Detailed information for compound 29905

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 459.456 | Formula: C20H25N7O6
  • H donors: 8 H acceptors: 8 LogP: 0.77 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC(=O)CCC(C(=O)O)NC(=O)c1ccc(cc1)NCC[C@H]1CNc2c(N1)c(O)nc(n2)N
  • InChi: 1S/C20H25N7O6/c21-20-26-16-15(18(31)27-20)24-12(9-23-16)7-8-22-11-3-1-10(2-4-11)17(30)25-13(19(32)33)5-6-14(28)29/h1-4,12-13,22,24H,5-9H2,(H,25,30)(H,28,29)(H,32,33)(H4,21,23,26,27,31)/t12-,13?/m0/s1
  • InChiKey: SVEJTXIHPDUQLZ-UEWDXFNNSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase Starlite/ChEMBL References
Mus musculus phosphoribosylglycinamide formyltransferase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Wolbachia endosymbiont of Brugia malayi phosphoribosylaminoimidazole synthetase Get druggable targets OG5_126894 All targets in OG5_126894
Mycobacterium tuberculosis Probable phosphoribosylformylglycinamidine CYCLO-ligase PurM (AIRS) (phosphoribosyl-aminoimidazole synthetase) (air synthase) Get druggable targets OG5_126894 All targets in OG5_126894
Onchocerca volvulus Get druggable targets OG5_126894 All targets in OG5_126894
Mycobacterium leprae PROBABLE PHOSPHORIBOSYLFORMYLGLYCINAMIDINE CYCLO-LIGASE PURM (AIRS) (PHOSPHORIBOSYL-AMINOIMIDAZOLE SYNTHETASE) (AIR SYNTHASE) Get druggable targets OG5_126894 All targets in OG5_126894
Mycobacterium ulcerans phosphoribosylamine--glycine ligase Get druggable targets OG5_126894 All targets in OG5_126894
Wolbachia endosymbiont of Brugia malayi phosphoribosylamine--glycine ligase Get druggable targets OG5_126894 All targets in OG5_126894
Onchocerca volvulus Get druggable targets OG5_126894 All targets in OG5_126894
Mycobacterium tuberculosis Probable phosphoribosylamine--glycine ligase PurD (GARS) (glycinamide ribonucleotide synthetase) (phosphoribosylglycinamide synt Get druggable targets OG5_126894 All targets in OG5_126894
Mycobacterium leprae PROBABLE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE PURD (GARS) (GLYCINAMIDE RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE SYNT Get druggable targets OG5_126894 All targets in OG5_126894
Mycobacterium ulcerans phosphoribosylaminoimidazole synthetase Get druggable targets OG5_126894 All targets in OG5_126894
Candida albicans N terminus of ADE5,7 bifunctional ligase Get druggable targets OG5_126894 All targets in OG5_126894
Candida albicans purine biosynthesis Get druggable targets OG5_126894 All targets in OG5_126894
Candida albicans ADE5,7 bifunctional ligase Get druggable targets OG5_126894 All targets in OG5_126894
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0107 0.1081 0.1324
Trypanosoma brucei trypanothione reductase 0.0229 0.2568 1
Plasmodium vivax glutathione reductase, putative 0.0229 0.2568 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0045 0.0323 0.2827
Mycobacterium ulcerans hypothetical protein 0.0107 0.1081 0.2596
Echinococcus granulosus protein jagged 1 0.0034 0.0177 0.0421
Onchocerca volvulus 0.0176 0.1925 0.8959
Schistosoma mansoni hypothetical protein 0.0034 0.0177 0.0328
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0191 0.0355
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0191 0.0183
Loa Loa (eye worm) thioredoxin reductase 0.0229 0.2568 0.7323
Loa Loa (eye worm) hypothetical protein 0.0034 0.0177 0.0506
Schistosoma mansoni laminin gamma-3 chain 0.0034 0.0177 0.0328
Loa Loa (eye worm) hypothetical protein 0.002 0.0008 0.0023
Brugia malayi beta-lactamase family protein 0.0107 0.1081 0.3068
Trichomonas vaginalis penicillin-binding protein, putative 0.0107 0.1081 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0079 0.0737 0.2869
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.0948 0.1823
Trichomonas vaginalis mercuric reductase, putative 0.0079 0.0737 0.6742
Brugia malayi nuclear receptor NHR-88 0.0021 0.0027 0.0054
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0027 0.0088
Toxoplasma gondii EGF family domain-containing protein 0.0034 0.0177 0.0661
Brugia malayi hypothetical protein 0.0176 0.1925 0.548
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0079 0.0737 0.2869
Mycobacterium leprae Probable lipase LipE 0.0107 0.1081 0.2554
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0079 0.0613
Loa Loa (eye worm) hypothetical protein 0.0051 0.039 0.1113
Loa Loa (eye worm) hypothetical protein 0.0026 0.0088 0.025
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0079 0.0737 0.2803
Loa Loa (eye worm) glutathione reductase 0.0229 0.2568 0.7323
Echinococcus multilocularis neurogenic locus notch protein 0.0034 0.0177 0.0169
Loa Loa (eye worm) hypothetical protein 0.0034 0.0177 0.0506
Leishmania major selenophosphate synthetase, putative 0.0027 0.0095 0.028
Mycobacterium tuberculosis Probable hydrolase 0.0107 0.1081 0.1324
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0058 0.0479 0.1346
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0079 0.0737 0.2803
Trichomonas vaginalis penicillin-binding protein, putative 0.0107 0.1081 1
Onchocerca volvulus 0.0176 0.1925 0.8959
Echinococcus multilocularis neurogenic locus notch protein 0.0034 0.0177 0.0169
Onchocerca volvulus 0.0021 0.0027 0.0088
Onchocerca volvulus Putative cubilin 0.0034 0.0177 0.0791
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0021 0.0024 0.0092
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0226 0.0797
Mycobacterium tuberculosis Probable esterase LipL 0.0107 0.1081 0.1324
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0027 0.0077
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0021 0.0024 0.0015
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0027 0.0036
Onchocerca volvulus 0.0107 0.1081 0.5015
Echinococcus multilocularis glutamate synthase 0.0021 0.0024 0.0015
Plasmodium falciparum selenide water dikinase, putative 0.0027 0.0095 0.0369
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0021 0.0024 0.0015
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0088 0.0341
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0079 0.0737 0.1722
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0291 0.3333 0.799
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0079 0.0737 0.2869
Schistosoma mansoni hypothetical protein 0.0035 0.0191 0.0355
Mycobacterium tuberculosis Conserved protein 0.0107 0.1081 0.1324
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0107 0.1081 0.2082
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0027 0.0019
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0027 0.0036
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0027 0.0088
Schistosoma mansoni hypothetical protein 0.0039 0.0247 0.0464
Loa Loa (eye worm) hypothetical protein 0.0021 0.0027 0.0077
Schistosoma mansoni notch 0.0034 0.0177 0.0328
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0291 0.3333 0.408
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0027 0.0036
Loa Loa (eye worm) hypothetical protein 0.0034 0.0177 0.0506
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0027 0.0054
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0079 0.0737 0.1811
Schistosoma mansoni hypothetical protein 0.0039 0.0247 0.0464
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0027 0.0054
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0027 0.0054
Loa Loa (eye worm) hypothetical protein 0.0034 0.0177 0.0506
Chlamydia trachomatis thioredoxin reductase 0.0021 0.0024 0.032
Mycobacterium tuberculosis Hypothetical protein 0.0093 0.0899 0.11
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0021 0.0024 0.0057
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0027 0.0077
Plasmodium vivax apical sushi protein, putative 0.0176 0.1925 0.7498
Onchocerca volvulus 0.0034 0.0177 0.0791
Echinococcus granulosus Niemann Pick C1 protein 0.0095 0.093 0.2292
Loa Loa (eye worm) hypothetical protein 0.0021 0.0027 0.0077
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0027 0.0047
Schistosoma mansoni slit 0.0034 0.0177 0.0328
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0226 0.0646
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0195 0.2148 0.8351
Brugia malayi EGF-like domain containing protein 0.0034 0.0177 0.0484
Brugia malayi Muscle positioning protein 4 0.0034 0.0177 0.0484
Loa Loa (eye worm) lectin C-type domain-containing protein 0.002 0.0008 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0265 0.2286
Onchocerca volvulus 0.0026 0.0079 0.0332
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0027 0.0077
Mycobacterium ulcerans thymidylate synthase 0.0195 0.2148 0.5157
Loa Loa (eye worm) hypothetical protein 0.0026 0.0079 0.0226
Echinococcus granulosus geminin 0.0347 0.4016 0.9965
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0027 0.0077
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0027 0.0054
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0027 0.0036
Loa Loa (eye worm) thymidylate synthase 0.0195 0.2148 0.6126
Loa Loa (eye worm) programmed cell death 8 0.0021 0.0024 0.0067
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0027 0.0019
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0233 0.262 0.3207
Mycobacterium ulcerans glutamate synthase subunit beta 0.0021 0.0024 0.0057
Schistosoma mansoni selinide water dikinase 0.0027 0.0095 0.0168
Schistosoma mansoni notch 0.0034 0.0177 0.0328
Loa Loa (eye worm) hypothetical protein 0.0107 0.1081 0.3084
Echinococcus granulosus delta-like protein 1 0.0034 0.0177 0.0421
Plasmodium falciparum histone acetyltransferase GCN5 0.0042 0.0276 0.1076
Giardia lamblia NADH oxidase lateral transfer candidate 0.0079 0.0737 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0008 0.0023
Echinococcus multilocularis Niemann Pick C1 protein 0.0095 0.093 0.0923
Echinococcus granulosus selenide water dikinase 0.0027 0.0095 0.0215
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0021 0.0024 0.0038
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0021 0.0024 0.006
Echinococcus multilocularis expressed conserved protein 0.0089 0.0859 0.0852
Echinococcus granulosus beta LACTamase domain containing family member 0.0107 0.1081 0.2668
Schistosoma mansoni sulfide quinone reductase 0.0021 0.0024 0.003
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.0968 0.1861
Echinococcus multilocularis 0.0027 0.0095 0.0087
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0021 0.0024 0.0029
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0226 0.2845
Brugia malayi hypothetical protein 0.0093 0.0899 0.2547
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0027 0.0054
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0021 0.0024 0.0044
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0265 0.0257
Echinococcus multilocularis beta LACTamase domain containing family member 0.0107 0.1081 0.1074
Plasmodium vivax thioredoxin reductase, putative 0.0229 0.2568 1
Echinococcus granulosus fibropellin Ia 0.0034 0.0177 0.0421
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0229 0.2568 0.3142
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0079 0.0203
Echinococcus multilocularis Niemann Pick C1 protein 0.0136 0.143 0.1422
Schistosoma mansoni glutamate synthase 0.0021 0.0024 0.003
Brugia malayi Calcium binding EGF domain containing protein 0.0034 0.0177 0.0484
Schistosoma mansoni hypothetical protein 0.0039 0.0247 0.0464
Leishmania major hypothetical protein, conserved 0.0026 0.0088 0.0252
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0027 0.0054
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0021 0.0024 0.0038
Mycobacterium ulcerans phosphoribosylamine--glycine ligase 0.0359 0.4166 1
Schistosoma mansoni hypothetical protein 0.0034 0.0177 0.0328
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0027 0.0036
Leishmania major trypanothione reductase 0.0229 0.2568 1
Wolbachia endosymbiont of Brugia malayi phosphoribosylformylglycinamidine synthase domain-containing protein 0.0027 0.0095 0.0172
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0191 0.0455
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0195 0.2148 0.8351
Brugia malayi ecdysteroid receptor 0.0021 0.0027 0.0054
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0027 0.0047
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.0968 0.1861
Plasmodium falciparum glutathione reductase 0.0229 0.2568 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0079 0.0737 0.2803
Echinococcus granulosus tumor protein p63 0.0348 0.403 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0027 0.0047
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0027 0.0036
Echinococcus multilocularis slit 2 protein 0.0034 0.0177 0.0169
Toxoplasma gondii NADPH-glutathione reductase 0.0079 0.0737 0.2847
Brugia malayi selenium donor protein 0.0027 0.0095 0.0248
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0226 0.0797
Echinococcus granulosus thymidylate synthase 0.0195 0.2148 0.532
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0027 0.0047
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0107 0.1081 0.3084
Loa Loa (eye worm) hypothetical protein 0.002 0.0008 0.0023
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0021 0.0024 0.0092
Entamoeba histolytica hypothetical protein 0.0035 0.0191 0.185
Loa Loa (eye worm) hypothetical protein 0.002 0.0008 0.0023
Entamoeba histolytica hypothetical protein 0.0035 0.0191 0.185
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0027 0.0036
Brugia malayi EGF-like domain containing protein 0.0034 0.0177 0.0484
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0195 0.2148 0.8351
Onchocerca volvulus 0.0034 0.0177 0.0791
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0027 0.0019
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0233 0.262 0.3207
Mycobacterium tuberculosis Probable phosphoribosylformylglycinamidine CYCLO-ligase PurM (AIRS) (phosphoribosyl-aminoimidazole synthetase) (air synthase) 0.0079 0.0737 0.0902
Loa Loa (eye worm) MH2 domain-containing protein 0.0129 0.1344 0.3832
Mycobacterium ulcerans monoxygenase 0.0021 0.0024 0.0057
Schistosoma mansoni notch 0.0034 0.0177 0.0328
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0107 0.1081 0.2082
Schistosoma mansoni notch 0.0034 0.0177 0.0328
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0195 0.2148 0.415
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0027 0.0077
Loa Loa (eye worm) hypothetical protein 0.0021 0.0027 0.0077
Mycobacterium ulcerans phosphoribosylaminoimidazole synthetase 0.0079 0.0737 0.1769
Echinococcus granulosus slit 2 protein 0.0034 0.0177 0.0421
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0027 0.0054
Loa Loa (eye worm) hypothetical protein 0.0095 0.093 0.2652
Schistosoma mansoni ap endonuclease 0.0038 0.0226 0.0423
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0079 0.0737 0.2803
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0079 0.0737 0.2803
Brugia malayi Thioredoxin reductase 0.0229 0.2568 0.7317
Loa Loa (eye worm) hypothetical protein 0.0034 0.0177 0.0506
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.0968 0.096
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0021 0.0024 0.006
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0226 0.0218
Toxoplasma gondii selenide, water dikinase 0.0048 0.0352 0.1345
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0195 0.2148 0.8366
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0088 0.031
Mycobacterium ulcerans beta-lactamase 0.0107 0.1081 0.2596
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0107 0.1081 0.1324
Echinococcus multilocularis protein dispatched 1 0.0047 0.0336 0.0328
Loa Loa (eye worm) hypothetical protein 0.0034 0.0177 0.0506
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0045 0.0323 0.1228
Loa Loa (eye worm) acetyltransferase 0.0155 0.1659 0.4732
Onchocerca volvulus 0.0034 0.0177 0.0791
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0034 0.0177 0.0484
Loa Loa (eye worm) hypothetical protein 0.0034 0.0177 0.0506
Loa Loa (eye worm) lectin C-type domain-containing protein 0.002 0.0008 0.0023
Brugia malayi Cadherin domain containing protein 0.0034 0.0177 0.0484
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0045 0.0323 0.1256
Brugia malayi EGF-like domain containing protein 0.0034 0.0177 0.0484
Trypanosoma cruzi hypothetical protein, conserved 0.0107 0.1081 0.4158
Brugia malayi steroid hormone receptor 0.0021 0.0027 0.0054
Trypanosoma cruzi hypothetical protein, conserved 0.0107 0.1081 0.4158
Mycobacterium leprae PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE II PURL (FGAM SYNTHASE II) 0.0027 0.0095 0.0172
Echinococcus granulosus neurogenic locus notch protein 0.0034 0.0177 0.0421
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0045 0.0323 0.2827
Schistosoma mansoni glutamate synthase 0.0021 0.0024 0.003
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0233 0.262 0.3207
Schistosoma mansoni cell polarity protein 0.0034 0.0177 0.0328
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0226 0.0797
Trichomonas vaginalis esterase, putative 0.0107 0.1081 1
Schistosoma mansoni ap endonuclease 0.0038 0.0226 0.0423
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0079 0.0737 0.1769
Echinococcus multilocularis fat cadherin tumor suppressor 0.0034 0.0177 0.0169
Loa Loa (eye worm) hypothetical protein 0.002 0.0008 0.0023
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0021 0.0024 0.0044
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0027 0.0019
Brugia malayi MH2 domain containing protein 0.0129 0.1344 0.3818
Mycobacterium tuberculosis Probable lipase LipD 0.0107 0.1081 0.1324
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0079 0.0613
Echinococcus multilocularis muscleblind protein 1 0.0306 0.3506 0.3501
Toxoplasma gondii thioredoxin reductase 0.0229 0.2568 1
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0021 0.0024 0.0044
Loa Loa (eye worm) hypothetical protein 0.0034 0.0177 0.0506
Echinococcus multilocularis protein jagged 1 0.0034 0.0177 0.0169
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0021 0.0024 0.0015
Brugia malayi Calcium binding EGF domain containing protein 0.0034 0.0177 0.0484
Mycobacterium leprae PROBABLE PHOSPHORIBOSYLFORMYLGLYCINAMIDINE CYCLO-LIGASE PURM (AIRS) (PHOSPHORIBOSYL-AMINOIMIDAZOLE SYNTHETASE) (AIR SYNTHASE) 0.0079 0.0737 0.1722
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0195 0.2148 0.8366
Loa Loa (eye worm) ShTK domain-containing protein 0.002 0.0008 0.0023
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0079 0.019
Loa Loa (eye worm) hypothetical protein 0.0107 0.1081 0.3084
Wolbachia endosymbiont of Brugia malayi phosphoribosylaminoimidazole synthetase 0.0079 0.0737 0.1722
Schistosoma mansoni disulfide oxidoreductase 0.0021 0.0024 0.003
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0079 0.0737 0.1413
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0021 0.0024 0.0057
Entamoeba histolytica acetyltransferase, GNAT family 0.0042 0.0276 0.2787
Loa Loa (eye worm) hypothetical protein 0.0034 0.0177 0.0506
Echinococcus granulosus neurogenic locus notch protein 4 0.0034 0.0177 0.0421
Schistosoma mansoni hypothetical protein 0.0021 0.0024 0.003
Brugia malayi beta-lactamase 0.0107 0.1081 0.3068
Echinococcus granulosus histone acetyltransferase KAT2B 0.015 0.1606 0.3972
Loa Loa (eye worm) hypothetical protein 0.0034 0.0177 0.0506
Mycobacterium ulcerans hypothetical protein 0.0026 0.0079 0.019
Schistosoma mansoni hypothetical protein 0.0039 0.0247 0.0464
Brugia malayi Calcium binding EGF domain containing protein 0.0034 0.0177 0.0484
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0079 0.0203
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0021 0.0024 0.0057
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0021 0.0024 0.0038
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0021 0.0024 0.0015
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0079 0.0219
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0195 0.2148 0.2629
Loa Loa (eye worm) hypothetical protein 0.0176 0.1925 0.5491
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0155 0.1659 0.3202
Brugia malayi Cadherin domain containing protein 0.0034 0.0177 0.0484
Mycobacterium tuberculosis Probable phosphoribosylamine--glycine ligase PurD (GARS) (glycinamide ribonucleotide synthetase) (phosphoribosylglycinamide synt 0.0052 0.0408 0.05
Brugia malayi GCC2 and GCC3 family protein 0.021 0.2337 0.6657
Schistosoma mansoni patched 1 0.0041 0.0265 0.0499
Loa Loa (eye worm) hypothetical protein 0.005 0.0378 0.1078
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0226 0.0882
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0226 0.0543
Loa Loa (eye worm) hypothetical protein 0.0196 0.2168 0.6182
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0021 0.0024 0.0057
Schistosoma mansoni hypothetical protein 0.0034 0.0177 0.0328
Echinococcus multilocularis geminin 0.0347 0.4016 0.4011
Echinococcus granulosus C type lectin domian containing protein 0.0176 0.1925 0.4766
Schistosoma mansoni hypothetical protein 0.0034 0.0177 0.0328
Trichomonas vaginalis D-aminoacylase, putative 0.0107 0.1081 1
Leishmania major hypothetical protein, conserved 0.0107 0.1081 0.4158
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0027 0.0047
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0021 0.0024 0.0029
Loa Loa (eye worm) hypothetical protein 0.0034 0.0177 0.0506
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0079 0.019
Treponema pallidum NADH oxidase 0.0079 0.0737 1
Loa Loa (eye worm) Notch2 0.0034 0.0177 0.0506
Loa Loa (eye worm) beta-lactamase 0.0107 0.1081 0.3084
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0021 0.0024 0.006
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0088 0.0252
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0079 0.0737 0.1769
Onchocerca volvulus 0.0107 0.1081 0.5015
Echinococcus multilocularis C type lectin domian containing protein 0.0176 0.1925 0.1919
Loa Loa (eye worm) hypothetical protein 0.0176 0.1925 0.5491
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0226 0.0544
Schistosoma mansoni c4b-binding protein beta chain 0.0176 0.1925 0.3718
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0021 0.0024 0.0057
Plasmodium falciparum glutathione reductase 0.0079 0.0737 0.2869
Echinococcus multilocularis fibropellin Ia 0.0034 0.0177 0.0169
Loa Loa (eye worm) hypothetical protein 0.0026 0.0079 0.0226
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0079 0.0219
Onchocerca volvulus 0.0176 0.1925 0.8959
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0095 0.093 1
Schistosoma mansoni coup transcription factor 0.0021 0.0027 0.0036
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0027 0.0019
Wolbachia endosymbiont of Brugia malayi phosphoribosylamine--glycine ligase 0.0359 0.4166 1
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0093 0.0899 0.3442
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0027 0.0047
Loa Loa (eye worm) hypothetical protein 0.0034 0.0177 0.0506
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0098 0.0968 0.276
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0021 0.0024 0.0038
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0233 0.262 0.3207
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0027 0.0054
Loa Loa (eye worm) hypothetical protein 0.0176 0.1925 0.5491
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.0968 0.096
Loa Loa (eye worm) hypothetical protein 0.0306 0.3506 1
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0021 0.0024 0.0029
Loa Loa (eye worm) hypothetical protein 0.0306 0.3506 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0079 0.0737 0.2803
Trypanosoma cruzi trypanothione reductase, putative 0.0079 0.0737 0.2803
Echinococcus multilocularis c4b binding protein beta chain 0.0176 0.1925 0.1919
Echinococcus multilocularis tumor protein p63 0.0348 0.403 0.4025
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0195 0.2148 0.5129
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0155 0.1659 0.1652
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0079 0.0613
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.0968 0.1861
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0027 0.0019
Trichomonas vaginalis D-aminoacylase, putative 0.0107 0.1081 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0107 0.1081 0.1324
Plasmodium falciparum ferrodoxin reductase-like protein 0.0021 0.0024 0.0092
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0021 0.0024 0.0029
Brugia malayi glutathione reductase 0.0229 0.2568 0.7317
Echinococcus multilocularis notch 0.0034 0.0177 0.0169
Giardia lamblia Histone acetyltransferase GCN5 0.0042 0.0276 0.3542
Schistosoma mansoni septate junction protein 0.0034 0.0177 0.0328
Trichomonas vaginalis glutathione reductase, putative 0.0079 0.0737 0.6742
Loa Loa (eye worm) hypothetical protein 0.0034 0.0177 0.0506
Onchocerca volvulus Slit protein homolog 0.0034 0.0177 0.0791
Brugia malayi beta-lactamase family protein 0.0107 0.1081 0.3068
Loa Loa (eye worm) hypothetical protein 0.0041 0.0265 0.0757
Echinococcus multilocularis protein jagged 1 0.0034 0.0177 0.0169
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0687 0.817 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0079 0.0737 0.2803
Mycobacterium leprae conserved hypothetical protein 0.0107 0.1081 0.2554
Loa Loa (eye worm) notch protein 0.0034 0.0177 0.0506
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0265 0.064
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0021 0.0024 0.0092
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0088 0.0341
Loa Loa (eye worm) hypothetical protein 0.002 0.0008 0.0023
Brugia malayi CHE-14 protein 0.0041 0.0265 0.0735
Loa Loa (eye worm) hypothetical protein 0.0034 0.0177 0.0506
Toxoplasma gondii exonuclease III APE 0.0038 0.0226 0.0853
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0058 0.0479 0.1346
Plasmodium falciparum thioredoxin reductase 0.0079 0.0737 0.2869
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0226 0.2845
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0233 0.262 0.6268
Plasmodium vivax selenophosphate synthetase, putative 0.0027 0.0095 0.0369
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0027 0.0088
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0021 0.0024 0.0029
Mycobacterium ulcerans ferredoxin reductase 0.0021 0.0024 0.0057
Mycobacterium ulcerans lipase LipD 0.0107 0.1081 0.2596
Echinococcus granulosus expressed conserved protein 0.0089 0.0859 0.2116
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0027 0.0019
Trypanosoma cruzi trypanothione reductase, putative 0.0229 0.2568 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0107 0.1081 0.2596
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0021 0.0024 0.0015
Loa Loa (eye worm) hypothetical protein 0.0107 0.1081 0.3084
Giardia lamblia High cysteine protein 0.0034 0.0177 0.2157
Brugia malayi hypothetical protein 0.0176 0.1925 0.548
Trypanosoma cruzi selenophosphate synthetase, putative 0.0027 0.0095 0.028
Echinococcus granulosus notch 0.0034 0.0177 0.0421
Mycobacterium tuberculosis Probable dehydrogenase 0.0233 0.262 0.3207
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0079 0.0737 0.0729
Loa Loa (eye worm) hypothetical protein 0.002 0.0008 0.0023
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0195 0.2148 0.8361
Toxoplasma gondii ABC1 family protein 0.0107 0.1081 0.4193
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0226 0.2238
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0027 0.0054
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0079 0.0737 0.2803
Echinococcus granulosus c4b binding protein beta chain 0.0176 0.1925 0.4766
Schistosoma mansoni notch 0.0034 0.0177 0.0328
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.0968 0.2386
Loa Loa (eye worm) hypothetical protein 0.0021 0.0027 0.0077
Trypanosoma brucei Selenophosphate synthetase 2 0.0027 0.0095 0.028
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0079 0.0737 0.2869
Mycobacterium ulcerans dehydrogenase 0.0021 0.0024 0.0057
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0079 0.0737 0.1769
Brugia malayi hypothetical protein 0.0176 0.1925 0.548
Plasmodium vivax ferrodoxin reductase, putative 0.0021 0.0024 0.0092
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0226 0.049
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0027 0.0019
Schistosoma mansoni hypothetical protein 0.0347 0.4016 0.7774
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0079 0.0737 0.2803
Loa Loa (eye worm) hypothetical protein 0.0107 0.1081 0.3084
Onchocerca volvulus 0.0195 0.2148 1
Echinococcus multilocularis neural cadherin 0.0034 0.0177 0.0169
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0098 0.0968 0.2743
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0027 0.0054
Echinococcus granulosus neurogenic locus notch protein 0.0034 0.0177 0.0421
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0027 0.0054
Brugia malayi acetyltransferase, GNAT family protein 0.0155 0.1659 0.4719
Brugia malayi Muscleblind-like protein 0.0306 0.3506 1
Onchocerca volvulus 0.0107 0.1081 0.5015
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0079 0.0737 0.2803
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0226 0.0624
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0027 0.0054
Loa Loa (eye worm) hypothetical protein 0.0176 0.1925 0.5491
Loa Loa (eye worm) hypothetical protein 0.0026 0.0079 0.0226
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0021 0.0024 0.006
Mycobacterium tuberculosis Phosphoribosylformylglycinamidine synthase II PurL (FGAM synthase II) 0.0027 0.0095 0.0116
Brugia malayi hypothetical protein 0.0176 0.1925 0.548
Brugia malayi hypothetical protein 0.0035 0.0191 0.0523
Loa Loa (eye worm) pregnancy-associated plasma protein-E 0.0176 0.1925 0.5491
Echinococcus multilocularis neurogenic locus protein delta 0.0034 0.0177 0.0169
Loa Loa (eye worm) hypothetical protein 0.0021 0.0027 0.0077
Onchocerca volvulus 0.0034 0.0177 0.0791
Onchocerca volvulus 0.0176 0.1925 0.8959
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0027 0.0036
Onchocerca volvulus 0.0063 0.054 0.2483
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0088 0.0252
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0027 0.0077
Loa Loa (eye worm) hypothetical protein 0.0107 0.1081 0.3084
Plasmodium falciparum apical sushi protein 0.0176 0.1925 0.7498
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0079 0.0737 0.2083
Loa Loa (eye worm) hypothetical protein 0.0176 0.1925 0.5491
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0226 0.1918
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0226 0.0882
Onchocerca volvulus 0.0176 0.1925 0.8959
Loa Loa (eye worm) hypothetical protein 0.0176 0.1925 0.5491
Loa Loa (eye worm) hypothetical protein 0.021 0.2337 0.6665
Echinococcus granulosus neurogenic locus protein delta 0.0034 0.0177 0.0421
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0079 0.0134
Brugia malayi hypothetical protein 0.0026 0.0088 0.0227
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0079 0.0737 0.2803
Loa Loa (eye worm) hypothetical protein 0.0034 0.0177 0.0506
Onchocerca volvulus 0.0176 0.1925 0.8959
Echinococcus granulosus histone acetyltransferase KAT2B 0.0045 0.0323 0.0782
Echinococcus multilocularis neurogenic locus notch protein 4 0.0034 0.0177 0.0169
Brugia malayi EGF-like domain containing protein 0.0034 0.0177 0.0484
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0107 0.1081 0.3068
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0079 0.0097
Loa Loa (eye worm) hypothetical protein 0.0034 0.0177 0.0506
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0021 0.0024 0.0038
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0226 0.1918
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0021 0.0024 0.0092
Echinococcus multilocularis muscleblind protein 0.0306 0.3506 0.3501
Mycobacterium tuberculosis Probable oxidoreductase 0.0291 0.3333 0.408
Mycobacterium ulcerans hypothetical protein 0.0021 0.0024 0.0057
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0079 0.0737 0.2803
Schistosoma mansoni hypothetical protein 0.0034 0.0177 0.0328
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0027 0.0054
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0027 0.0019
Mycobacterium tuberculosis Conserved protein 0.0107 0.1081 0.1324
Loa Loa (eye worm) lectin C-type domain-containing protein 0.002 0.0008 0.0023
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0079 0.0097
Echinococcus granulosus thioredoxin glutathione reductase 0.0229 0.2568 0.6363
Brugia malayi Niemann-Pick C1 protein precursor 0.0095 0.093 0.2635
Echinococcus granulosus muscleblind protein 0.0306 0.3506 0.8697
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0027 0.0036
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0079 0.0134
Loa Loa (eye worm) transcription factor SMAD2 0.0129 0.1344 0.3832
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0265 0.0757
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.0968 0.2386
Loa Loa (eye worm) hypothetical protein 0.0176 0.1925 0.5491
Onchocerca volvulus 0.0034 0.0177 0.0791
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0045 0.0323 0.1228
Schistosoma mansoni notch 0.0034 0.0177 0.0328
Loa Loa (eye worm) hypothetical protein 0.0034 0.0177 0.0506
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0265 0.064
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0079 0.019
Onchocerca volvulus 0.0176 0.1925 0.8959
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0226 0.0277
Schistosoma mansoni sulfide quinone reductase 0.0021 0.0024 0.003
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0226 0.0797
Brugia malayi Delta serrate ligand family protein 0.0034 0.0177 0.0484
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.0067
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0027 0.0077
Onchocerca volvulus 0.0051 0.039 0.1785
Plasmodium falciparum thioredoxin reductase 0.0229 0.2568 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0079 0.0737 1
Onchocerca volvulus Neurogenic locus notch homolog 0.0034 0.0177 0.0791
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0021 0.0024 0.0029
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0027 0.0036
Schistosoma mansoni glutamate synthase 0.0021 0.0024 0.003
Plasmodium vivax hypothetical protein, conserved 0.0107 0.1081 0.4212
Schistosoma mansoni hypothetical protein 0.0034 0.0177 0.0328
Trypanosoma cruzi selenophosphate synthetase, putative 0.0027 0.0095 0.028
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0034 0.0177 0.0791
Brugia malayi EGF-like domain containing protein 0.0034 0.0177 0.0484
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0027 0.0036
Brugia malayi EGF-like domain containing protein 0.0034 0.0177 0.0484
Echinococcus multilocularis thioredoxin glutathione reductase 0.0229 0.2568 0.2561
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0034 0.0177 0.0328
Onchocerca volvulus 0.0176 0.1925 0.8959
Brugia malayi Sushi domain 0.0176 0.1925 0.548
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0021 0.0024 0.0067
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0027 0.0047
Echinococcus multilocularis protein jagged 2 0.0034 0.0177 0.0169
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0027 0.0054
Echinococcus granulosus protein jagged 2 0.0034 0.0177 0.0421
Echinococcus granulosus glutamate synthase 0.0021 0.0024 0.0038
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0079 0.0737 0.0902
Loa Loa (eye worm) hypothetical protein 0.0107 0.1081 0.3084
Mycobacterium ulcerans esterase/lipase LipP 0.0107 0.1081 0.2596
Echinococcus multilocularis protein patched 0.0041 0.0265 0.0257
Brugia malayi notch-like transmembrane receptor 0.0034 0.0177 0.0484
Brugia malayi glutamate synthase 0.0021 0.0024 0.0044
Loa Loa (eye worm) hypothetical protein 0.002 0.0008 0.0023
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0079 0.0737 0.2803
Mycobacterium ulcerans NADH dehydrogenase 0.0021 0.0024 0.0057
Toxoplasma gondii rhoptry neck protein RON1 0.0176 0.1925 0.749
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0021 0.0024 0.0057
Schistosoma mansoni hypothetical protein 0.0034 0.0177 0.0328
Loa Loa (eye worm) hypothetical protein 0.0021 0.0027 0.0077
Loa Loa (eye worm) hypothetical protein 0.0021 0.0027 0.0077
Mycobacterium ulcerans phosphoribosylformylglycinamidine synthase II 0.0027 0.0095 0.0228
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.039 0.0741
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0079 0.019
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0079 0.0203
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0027 0.0047
Loa Loa (eye worm) hypothetical protein 0.0034 0.0177 0.0506
Mycobacterium tuberculosis Conserved protein 0.0107 0.1081 0.1324
Mycobacterium tuberculosis Probable reductase 0.0233 0.262 0.3207
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0027 0.0047
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0079 0.0737 0.2803
Brugia malayi hypothetical protein 0.0176 0.1925 0.548
Echinococcus multilocularis neurogenic locus protein delta 0.0034 0.0177 0.0169
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0079 0.0219
Loa Loa (eye worm) hypothetical protein 0.0021 0.0027 0.0077
Brugia malayi nuclear hormone receptor 0.0021 0.0027 0.0054
Echinococcus granulosus neural cadherin 0.0034 0.0177 0.0421
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0079 0.019
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0021 0.0024 0.0057
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0079 0.019
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0088 0.0252
Mycobacterium leprae PROBABLE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE PURD (GARS) (GLYCINAMIDE RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE SYNT 0.0359 0.4166 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0027 0.0054
Toxoplasma gondii rhoptry neck protein RON9 0.0176 0.1925 0.749
Onchocerca volvulus 0.0079 0.0737 0.3406
Echinococcus granulosus protein jagged 1 0.0034 0.0177 0.0421
Brugia malayi hypothetical protein 0.0176 0.1925 0.548
Brugia malayi thymidylate synthase 0.0195 0.2148 0.6117
Loa Loa (eye worm) lectin C-type domain-containing protein 0.002 0.0008 0.0023
Brugia malayi EGF-like domain containing protein 0.0034 0.0177 0.0484
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0291 0.3333 0.408
Brugia malayi hypothetical protein 0.0176 0.1925 0.548
Loa Loa (eye worm) hypothetical protein 0.0034 0.0177 0.0506
Mycobacterium tuberculosis Probable lipase LipE 0.0107 0.1081 0.1324
Loa Loa (eye worm) hypothetical protein 0.002 0.0008 0.0023
Echinococcus granulosus Niemann Pick C1 protein 0.0136 0.143 0.3534
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0079 0.0737 0.1722
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0079 0.0737 0.2847
Trypanosoma brucei hypothetical protein, conserved 0.0107 0.1081 0.4158
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0088 0.0341
Entamoeba histolytica hypothetical protein 0.0035 0.0191 0.185
Onchocerca volvulus 0.0176 0.1925 0.8959
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0027 0.0077
Trichomonas vaginalis D-aminoacylase, putative 0.0107 0.1081 1
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0021 0.0024 0.0015
Loa Loa (eye worm) hypothetical protein 0.0034 0.0177 0.0506
Onchocerca volvulus 0.0176 0.1925 0.8959
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0021 0.0024 0.0038
Echinococcus multilocularis thymidylate synthase 0.0195 0.2148 0.2142
Trichomonas vaginalis conserved hypothetical protein 0.0093 0.0899 0.8277
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0027 0.0036
Echinococcus granulosus protein jagged 2 0.0034 0.0177 0.0421
Brugia malayi pregnancy-associated plasma protein-A 0.0176 0.1925 0.548
Loa Loa (eye worm) selenium donor protein 0.0027 0.0095 0.027
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0079 0.019
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0021 0.0024 0.006
Schistosoma mansoni hypothetical protein 0.0347 0.4016 0.7774
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0079 0.0737 0.2803
Onchocerca volvulus 0.0021 0.0024 0.0072
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0027 0.0054
Loa Loa (eye worm) hypothetical protein 0.0034 0.0177 0.0506
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0079 0.0737 0.2803
Entamoeba histolytica hypothetical protein 0.0035 0.0191 0.185

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.000001 uM Inhibition of the GAR transformylase in lactobacillus casei ChEMBL. 2498518
IC50 (binding) = 0.000001 uM Inhibition of the GAR transformylase in lactobacillus casei ChEMBL. 2498518
IC50 (binding) > 0.00002 uM Inhibition of the GAR transformylase in L1210 ChEMBL. 2498518
IC50 (binding) > 0.00002 uM Inhibition of the GAR transformylase in L1210 ChEMBL. 2498518

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.