echinococcus multilocularis | sex peptide receptor | 0.1357 | 1 | 1 |
| Echinococcus granulosus | g protein coupled receptor | 0.1357 | 1 | 1 |
| Brugia malayi | Melatonin receptor type 1A | 0.1357 | 1 | 1 |
| Brugia malayi | hypothetical protein | 0.1357 | 1 | 1 |
| Echinococcus multilocularis | alpha 1A adrenergic receptor | 0.1357 | 1 | 1 |
| Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.1357 | 1 | 1 |
| Mycobacterium ulcerans | secreted antigen 85-C FbpC | 0.0891 | 0.6288 | 0.5 |
| Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.011 | 0.0063 | 0.0063 |
| Schistosoma mansoni | neuropeptide f receptor 76f | 0.1357 | 1 | 1 |
| Loa Loa (eye worm) | G-protein coupled receptor | 0.1357 | 1 | 1 |
| Schistosoma mansoni | amine GPCR | 0.1357 | 1 | 1 |
| Loa Loa (eye worm) | neuropeptide F receptor | 0.1357 | 1 | 1 |
| Echinococcus multilocularis | neuropeptide s receptor | 0.1357 | 1 | 1 |
| Echinococcus granulosus | thyrotropin releasing hormone receptor | 0.1357 | 1 | 1 |
| Brugia malayi | neuropeptide F receptor | 0.1357 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.1357 | 1 | 1 |
| Echinococcus multilocularis | serotonin receptor | 0.1357 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.1357 | 1 | 1 |
| Echinococcus granulosus | neuropeptides capa receptor | 0.1357 | 1 | 1 |
| Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.1357 | 1 | 1 |
| Schistosoma mansoni | neuropeptide receptor | 0.1357 | 1 | 1 |
| Echinococcus granulosus | rhodopsin orphan GPCR | 0.1357 | 1 | 1 |
| Brugia malayi | Dopamine receptor protein 1, putative (partial) | 0.1357 | 1 | 1 |
| Schistosoma mansoni | biogenic amine receptor | 0.1357 | 1 | 1 |
| Echinococcus granulosus | rhodopsin orphan GPCR | 0.1357 | 1 | 1 |
| Echinococcus multilocularis | peptide (allatostatin:somatostatin) | 0.1357 | 1 | 1 |
| Schistosoma mansoni | amine GPCR | 0.1357 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.1357 | 1 | 1 |
| Brugia malayi | hypothetical protein | 0.1357 | 1 | 1 |
| Schistosoma mansoni | neuropeptide receptor | 0.1357 | 1 | 1 |
| Echinococcus granulosus | peptide allatostatin:somatostatin | 0.1357 | 1 | 1 |
| Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | 0.1357 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.0063 | 0.0063 |
| Echinococcus multilocularis | neuropeptide Y receptor | 0.1357 | 1 | 1 |
| Brugia malayi | hypothetical protein | 0.1357 | 1 | 1 |
| Echinococcus multilocularis | g protein coupled receptor | 0.1357 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.1357 | 1 | 1 |
| Echinococcus granulosus | neuropeptide receptor A26 | 0.1357 | 1 | 1 |
| Echinococcus granulosus | tachykinin peptides receptor 99D | 0.1357 | 1 | 1 |
| Schistosoma mansoni | biogenic amine receptor | 0.1357 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.1357 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.1357 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.0063 | 0.0063 |
| Mycobacterium leprae | SECRETED ANTIGEN 85-C FBPC (85C) (ANTIGEN 85 COMPLEX C) (AG58C) (MYCOLYL TRANSFERASE 85C) (FIBRONECTIN-BINDING PROTEIN C) | 0.0891 | 0.6288 | 0.5 |
| Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.1357 | 1 | 1 |
| Brugia malayi | larval opioid receptor | 0.1357 | 1 | 1 |
| Echinococcus granulosus | neuropeptide Y receptor | 0.1357 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.1357 | 1 | 1 |
| Schistosoma mansoni | opsin-like receptor | 0.1357 | 1 | 1 |
| Onchocerca volvulus | 0.1357 | 1 | 1 | |
| Brugia malayi | hypothetical protein | 0.1357 | 1 | 1 |
| Onchocerca volvulus | 0.1357 | 1 | 1 | |
| Echinococcus granulosus | dro:myosuppressin receptor | 0.1357 | 1 | 1 |
| Schistosoma mansoni | neuropeptide F-like receptor | 0.1357 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.0063 | 0.0063 |
| Loa Loa (eye worm) | hypothetical protein | 0.1357 | 1 | 1 |
| Echinococcus multilocularis | neuropeptides capa receptor | 0.1357 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.1357 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.1357 | 1 | 1 |
| Loa Loa (eye worm) | G-protein-linked acetylcholine receptor protein 2 | 0.1357 | 1 | 1 |
| Brugia malayi | hypothetical protein | 0.1357 | 1 | 1 |
| Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.1357 | 1 | 1 |
| Echinococcus granulosus | serotonin receptor | 0.1357 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.1357 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.1357 | 1 | 1 |
| Schistosoma mansoni | histamine h1 receptor | 0.1357 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.1357 | 1 | 1 |
| Schistosoma mansoni | amine GPCR | 0.1357 | 1 | 1 |
| Onchocerca volvulus | 0.1357 | 1 | 1 | |
| Brugia malayi | Serotonin receptor | 0.1357 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.1357 | 1 | 1 |
| Schistosoma mansoni | amine GPCR | 0.1357 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.1357 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.1357 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.1357 | 1 | 1 |
| Echinococcus multilocularis | rhodopsin orphan GPCR | 0.1357 | 1 | 1 |
| Echinococcus granulosus | growth hormone secretagogue receptor type 1 | 0.1357 | 1 | 1 |
| Echinococcus granulosus | g-protein coupled receptor | 0.1357 | 1 | 1 |
| Schistosoma mansoni | biogenic amine (5HT) receptor | 0.1357 | 1 | 1 |
| Echinococcus granulosus | fmrfamide receptor | 0.1357 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.1357 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.1357 | 1 | 1 |
| Loa Loa (eye worm) | steroid hormone receptor | 0.011 | 0.0063 | 0.0063 |
| Schistosoma mansoni | peptide (allatostatin/somatostatin)-like receptor | 0.1357 | 1 | 1 |
| Brugia malayi | RE15519p | 0.1357 | 1 | 1 |
| Echinococcus multilocularis | thyrotropin releasing hormone receptor | 0.1357 | 1 | 1 |
| Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.1357 | 1 | 1 |
| Onchocerca volvulus | 0.1357 | 1 | 1 | |
| Loa Loa (eye worm) | hypothetical protein | 0.1357 | 1 | 1 |
| Echinococcus multilocularis | tachykinin peptides receptor 99D | 0.1357 | 1 | 1 |
| Echinococcus multilocularis | orexin receptor type 2 | 0.1357 | 1 | 1 |
| Onchocerca volvulus | Neuropeptide F receptor homolog | 0.1357 | 1 | 1 |
| Echinococcus granulosus | neuropeptides capa receptor | 0.1357 | 1 | 1 |
| Loa Loa (eye worm) | neuropeptide F receptor | 0.1357 | 1 | 1 |
| Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.1357 | 1 | 1 |
| Brugia malayi | Tachykinin-like peptides receptor 99D | 0.1357 | 1 | 1 |
| Loa Loa (eye worm) | G-protein coupled receptor | 0.1357 | 1 | 1 |
| Echinococcus multilocularis | rhodopsin orphan GPCR | 0.1357 | 1 | 1 |
| Echinococcus multilocularis | g protein coupled receptor | 0.1357 | 1 | 1 |
| Onchocerca volvulus | 0.1357 | 1 | 1 | |
| Schistosoma mansoni | hypothetical protein | 0.1357 | 1 | 1 |
| Brugia malayi | putative neuropeptide receptor NPR1 | 0.1357 | 1 | 1 |
| Echinococcus multilocularis | g protein linked acetylcholine receptor gar 2a | 0.1357 | 1 | 1 |
| Echinococcus granulosus | g protein linked acetylcholine receptor gar 2a | 0.1357 | 1 | 1 |
| Loa Loa (eye worm) | melatonin receptor type 1A | 0.1357 | 1 | 1 |
| Echinococcus granulosus | rhodopsin orphan GPCR | 0.1357 | 1 | 1 |
| Schistosoma mansoni | adenoreceptor | 0.1357 | 1 | 1 |
| Schistosoma mansoni | neuropeptide F-like receptor | 0.1357 | 1 | 1 |
| Schistosoma mansoni | ancient conserved domain protein 2 (cyclin m2) | 0.1357 | 1 | 1 |
| Mycobacterium tuberculosis | Secreted antigen 85-C FbpC (85C) (antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) | 0.0891 | 0.6288 | 0.5 |
| Loa Loa (eye worm) | hypothetical protein | 0.1357 | 1 | 1 |
| Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.011 | 0.0063 | 0.0063 |
| Loa Loa (eye worm) | hypothetical protein | 0.1357 | 1 | 1 |
| Echinococcus multilocularis | rhodopsin orphan GPCR | 0.1357 | 1 | 1 |
| Onchocerca volvulus | 0.1357 | 1 | 1 | |
| Loa Loa (eye worm) | hypothetical protein | 0.1357 | 1 | 1 |
| Echinococcus multilocularis | serotonin receptor | 0.1357 | 1 | 1 |
| Echinococcus granulosus | g protein coupled receptor | 0.1357 | 1 | 1 |
| Loa Loa (eye worm) | TYRA-2 protein | 0.1357 | 1 | 1 |
| Echinococcus granulosus | pyroglutamylated rfamide peptide receptor | 0.1357 | 1 | 1 |
| Echinococcus multilocularis | g protein linked acetylcholine receptor gar 2a | 0.1357 | 1 | 1 |
| Schistosoma mansoni | alpha-1 adrenergic receptor | 0.1357 | 1 | 1 |
| Echinococcus multilocularis | allatostatin A receptor | 0.1357 | 1 | 1 |
| Echinococcus multilocularis | G-protein coupled receptor, putative | 0.1357 | 1 | 1 |
| Onchocerca volvulus | 0.1357 | 1 | 1 | |
| Loa Loa (eye worm) | hypothetical protein | 0.1357 | 1 | 1 |
| Echinococcus multilocularis | rhodopsin orphan GPCR | 0.1357 | 1 | 1 |
| Echinococcus granulosus | G protein coupled 5 hydroxytryptamine receptor | 0.1357 | 1 | 1 |
| Echinococcus granulosus | neuropeptide receptor | 0.1357 | 1 | 1 |
| Brugia malayi | neuropeptide F receptor | 0.1357 | 1 | 1 |
| Brugia malayi | Dopamine receptor protein 1 | 0.1357 | 1 | 1 |
| Onchocerca volvulus | 0.1357 | 1 | 1 | |
| Brugia malayi | AKH receptor | 0.1357 | 1 | 1 |
| Echinococcus granulosus | tm gpcr rhodopsin | 0.1357 | 1 | 1 |
| Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.1357 | 1 | 1 |
| Echinococcus granulosus | somatostatin receptor | 0.1357 | 1 | 1 |
| Echinococcus multilocularis | pyroglutamylated rfamide peptide receptor | 0.1357 | 1 | 1 |
| Echinococcus multilocularis | G protein coupled receptor 139 | 0.1357 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.1357 | 1 | 1 |
| Echinococcus multilocularis | g protein coupled receptor | 0.1357 | 1 | 1 |
| Brugia malayi | ORL1-like opioid receptor | 0.1357 | 1 | 1 |
| Loa Loa (eye worm) | 5-hydroxytryptamine 2C receptor | 0.1357 | 1 | 1 |
| Onchocerca volvulus | 0.1357 | 1 | 1 | |
| Onchocerca volvulus | 0.1357 | 1 | 1 | |
| Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.1357 | 1 | 1 |
| Echinococcus multilocularis | G protein coupled 5 hydroxytryptamine receptor | 0.1357 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.1357 | 1 | 1 |
| Schistosoma mansoni | opsin-like receptor | 0.1357 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.1357 | 1 | 1 |
| Echinococcus granulosus | tm gpcr rhodopsin | 0.1357 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.1357 | 1 | 1 |
| Loa Loa (eye worm) | unidentified vitellogenin-linked transcript protein 6 | 0.1357 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.1357 | 1 | 1 |
| Brugia malayi | G-protein-linked acetylcholine receptor protein 2, putative | 0.1357 | 1 | 1 |
| Brugia malayi | hypothetical protein | 0.1357 | 1 | 1 |
| Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.1357 | 1 | 1 |
| Echinococcus granulosus | 7TM GPCR rhodopsin | 0.1357 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.1357 | 1 | 1 |
| Brugia malayi | G-protein coupled receptor | 0.1357 | 1 | 1 |
| Echinococcus granulosus | neuropeptide Y receptor | 0.1357 | 1 | 1 |
| Echinococcus granulosus | hypothetical protein | 0.1357 | 1 | 1 |
| Onchocerca volvulus | 0.1357 | 1 | 1 | |
| Brugia malayi | follicle stimulating hormone receptor | 0.1357 | 1 | 1 |
| Echinococcus granulosus | rhodopsin orphan GPCR | 0.1357 | 1 | 1 |
| Onchocerca volvulus | 0.1357 | 1 | 1 | |
| Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.1357 | 1 | 1 |
| Echinococcus granulosus | neuropeptide s receptor | 0.1357 | 1 | 1 |
| Echinococcus granulosus | biogenic amine 5HT receptor | 0.1357 | 1 | 1 |
| Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.1357 | 1 | 1 |
Activities
| Activity type | Activity value | Assay description | Source | Reference |
|---|---|---|---|---|
| IC50 (binding) | = 0.75 uM | Inhibition of human Placental Cytochrome P450 19A1 in vitro using human placental microsomes and testosterone | ChEMBL. | 8176705 |
| IC50 (binding) | = 0.75 uM | Inhibition of human Placental Cytochrome P450 19A1 in vitro using human placental microsomes and testosterone | ChEMBL. | 8176705 |
| Inhibition (binding) | = 10 % | Evaluated for percent inhibition of Bovine Adrenal Desmolase in vitro using bovine adrenal mitochondria and cholesterol | ChEMBL. | 8176705 |
| Inhibition (binding) | = 10 % | Evaluated for percent inhibition of Bovine Adrenal Desmolase in vitro using bovine adrenal mitochondria and cholesterol | ChEMBL. | 8176705 |
| Relative potency (binding) | = 49 | Potency relative to AG(IC50 37 uM) | ChEMBL. | 8176705 |
| Relative potency (binding) | = 49 | Potency relative to AG(IC50 37 uM) | ChEMBL. | 8176705 |
Phenotypes
Whole-cell/tissue/organism interactions
We have no records of whole-cell/tissue assays done with this compound
What does this mean?
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
Annotated phenotypes:
We have no manually annotated phenotypes for this drug.
What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by
drugs, or by genetic manipulation of cells (e.g. gene knockouts or
knockdowns) is manually curated from the literature. These
descriptions help to describe the potential of the target for drug
development. If no information is available for this gene or if the
information is incomplete, this may mean that i) the papers
containing this information either appeared after the curation
effort for this organism was carried out or they were inadvertently
missed by curators; or that ii) the curation effort for this
organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.
External resources for this compound
- ChEMBL: CHEMBL279940
- PubChem: 10466776
Bibliographic References
1 literature reference was collected for this gene.
If you have references for this compound, please enter them in a user comment (below) or Contact us.