TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 278.309 | Formula: C16H14N4O
H donors: 2 H acceptors: 3 LogP: 1.89 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: O=C1Nc2c(C1(C)C)cc1c(c2)[nH]c(n1)c1ccccn1
InChi: 1S/C16H14N4O/c1-16(2)9-7-12-13(8-11(9)20-15(16)21)19-14(18-12)10-5-3-4-6-17-10/h3-8H,1-2H3,(H,18,19)(H,20,21)
InChiKey: CHCFUMRMLFYUTE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	orexin receptor type 2	0.0066	0.0643	0.0643
Echinococcus multilocularis	neuropeptides capa receptor	0.0066	0.0643	0.0643
Toxoplasma gondii	glyceraldehyde-3-phosphate dehydrogenase GAPDH2	0.0131	0.1379	0.1378
Schistosoma mansoni	myosin xvIII	0.0066	0.0643	0.0643
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0046	0.0046
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0131	0.1379	0.4266
Trypanosoma brucei	cytidine deaminase	0.0052	0.0488	0.1451
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0643	0.0643
Brugia malayi	Cytochrome P450 family protein	0.0012	0.0038	0.0038
Echinococcus granulosus	proto oncogene serine:threonine protein kinase	0.0192	0.2069	0.2069
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0066	0.0643	0.0643
Leishmania major	cytochrome p450-like protein	0.0012	0.0038	0.001
Echinococcus multilocularis	dro:myosuppressin receptor	0.0066	0.0643	0.0643
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.001	0.0015	0.0014
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0066	0.0643	0.0643
Echinococcus granulosus	glyceraldehyde 3 phosphate dehydrogenase	0.0131	0.1379	0.1378
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.001	0.0015	0.0014
Onchocerca volvulus		0.0066	0.0643	0.0629
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0229	0.0229
Entamoeba histolytica	cytidine deaminase, putative	0.0052	0.0488	0.0461
Schistosoma mansoni	neuropeptide receptor	0.0066	0.0643	0.0643
Echinococcus granulosus	neuropeptide s receptor	0.0066	0.0643	0.0643
Brugia malayi	hypothetical protein	0.0066	0.0643	0.0643
Loa Loa (eye worm)	adenosylhomocysteinase	0.0127	0.1329	0.1329
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0643	0.0643
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0066	0.0643	0.0643
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0131	0.1379	0.1354
Loa Loa (eye worm)	neuropeptide F receptor	0.0066	0.0643	0.0643
Onchocerca volvulus		0.0048	0.0442	0.0428
Onchocerca volvulus		0.0052	0.0488	0.0474
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0643	0.0643
Echinococcus granulosus	glyceraldehyde 3 phosphate dehydrogenase	0.0131	0.1379	0.1378
Brugia malayi	Serine/threonine-protein kinase Pim-3	0.0192	0.2069	0.2069
Echinococcus granulosus	fmrfamide receptor	0.0066	0.0643	0.0643
Trypanosoma brucei	AMP deaminase, putative	0.0292	0.3193	1
Schistosoma mansoni	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)	0.0131	0.1379	0.1378
Echinococcus multilocularis	neuropeptides capa receptor	0.0066	0.0643	0.0643
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0015	0.0014
Echinococcus granulosus	neuropeptides capa receptor	0.0066	0.0643	0.0643
Trypanosoma brucei	glyceraldehyde 3-phosphate dehydrogenase, glycosomal	0.0131	0.1379	0.4266
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.001	0.0015	0.0014
Echinococcus granulosus	biogenic amine 5HT receptor	0.0066	0.0643	0.0643
Echinococcus granulosus	rhodopsin orphan GPCR	0.0066	0.0643	0.0643
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0066	0.0643	0.0643
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.001	0.0015	0.0015
Schistosoma mansoni	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)	0.0131	0.1379	0.1378
Brugia malayi	AKH receptor	0.0066	0.0643	0.0643
Entamoeba histolytica	adenosylhomocysteinase, putative	0.0127	0.1329	0.1304
Trypanosoma brucei	AMP deaminase, putative	0.0292	0.3193	1
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0643	0.0643
Echinococcus granulosus	bloom syndrome protein	0.0021	0.0137	0.0136
Echinococcus granulosus	G protein coupled receptor 139	0.0066	0.0643	0.0643
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0643	0.0643
Brugia malayi	nuclear hormone receptor	0.001	0.0015	0.0014
Trypanosoma cruzi	AMP deaminase, putative	0.0292	0.3193	1
Brugia malayi	GnHR receptor homolog	0.0066	0.0643	0.0643
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0229	0.0229
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0643	0.0643
Trichomonas vaginalis	cytidine deaminase, putative	0.0052	0.0488	0.0461
Mycobacterium ulcerans	glyceraldehyde 3-phosphate dehydrogenase Gap	0.0131	0.1379	0.1346
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0066	0.0643	0.0643
Onchocerca volvulus		0.0026	0.0198	0.0183
Trichomonas vaginalis	adenosine deaminase, putative	0.0898	1	1
Brugia malayi	Glyceraldehyde 3-phosphate dehydrogenase	0.0131	0.1379	0.1378
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0086	0.0871	0.0844
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0066	0.0643	0.0643
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0018	0.0109	0.0109
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0066	0.0643	0.0643
Onchocerca volvulus		0.0292	0.3193	0.3183
Echinococcus granulosus	dro:myosuppressin receptor	0.0066	0.0643	0.0643
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0066	0.0643	0.0643
Onchocerca volvulus		0.0066	0.0643	0.0629
Toxoplasma gondii	Adenosine/AMP deaminase domain-containing protein	0.0898	1	1
Plasmodium vivax	SET domain protein, putative	0.0029	0.0229	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0643	0.0643
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0009	0.0001	0.000000000043584
Schistosoma mansoni	neuropeptide receptor	0.0066	0.0643	0.0643
Echinococcus multilocularis	allatostatin A receptor	0.0066	0.0643	0.0643
Toxoplasma gondii	adenosylhomocysteinase, putative	0.0127	0.1329	0.1329
Echinococcus multilocularis	adenosine deaminase	0.0898	1	1
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0066	0.0643	0.0643
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0066	0.0643	0.0643
Brugia malayi	Serotonin receptor	0.0066	0.0643	0.0643
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.001	0.0015	0.0015
Mycobacterium leprae	PROBABLE CYTIDINE DEAMINASE CDD (CYTIDINE AMINOHYDROLASE) (CYTIDINE NUCLEOSIDE DEAMINASE)	0.0052	0.0488	0.0077
Schistosoma mansoni	adenosylhomocysteinase	0.0078	0.0786	0.0786
Loa Loa (eye worm)	G-protein coupled receptor	0.0066	0.0643	0.0643
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0066	0.0643	0.0643
Echinococcus granulosus	neuropeptide FF receptor 2	0.0066	0.0643	0.0643
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0066	0.0643	0.0643
Schistosoma mansoni	neuropeptide F-like receptor	0.0066	0.0643	0.0643
Brugia malayi	hypothetical protein	0.0066	0.0643	0.0643
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0066	0.0643	0.0643
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0066	0.0643	0.0643
Trypanosoma cruzi	S-adenosylhomocysteine hydrolase, putative	0.0127	0.1329	0.4109
Trypanosoma brucei	S-adenosylhomocysteine hydrolase, putative	0.0127	0.1329	0.4109
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0029	0.0229	0.0229
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.0109	0.0081
Echinococcus granulosus	AMP deaminase 2	0.0292	0.3193	0.3193
Echinococcus granulosus	rhodopsin orphan GPCR	0.0066	0.0643	0.0643
Chlamydia trachomatis	glyceraldehyde-3-phosphate dehydrogenase	0.0131	0.1379	0.5
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0066	0.0643	0.0643
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0086	0.0871	0.0844
Echinococcus granulosus	histone lysine methyltransferase setb	0.0029	0.0229	0.0229
Mycobacterium leprae	putative S-adenosyl-L-homocysteine hydrolase SahH	0.0127	0.1329	0.0955
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0066	0.0643	0.0643
Trypanosoma cruzi	AMP deaminase 2, putative	0.0292	0.3193	1
Trichomonas vaginalis	DNA helicase recq1, putative	0.0021	0.0137	0.0108
Echinococcus granulosus	adenosylhomocysteinase	0.0127	0.1329	0.1329
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.001	0.0015	0.0015
Echinococcus granulosus	rhodopsin orphan GPCR	0.0066	0.0643	0.0643
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0643	0.0643
Plasmodium vivax	adenosine/AMP deaminase, putative	0.0292	0.3193	0.3151
Echinococcus granulosus	neuropeptides capa receptor	0.0066	0.0643	0.0643
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.0109	0.0109
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0018	0.0109	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0643	0.0643
Onchocerca volvulus		0.0066	0.0643	0.0629
Loa Loa (eye worm)	hypothetical protein	0.0016	0.009	0.009
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0643	0.0643
Brugia malayi	exodeoxyribonuclease III family protein	0.0018	0.0109	0.0109
Leishmania major	adenine aminohydrolase	0.0898	1	1
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0066	0.0643	0.0629
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0014	0.006	0.0059
Brugia malayi	hypothetical protein	0.0066	0.0643	0.0643
Schistosoma mansoni	amine GPCR	0.0066	0.0643	0.0643
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative	0.0131	0.1379	0.4266
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.001	0.0015	0.0015
Onchocerca volvulus		0.0066	0.0643	0.0629
Brugia malayi	ORL1-like opioid receptor	0.0066	0.0643	0.0643
Echinococcus granulosus	orexin receptor type 2	0.0066	0.0643	0.0643
Echinococcus granulosus	glyceraldehyde 3 phosphate dehydrogenase	0.0086	0.0871	0.087
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0131	0.1379	0.4266
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0066	0.0643	0.0643
Echinococcus multilocularis	proto oncogene serine:threonine protein kinase	0.0192	0.2069	0.2069
Schistosoma mansoni	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)	0.0131	0.1379	0.1378
Loa Loa (eye worm)	hypothetical protein	0.001	0.0015	0.0015
Trypanosoma cruzi	cytidine deaminase-like protein	0.0052	0.0488	0.1451
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0643	0.0643
Brugia malayi	intermediate filament protein	0.0026	0.0198	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0643	0.0643
Trichomonas vaginalis	adenosylhomocysteinase, putative	0.004	0.0352	0.0324
Toxoplasma gondii	glyceraldehyde-3-phosphate dehydrogenase GAPDH1	0.0131	0.1379	0.1378
Echinococcus granulosus	neuropeptide receptor A26	0.0066	0.0643	0.0643
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0131	0.1379	0.1354
Plasmodium vivax	adenosine deaminase, putative	0.0898	1	1
Trypanosoma cruzi	AMP deaminase, putative	0.0292	0.3193	1
Entamoeba histolytica	adenosine deaminase, putative	0.0898	1	1
Onchocerca volvulus		0.0066	0.0643	0.0629
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0131	0.1379	0.4266
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0066	0.0643	0.0643
Mycobacterium ulcerans	adenosine deaminase	0.0898	1	1
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.0198	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0605	0.6711	0.6711
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0013	0.0046	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0643	0.0643
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0018	0.0109	0.0109
Trypanosoma brucei	adenosine monophosphate deaminase, putative	0.0292	0.3193	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0066	0.0643	0.0643
Loa Loa (eye worm)	hypothetical protein	0.001	0.0015	0.0015
Loa Loa (eye worm)	glyceraldehyde-3-phosphate dehydrogenase	0.009	0.0922	0.0922
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0029	0.0229	0.0229
Schistosoma mansoni	opsin-like receptor	0.0066	0.0643	0.0643
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative	0.0131	0.1379	0.4266
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.001	0.0015	0.0015
Onchocerca volvulus		0.0066	0.0643	0.0629
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0041	0.0361	0.1052
Schistosoma mansoni	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)	0.0131	0.1379	0.1378
Schistosoma mansoni	adenosylhomocysteinase	0.0127	0.1329	0.1329
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0066	0.0643	0.0643
Trichomonas vaginalis	adenosylhomocysteinase, putative	0.0127	0.1329	0.1304
Giardia lamblia	Glyceraldehyde 3-phosphate dehydrogenase	0.0131	0.1379	1
Echinococcus multilocularis	FTZ F1 alpha	0.001	0.0015	0.0014
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0066	0.0643	0.0643
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0643	0.0643
Echinococcus granulosus	allatostatin A receptor	0.0066	0.0643	0.0643
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0229	0.0229
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0066	0.0643	0.0643
Onchocerca volvulus		0.0066	0.0643	0.0629
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0192	0.0192
Loa Loa (eye worm)	hypothetical protein	0.001	0.0015	0.0015
Mycobacterium leprae	Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE)	0.0898	1	1
Echinococcus multilocularis	cytidine deaminase	0.0052	0.0488	0.0487
Echinococcus granulosus	sex peptide receptor	0.0066	0.0643	0.0643
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.001	0.0015	0.0014
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0066	0.0643	0.0643
Onchocerca volvulus	Serine\/threonine protein kinase homolog	0.0192	0.2069	0.2058
Onchocerca volvulus		0.0052	0.0488	0.0474
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0066	0.0643	0.0643
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0131	0.1379	0.1354
Echinococcus multilocularis	neuropeptide Y receptor	0.0066	0.0643	0.0643
Toxoplasma gondii	S-Adenosyl homocysteine hydrolase	0.0127	0.1329	0.1329
Loa Loa (eye worm)	hypothetical protein	0.0605	0.6711	0.6711
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.001	0.0015	0.0014
Schistosoma mansoni	hypothetical protein	0.0066	0.0643	0.0643
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0643	0.0643
Mycobacterium tuberculosis	Probable cytidine deaminase Cdd (cytidine aminohydrolase) (cytidine nucleoside deaminase)	0.0052	0.0488	0.0383
Echinococcus granulosus	cytidine deaminase	0.0052	0.0488	0.0487
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0015	0.0014
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0066	0.0643	0.0643
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.001	0.0015	0.0014
Schistosoma mansoni	steroid hormone receptor ad4bp	0.001	0.0015	0.0014
Brugia malayi	hypothetical protein	0.0066	0.0643	0.0643
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.001	0.0015	0.0014
Leishmania major	glyceraldehyde 3-phosphate dehydrogenase, glycosomal	0.0131	0.1379	0.1354
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0066	0.0643	0.0643
Schistosoma mansoni	adenosine deaminase	0.0898	1	1
Echinococcus granulosus	serotonin receptor	0.0066	0.0643	0.0643
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.001	0.0015	0.0014
Echinococcus granulosus	g protein coupled receptor	0.0066	0.0643	0.0643
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.0192	0.2069	0.2069
Entamoeba histolytica	AMP deaminase, putative	0.0292	0.3193	0.3174
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0018	0.0109	0.0071
Echinococcus granulosus	rhodopsin orphan GPCR	0.0066	0.0643	0.0643
Plasmodium falciparum	glyceraldehyde-3-phosphate dehydrogenase	0.0131	0.1379	0.1378
Entamoeba histolytica	adenosine deaminase, putative	0.0898	1	1
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative	0.0041	0.0361	0.1052
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative	0.0041	0.0361	0.1052
Echinococcus granulosus	FTZ F1 alpha	0.001	0.0015	0.0014
Schistosoma mansoni	lamin	0.0026	0.0198	0.0197
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0066	0.0643	0.0643
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.001	0.0015	0.0014
Schistosoma mansoni	amine GPCR	0.0066	0.0643	0.0643
Brugia malayi	RE15519p	0.0066	0.0643	0.0643
Brugia malayi	sulfakinin receptor protein	0.0066	0.0643	0.0643
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0041	0.0041
Brugia malayi	adenosine monophosphate deaminase	0.0292	0.3193	0.3193
Schistosoma mansoni	neuropeptide receptor	0.0066	0.0643	0.0643
Brugia malayi	hypothetical protein	0.0066	0.0643	0.0643
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0066	0.0643	0.0643
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.001	0.0015	0.0014
Mycobacterium tuberculosis	Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase)	0.0127	0.1329	0.1233
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0018	0.0109	0.0254
Trypanosoma cruzi	cytochrome P450, putative	0.0012	0.0038	0.0031
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0066	0.0643	0.0643
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0643	0.0643
Schistosoma mansoni	AMP deaminase	0.0292	0.3193	0.3193
Echinococcus granulosus	g protein coupled receptor	0.0066	0.0643	0.0643
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0015	0.0014
Echinococcus multilocularis	neuropeptide receptor	0.0066	0.0643	0.0643
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.0192	0.2069	0.2069
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.001	0.0015	0.0014
Echinococcus granulosus	7TM GPCR rhodopsin	0.0066	0.0643	0.0643
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0643	0.0643
Schistosoma mansoni	lamin	0.0026	0.0198	0.0197
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0066	0.0643	0.0643
Echinococcus multilocularis	g protein coupled receptor	0.0066	0.0643	0.0643
Plasmodium falciparum	adenosylhomocysteinase	0.0127	0.1329	0.1329
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.001	0.0015	0.0014
Brugia malayi	hypothetical protein	0.0066	0.0643	0.0643
Brugia malayi	Bloom's syndrome protein homolog	0.0021	0.0137	0.0136
Brugia malayi	G protein-coupled receptor F59B2.13	0.0066	0.0643	0.0643
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0015	0.0014
Brugia malayi	G protein-coupled receptor	0.0066	0.0643	0.0643
Trypanosoma brucei	glyceraldehyde 3-phosphate dehydrogenase, glycosomal	0.0131	0.1379	0.4266
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0131	0.1379	0.1354
Loa Loa (eye worm)	steroid hormone receptor	0.001	0.0015	0.0015
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0066	0.0643	0.0643
Echinococcus multilocularis	G protein coupled receptor 139	0.0066	0.0643	0.0643
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0131	0.1379	0.1354
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0041	0.0041
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0045	0.0413	0.0386
Entamoeba histolytica	glyceraldehyde-3-phosphate dehydrogenase, putative	0.0131	0.1379	0.1354
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0066	0.0643	0.0643
Treponema pallidum	adenosine deaminase	0.0898	1	1
Leishmania major	cytidine deaminase-like protein	0.0052	0.0488	0.0461
Echinococcus multilocularis	thyroid hormone receptor alpha	0.001	0.0015	0.0014
Plasmodium falciparum	AMP deaminase, putative	0.0292	0.3193	0.3193
Onchocerca volvulus		0.0026	0.0198	0.0183
Echinococcus multilocularis	neuropeptide s receptor	0.0066	0.0643	0.0643
Brugia malayi	putative neuropeptide receptor	0.0066	0.0643	0.0643
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0029	0.0229	0.0229
Trichomonas vaginalis	adenosine deaminase, putative	0.0898	1	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.001	0.0015	0.0014
Echinococcus granulosus	adenosine deaminase	0.0898	1	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0066	0.0643	0.0643
Schistosoma mansoni	neuropeptide F-like receptor	0.0066	0.0643	0.0643
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.001	0.0015	0.0015
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0015	0.0014
Brugia malayi	steroid hormone receptor	0.001	0.0015	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0643	0.0643
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0643	0.0643
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0643	0.0643
Giardia lamblia	Cytidine deaminase	0.0052	0.0488	0.3536
Trypanosoma brucei	glyceraldehyde 3-phosphate dehydrogenase, cytosolic	0.0131	0.1379	0.4266
Brugia malayi	hypothetical protein	0.0066	0.0643	0.0643
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0066	0.0643	0.0643
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0066	0.0643	0.0643
Onchocerca volvulus		0.0066	0.0643	0.0629
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0643	0.0643
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative	0.0041	0.0361	0.1052
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0109	0.0254
Trypanosoma cruzi	cytidine deaminase-like protein, putative	0.0052	0.0488	0.1451
Echinococcus multilocularis	glyceraldehyde 3 phosphate dehydrogenase	0.0131	0.1379	0.1378
Loa Loa (eye worm)	CYP4Cod1	0.0012	0.0038	0.0038
Brugia malayi	neuropeptide F receptor	0.0066	0.0643	0.0643
Echinococcus multilocularis	AMP deaminase 2	0.0292	0.3193	0.3193
Trypanosoma cruzi	adenosine monophosphate deaminase, putative	0.0292	0.3193	1
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0643	0.0643
Schistosoma mansoni	adenosylhomocysteinase	0.0078	0.0786	0.0786
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0066	0.0643	0.0643
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0066	0.0643	0.0643
Echinococcus multilocularis	lamin	0.0026	0.0198	0.0197
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.0109	0.0048
Schistosoma mansoni	ap endonuclease	0.0018	0.0109	0.0109
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0066	0.0643	0.0643
Echinococcus granulosus	rhodopsin orphan GPCR	0.0066	0.0643	0.0643
Echinococcus multilocularis	neuropeptide receptor	0.0066	0.0643	0.0643
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0066	0.0643	0.0643
Loa Loa (eye worm)	cytochrome P450 family protein	0.0012	0.0038	0.0038
Onchocerca volvulus		0.0066	0.0643	0.0629
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.001	0.0015	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0643	0.0643
Leishmania major	AMP deaminase, putative,amp deaminase-like protein	0.0292	0.3193	0.3174
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0198	0.0198
Loa Loa (eye worm)	hypothetical protein	0.0292	0.3193	0.3193
Echinococcus granulosus	tm gpcr rhodopsin	0.0066	0.0643	0.0643
Loa Loa (eye worm)	hypothetical protein	0.0898	1	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0066	0.0643	0.0643
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0015	0.0014
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.001	0.0015	0.0014
Mycobacterium tuberculosis	Probable adenosine deaminase Add (adenosine aminohydrolase)	0.0898	1	1
Schistosoma mansoni	serine/threonine protein kinase	0.0192	0.2069	0.2069
Trichomonas vaginalis	cytidine deaminase, putative	0.0052	0.0488	0.0461
Schistosoma mansoni	opsin-like receptor	0.0066	0.0643	0.0643
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0014	0.0062	0.0062
Echinococcus multilocularis	serotonin receptor	0.0066	0.0643	0.0643
Brugia malayi	G-protein coupled receptor	0.0066	0.0643	0.0643
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.0009	0.0001	0.0001
Loa Loa (eye worm)	AMP deaminase	0.0292	0.3193	0.3193
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0066	0.0643	0.0643
Brugia malayi	follicle stimulating hormone receptor	0.0066	0.0643	0.0643
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0643	0.0643
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0643	0.0643
Echinococcus granulosus	ecdysone induced protein 78C	0.001	0.0015	0.0014
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.001	0.0015	0.0014
Brugia malayi	ecdysteroid receptor	0.001	0.0015	0.0014
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.001	0.0015	0.0014
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0015	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0643	0.0643
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0066	0.0643	0.0643
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0066	0.0643	0.0643
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0643	0.0643
Schistosoma mansoni	histamine h1 receptor	0.0066	0.0643	0.0643
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0643	0.0643
Brugia malayi	Dopamine receptor protein 2	0.0066	0.0643	0.0643
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0018	0.0109	0.0788
Loa Loa (eye worm)	hypothetical protein	0.0605	0.6711	0.6711
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.001	0.0015	0.0014
Echinococcus granulosus	tm gpcr rhodopsin	0.0066	0.0643	0.0643
Trypanosoma brucei	cytochrome P450, putative	0.0012	0.0038	0.0031
Schistosoma mansoni	ap endonuclease	0.0018	0.0109	0.0109
Leishmania major	hypothetical protein, conserved	0.0292	0.3193	0.3174
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0018	0.0109	0.0109
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0015	0.0014
Onchocerca volvulus	Adenosine deaminase homolog	0.0898	1	1
Brugia malayi	photoreceptor-specific nuclear receptor	0.001	0.0015	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0643	0.0643
Schistosoma mansoni	hypothetical protein	0.0066	0.0643	0.0643
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0018	0.0108	0.0108
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.0198	0.0198
Mycobacterium ulcerans	S-adenosyl-L-homocysteine hydrolase	0.0127	0.1329	0.1296
Echinococcus multilocularis	musashi	0.0026	0.0198	0.0197
Trypanosoma cruzi	glyceraldehyde-3-phosphate dehydrogenase, putative	0.0086	0.087	0.2658
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0643	0.0643
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0066	0.0643	0.0629
Echinococcus multilocularis	lamin dm0	0.0026	0.0198	0.0197
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0066	0.0643	0.0643
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0109	0.0254
Brugia malayi	cytidine deaminase, identical	0.0052	0.0488	0.0487
Loa Loa (eye worm)	hypothetical protein	0.0605	0.6711	0.6711
Echinococcus granulosus	neuropeptide Y receptor	0.0066	0.0643	0.0643
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0013	0.0046	0.0046
Loa Loa (eye worm)	hypothetical protein	0.001	0.0015	0.0015
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0015	0.0014
Trypanosoma brucei	glyceraldehyde-3-phosphate dehydrogenase, putative	0.0086	0.087	0.2658
Brugia malayi	Protein kinase domain containing protein	0.0192	0.2069	0.2069
Schistosoma mansoni	biogenic amine receptor	0.0066	0.0643	0.0643
Schistosoma mansoni	coup transcription factor	0.001	0.0015	0.0014
Brugia malayi	Cytochrome P450 family protein	0.0012	0.0038	0.0038
Echinococcus granulosus	lamin dm0	0.0026	0.0198	0.0197
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0066	0.0643	0.0643
Schistosoma mansoni	RAR-like nuclear receptor	0.001	0.0015	0.0014
Echinococcus multilocularis	g protein coupled receptor	0.0066	0.0643	0.0643
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0643	0.0643
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0217	0.0217
Echinococcus granulosus	intermediate filament protein	0.0026	0.0198	0.0197
Echinococcus granulosus	neuropeptide receptor	0.0066	0.0643	0.0643
Loa Loa (eye worm)	cytochrome P450 family protein	0.0012	0.0038	0.0038
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0066	0.0643	0.0643
Echinococcus granulosus	rhodopsin orphan GPCR	0.0066	0.0643	0.0643
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative	0.0131	0.1379	0.4266
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0066	0.0643	0.0643
Loa Loa (eye worm)	glyceraldehyde 3-phosphate dehydrogenase	0.0086	0.0871	0.0871
Echinococcus granulosus	lamin	0.0026	0.0198	0.0197
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0029	0.0229	0.0229
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0643	0.0643
Echinococcus granulosus	hypothetical protein	0.0066	0.0643	0.0643
Echinococcus granulosus	rhodopsin orphan GPCR	0.0066	0.0643	0.0643
Schistosoma mansoni	amine GPCR	0.0066	0.0643	0.0643
Toxoplasma gondii	AMP deaminase	0.0292	0.3193	0.3193
Brugia malayi	Serotonin receptor	0.0066	0.0643	0.0643
Brugia malayi	nuclear receptor NHR-88	0.001	0.0015	0.0014
Trichomonas vaginalis	adenosylhomocysteinase, putative	0.0127	0.1329	0.1304
Leishmania major	glyceraldehyde-3-phosphate dehydrogenase-like protein	0.0086	0.087	0.0843
Loa Loa (eye worm)	G-protein coupled receptor	0.0066	0.0643	0.0643
Brugia malayi	Melatonin receptor type 1A	0.0066	0.0643	0.0643
Leishmania major	glyceraldehyde 3-phosphate dehydrogenase, glycosomal	0.0131	0.1379	0.1354
Schistosoma mansoni	neuropeptide receptor	0.0066	0.0643	0.0643
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0643	0.0643
Entamoeba histolytica	AMP deaminase, putative	0.0292	0.3193	0.3174
Loa Loa (eye worm)	glyceraldehyde-3-phosphate dehydrogenase	0.009	0.0922	0.0922
Trypanosoma cruzi	AMP deaminase, putative	0.0292	0.3193	1
Onchocerca volvulus		0.0066	0.0643	0.0629
Trypanosoma cruzi	S-adenosylhomocysteine hydrolase, putative	0.0127	0.1329	0.4109
Onchocerca volvulus		0.0066	0.0643	0.0629
Echinococcus multilocularis	serotonin receptor	0.0066	0.0643	0.0643
Schistosoma mansoni	intermediate filament proteins	0.0026	0.0198	0.0197
Onchocerca volvulus		0.0066	0.0643	0.0629
Brugia malayi	Pre-SET motif family protein	0.0029	0.0229	0.0229
Plasmodium vivax	adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative	0.0127	0.1329	0.1275
Wolbachia endosymbiont of Brugia malayi	glyceraldehyde-3-phosphate dehydrogenase, GapA	0.0131	0.1379	1
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0066	0.0643	0.0643
Schistosoma mansoni	adenosylhomocysteinase	0.0078	0.0786	0.0786
Onchocerca volvulus		0.0066	0.0643	0.0629
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0066	0.0643	0.0643
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0066	0.0643	0.0643
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0066	0.0643	0.0643
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0066	0.0643	0.0643
Echinococcus multilocularis	sex peptide receptor	0.0066	0.0643	0.0643
Trypanosoma cruzi	adenosine monophosphate deaminase-like protein, putative	0.0292	0.3193	1
Mycobacterium tuberculosis	Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH)	0.0045	0.0414	0.0308
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0643	0.0643
Schistosoma mansoni	adenoreceptor	0.0066	0.0643	0.0643
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative	0.0041	0.0361	0.1052
Trichomonas vaginalis	set domain proteins, putative	0.0229	0.2478	0.2457
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0015	0.0014
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0018	0.0109	0.0081
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0015	0.0014
Brugia malayi	Glyceraldehyde 3-phosphate dehydrogenase	0.0045	0.0413	0.0413
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0066	0.0643	0.0643
Brugia malayi	glyceraldehyde 3-phosphate dehydrogenase	0.0041	0.0361	0.0361
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0643	0.0643
Echinococcus multilocularis	glyceraldehyde 3 phosphate dehydrogenase	0.0086	0.0871	0.087
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0131	0.1379	0.4266
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0066	0.0643	0.0643
Echinococcus granulosus	neuropeptide receptor	0.0066	0.0643	0.0643
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.001	0.0015	0.0014
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0066	0.0643	0.0643
Schistosoma mansoni	cellular tumor antigen P53	0.0048	0.0442	0.0442
Echinococcus granulosus	tm gpcr rhodopsin	0.0066	0.0643	0.0643
Schistosoma mansoni	hypothetical protein	0.0066	0.0643	0.0643
Loa Loa (eye worm)	hypothetical protein	0.001	0.0015	0.0015
Toxoplasma gondii	exonuclease III APE	0.0018	0.0109	0.0109
Brugia malayi	hypothetical protein	0.0066	0.0643	0.0643
Toxoplasma gondii	Adenosine/AMP deaminase domain-containing protein	0.0898	1	1
Schistosoma mansoni	retinoic acid receptor RXR	0.001	0.0015	0.0014
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0066	0.0643	0.0643
Treponema pallidum	glyceraldehyde 3-phosphate dehydrogenase (gap)	0.0131	0.1379	0.1284
Brugia malayi	larval opioid receptor	0.0066	0.0643	0.0643
Onchocerca volvulus		0.0066	0.0643	0.0629
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0066	0.0643	0.0643
Leishmania major	adenosine monophosphate deaminase, putative,AMP deaminase, putative	0.0292	0.3193	0.3174
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0643	0.0643
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0643	0.0643
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0066	0.0643	0.0643
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0066	0.0643	0.0643
Echinococcus multilocularis	glyceraldehyde 3 phosphate dehydrogenase	0.0131	0.1379	0.1378
Entamoeba histolytica	glyceraldehyde-3-phosphate dehydrogenase, putative	0.0131	0.1379	0.1354
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0066	0.0643	0.0643
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0643	0.0643
Leishmania major	AMP deaminase, putative,adenosine monophosphate deaminase-like protein	0.0292	0.3193	0.3174
Schistosoma mansoni	hypothetical protein	0.0066	0.0643	0.0643
Trichomonas vaginalis	DNA helicase recq, putative	0.0021	0.0137	0.0108
Trypanosoma cruzi	AMP deaminase, putative	0.0292	0.3193	1
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0066	0.0643	0.0643
Loa Loa (eye worm)	glyceraldehyde 3-phosphate dehydrogenase	0.0086	0.0871	0.0871
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0442	0.0442
Plasmodium falciparum	adenosine deaminase	0.0898	1	1
Brugia malayi	hypothetical protein	0.0066	0.0643	0.0643
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0015	0.0014
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.0109	0.0081
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.0198	0.0198
Brugia malayi	Adenosylhomocysteinase	0.0127	0.1329	0.1329
Echinococcus granulosus	neuropeptide Y receptor	0.0066	0.0643	0.0643
Brugia malayi	putative neuropeptide receptor NPR1	0.0066	0.0643	0.0643
Echinococcus multilocularis	somatostatin receptor	0.0066	0.0643	0.0643
Echinococcus multilocularis	g-protein coupled receptor	0.0066	0.0643	0.0643
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0643	0.0643
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0643	0.0643
Trypanosoma cruzi	cytochrome P450, putative	0.0012	0.0038	0.0031
Echinococcus granulosus	tumor protein p63	0.0326	0.3576	0.3575
Echinococcus granulosus	7tm_1 domain containing protein	0.0066	0.0643	0.0643
Brugia malayi	Dopamine receptor protein 1	0.0066	0.0643	0.0643
Schistosoma mansoni	biogenic amine receptor	0.0066	0.0643	0.0643
Echinococcus multilocularis	fmrfamide receptor	0.0066	0.0643	0.0643
Toxoplasma gondii	cytidine and deoxycytidylate deaminase zinc-binding region domain-containing protein	0.0052	0.0488	0.0487
Schistosoma mansoni	blooms syndrome DNA helicase	0.0016	0.0088	0.0087
Schistosoma mansoni	adenosylhomocysteinase	0.0078	0.0786	0.0786
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0066	0.0643	0.0643
Echinococcus granulosus	somatostatin receptor	0.0066	0.0643	0.0643
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.001	0.0015	0.0014
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0015	0.0014
Loa Loa (eye worm)	TYRA-2 protein	0.0066	0.0643	0.0643
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0201	0.2166	0.2166
Loa Loa (eye worm)	RecQ helicase	0.0021	0.0137	0.0137
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0066	0.0643	0.0643
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0066	0.0643	0.0643
Echinococcus multilocularis	adenosylhomocysteinase	0.0127	0.1329	0.1329
Mycobacterium ulcerans	cytidine deaminase	0.0052	0.0488	0.0451
Leishmania major	S-adenosylhomocysteine hydrolase	0.0127	0.1329	0.1304
Echinococcus multilocularis	fmrfamide receptor	0.0066	0.0643	0.0643
Leishmania major	AMP deaminase, putative	0.0292	0.3193	0.3174
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.001	0.0015	0.0014
Loa Loa (eye worm)	neuropeptide F receptor	0.0066	0.0643	0.0643
Brugia malayi	G-protein coupled receptor	0.0066	0.0643	0.0643
Onchocerca volvulus		0.0066	0.0643	0.0629
Onchocerca volvulus		0.0029	0.0229	0.0215
Giardia lamblia	Glyceraldehyde 3-phosphate dehydrogenase	0.0086	0.087	0.6306
Trypanosoma cruzi	glyceraldehyde-3-phosphate dehydrogenase, putative	0.0086	0.087	0.2658
Schistosoma mansoni	biogenic amine receptor	0.0066	0.0643	0.0643
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0643	0.0643
Echinococcus granulosus	g protein coupled receptor	0.0066	0.0643	0.0643
Schistosoma mansoni	opsin-like receptor	0.0066	0.0643	0.0643
Brugia malayi	hypothetical protein	0.0066	0.0643	0.0643
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0643	0.0643
Plasmodium vivax	glyceraldehyde-3-phosphate dehydrogenase, putative	0.0131	0.1379	0.1325
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0066	0.0643	0.0643
Schistosoma mansoni	amine GPCR	0.0066	0.0643	0.0643
Schistosoma mansoni	neuropeptide f receptor 76f	0.0066	0.0643	0.0643
Schistosoma mansoni	amine GPCR	0.0066	0.0643	0.0643
Onchocerca volvulus		0.0229	0.2478	0.2467
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.001	0.0015	0.0015
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0066	0.0643	0.0643
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0001	0.0001
Echinococcus multilocularis	neuropeptide Y receptor	0.0066	0.0643	0.0643
Echinococcus multilocularis	ecdysone induced protein 78C	0.001	0.0015	0.0014
Loa Loa (eye worm)	hypothetical protein	0.001	0.0015	0.0015
Brugia malayi	cytoplasmic intermediate filament protein	0.0014	0.0062	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0871	0.0871
Loa Loa (eye worm)	melatonin receptor type 1A	0.0066	0.0643	0.0643
Brugia malayi	Pre-SET motif family protein	0.0201	0.2166	0.2165
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.001	0.0015	0.0014
Brugia malayi	neuropeptide F receptor	0.0066	0.0643	0.0643
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0643	0.0643
Echinococcus granulosus	g-protein coupled receptor	0.0066	0.0643	0.0643
Trypanosoma brucei	AMP deaminase, putative	0.0292	0.3193	1
Echinococcus multilocularis	g protein coupled receptor	0.0066	0.0643	0.0643
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0066	0.0643	0.0643
Schistosoma mansoni	adenosine deaminase-related	0.0898	1	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0015	0.0015
Trypanosoma cruzi	AMP deaminase, putative	0.0292	0.3193	1
Onchocerca volvulus		0.0066	0.0643	0.0629
Echinococcus granulosus	biogenic amine 5HT receptor	0.0066	0.0643	0.0643
Echinococcus multilocularis	bloom syndrome protein	0.0021	0.0137	0.0136
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0066	0.0643	0.0643
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0643	0.0643
Brugia malayi	Dopamine receptor	0.0066	0.0643	0.0643
Schistosoma mansoni	growth hormone secretagogue receptor	0.0066	0.0643	0.0643
Onchocerca volvulus	AMP deaminase 2 homolog	0.0292	0.3193	0.3183
Loa Loa (eye worm)	hypothetical protein	0.001	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0643	0.0643
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.0015	0.0014
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0066	0.0643	0.0643
Entamoeba histolytica	glyceraldehyde-3-phosphate dehydrogenase, putative	0.0131	0.1379	0.1354
Brugia malayi	Steroid receptor seven-up type 2	0.001	0.0015	0.0014
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0066	0.0643	0.0643
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0229	0.0229
Onchocerca volvulus		0.0066	0.0643	0.0629
Echinococcus multilocularis	tumor protein p63	0.0326	0.3576	0.3575

Activities

Activity type	Activity value	Assay description	Source	Reference
ED1.5 (functional)	= 0.23 mg kg-1	Effective dose required to produce an increase in dP/dt50, blood pressure by 1500 mmHg/s was determined in cat by intravenous administration	ChEMBL.	3612681
ED1.5 (functional)	= 0.96 mg kg-1	Effective dose required to produce an increase in dP/dt50, blood pressure by 1500 mmHg/s was determined in rat by intravenous administration	ChEMBL.	3612681
ED1.5 (functional)	= 1.11 mg kg-1	Effective dose required to produce an increase in dP/dt50, blood pressure by 1500 mmHg/s was determined in dog by intravenous administration	ChEMBL.	3612681
Max (functional)	= 1.7	Maximum increase in dP/dt recorded in mmHg/s at the dose 3.0 mg/kg administered intravenously in dog	ChEMBL.	3612681
Max (functional)	= 2.4	Maximum increase in dP/dt recorded in mmHg/s at the dose 3.0 mg/kg administered intravenously in rat.	ChEMBL.	3612681
Max (functional)	= 2.7	Maximum increase in dP/dt recorded in mmHg/s at the dose 3.0 mg/kg administered intravenously in cat	ChEMBL.	3612681

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL24435

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 29899