TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 346.51 | Formula: C20H34N4O
H donors: 1 H acceptors: 1 LogP: 7.06 Rotable bonds: 14
Rule of 5 violations (Lipinski): 1
SMILES: CCCCCCCCCCCCN(/N=N/c1ccc(cc1)C(=O)N)C
InChi: 1S/C20H34N4O/c1-3-4-5-6-7-8-9-10-11-12-17-24(2)23-22-19-15-13-18(14-16-19)20(21)25/h13-16H,3-12,17H2,1-2H3,(H2,21,25)/b23-22+
InChiKey: NYYCGIQQDRVZAF-GHVJWSGMSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0543	0.0912	0.0957
Mycobacterium tuberculosis	Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)	0.0008	0.0001	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0543	0.0912	0.0957
Mycobacterium ulcerans	cytochrome P450 144A4 Cyp144A4	0.0008	0.0001	0.5
Mycobacterium ulcerans	cytochrome P450 142A3 Cyp142A3	0.0008	0.0001	0.5
Mycobacterium ulcerans	cytochrome P450 187A5 Cyp187A5	0.0008	0.0001	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0543	0.0912	0.0957
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0048	0.0069	0.6986
Schistosoma mansoni	nuclear receptor	0.0256	0.0424	0.0664
Leishmania major	cytochrome p450-like protein	0.0008	0.0001	0.5
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0543	0.0912	0.1431
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0543	0.0912	0.0957
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0543	0.0912	0.0957
Loa Loa (eye worm)	hypothetical protein	0.0256	0.0424	0.0444
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0256	0.0424	0.0664
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0543	0.0912	0.1431
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0287	0.0476	0.0746
Loa Loa (eye worm)	hypothetical protein	0.0256	0.0424	0.0444
Loa Loa (eye worm)	nuclear hormone receptor	0.0256	0.0424	0.0444
Echinococcus multilocularis	dnaJ subfamily B	0.0458	0.0767	0.1303
Mycobacterium tuberculosis	Probable cytochrome P450 130 Cyp130	0.0008	0.0001	0.5
Brugia malayi	tailless protein	0.0256	0.0424	0.0444
Loa Loa (eye worm)	hypothetical protein	0.0141	0.0227	0.0237
Leishmania major	lanosterol 14-alpha-demethylase, putative	0.0008	0.0001	0.5
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0543	0.0912	0.0957
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0048	0.0069	0.6986
Schistosoma mansoni	hypothetical protein	0.0458	0.0767	0.1203
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0543	0.0912	0.155
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0008	0.0001	0.5
Mycobacterium tuberculosis	Probable cytochrome P450 125 Cyp125	0.0008	0.0001	0.5
Loa Loa (eye worm)	histone methyltransferase	0.001	0.0005	0.0004
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0543	0.0912	0.1431
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0048	0.0069	1
Onchocerca volvulus		0.0256	0.0424	0.0383
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.004	0.0056	0.0087
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0397	0.0663	0.0696
Brugia malayi	conserved hypotetical protein	0.0256	0.0424	0.0444
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0543	0.0912	0.0957
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0543	0.0912	0.1431
Mycobacterium tuberculosis	Probable cytochrome P450 136 Cyp136	0.0008	0.0001	0.5
Schistosoma mansoni	hypothetical protein	0.0058	0.0086	0.0134
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0256	0.0424	0.0719
Loa Loa (eye worm)	hypothetical protein	0.0256	0.0424	0.0444
Loa Loa (eye worm)	hypothetical protein	0.0543	0.0912	0.0957
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0008	0.0001	0.5
Brugia malayi	Nuclear hormone receptor-like 1	0.0287	0.0476	0.0499
Mycobacterium ulcerans	cytochrome P450 187A4 Cyp187A4	0.0008	0.0001	0.5
Brugia malayi	ecdysteroid receptor	0.0543	0.0912	0.0957
Loa Loa (eye worm)	steroid hormone receptor	0.0543	0.0912	0.0957
Mycobacterium ulcerans	cytochrome P450 123A3 Cyp123A3	0.0008	0.0001	0.5
Leishmania major	cytochrome p450-like protein	0.0008	0.0001	0.5
Mycobacterium leprae	Conserved hypothetical protein	0.0008	0.0001	0.5
Echinococcus multilocularis	cpg binding protein	0.0034	0.0045	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0256	0.0424	0.0444
Schistosoma mansoni	cpg binding protein	0.0032	0.0042	0.0065
Schistosoma mansoni	retinoic acid receptor RXR	0.3749	0.6365	1
Loa Loa (eye worm)	hypothetical protein	0.0256	0.0424	0.0444
Brugia malayi	steroid hormone receptor	0.0543	0.0912	0.0957
Mycobacterium tuberculosis	Probable cytochrome P450 123 Cyp123	0.0008	0.0001	0.5
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0256	0.0424	0.0444
Mycobacterium tuberculosis	Probable cytochrome P450 132 Cyp132	0.0008	0.0001	0.5
Brugia malayi	ecdysone receptor	0.0256	0.0424	0.0444
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0543	0.0912	0.155
Mycobacterium ulcerans	cytochrome P450 143A3 Cyp143A3	0.0008	0.0001	0.5
Mycobacterium tuberculosis	Cytochrome P450 121 Cyp121	0.0008	0.0001	0.5
Schistosoma mansoni	nuclear receptor	0.0256	0.0424	0.0664
Brugia malayi	hypothetical protein	0.0287	0.0476	0.0499
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0543	0.0912	0.155
Giardia lamblia	Histone acetyltransferase GCN5	0.0044	0.0062	0.5
Echinococcus granulosus	ecdysone induced protein 78C	0.0543	0.0912	0.1431
Loa Loa (eye worm)	hypothetical protein	0.0287	0.0476	0.0499
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0543	0.0912	0.0957
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0543	0.0912	0.0957
Onchocerca volvulus		0.0543	0.0912	0.0873
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0256	0.0424	0.0719
Loa Loa (eye worm)	hypothetical protein	0.5342	0.9076	0.9542
Mycobacterium tuberculosis	Probable cytochrome P450 144 Cyp144	0.0008	0.0001	0.5
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0287	0.0476	0.0808
Mycobacterium ulcerans	cytochrome P450 105Q4 Cyp105Q4	0.0008	0.0001	0.5
Brugia malayi	nuclear receptor RXR	0.0256	0.0424	0.0444
Brugia malayi	Nuclear hormone receptor E75	0.0256	0.0424	0.0444
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.5599	0.9512	1
Brugia malayi	CXXC zinc finger family protein	0.0032	0.0042	0.0043
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0256	0.0424	0.0383
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0256	0.0424	0.0444
Brugia malayi	F/Y-rich N-terminus family protein	0.001	0.0004	0.0003
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0256	0.0424	0.0664
Entamoeba histolytica	acetyltransferase, GNAT family	0.0044	0.0062	1
Schistosoma mansoni	thyroid hormone receptor	0.0543	0.0912	0.1431
Mycobacterium ulcerans	cytochrome P450 189A7 Cyp189A7	0.0008	0.0001	0.5
Brugia malayi	nuclear hormone receptor family member odr-7	0.0256	0.0424	0.0444
Echinococcus granulosus	thyroid hormone receptor alpha	0.0256	0.0424	0.0664
Mycobacterium ulcerans	cytochrome P450 188A3 Cyp188A3	0.0008	0.0001	0.5
Brugia malayi	nuclear receptor NHR-67	0.0256	0.0424	0.0444
Mycobacterium ulcerans	cytochrome P450 124A1, Cyp124A1	0.0008	0.0001	0.5
Brugia malayi	Nuclear hormone receptor E75	0.0256	0.0424	0.0444
Loa Loa (eye worm)	hypothetical protein	0.0287	0.0476	0.0499
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0032	0.0042	0.0043
Brugia malayi	Nuclear hormone receptor-like 1	0.0543	0.0912	0.0957
Loa Loa (eye worm)	hypothetical protein	0.0256	0.0424	0.0444
Mycobacterium tuberculosis	Probable cytochrome P450 128 Cyp128	0.0008	0.0001	0.5
Loa Loa (eye worm)	hypothetical protein	0.0287	0.0476	0.0499
Echinococcus multilocularis	FTZ F1 alpha	0.0543	0.0912	0.155
Brugia malayi	nuclear hormone receptor	0.5599	0.9512	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0543	0.0912	0.1431
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0543	0.0912	0.1431
Mycobacterium tuberculosis	Probable cytochrome P450 143 Cyp143	0.0008	0.0001	0.5
Schistosoma mansoni	thyroid hormone receptor	0.0543	0.0912	0.1431
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0158	0.0256	0.0401
Schistosoma mansoni	nuclear hormone receptor	0.0543	0.0912	0.1431
Loa Loa (eye worm)	hypothetical protein	0.0256	0.0424	0.0444
Mycobacterium tuberculosis	Possible cytochrome P450 126 Cyp126	0.0008	0.0001	0.5
Mycobacterium tuberculosis	Probable cytochrome P450 140 Cyp140	0.0008	0.0001	0.5
Leishmania major	cytochrome p450-like protein	0.0008	0.0001	0.5
Mycobacterium ulcerans	cytochrome P450 125A7 Cyp125A7	0.0008	0.0001	0.5
Mycobacterium ulcerans	cytochrome P450 140A5 Cyp140A5	0.0008	0.0001	0.5
Loa Loa (eye worm)	acetyltransferase	0.0162	0.0264	0.0276
Mycobacterium ulcerans	cytochrome P450 150A6 Cyp150A6	0.0008	0.0001	0.5
Echinococcus multilocularis	ecdysone induced protein 78C	0.0543	0.0912	0.155
Echinococcus granulosus	cpg binding protein	0.0034	0.0045	0.007
Trypanosoma cruzi	cytochrome p450-like protein, putative	0.0008	0.0001	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0543	0.0912	0.0957
Brugia malayi	nuclear receptor NHR-88	0.0543	0.0912	0.0957
Plasmodium falciparum	histone acetyltransferase GCN5	0.0044	0.0062	0.5
Mycobacterium tuberculosis	Probable cytochrome P450 141 Cyp141	0.0008	0.0001	0.5
Loa Loa (eye worm)	hypothetical protein	0.0543	0.0912	0.0957
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0543	0.0912	0.155
Mycobacterium ulcerans	cytochrome P450 143A4 Cyp143A4	0.0008	0.0001	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0543	0.0912	0.0957
Brugia malayi	acetyltransferase, GNAT family protein	0.0162	0.0264	0.0276
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0543	0.0912	0.0957
Mycobacterium tuberculosis	Probable cytochrome P450 124 Cyp124	0.0008	0.0001	0.5
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0162	0.0264	0.0413
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0543	0.0912	0.0957
Schistosoma mansoni	transcription factor LCR-F1	0.004	0.0056	0.0087
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0256	0.0424	0.0719
Schistosoma mansoni	nuclear receptor nhr-48	0.0256	0.0424	0.0664
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0256	0.0424	0.0664
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0543	0.0912	0.0957
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0543	0.0912	0.1431
Schistosoma mansoni	cpg binding protein	0.0034	0.0045	0.007
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0543	0.0912	0.0957
Mycobacterium tuberculosis	Probable cytochrome P450 139 Cyp139	0.0008	0.0001	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0543	0.0912	0.0957
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0543	0.0912	0.1431
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0048	0.0069	1
Trypanosoma brucei	Lanosterol 14-alpha demethylase	0.0008	0.0001	0.5
Mycobacterium ulcerans	cytochrome P450 136A2 Cyp136A2	0.0008	0.0001	0.5
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0068	0.0104	0.0161
Mycobacterium tuberculosis	Probable cytochrome P450 137 Cyp137	0.0008	0.0001	0.5
Brugia malayi	Steroid receptor seven-up type 2	0.0543	0.0912	0.0957
Trypanosoma brucei	cytochrome P450, putative	0.0008	0.0001	0.5
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0048	0.0069	0.5
Echinococcus granulosus	dnaJ subfamily B	0.0458	0.0767	0.1203
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0543	0.0912	0.0957
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.3749	0.6365	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0543	0.0912	0.1431
Mycobacterium tuberculosis	Possible cytochrome P450 135A1 Cyp135A1	0.0008	0.0001	0.5
Mycobacterium ulcerans	cytochrome P450 51B1 Cyp51B1	0.0008	0.0001	0.5
Brugia malayi	nuclear receptor NHR-88	0.0256	0.0424	0.0444
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0162	0.0264	0.0447
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0543	0.0912	0.155
Loa Loa (eye worm)	DR-78	0.0256	0.0424	0.0444
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0543	0.0912	0.155
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0256	0.0424	0.0383
Loa Loa (eye worm)	hypothetical protein	0.0543	0.0912	0.0957
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.0005	0.0005
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0543	0.0912	0.0957
Mycobacterium tuberculosis	Probable cytochrome P450 monooxygenase 142 Cyp142	0.0008	0.0001	0.5
Onchocerca volvulus		0.0256	0.0424	0.0383
Brugia malayi	nuclear hormone receptor	0.0543	0.0912	0.0957
Brugia malayi	hypothetical protein	0.0287	0.0476	0.0499
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0065	0.0098	1
Schistosoma mansoni	nuclear hormone receptor	0.0256	0.0424	0.0664
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0543	0.0912	0.1431
Loa Loa (eye worm)	hypothetical protein	0.0256	0.0424	0.0444
Brugia malayi	nuclear receptor RXR	0.0287	0.0476	0.0499
Brugia malayi	hypothetical protein	0.0256	0.0424	0.0444
Brugia malayi	hypothetical protein	0.0256	0.0424	0.0444
Brugia malayi	Nuclear hormone receptor-like 1	0.0287	0.0476	0.0499
Trypanosoma cruzi	cytochrome P450, putative	0.0008	0.0001	0.5
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0543	0.0912	0.1431
Onchocerca volvulus	Protein ultraspiracle homolog	0.0543	0.0912	0.0873
Mycobacterium leprae	putative cytochrome p450	0.0008	0.0001	0.5
Trypanosoma cruzi	cytochrome P450, putative	0.0008	0.0001	0.5
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0287	0.0476	0.0746
Mycobacterium ulcerans	cytochrome P450 191A3 Cyp191A3	0.0008	0.0001	0.5
Loa Loa (eye worm)	hypothetical protein	0.0543	0.0912	0.0957
Loa Loa (eye worm)	hypothetical protein	0.0256	0.0424	0.0444
Schistosoma mansoni	hypothetical protein	0.004	0.0056	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0543	0.0912	0.0957
Mycobacterium tuberculosis	Probable cytochrome P450 138 Cyp138	0.0008	0.0001	0.5
Loa Loa (eye worm)	hypothetical protein	0.0256	0.0424	0.0444
Schistosoma mansoni	nuclear hormone receptor	0.0256	0.0424	0.0664
Loa Loa (eye worm)	hypothetical protein	0.0543	0.0912	0.0957
Loa Loa (eye worm)	hypothetical protein	0.0256	0.0424	0.0444
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0256	0.0424	0.0664
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0287	0.0476	0.0499
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0287	0.0476	0.0746
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0048	0.0069	0.0106
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0008	0.0001	0.5
Schistosoma mansoni	zinc finger protein	0.0256	0.0424	0.0664
Mycobacterium ulcerans	cytochrome P450 108B4 Cyp108B4	0.0008	0.0001	0.5
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.3462	0.5877	1
Mycobacterium ulcerans	cytochrome P450 126A3 Cyp126A3	0.0008	0.0001	0.5
Loa Loa (eye worm)	hypothetical protein	0.0256	0.0424	0.0444
Onchocerca volvulus	Bile acid receptor homolog	0.0543	0.0912	0.0873
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0543	0.0912	0.1431
Loa Loa (eye worm)	hypothetical protein	0.0543	0.0912	0.0957
Brugia malayi	orphan nuclear receptor NR2E1	0.0256	0.0424	0.0444
Schistosoma mansoni	RAR-like nuclear receptor	0.0543	0.0912	0.1431
Loa Loa (eye worm)	hypothetical protein	0.0287	0.0476	0.0499
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0543	0.0912	0.0957
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0543	0.0912	0.1431
Brugia malayi	photoreceptor-specific nuclear receptor	0.0543	0.0912	0.0957
Mycobacterium ulcerans	cytochrome p450 150 cyp150	0.0008	0.0001	0.5
Echinococcus granulosus	nuclear receptor nhr 48	0.0256	0.0424	0.0664
Brugia malayi	hypothetical protein	0.004	0.0056	0.0058
Schistosoma mansoni	coup transcription factor	0.0543	0.0912	0.1431
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0256	0.0424	0.0664
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.004	0.0056	0.0094
Echinococcus granulosus	FTZ F1 alpha	0.0543	0.0912	0.1431
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0543	0.0912	0.0957
Echinococcus multilocularis	nuclear receptor nhr 48	0.0256	0.0424	0.0719
Mycobacterium tuberculosis	Possible cytochrome P450 135B1 Cyp135B1	0.0008	0.0001	0.5
Loa Loa (eye worm)	hypothetical protein	0.0397	0.0663	0.0696
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0543	0.0912	0.155
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.0005	0.0006
Schistosoma mansoni	cpg binding protein	0.0034	0.0045	0.007
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0256	0.0424	0.0719
Loa Loa (eye worm)	hypothetical protein	0.0287	0.0476	0.0499
Loa Loa (eye worm)	hypothetical protein	0.0543	0.0912	0.0957
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0256	0.0424	0.0664

Activities

Activity type	Activity value	Assay description	Source	Reference
Cmax (functional)	= 0.023 uM-1 kg-1	Compound is evaluated for maximum percentage of (Cmax) increase in life span (ILS) in tumor bearing mice	ChEMBL.	6737430
Cmax (functional)	= 0.023 uM-1 kg-1	Compound is evaluated for maximum percentage of (Cmax) increase in life span (ILS) in tumor bearing mice	ChEMBL.	6737430
Increase (functional)	= -1 %	Antitumor activity of the compound is evaluated as the percent increase in lifespan of TLX/5 tumor bearing animals at 100 mg/kg , daily x 5	ChEMBL.	6737430
Increase (functional)	= -1 %	Antitumor activity of the compound is evaluated as the percent increase in lifespan of TLX/5 tumor bearing animals at 100 mg/kg , daily x 5	ChEMBL.	6737430
Increase (functional)	= 1 %	Antitumor activity of the compound is evaluated as the percent increase in lifespan of TLX/5 tumor bearing animals at 12.5 mg/kg , daily x 5	ChEMBL.	6737430
Increase (functional)	= 1 %	Antitumor activity of the compound is evaluated as the percent increase in lifespan of TLX/5 tumor bearing animals at 12.5 mg/kg , daily x 5	ChEMBL.	6737430
Increase (functional)	= 3 %	Antitumor activity of the compound is evaluated as the percent increase in lifespan of TLX/5 tumor bearing animals at 25 mg/kg , daily x 5	ChEMBL.	6737430
Increase (functional)	= 3 %	Antitumor activity of the compound is evaluated as the percent increase in lifespan of TLX/5 tumor bearing animals at 50 mg/kg , daily x 5	ChEMBL.	6737430
Increase (functional)	= 3 %	Antitumor activity of the compound is evaluated as the percent increase in lifespan of TLX/5 tumor bearing animals at 25 mg/kg , daily x 5	ChEMBL.	6737430
Increase (functional)	= 3 %	Antitumor activity of the compound is evaluated as the percent increase in lifespan of TLX/5 tumor bearing animals at 50 mg/kg , daily x 5	ChEMBL.	6737430
Increase (functional)	= 9 %	Antitumor activity of the compound is evaluated as the percent increase in lifespan of TLX/5 tumor bearing animals at 400 mg/kg , daily x 5	ChEMBL.	6737430
Increase (functional)	= 9 %	Antitumor activity of the compound is evaluated as the percent increase in lifespan of TLX/5 tumor bearing animals at 400 mg/kg , daily x 5	ChEMBL.	6737430
Increase (functional)	= 13 %	Antitumor activity of the compound is evaluated as the percent increase in lifespan of TLX/5 tumor bearing animals at 200 mg/kg , daily x 5	ChEMBL.	6737430
Increase (functional)	= 13 %	Antitumor activity of the compound is evaluated as the percent increase in lifespan of TLX/5 tumor bearing animals at 200 mg/kg , daily x 5	ChEMBL.	6737430

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL367195

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 300063