Detailed information for compound 300012

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 348.435 | Formula: C23H24O3
  • H donors: 1 H acceptors: 2 LogP: 4.15 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: O[C@@H]1C[C@@H](OC(=O)C1)C=C1c2cc(C)cc(c2c2c1c(C)cc(c2)C)C
  • InChi: 1S/C23H24O3/c1-12-5-14(3)22-18(7-12)19(11-17-9-16(24)10-21(25)26-17)23-15(4)6-13(2)8-20(22)23/h5-8,11,16-17,24H,9-10H2,1-4H3/b19-11+/t16-,17?/m1/s1
  • InChiKey: YJDJAAUKUBEUGL-VIPGJUSRSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum cysteine--tRNA ligase 0.0084 0.011 1
Entamoeba histolytica transcription factor BTF3, putative 0.0074 0.0092 0.8382
Schistosoma mansoni biogenic amine receptor 0.0052 0.0055 0.0934
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0052 0.0055 0.0934
Toxoplasma gondii transporter, cation channel family protein 0.0129 0.0188 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0022 0.0002 0.01
Trypanosoma brucei cytochrome P450, putative 0.0038 0.003 0.1178
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0052 0.0055 0.0934
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.0055 0.0934
Schistosoma mansoni lamin 0.0083 0.0108 0.1845
Echinococcus granulosus serotonin receptor 0.0052 0.0055 0.0934
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0129 0.0188 0.3206
Trypanosoma cruzi trypanothione reductase, putative 0.0022 0.0002 0.0074
Brugia malayi G protein-coupled receptor 0.0052 0.0055 0.0609
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0027 0.1294
Leishmania major cytochrome p450-like protein 0.0038 0.003 0.1178
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0052 0.0055 0.0609
Loa Loa (eye worm) hypothetical protein 0.0129 0.0188 0.2089
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.007 0.0086 0.0954
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.006 0.0665
Echinococcus multilocularis neuropeptides capa receptor 0.0052 0.0055 0.0934
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0052 0.0055 0.0934
Brugia malayi Serotonin receptor 0.0052 0.0055 0.0609
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.0055 0.0934
Echinococcus multilocularis musashi 0.0083 0.0108 0.1845
Loa Loa (eye worm) hypothetical protein 0.0052 0.0055 0.0609
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0055 0.0934
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0129 0.0188 0.3206
Onchocerca volvulus 0.0083 0.0108 0.5056
Loa Loa (eye worm) hypothetical protein 0.0052 0.0055 0.0609
Schistosoma mansoni biogenic amine receptor 0.0052 0.0055 0.0934
Mycobacterium ulcerans cysteinyl-tRNA synthetase 0.5757 1 1
Echinococcus granulosus neuropeptide receptor 0.0052 0.0055 0.0934
Brugia malayi cysteinyl tRNA synthetase protein 1 0.0084 0.011 0.1222
Echinococcus granulosus g protein coupled receptor 0.0052 0.0055 0.0934
Echinococcus granulosus allatostatin A receptor 0.0052 0.0055 0.0934
Loa Loa (eye worm) hypothetical protein 0.0068 0.0082 0.0914
Schistosoma mansoni voltage-gated potassium channel 0.0129 0.0188 0.3206
Loa Loa (eye worm) hypothetical protein 0.0052 0.0055 0.0609
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0078 0.0099 0.4808
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0129 0.0188 0.2089
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0139 0.0206 0.3504
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.004 0.0033 0.0571
Echinococcus granulosus tm gpcr rhodopsin 0.0052 0.0055 0.0934
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0052 0.0055 0.0934
Echinococcus multilocularis neuropeptide receptor 0.0052 0.0055 0.0934
Brugia malayi hypothetical protein 0.0052 0.0055 0.0609
Schistosoma mansoni voltage-gated ion channel 0.0129 0.0188 0.3206
Onchocerca volvulus 0.0052 0.0055 0.1746
Loa Loa (eye worm) hypothetical protein 0.0039 0.0031 0.0342
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0052 0.0055 0.0609
Loa Loa (eye worm) hypothetical protein 0.0052 0.0055 0.0609
Echinococcus granulosus leucyl tRNA synthetase 0.0084 0.011 0.1876
Plasmodium falciparum glutathione reductase 0.0063 0.0074 0.6709
Loa Loa (eye worm) hypothetical protein 0.0052 0.0055 0.0609
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0139 0.0206 0.3504
Onchocerca volvulus 0.0052 0.0055 0.1746
Brugia malayi ion channel NompC 0.0129 0.0188 0.2089
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0129 0.0188 0.3206
Echinococcus multilocularis sodium leak channel non selective protein 0.0129 0.0188 0.3206
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0027 0.1057
Loa Loa (eye worm) beta-lactamase 0.0036 0.0027 0.0295
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0052 0.0055 0.0934
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0129 0.0188 0.3206
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0071 0.0087 0.4241
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0129 0.0188 0.3206
Echinococcus multilocularis transient receptor potential gamma protein 0.0129 0.0188 0.3206
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0052 0.0055 0.0934
Schistosoma mansoni transcription factor btf3 0.0074 0.0092 0.1572
Loa Loa (eye worm) hypothetical protein 0.0052 0.0055 0.0609
Onchocerca volvulus 0.0052 0.0055 0.1746
Toxoplasma gondii ABC1 family protein 0.0036 0.0027 0.1414
Schistosoma mansoni neuropeptide receptor 0.0052 0.0055 0.0934
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0129 0.0188 0.2089
Loa Loa (eye worm) hypothetical protein 0.0052 0.0055 0.0609
Echinococcus multilocularis potassium large conductance calcium activated 0.0129 0.0188 0.3206
Mycobacterium ulcerans hypothetical protein 0.0036 0.0027 0.0027
Echinococcus granulosus thioredoxin glutathione reductase 0.0063 0.0074 0.1259
Schistosoma mansoni hypothetical protein 0.0052 0.0055 0.0934
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0139 0.0206 0.2283
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0052 0.0055 0.0934
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0022 0.0002 0.0032
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0129 0.0188 0.3206
Schistosoma mansoni transient receptor potential channel 0.0129 0.0188 0.3206
Echinococcus multilocularis potassium voltage gated channel protein 0.0129 0.0188 0.3206
Onchocerca volvulus 0.0052 0.0055 0.1746
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0139 0.0206 0.3504
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0022 0.0002 0.017
Brugia malayi GnHR receptor homolog 0.0052 0.0055 0.0609
Schistosoma mansoni voltage-gated potassium channel 0.0136 0.02 0.3413
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0129 0.0188 1
Schistosoma mansoni voltage-gated potassium channel 0.0146 0.0218 0.3711
Loa Loa (eye worm) hypothetical protein 0.0129 0.0188 0.2089
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0129 0.0188 0.3206
Brugia malayi G protein-coupled receptor F59B2.13 0.0052 0.0055 0.0609
Loa Loa (eye worm) hypothetical protein 0.004 0.0033 0.0372
Schistosoma mansoni cysteinyl-tRNA synthetase 0.0084 0.011 0.1876
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0055 0.0934
Brugia malayi AKH receptor 0.0052 0.0055 0.0609
Loa Loa (eye worm) hypothetical protein 0.0052 0.0055 0.0609
Loa Loa (eye worm) hypothetical protein 0.0038 0.0029 0.0327
Loa Loa (eye worm) hypothetical protein 0.0039 0.0031 0.0342
Trypanosoma brucei transcription factor BTF3, putative 0.0074 0.0092 0.3664
Echinococcus granulosus Protein patched homolog 1 0.0068 0.0082 0.1403
Onchocerca volvulus 0.0052 0.0055 0.1746
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0129 0.0188 0.3206
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0002 0.0074
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0027 0.0453
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.006 0.0665
Loa Loa (eye worm) hypothetical protein 0.0052 0.0055 0.0609
Echinococcus granulosus hyperpolarization activated cyclic 0.0139 0.0206 0.3504
Brugia malayi beta-NAC-like protein 0.0074 0.0092 0.1024
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0139 0.0206 0.3504
Schistosoma mansoni neuropeptide receptor 0.0052 0.0055 0.0934
Loa Loa (eye worm) voltage-gated calcium channel 0.0129 0.0188 0.2089
Brugia malayi G-protein coupled receptor 0.0052 0.0055 0.0609
Loa Loa (eye worm) intermediate filament protein 0.0083 0.0108 0.1202
Treponema pallidum cysteinyl-tRNA synthetase 0.0084 0.011 1
Schistosoma mansoni voltage-gated potassium channel 0.0146 0.0218 0.3711
Loa Loa (eye worm) hypothetical protein 0.019 0.0294 0.3266
Mycobacterium tuberculosis Probable oxidoreductase 0.0022 0.0002 0.0002
Schistosoma mansoni tar DNA-binding protein 0.007 0.0086 0.1465
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0068 0.0082 0.0914
Toxoplasma gondii hypothetical protein 0.0129 0.0188 1
Echinococcus multilocularis voltage gated potassium channel 0.0129 0.0188 0.3206
Brugia malayi Cyclic-nucleotide gated cation channel 0.0139 0.0206 0.2283
Schistosoma mansoni opsin-like receptor 0.0052 0.0055 0.0934
Plasmodium falciparum thioredoxin reductase 0.0063 0.0074 0.6709
Loa Loa (eye worm) hypothetical protein 0.0052 0.0055 0.0609
Loa Loa (eye worm) ryanodine receptor 0.0129 0.0188 0.2089
Loa Loa (eye worm) hypothetical protein 0.0052 0.0055 0.0609
Loa Loa (eye worm) TAR-binding protein 0.007 0.0086 0.0954
Loa Loa (eye worm) voltage-gated potassium channel 0.0129 0.0188 0.2089
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0022 0.0002 0.0074
Schistosoma mansoni two-pore calcium channel 0.0129 0.0188 0.3206
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0022 0.0002 0.0002
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0027 0.0453
Onchocerca volvulus 0.0052 0.0055 0.1746
Loa Loa (eye worm) hypothetical protein 0.0052 0.0055 0.0609
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0129 0.0188 0.3206
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0129 0.0188 0.3206
Mycobacterium ulcerans cysteinyl-tRNA synthetase 0.0084 0.011 0.011
Echinococcus multilocularis serotonin receptor 0.0052 0.0055 0.0934
Loa Loa (eye worm) hypothetical protein 0.0036 0.0027 0.0295
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0052 0.0055 0.0934
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0052 0.0055 0.0609
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0139 0.0206 0.3504
Echinococcus granulosus transient receptor potential gamma protein 0.0129 0.0188 0.3206
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0052 0.0055 0.1746
Loa Loa (eye worm) hypothetical protein 0.0052 0.0055 0.0609
Loa Loa (eye worm) hypothetical protein 0.0129 0.0188 0.2089
Loa Loa (eye worm) hypothetical protein 0.0129 0.0188 0.2089
Echinococcus multilocularis neuropeptide receptor 0.0052 0.0055 0.0934
Echinococcus granulosus neuropeptides capa receptor 0.0052 0.0055 0.0934
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0165 0.0252 1
Entamoeba histolytica hypothetical protein 0.0074 0.0092 0.8382
Echinococcus granulosus voltage dependent calcium channel 0.0129 0.0188 0.3206
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0022 0.0002 0.017
Echinococcus granulosus Niemann Pick C1 protein 0.0068 0.0082 0.1403
Loa Loa (eye worm) hypothetical protein 0.0052 0.0055 0.0609
Brugia malayi hypothetical protein 0.0052 0.0055 0.0609
Echinococcus granulosus g-protein coupled receptor 0.0052 0.0055 0.0934
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0129 0.0188 0.7472
Onchocerca volvulus 0.0052 0.0055 0.1746
Brugia malayi Transient-receptor-potential like protein 0.0129 0.0188 0.2089
Echinococcus multilocularis two pore calcium channel protein 1 0.0129 0.0188 0.3206
Echinococcus granulosus fmrfamide receptor 0.0052 0.0055 0.0934
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0129 0.0188 0.3206
Brugia malayi beta-lactamase family protein 0.0036 0.0027 0.0295
Echinococcus granulosus hypothetical protein 0.0052 0.0055 0.0934
Echinococcus multilocularis transfer RNA-Gly 0.0129 0.0188 0.3206
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0022 0.0002 0.0021
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0118 0.0169 0.2883
Echinococcus multilocularis G-protein coupled receptor, putative 0.0052 0.0055 0.0934
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0129 0.0188 0.7472
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.0055 0.0934
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0052 0.0055 0.0609
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0027 0.1057
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0052 0.0055 0.0934
Mycobacterium tuberculosis Possible penicillin-binding protein 0.023 0.0366 0.0366
Schistosoma mansoni voltage-gated potassium channel 0.0129 0.0188 0.3206
Schistosoma mansoni hypothetical protein 0.0052 0.0055 0.0934
Echinococcus granulosus two pore calcium channel protein 1 0.0129 0.0188 0.3206
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0022 0.0002 0.0074
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0027 0.1294
Echinococcus granulosus somatostatin receptor 0.0052 0.0055 0.0934
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0052 0.0055 0.0934
Loa Loa (eye worm) hypothetical protein 0.0052 0.0055 0.0609
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.0165 0.0252 0.4291
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0022 0.0002 0.0002
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0063 0.0074 0.0074
Trichomonas vaginalis esterase, putative 0.0036 0.0027 0.1294
Echinococcus multilocularis dro:myosuppressin receptor 0.0052 0.0055 0.0934
Brugia malayi glutathione reductase 0.0063 0.0074 0.082
Schistosoma mansoni transient receptor potential channel 0.0134 0.0197 0.3365
Echinococcus multilocularis hyperpolarization activated cyclic 0.0139 0.0206 0.3504
Schistosoma mansoni adenoreceptor 0.0052 0.0055 0.0934
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.0165 0.0252 0.4291
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0022 0.0002 0.0074
Echinococcus granulosus lamin dm0 0.0083 0.0108 0.1845
Treponema pallidum NADH oxidase 0.0022 0.0002 0.017
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0055 0.0934
Echinococcus granulosus transient receptor potential cation channel 0.0129 0.0188 0.3206
Schistosoma mansoni voltage-gated potassium channel 0.0129 0.0188 0.3206
Schistosoma mansoni transient receptor potential channel 0.0129 0.0188 0.3206
Loa Loa (eye worm) hypothetical protein 0.0052 0.0055 0.0609
Loa Loa (eye worm) hypothetical protein 0.0052 0.0055 0.0609
Schistosoma mansoni amine GPCR 0.0052 0.0055 0.0934
Trichomonas vaginalis cysteinyl-tRNA synthetase, putative 0.0084 0.011 0.5354
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0146 0.0218 0.3711
Echinococcus multilocularis hyperpolarization activated cyclic 0.0139 0.0206 0.3504
Echinococcus granulosus neuropeptides capa receptor 0.0052 0.0055 0.0934
Toxoplasma gondii thioredoxin reductase 0.0063 0.0074 0.3925
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0022 0.0002 0.017
Mycobacterium tuberculosis Conserved protein 0.0036 0.0027 0.0027
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0002 0.0074
Brugia malayi hypothetical protein 0.0052 0.0055 0.0609
Schistosoma mansoni myosin xvIII 0.0052 0.0055 0.0934
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0129 0.0188 0.2089
Loa Loa (eye worm) hypothetical protein 0.0129 0.0188 0.2089
Echinococcus multilocularis transient receptor potential cation channel 0.0129 0.0188 0.3206
Echinococcus granulosus sodium channel protein 0.0129 0.0188 0.3206
Brugia malayi hypothetical protein 0.0052 0.0055 0.0609
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0129 0.0188 0.2089
Trypanosoma brucei cysteinyl-tRNA synthetase, putative 0.0084 0.011 0.4372
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0129 0.0188 0.2089
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0052 0.0055 0.0934
Onchocerca volvulus 0.0052 0.0055 0.1746
Echinococcus multilocularis geminin 0.0357 0.0587 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0027 0.0027
Echinococcus granulosus tm gpcr rhodopsin 0.0052 0.0055 0.0934
Loa Loa (eye worm) hypothetical protein 0.0129 0.0188 0.2089
Echinococcus multilocularis potassium voltage gated channel protein 0.0129 0.0188 0.3206
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0055 0.0934
Loa Loa (eye worm) hypothetical protein 0.0052 0.0055 0.0609
Echinococcus multilocularis transient receptor potential cation channel 0.0129 0.0188 0.3206
Loa Loa (eye worm) neuropeptide F receptor 0.0052 0.0055 0.0609
Echinococcus granulosus potassium voltage gated channel subfamily H 0.02 0.0312 0.5311
Loa Loa (eye worm) hypothetical protein 0.0129 0.0188 0.2089
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0022 0.0002 0.0032
Loa Loa (eye worm) hypothetical protein 0.0052 0.0055 0.0609
Brugia malayi hypothetical protein 0.0052 0.0055 0.0609
Brugia malayi hypothetical protein 0.0052 0.0055 0.0609
Echinococcus multilocularis tar DNA binding protein 0.007 0.0086 0.1465
Loa Loa (eye worm) hypothetical protein 0.0129 0.0188 0.2089
Loa Loa (eye worm) neuropeptide F receptor 0.0052 0.0055 0.0609
Onchocerca volvulus 0.0052 0.0055 0.1746
Loa Loa (eye worm) cytochrome P450 family protein 0.0038 0.003 0.0329
Leishmania major cysteinyl-tRNA synthetase, putative 0.0084 0.011 0.4372
Schistosoma mansoni hypothetical protein 0.0357 0.0587 1
Schistosoma mansoni neuropeptide receptor 0.0052 0.0055 0.0934
Plasmodium falciparum glutathione reductase 0.0022 0.0002 0.017
Loa Loa (eye worm) ion channel NompC 0.0129 0.0188 0.2089
Echinococcus granulosus neuropeptide FF receptor 2 0.0052 0.0055 0.0934
Echinococcus granulosus neuropeptide Y receptor 0.0052 0.0055 0.0934
Brugia malayi neuropeptide F receptor 0.0052 0.0055 0.0609
Onchocerca volvulus 0.0052 0.0055 0.1746
Loa Loa (eye worm) hypothetical protein 0.0027 0.0011 0.0119
Trypanosoma cruzi trypanothione reductase, putative 0.0063 0.0074 0.2933
Echinococcus multilocularis sex peptide receptor 0.0052 0.0055 0.0934
Loa Loa (eye worm) hypothetical protein 0.0052 0.0055 0.0609
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0129 0.0188 0.3206
Loa Loa (eye worm) hypothetical protein 0.0052 0.0055 0.0609
Brugia malayi Dopamine receptor 0.0052 0.0055 0.0609
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.0078 0.0099 0.8981
Giardia lamblia NADH oxidase lateral transfer candidate 0.0022 0.0002 0.017
Schistosoma mansoni tar DNA-binding protein 0.007 0.0086 0.1465
Brugia malayi RE15519p 0.0052 0.0055 0.0609
Echinococcus granulosus geminin 0.0357 0.0587 1
Schistosoma mansoni biogenic amine receptor 0.0052 0.0055 0.0934
Echinococcus granulosus ryanodine receptor 44f 0.0129 0.0188 0.3206
Trypanosoma brucei trypanothione reductase 0.0063 0.0074 0.2933
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0146 0.0218 0.3711
Echinococcus granulosus cytoplasmic intermediate filament protein 0.004 0.0033 0.0571
Loa Loa (eye worm) hypothetical protein 0.0081 0.0106 0.1173
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0022 0.0002 0.0032
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.0055 0.0934
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0052 0.0055 0.0934
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.0165 0.0252 1
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.02 0.0312 0.346
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0129 0.0188 0.3206
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0027 0.0027
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.006 0.0665
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0055 0.0934
Echinococcus multilocularis protein dispatched 1 0.0068 0.0082 0.1403
Schistosoma mansoni hypothetical protein 0.0052 0.0054 0.0921
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0055 0.0934
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0139 0.0206 0.3504
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0052 0.0055 0.0934
Brugia malayi hypothetical protein 0.0052 0.0055 0.0609
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0052 0.0055 0.0609
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0002 0.0074
Echinococcus multilocularis thioredoxin glutathione reductase 0.0063 0.0074 0.1259
Schistosoma mansoni amine GPCR 0.0052 0.0055 0.0934
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0052 0.0055 0.0934
Loa Loa (eye worm) hypothetical protein 0.0129 0.0188 0.2089
Schistosoma mansoni voltage-dependent calcium channel 0.0129 0.0188 0.3206
Schistosoma mansoni biogenic amine (5HT) receptor 0.0052 0.0055 0.0934
Brugia malayi RNA recognition motif domain containing protein 0.007 0.0086 0.0954
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0052 0.0055 0.0934
Echinococcus granulosus sterol regulatory element binding protein 0.0068 0.0082 0.1403
Onchocerca volvulus 0.0052 0.0055 0.1746
Loa Loa (eye worm) hypothetical protein 0.0052 0.0055 0.0609
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0022 0.0002 0.0074
Echinococcus granulosus neuropeptide receptor 0.0052 0.0055 0.0934
Loa Loa (eye worm) hypothetical protein 0.0052 0.0055 0.0609
Trypanosoma cruzi cytochrome P450, putative 0.0038 0.003 0.1178
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0129 0.0188 0.3206
Echinococcus multilocularis neuropeptide Y receptor 0.0052 0.0055 0.0934
Brugia malayi Melatonin receptor type 1A 0.0052 0.0055 0.0609
Echinococcus multilocularis short transient receptor potential channel 6 0.0129 0.0188 0.3206
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.02 0.0312 0.346
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0129 0.0188 0.3206
Echinococcus granulosus 7tm_1 domain containing protein 0.0052 0.0055 0.0934
Echinococcus multilocularis neuropeptide receptor A26 0.0052 0.0055 0.0934
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0092 0.4487
Echinococcus multilocularis orexin receptor type 2 0.0052 0.0055 0.0934
Echinococcus multilocularis potassium voltage gated channel protein 0.0129 0.0188 0.3206
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.0165 0.0252 1
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0129 0.0188 0.2089
Loa Loa (eye worm) hypothetical protein 0.0036 0.0027 0.0295
Schistosoma mansoni histamine h1 receptor 0.0052 0.0055 0.0934
Loa Loa (eye worm) hypothetical protein 0.0052 0.0055 0.0609
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0052 0.0055 0.0934
Loa Loa (eye worm) hypothetical protein 0.0165 0.0252 0.2796
Loa Loa (eye worm) hypothetical protein 0.0036 0.0027 0.0295
Schistosoma mansoni ryanodine receptor related 0.0129 0.0188 0.3206
Echinococcus multilocularis voltage gated potassium channel 0.0146 0.0218 0.3711
Schistosoma mansoni patched 1 0.0068 0.0082 0.1403
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0083 0.0108 0.1202
Toxoplasma gondii cysteine-tRNA synthetase (CysRS) 0.0084 0.011 0.585
Echinococcus granulosus transient receptor potential cation channel 0.0129 0.0188 0.3206
Giardia lamblia Cysteinyl-tRNA synthetase 0.0084 0.011 1
Mycobacterium tuberculosis Conserved protein 0.0036 0.0027 0.0027
Echinococcus multilocularis Niemann Pick C1 protein 0.0068 0.0082 0.1403
Echinococcus granulosus short transient receptor potential channel 6 0.0134 0.0197 0.3365
Leishmania major hypothetical protein, conserved 0.0036 0.0027 0.1057
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0055 0.0934
Brugia malayi cation channel family protein 0.0129 0.0188 0.2089
Schistosoma mansoni hypothetical protein 0.0052 0.0055 0.0934
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0068 0.0082 0.1403
Schistosoma mansoni retinoic acid receptor RXR 0.0128 0.0186 0.3174
Onchocerca volvulus 0.0052 0.0055 0.1746
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0027 0.0295
Echinococcus multilocularis shaker cognate 0.0129 0.0188 0.3206
Loa Loa (eye worm) hypothetical protein 0.0036 0.0027 0.0295
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0129 0.0188 0.3206
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0002 0.0074
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0027 0.2417
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0078 0.0099 0.4808
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0129 0.0188 0.2089
Schistosoma mansoni amine GPCR 0.0052 0.0055 0.0934
Echinococcus granulosus tm gpcr rhodopsin 0.0052 0.0055 0.0934
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0082 0.4003
Schistosoma mansoni amine GPCR 0.0052 0.0055 0.0934
Schistosoma mansoni neuropeptide F-like receptor 0.0052 0.0055 0.0934
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0129 0.0188 1
Loa Loa (eye worm) thioredoxin reductase 0.0063 0.0074 0.082
Echinococcus multilocularis transient receptor potential cation channel 0.0129 0.0188 0.3206
Schistosoma mansoni 60S ribosomal protein L21 0.0136 0.02 0.3413
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0139 0.0206 0.3504
Echinococcus granulosus neuropeptide s receptor 0.0052 0.0055 0.0934
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0022 0.0002 0.0002
Schistosoma mansoni voltage-gated potassium channel 0.0207 0.0324 0.5518
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0027 0.1294
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0129 0.0188 0.3206
Echinococcus multilocularis transient receptor potential cation channel 0.0134 0.0197 0.3365
Loa Loa (eye worm) hypothetical protein 0.0139 0.0206 0.2283
Loa Loa (eye worm) hypothetical protein 0.0052 0.0055 0.0609
Loa Loa (eye worm) cytochrome P450 family protein 0.0038 0.003 0.0329
Loa Loa (eye worm) hypothetical protein 0.0052 0.0055 0.0609
Schistosoma mansoni hypothetical protein 0.0038 0.0029 0.0502
Echinococcus multilocularis conserved hypothetical protein 0.0129 0.0188 0.3206
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0165 0.0252 1
Schistosoma mansoni intermediate filament proteins 0.0083 0.0108 0.1845
Loa Loa (eye worm) hypothetical protein 0.0036 0.0027 0.0295
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0029 0.0327
Echinococcus granulosus biogenic amine 5HT receptor 0.0052 0.0055 0.0934
Loa Loa (eye worm) melatonin receptor type 1A 0.0052 0.0055 0.0609
Loa Loa (eye worm) hypothetical protein 0.0052 0.0055 0.0609
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0022 0.0002 0.017
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0129 0.0188 0.3206
Echinococcus granulosus potassium large conductance calcium activated 0.0129 0.0188 0.3206
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0052 0.0055 0.0934
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0055 0.0934
Echinococcus granulosus tar DNA binding protein 0.007 0.0086 0.1465
Entamoeba histolytica cysteinyl-tRNA synthetase, putative 0.0084 0.011 1
Brugia malayi Intermediate filament tail domain containing protein 0.0083 0.0108 0.1202
Schistosoma mansoni voltage-gated potassium channel 0.0207 0.0324 0.5518
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0129 0.0188 0.2089
Brugia malayi G-protein coupled receptor 0.0052 0.0055 0.0609
Toxoplasma gondii transporter, cation channel family protein 0.0129 0.0188 1
Loa Loa (eye worm) hypothetical protein 0.0129 0.0188 0.2089
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0129 0.0188 0.3206
Echinococcus granulosus potassium voltage gated channel protein 0.0129 0.0188 0.3206
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0055 0.0934
Loa Loa (eye worm) hypothetical protein 0.0052 0.0055 0.0609
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0055 0.0934
Schistosoma mansoni voltage-gated potassium channel 0.0129 0.0188 0.3206
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0022 0.0002 0.0074
Onchocerca volvulus 0.0052 0.0055 0.1746
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0052 0.0055 0.0934
Schistosoma mansoni growth hormone secretagogue receptor 0.0052 0.0055 0.0934
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0071 0.0087 0.4241
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0139 0.0206 0.3504
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0027 0.0027
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0027 0.0027
Trypanosoma cruzi cysteinyl-tRNA synthetase, putative 0.0084 0.011 0.4372
Echinococcus multilocularis neuropeptide s receptor 0.0052 0.0055 0.0934
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0092 0.4487
Schistosoma mansoni hypothetical protein 0.0129 0.0188 0.3206
Schistosoma mansoni voltage-gated potassium channel 0.0129 0.0188 0.3206
Loa Loa (eye worm) RNA binding protein 0.007 0.0086 0.0954
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0129 0.0188 0.3206
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0022 0.0002 0.017
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0022 0.0002 0.0074
Toxoplasma gondii hypothetical protein 0.0129 0.0188 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0052 0.0055 0.0934
Echinococcus granulosus voltage dependent calcium channel 0.0129 0.0188 0.3206
Echinococcus granulosus transient receptor potential cation channel 0.0129 0.0188 0.3206
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0537 0.0901 1
Schistosoma mansoni voltage-gated potassium channel 0.0129 0.0188 0.3206
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0129 0.0188 0.3206
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0139 0.0206 1
Toxoplasma gondii NADPH-glutathione reductase 0.0022 0.0002 0.01
Loa Loa (eye worm) hypothetical protein 0.0052 0.0055 0.0609
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0022 0.0002 0.0074
Brugia malayi follicle stimulating hormone receptor 0.0537 0.0901 1
Echinococcus granulosus neuropeptide receptor A26 0.0052 0.0055 0.0934
Schistosoma mansoni voltage-gated potassium channel 0.0139 0.0206 0.3504
Echinococcus granulosus short transient receptor potential channel 6 0.0129 0.0188 0.3206
Schistosoma mansoni amine GPCR 0.0052 0.0055 0.0934
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0129 0.0188 0.3206
Loa Loa (eye worm) hypothetical protein 0.0052 0.0055 0.0609
Echinococcus granulosus biogenic amine 5HT receptor 0.0052 0.0055 0.0934
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0052 0.0055 0.0609
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0027 0.0027
Brugia malayi Cytochrome P450 family protein 0.0038 0.003 0.0329
Loa Loa (eye worm) G-protein coupled receptor 0.0052 0.0055 0.0609
Onchocerca volvulus 0.0052 0.0055 0.1746
Echinococcus granulosus G protein coupled receptor 139 0.0052 0.0055 0.0934
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0129 0.0188 0.3206
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0052 0.0055 0.0934
Echinococcus granulosus calcium activated potassium channel 0.0129 0.0188 0.3206
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0129 0.0188 0.3206
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.0055 0.0934
Brugia malayi RNA binding protein 0.007 0.0086 0.0954
Echinococcus multilocularis transient receptor potential cation channel 0.0129 0.0188 0.3206
Mycobacterium tuberculosis Conserved protein 0.0036 0.0027 0.0027
Echinococcus multilocularis somatostatin receptor 0.0052 0.0055 0.0934
Echinococcus granulosus dro:myosuppressin receptor 0.0052 0.0055 0.0934
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0027 0.0453
Schistosoma mansoni opsin-like receptor 0.0052 0.0055 0.0934
Echinococcus granulosus potassium voltage gated channel protein 0.0129 0.0188 0.3206
Echinococcus multilocularis cysteinyl tRNA synthetase 0.0084 0.011 0.1876
Wolbachia endosymbiont of Brugia malayi cysteinyl-tRNA synthetase 0.0084 0.011 1
Schistosoma mansoni neuropeptide receptor 0.0052 0.0055 0.0934
Loa Loa (eye worm) cysteinyl tRNA synthetase 1 0.0084 0.011 0.1222
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0139 0.0206 0.3504
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0129 0.0188 0.3206
Echinococcus multilocularis g-protein coupled receptor 0.0052 0.0055 0.0934
Echinococcus granulosus two pore calcium channel protein 2 0.0129 0.0188 0.3206
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0129 0.0188 0.3206
Plasmodium falciparum thioredoxin reductase 0.0022 0.0002 0.017
Plasmodium falciparum basic transcription factor 3b, putative 0.0074 0.0092 0.8382
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.0055 0.0934
Echinococcus multilocularis protein patched 0.0068 0.0082 0.1403
Loa Loa (eye worm) hypothetical protein 0.0129 0.0188 0.2089
Loa Loa (eye worm) hypothetical protein 0.0052 0.0055 0.0609
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0052 0.0055 0.0934
Schistosoma mansoni hypothetical protein 0.0052 0.0055 0.0934
Echinococcus granulosus shaker cognate 0.0129 0.0188 0.3206
Chlamydia trachomatis cysteine--tRNA ligase 0.0084 0.011 1
Toxoplasma gondii NAC domain-containing protein 0.0074 0.0092 0.4904
Loa Loa (eye worm) hypothetical protein 0.0084 0.011 0.1222
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0027 0.0027
Schistosoma mansoni voltage-gated potassium channel 0.0129 0.0188 0.3206
Brugia malayi cytoplasmic intermediate filament protein 0.0044 0.0041 0.0457
Onchocerca volvulus 0.0083 0.0108 0.5056
Leishmania major basic transcription factor 3a, putative 0.0074 0.0092 0.3664
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0027 0.0025
Brugia malayi hypothetical protein 0.0052 0.0055 0.0609
Trichomonas vaginalis glutathione reductase, putative 0.0022 0.0002 0.0091
Loa Loa (eye worm) voltage-gated potassium channel 0.0129 0.0188 0.2089
Brugia malayi voltage-dependent calcium channel 0.0129 0.0188 0.2089
Echinococcus granulosus g protein coupled receptor 0.0052 0.0055 0.0934
Schistosoma mansoni transient receptor potential channel 4 0.0129 0.0188 0.3206
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0129 0.0188 0.3206
Schistosoma mansoni calcium-activated potassium channel 0.0129 0.0188 0.3206
Loa Loa (eye worm) hypothetical protein 0.0129 0.0188 0.2089
Echinococcus multilocularis voltage dependent calcium channel 0.0129 0.0188 0.3206
Loa Loa (eye worm) TYRA-2 protein 0.0052 0.0055 0.0609
Echinococcus granulosus tachykinin peptides receptor 99D 0.0052 0.0055 0.0934
Brugia malayi CHE-14 protein 0.0068 0.0082 0.0914
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0052 0.0055 0.0934
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0055 0.0934
Brugia malayi intermediate filament protein 0.0083 0.0108 0.1202
Plasmodium vivax cysteine--tRNA ligase, putative 0.0084 0.011 1
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0129 0.0188 1
Brugia malayi hypothetical protein 0.0052 0.0055 0.0609
Trichomonas vaginalis mercuric reductase, putative 0.0022 0.0002 0.0091
Echinococcus multilocularis serotonin receptor 0.0052 0.0055 0.0934
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0092 0.4487
Loa Loa (eye worm) voltage-dependent calcium channel 0.0129 0.0188 0.2089
Echinococcus granulosus orexin receptor type 2 0.0052 0.0055 0.0934
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0139 0.0206 0.3504
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0052 0.0055 0.0609
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.0055 0.0934
Echinococcus granulosus peptide allatostatin:somatostatin 0.0052 0.0055 0.0934
Brugia malayi sulfakinin receptor protein 0.0052 0.0055 0.0609
Brugia malayi putative neuropeptide receptor NPR1 0.0052 0.0055 0.0609
Onchocerca volvulus 0.0052 0.0055 0.1746
Echinococcus multilocularis fmrfamide receptor 0.0052 0.0055 0.0934
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0052 0.0055 0.0609
Onchocerca volvulus Neuropeptide F receptor homolog 0.0052 0.0055 0.1746
Echinococcus multilocularis short transient receptor potential channel 6 0.0134 0.0197 0.3365
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0129 0.0188 0.3206
Schistosoma mansoni neuropeptide F-like receptor 0.0052 0.0055 0.0934
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0027 0.1057
Loa Loa (eye worm) hypothetical protein 0.0052 0.0055 0.0609
Brugia malayi cation channel family protein 0.0129 0.0188 0.2089
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0002 0.0074
Brugia malayi olfactory channel protein osm-9 0.0134 0.0197 0.2192
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.0165 0.0252 0.4291
Brugia malayi beta-lactamase family protein 0.0036 0.0027 0.0295
Echinococcus granulosus cysteinyl tRNA synthetase 0.0084 0.011 0.1876
Loa Loa (eye worm) hypothetical protein 0.0083 0.0108 0.1202
Loa Loa (eye worm) hypothetical protein 0.0129 0.0188 0.2089
Mycobacterium ulcerans beta-lactamase 0.0036 0.0027 0.0027
Trypanosoma cruzi cytochrome P450, putative 0.0038 0.003 0.1178
Schistosoma mansoni vesicular amine transporter 0.0129 0.0188 0.3206
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0027 0.1294
Loa Loa (eye worm) hypothetical protein 0.0036 0.0027 0.0295
Echinococcus multilocularis neuropeptide FF receptor 2 0.0052 0.0055 0.0934
Loa Loa (eye worm) hypothetical protein 0.0052 0.0055 0.0609
Echinococcus granulosus hyperpolarization activated cyclic 0.0139 0.0206 0.3504
Echinococcus granulosus lamin 0.0083 0.0108 0.1845
Schistosoma mansoni opsin-like receptor 0.0052 0.0055 0.0934
Schistosoma mansoni lamin 0.0083 0.0108 0.1845
Schistosoma mansoni alpha-1 adrenergic receptor 0.0052 0.0055 0.0934
Schistosoma mansoni voltage-gated potassium channel 0.0129 0.0188 0.3206
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0022 0.0002 0.0074
Leishmania major hypothetical protein, conserved 0.0129 0.0188 0.7472
Brugia malayi TAR-binding protein 0.007 0.0086 0.0954
Echinococcus multilocularis fmrfamide receptor 0.0052 0.0055 0.0934
Loa Loa (eye worm) hypothetical protein 0.0146 0.0218 0.2418
Echinococcus multilocularis neuropeptide Y receptor 0.0052 0.0055 0.0934
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0129 0.0188 0.2089
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0022 0.0002 0.0074
Loa Loa (eye worm) hypothetical protein 0.0052 0.0055 0.0609
Loa Loa (eye worm) hypothetical protein 0.0052 0.0055 0.0609
Brugia malayi hypothetical protein 0.0052 0.0055 0.0609
Brugia malayi Dopamine receptor protein 1 0.0052 0.0055 0.0609
Brugia malayi beta-lactamase 0.0036 0.0027 0.0295
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0022 0.0002 0.0002
Brugia malayi Serotonin receptor 0.0052 0.0055 0.0609
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0129 0.0188 0.3206
Trypanosoma cruzi transcription factor btf3, putative 0.0074 0.0092 0.3664
Echinococcus multilocularis potassium voltage gated channel protein 0.0129 0.0188 0.3206
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0129 0.0188 0.2089
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0027 0.0027
Schistosoma mansoni neuropeptide f receptor 76f 0.0052 0.0055 0.0934
Echinococcus granulosus transcription factor btf3 0.0074 0.0092 0.1572
Brugia malayi hypothetical protein 0.0129 0.0188 0.2089
Brugia malayi ORL1-like opioid receptor 0.0052 0.0055 0.0609
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0052 0.0055 0.0934
Onchocerca volvulus 0.0052 0.0055 0.1746
Loa Loa (eye worm) hypothetical protein 0.0129 0.0188 0.2089
Echinococcus multilocularis lamin 0.0083 0.0108 0.1845
Mycobacterium ulcerans lipase LipD 0.0036 0.0027 0.0027
Trypanosoma cruzi cysteinyl-tRNA synthetase, putative 0.0084 0.011 0.4372
Plasmodium vivax thioredoxin reductase, putative 0.0063 0.0074 0.6709
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0022 0.0002 0.0002
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0146 0.0218 0.2418
Loa Loa (eye worm) hypothetical protein 0.0052 0.0055 0.0609
Leishmania major trypanothione reductase 0.0063 0.0074 0.2933
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0139 0.0206 0.3504
Echinococcus granulosus transient receptor potential cation channel 0.0134 0.0197 0.3365
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0139 0.0206 0.2283
Echinococcus multilocularis neuropeptides capa receptor 0.0052 0.0055 0.0934
Echinococcus multilocularis calcium activated potassium channel 0.0129 0.0188 0.3206
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0055 0.0934
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0129 0.0188 0.7472
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0129 0.0188 0.3206
Echinococcus granulosus neuropeptide Y receptor 0.0052 0.0055 0.0934
Onchocerca volvulus 0.0084 0.011 0.5167
Echinococcus multilocularis sodium channel protein 0.0129 0.0188 0.3206
Echinococcus multilocularis sterol regulatory element binding protein 0.0068 0.0082 0.1403
Loa Loa (eye worm) hypothetical protein 0.0129 0.0188 0.2089
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0027 0.0295
Brugia malayi Tachykinin-like peptides receptor 99D 0.0052 0.0055 0.0609
Loa Loa (eye worm) hypothetical protein 0.0052 0.0055 0.0609
Echinococcus multilocularis transient receptor potential cation channel 0.0134 0.0197 0.3365
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0129 0.0188 0.3206
Mycobacterium tuberculosis Cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC 0.5757 1 1
Onchocerca volvulus 0.0052 0.0055 0.1746
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0129 0.0188 0.3206
Schistosoma mansoni voltage-gated potassium channel 0.0129 0.0188 0.3206
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0052 0.0055 0.0609
Echinococcus granulosus hypothetical protein 0.0129 0.0188 0.3206
Echinococcus granulosus potassium voltage gated channel protein 0.0129 0.0188 0.3206
Loa Loa (eye worm) hypothetical protein 0.0052 0.0055 0.0609
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0022 0.0002 0.0002
Echinococcus granulosus intermediate filament protein 0.0083 0.0108 0.1845
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0129 0.0188 0.2089
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0055 0.0934
Echinococcus multilocularis g protein coupled receptor 0.0052 0.0055 0.0934
Schistosoma mansoni cysteinyl-tRNA synthetase 0.0084 0.011 0.1876
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0129 0.0188 1
Onchocerca volvulus 0.0129 0.0188 1
Schistosoma mansoni tar DNA-binding protein 0.007 0.0086 0.1465
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0129 0.0188 0.3206
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0139 0.0206 1
Echinococcus granulosus voltage gated potassium channel 0.0146 0.0218 0.3711
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0052 0.0055 0.0934
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0052 0.0055 0.0934
Loa Loa (eye worm) hypothetical protein 0.0129 0.0188 0.2089
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0052 0.0055 0.0934
Loa Loa (eye worm) hypothetical protein 0.0055 0.006 0.0665
Brugia malayi neuropeptide F receptor 0.0052 0.0055 0.0609
Plasmodium falciparum cysteine--tRNA ligase 0.0084 0.011 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0052 0.0055 0.0934
Schistosoma mansoni tar DNA-binding protein 0.007 0.0086 0.1465
Loa Loa (eye worm) glutathione reductase 0.0063 0.0074 0.082
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0052 0.0055 0.0934
Loa Loa (eye worm) hypothetical protein 0.0052 0.0055 0.0609
Loa Loa (eye worm) ICD-1 protein 0.0074 0.0092 0.1024
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0027 0.0027
Schistosoma mansoni voltage-gated potassium channel 0.0129 0.0188 0.3206
Echinococcus granulosus sex peptide receptor 0.0052 0.0055 0.0934
Mycobacterium leprae Probable lipase LipE 0.0036 0.0027 0.0025
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0129 0.0188 0.2089
Echinococcus multilocularis transcription factor btf3 0.0074 0.0092 0.1572
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0055 0.0934
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0129 0.0188 0.2089
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0022 0.0002 0.0074
Echinococcus multilocularis two pore calcium channel protein 2 0.0129 0.0188 0.3206
Brugia malayi Cytochrome P450 family protein 0.0038 0.003 0.0329
Echinococcus granulosus sodium leak channel non selective protein 0.0129 0.0188 0.3206
Brugia malayi putative neuropeptide receptor 0.0052 0.0055 0.0609
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0044 0.0041 0.0457
Echinococcus multilocularis g protein coupled receptor 0.0052 0.0055 0.0934
Echinococcus granulosus transient receptor potential cation channel 0.0129 0.0188 0.3206
Echinococcus granulosus potassium voltage gated channel protein 0.0129 0.0188 0.3206
Echinococcus granulosus transient receptor potential cation channel 0.0129 0.0188 0.3206
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0052 0.0055 0.0934
Echinococcus granulosus voltage gated hydrogen channel 1 0.0129 0.0188 0.3206
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0052 0.0055 0.0934
Schistosoma mansoni voltage-gated potassium channel 0.0129 0.0188 0.3206
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0027 0.1294
Plasmodium vivax basic transcription factor 3b, putative 0.0074 0.0092 0.8382
Loa Loa (eye worm) calcium channel 0.0129 0.0188 0.2089
Loa Loa (eye worm) G-protein coupled receptor 0.0052 0.0055 0.0609
Schistosoma mansoni voltage-gated potassium channel 0.0129 0.0188 0.3206
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0052 0.0055 0.0934
Trypanosoma cruzi transcription factor btf3, putative 0.0074 0.0092 0.3664
Schistosoma mansoni tar DNA-binding protein 0.007 0.0086 0.1465
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein 0.0165 0.0252 0.2796
Echinococcus granulosus alpha 1A adrenergic receptor 0.0052 0.0055 0.0934
Loa Loa (eye worm) hypothetical protein 0.0129 0.0188 0.2089
Brugia malayi larval opioid receptor 0.0052 0.0055 0.0609
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0129 0.0188 0.3206
Loa Loa (eye worm) CYP4Cod1 0.0038 0.003 0.0329
Echinococcus multilocularis G protein coupled receptor 139 0.0052 0.0055 0.0934
Loa Loa (eye worm) hypothetical protein 0.0052 0.0055 0.0609
Loa Loa (eye worm) hypothetical protein 0.0052 0.0055 0.0609
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0052 0.0055 0.0934
Brugia malayi Thioredoxin reductase 0.0063 0.0074 0.082
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0038 0.003 0.003
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0055 0.0934
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0129 0.0188 0.7472
Loa Loa (eye worm) hypothetical protein 0.0052 0.0055 0.0609
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.0165 0.0252 0.0252
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0002 0.0074
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0055 0.0934
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0027 0.0453
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0055 0.0934
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0022 0.0002 0.017
Loa Loa (eye worm) hypothetical protein 0.0129 0.0188 0.2089
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0129 0.0188 0.7472
Loa Loa (eye worm) hypothetical protein 0.0134 0.0197 0.2192
Loa Loa (eye worm) hypothetical protein 0.0052 0.0055 0.0609
Echinococcus multilocularis voltage dependent calcium channel 0.0129 0.0188 0.3206
Loa Loa (eye worm) hypothetical protein 0.0052 0.0055 0.0609
Leishmania major hypothetical protein, unknown function 0.0129 0.0188 0.7472
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0139 0.0206 0.3504
Echinococcus granulosus g protein coupled receptor 0.0052 0.0055 0.0934
Echinococcus granulosus potassium voltage gated channel protein 0.0129 0.0188 0.3206
Echinococcus multilocularis ryanodine receptor 44f 0.0129 0.0188 0.3206
Echinococcus granulosus 7TM GPCR rhodopsin 0.0052 0.0055 0.0934
Schistosoma mansoni biogenic amine (5HT) receptor 0.0052 0.0055 0.0934
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.02 0.0312 0.5311
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0052 0.0055 0.0934
Schistosoma mansoni hypothetical protein 0.0357 0.0587 1
Toxoplasma gondii transporter, cation channel family protein 0.0129 0.0188 1
Echinococcus multilocularis lamin dm0 0.0083 0.0108 0.1845
Echinococcus multilocularis g protein coupled receptor 0.0052 0.0055 0.0934
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0128 0.0186 0.3174
Loa Loa (eye worm) hypothetical protein 0.0052 0.0055 0.0609
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0027 0.0027
Brugia malayi Dopamine receptor protein 2 0.0052 0.0055 0.0609
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0078 0.0099 0.4808
Echinococcus granulosus voltage gated potassium channel 0.0129 0.0188 0.3206
Schistosoma mansoni voltage-gated cation channel 0.0129 0.0188 0.3206
Echinococcus multilocularis allatostatin A receptor 0.0052 0.0055 0.0934
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0129 0.0188 0.3206
Plasmodium vivax glutathione reductase, putative 0.0063 0.0074 0.6709
Echinococcus granulosus TRP transient receptor potential channel 0.0129 0.0188 0.3206

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.83 uM Compound was tested in vitro for its ability to inhibit rat liver HMG-CoA reductase ChEMBL. 3701793
Relative potency (binding) = 1.7 Compound was tested for its ability to inhibit solubilized, purified rat liver HMG-CoA reductase, relative to compactin(100) ChEMBL. 3701793

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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