TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 292.767 | Formula: C12H11ClN5S-
H donors: 2 H acceptors: 3 LogP: 3.36 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccccc1c1nnc(s1)Nc1[nH]ccn1.[Cl-]
InChi: 1S/C12H11N5S.ClH/c1-8-4-2-3-5-9(8)10-16-17-12(18-10)15-11-13-6-7-14-11;/h2-7H,1H3,(H2,13,14,15,17);1H/p-1
InChiKey: DAXKGVIIGIFRTM-UHFFFAOYSA-M

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0498	0.0498
Loa Loa (eye worm)	heat shock protein 75	0.0032	0.048	0.048
Trypanosoma brucei	heat shock protein, putative	0.0048	0.0983	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.003	0.0442	0.063
Brugia malayi	RNA, U transporter 1	0.0089	0.2285	0.3022
Schistosoma mansoni	hypothetical protein	0.0035	0.0599	0.0599
Plasmodium vivax	heat shock protein, putative	0.0181	0.5165	1
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0043	0.0841	0.816
Mycobacterium leprae	PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G)	0.0045	0.0891	1
Schistosoma mansoni	tar DNA-binding protein	0.0136	0.3744	0.3744
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0873	0.0873
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0032	0.0504	0.0974
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0032	0.0498	0.5
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0033	0.0525	0.0525
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0662	0.0943
Schistosoma mansoni	coup transcription factor	0.0033	0.0525	0.0525
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0033	0.0525	0.0694
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0033	0.0525	0.0525
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0025	0.0283	0.01
Brugia malayi	RNA binding protein	0.0136	0.3744	0.4951
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0034	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0525	0.0525
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0023	0.0209	0.0403
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0034	0.0034
Leishmania major	heat shock protein 83-1	0.0048	0.0983	1
Trypanosoma cruzi	heat shock protein, putative	0.0032	0.048	0.4877
Echinococcus multilocularis	geminin	0.0176	0.5028	0.5028
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0016	0.0001	0.0001
Schistosoma mansoni	thyroid hormone receptor	0.0033	0.0525	0.0525
Mycobacterium tuberculosis	Probable lipase LipD	0.0037	0.0662	0.0943
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0043	0.0841	0.8721
Trichomonas vaginalis	heat shock protein, putative	0.0035	0.0572	0.0493
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0048	0.0983	1
Trypanosoma brucei	heat shock protein, putative	0.0048	0.0983	1
Leishmania major	heat shock protein 83-1	0.0048	0.0983	1
Echinococcus multilocularis	ecdysone induced protein 78C	0.0033	0.0525	0.0525
Trypanosoma brucei	heat shock protein, putative	0.0048	0.0983	1
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0033	0.0525	0.0063
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0334	1	1
Brugia malayi	isocitrate dehydrogenase	0.0016	0.0001	0.0001
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0001	0.0001
Loa Loa (eye worm)	heat shock protein 90	0.0048	0.0983	0.0983
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0037	0.0662	0.0662
Entamoeba histolytica	heat shock protein 90, putative	0.0048	0.0983	1
Trypanosoma brucei	heat shock protein 90, putative	0.0048	0.0983	1
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0032	0.0504	0.0504
Mycobacterium ulcerans	hypothetical protein	0.0043	0.0841	0.8721
Brugia malayi	Endoplasmin precursor	0.0048	0.0983	0.13
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0034	0.0034
Leishmania major	heat shock protein, putative	0.0032	0.048	0.4877
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0033	0.0525	0.0694
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0873	0.0873
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.003	0.0442	0.063
Loa Loa (eye worm)	steroid hormone receptor	0.0033	0.0525	0.0525
Mycobacterium tuberculosis	Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G)	0.0045	0.0891	0.127
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0043	0.0841	0.8721
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0033	0.0525	0.0525
Trichomonas vaginalis	heat shock protein, putative	0.0045	0.0891	0.0926
Onchocerca volvulus		0.0043	0.0841	0.0508
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0043	0.0841	0.8721
Plasmodium vivax	SET domain protein, putative	0.0032	0.0504	0.0974
Plasmodium vivax	hypothetical protein, conserved	0.0037	0.0662	0.128
Entamoeba histolytica	90 kDa heat shock protein, putative	0.0032	0.048	0.35
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0037	0.0662	0.0875
Onchocerca volvulus		0.0032	0.0504	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0469	0.0469
Brugia malayi	latrophilin 2 splice variant baaae	0.0035	0.0599	0.0792
Trichomonas vaginalis	esterase, putative	0.0037	0.0662	0.0615
Echinococcus granulosus	heat shock protein heat shock protein 90 alpha	0.0041	0.0766	0.0766
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0025	0.0283	0.01
Trypanosoma cruzi	heat shock protein 85, putative	0.0048	0.0983	1
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0023	0.0209	0.2119
Echinococcus multilocularis	survival motor neuron protein 1	0.0257	0.7562	0.7562
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0239	0.7009	1
Onchocerca volvulus		0.0052	0.1132	0.0919
Schistosoma mansoni	nuclear hormone receptor	0.0033	0.0525	0.0525
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0033	0.0525	0.0525
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0525	0.0525
Schistosoma mansoni	retinoic acid receptor RXR	0.0033	0.0525	0.0525
Schistosoma mansoni	survival motor neuron protein	0.0052	0.1132	0.1132
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0525	0.0525
Plasmodium vivax	heat shock protein 86, putative	0.0048	0.0983	0.1902
Brugia malayi	Isocitrate dehydrogenase	0.0016	0.0001	0.0001
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0017	0.0034	0.0034
Leishmania major	heat shock protein 83-1	0.0048	0.0983	1
Leishmania major	heat shock protein 83-1	0.0048	0.0983	1
Plasmodium vivax	endoplasmin, putative	0.0048	0.0983	0.1902
Trypanosoma brucei	hypothetical protein, conserved	0.0037	0.0662	0.673
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0033	0.0525	0.0694
Echinococcus granulosus	histone lysine methyltransferase setb	0.0032	0.0504	0.0504
Giardia lamblia	Grp94/Hsp90	0.0045	0.0891	0.881
Schistosoma mansoni	endoplasmin	0.0048	0.0983	0.0983
Brugia malayi	Nuclear hormone receptor-like 1	0.0017	0.0034	0.0045
Schistosoma mansoni	hypothetical protein	0.0176	0.5028	0.5028
Echinococcus granulosus	beta LACTamase domain containing family member	0.0037	0.0662	0.0662
Echinococcus multilocularis	heat shock protein 75 kDa, mitochondrial	0.0032	0.048	0.048
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0504	0.0504
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0052	0.1115	0.1115
Brugia malayi	AMP-binding enzyme family protein	0.0043	0.0841	0.1112
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0043	0.0841	0.1198
Schistosoma mansoni	heat shock protein	0.0048	0.0983	0.0983
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0033	0.0525	0.0525
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0033	0.0525	0.0525
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0498	0.0498
Trypanosoma cruzi	heat shock protein 90, putative	0.002	0.0112	0.1128
Trichomonas vaginalis	endoplasmin, putative	0.0035	0.0572	0.0493
Schistosoma mansoni	hypothetical protein	0.0176	0.5028	0.5028
Loa Loa (eye worm)	hypothetical protein	0.0257	0.7562	0.7562
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0662	0.0615
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0226	0.6594	0.6594
Onchocerca volvulus		0.0037	0.0662	0.0256
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0052	0.1132	0.1497
Schistosoma mansoni	tar DNA-binding protein	0.0136	0.3744	0.3744
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0662	0.0662
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0662	0.0615
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0017	0.0034	0.0034
Brugia malayi	ecdysteroid receptor	0.0033	0.0525	0.0694
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0033	0.0525	0.0694
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0662	0.0943
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0033	0.0525	0.0694
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0023	0.0209	0.2119
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0033	0.0525	0.0525
Echinococcus granulosus	heat shock protein 90	0.0048	0.0983	0.0983
Leishmania major	heat shock protein 83-1	0.0048	0.0983	1
Schistosoma mansoni	RAR-like nuclear receptor	0.0033	0.0525	0.0525
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0034	0.0034
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0504	0.0504
Trichomonas vaginalis	heat shock protein, putative	0.0041	0.0766	0.0757
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0017	0.0034	0.0034
Brugia malayi	hypothetical protein	0.0017	0.0034	0.0045
Trichomonas vaginalis	heat shock protein, putative	0.0045	0.0891	0.0926
Brugia malayi	nuclear receptor NHR-88	0.0033	0.0525	0.0694
Trichomonas vaginalis	heat shock protein, putative	0.0028	0.0355	0.0199
Schistosoma mansoni	tar DNA-binding protein	0.0136	0.3744	0.3744
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0662	0.0662
Loa Loa (eye worm)	helix-loop-helix DNA-binding domain-containing protein	0.0112	0.2998	0.2998
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0033	0.0525	0.0525
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0017	0.0034	0.0034
Brugia malayi	hypothetical protein	0.0017	0.0034	0.0045
Brugia malayi	Hsp90 protein	0.0032	0.048	0.0635
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0841	0.0841
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0873	0.0873
Entamoeba histolytica	hypothetical protein	0.0025	0.0283	0.0953
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0873	0.0873
Entamoeba histolytica	heat shock protein 90, putative	0.0048	0.0983	1
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0033	0.0525	0.0525
Echinococcus granulosus	importin subunit beta 1	0.0031	0.0469	0.0469
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0033	0.0525	0.0694
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0662	0.0662
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0052	0.1115	0.1474
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0037	0.0662	0.0662
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0525	0.0525
Toxoplasma gondii	HEAT repeat-containing protein	0.0031	0.0469	0.0907
Loa Loa (eye worm)	endoplasmin	0.0048	0.0983	0.0983
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0525	0.0525
Entamoeba histolytica	acyl-coA synthetase, putative	0.0043	0.0841	0.816
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0841	0.0841
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0033	0.0525	0.0694
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0873	0.0873
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0041	0.0766	0.7202
Brugia malayi	beta-lactamase family protein	0.0037	0.0662	0.0875
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0034	0.0034
Onchocerca volvulus	Protein ultraspiracle homolog	0.0033	0.0525	0.0063
Plasmodium falciparum	importin beta, putative	0.0031	0.0469	0.0907
Schistosoma mansoni	ran	0.0023	0.0209	0.0209
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0017	0.0034	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0498	0.0498
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0032	0.0498	0.0709
Leishmania major	heat shock protein 83-1	0.0048	0.0983	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0033	0.0525	0.0525
Echinococcus multilocularis	importin subunit beta 1	0.0031	0.0469	0.0469
Toxoplasma gondii	heat shock protein 90, putative	0.0048	0.0983	0.1902
Leishmania major	heat shock protein 83-1	0.0048	0.0983	1
Schistosoma mansoni	ran	0.0023	0.0209	0.0209
Trypanosoma cruzi	heat shock protein 85, putative	0.0048	0.0983	1
Onchocerca volvulus		0.0257	0.7576	1
Mycobacterium tuberculosis	Probable hydrolase	0.0037	0.0662	0.0943
Onchocerca volvulus	Bile acid receptor homolog	0.0033	0.0525	0.0063
Schistosoma mansoni	heat shock protein	0.0048	0.0983	0.0983
Mycobacterium tuberculosis	Probable lipase LipE	0.0037	0.0662	0.0943
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0023	0.0209	0.0276
Schistosoma mansoni	thyroid hormone receptor	0.0033	0.0525	0.0525
Leishmania major	heat shock protein 83-1	0.0048	0.0983	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0525	0.0525
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0033	0.0525	0.0525
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0023	0.0209	0.0209
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0044	0.0873	0.0873
Schistosoma mansoni	hypothetical protein	0.0052	0.1132	0.1132
Brugia malayi	Nuclear hormone receptor-like 1	0.0017	0.0034	0.0045
Schistosoma mansoni	endoplasmin	0.0048	0.0983	0.0983
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0033	0.0525	0.0525
Echinococcus multilocularis	tar DNA binding protein	0.0136	0.3744	0.3744
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0033	0.0525	0.0525
Brugia malayi	nuclear receptor RXR	0.0017	0.0034	0.0045
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0037	0.0662	0.0943
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0023	0.0209	0.0403
Leishmania major	heat shock protein 83-1	0.0048	0.0983	1
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0033	0.0525	0.0525
Echinococcus multilocularis	FTZ F1 alpha	0.0033	0.0525	0.0525
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0037	0.0662	0.0943
Brugia malayi	AMP-binding enzyme family protein	0.0043	0.0841	0.1112
Brugia malayi	beta-lactamase family protein	0.0037	0.0662	0.0875
Plasmodium falciparum	heat shock protein 90, putative	0.0181	0.5165	1
Trypanosoma cruzi	Heat shock protein 83, putative	0.0048	0.0983	1
Brugia malayi	photoreceptor-specific nuclear receptor	0.0033	0.0525	0.0694
Trypanosoma cruzi	heat shock protein 85, putative	0.0041	0.0766	0.7795
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0016	0.0001	0.0001
Onchocerca volvulus		0.0037	0.0662	0.0256
Plasmodium falciparum	acyl-CoA synthetase	0.0032	0.0498	0.0962
Echinococcus multilocularis	heat shock protein 90	0.0048	0.0983	0.0983
Trypanosoma cruzi	heat shock protein 90, putative	0.0041	0.0766	0.7795
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0033	0.0525	0.0525
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0023	0.0209	0.0209
Schistosoma mansoni	tar DNA-binding protein	0.0136	0.3744	0.3744
Echinococcus granulosus	survival motor neuron protein 1	0.0257	0.7562	0.7562
Echinococcus granulosus	heat shock protein	0.0048	0.0983	0.0983
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0033	0.0525	0.0525
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0662	0.0662
Brugia malayi	Nuclear hormone receptor-like 1	0.0033	0.0525	0.0694
Trichomonas vaginalis	importin beta-1, putative	0.0025	0.0283	0.01
Leishmania major	heat shock protein 83-1	0.0048	0.0983	1
Mycobacterium ulcerans	heat shock protein 90	0.0045	0.0891	1
Echinococcus granulosus	heat shock protein 90	0.0041	0.0766	0.0766
Echinococcus multilocularis	transcription factor eb	0.0112	0.3015	0.3015
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0033	0.0525	0.0525
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0504	0.0504
Leishmania major	heat shock protein 83-1	0.0048	0.0983	1
Echinococcus multilocularis	isocitrate dehydrogenase	0.0016	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1115	0.1115
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0043	0.0841	0.7804
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0033	0.0525	0.0694
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0662	0.0662
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.003	0.0442	0.063
Trypanosoma brucei	heat shock protein 90, putative	0.0048	0.0983	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0033	0.0525	0.0694
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0037	0.0662	0.0943
Plasmodium vivax	acyl-CoA synthetase, putative	0.0032	0.0498	0.0962
Leishmania major	heat shock protein 83-1	0.0048	0.0983	1
Brugia malayi	AMP-binding enzyme family protein	0.0043	0.0841	0.1112
Mycobacterium tuberculosis	Probable esterase LipL	0.0037	0.0662	0.0943
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0033	0.0525	0.0525
Trypanosoma brucei	importin beta-1 subunit, putative	0.0031	0.0469	0.4767
Echinococcus multilocularis	heat shock protein	0.0048	0.0983	0.0983
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0032	0.0504	0.0504
Mycobacterium ulcerans	acyl-CoA synthetase	0.0043	0.0841	0.8721
Brugia malayi	TAR-binding protein	0.0136	0.3744	0.4951
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0001	0.0001
Plasmodium falciparum	heat shock protein 90, putative	0.0028	0.0355	0.0686
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0033	0.0525	0.0694
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0504	0.0504
Trypanosoma cruzi	heat shock protein 90, putative	0.0048	0.0983	1
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0033	0.0525	0.0525
Trichomonas vaginalis	set domain proteins, putative	0.0257	0.7576	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0052	0.1115	0.1474
Trypanosoma brucei	heat shock protein, putative	0.0048	0.0983	1
Leishmania major	heat shock protein 83-1	0.0048	0.0983	1
Echinococcus granulosus	FTZ F1 alpha	0.0033	0.0525	0.0525
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0033	0.0525	0.0694
Leishmania major	heat shock protein 83-1	0.0048	0.0983	1
Leishmania major	importin beta-1 subunit, putative	0.0025	0.0283	0.287
Mycobacterium ulcerans	acyl-CoA synthetase	0.0043	0.0841	0.8721
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0662	0.673
Echinococcus multilocularis	snurportin 1	0.0334	1	1
Trypanosoma brucei	heat shock protein, putative	0.0048	0.0983	1
Toxoplasma gondii	ABC1 family protein	0.0037	0.0662	0.128
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0016	0.0001	0.0001
Loa Loa (eye worm)	beta-lactamase	0.0037	0.0662	0.0662
Leishmania major	heat shock protein 83-1	0.0048	0.0983	1
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0037	0.0662	0.4175
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0662	0.0943
Leishmania major	hypothetical protein, conserved	0.0037	0.0662	0.673
Brugia malayi	Pre-SET motif family protein	0.0032	0.0504	0.0666
Mycobacterium ulcerans	hypothetical protein	0.0037	0.0662	0.4175
Leishmania major	4-coumarate:coa ligase-like protein	0.0043	0.0841	0.855
Leishmania major	4-coumarate:coa ligase-like protein	0.0043	0.0841	0.855
Leishmania major	GTP-binding protein, putative	0.0023	0.0209	0.2119
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0498	0.0498
Loa Loa (eye worm)	TAR-binding protein	0.0136	0.3744	0.3744
Leishmania major	heat shock protein 83-1	0.0048	0.0983	1
Trypanosoma brucei	heat shock protein, putative	0.0048	0.0983	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0033	0.0525	0.0525
Trypanosoma brucei	Heat shock protein 83, putative	0.0048	0.0983	1
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0033	0.0525	0.0525
Mycobacterium ulcerans	acyl-CoA synthetase	0.0043	0.0841	0.8721
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0033	0.0525	0.0525
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0023	0.0209	0.0209
Leishmania major	heat shock protein 83-1	0.0048	0.0983	1
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0023	0.0209	0.2119
Onchocerca volvulus		0.0033	0.0525	0.0063
Echinococcus granulosus	endoplasmin	0.0045	0.0891	0.0891
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0033	0.0525	0.0525
Echinococcus granulosus	transcription factor eb	0.0112	0.3015	0.3015
Loa Loa (eye worm)	hypothetical protein	0.0112	0.2998	0.2998
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0043	0.0841	0.1198
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0662	0.0615
Echinococcus multilocularis	heat shock protein 90	0.0041	0.0766	0.0766
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0033	0.0525	0.0525
Trypanosoma brucei	heat shock protein 84, putative	0.0032	0.048	0.4877
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.003	0.0442	0.063
Brugia malayi	heat shock protein 90	0.0048	0.0983	0.13
Plasmodium falciparum	heat shock protein 90	0.0048	0.0983	0.1902
Leishmania major	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	0.0045	0.0891	0.9062
Trichomonas vaginalis	heat shock protein, putative	0.0048	0.0983	0.1051
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0599	0.0599
Toxoplasma gondii	heat shock protein HSP90	0.0048	0.0983	0.1902
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0033	0.0525	0.0525
Brugia malayi	hypothetical protein	0.0257	0.7562	1
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0043	0.0841	0.7804
Brugia malayi	beta-lactamase	0.0037	0.0662	0.0875
Mycobacterium ulcerans	beta-lactamase	0.0037	0.0662	0.4175
Schistosoma mansoni	importin beta-1	0.0031	0.0469	0.0469
Plasmodium vivax	importin-beta 2, putative	0.0031	0.0469	0.0907
Toxoplasma gondii	Hsp90 domain-containing protein	0.0181	0.5165	1
Brugia malayi	RNA recognition motif domain containing protein	0.0136	0.3744	0.4951
Brugia malayi	Pre-SET motif family protein	0.0226	0.6594	0.8719
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0662	0.0662
Trypanosoma cruzi	heat shock protein 85, putative	0.0048	0.0983	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0662	0.0662
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0525	0.0525
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0662	0.0615
Loa Loa (eye worm)	RNA binding protein	0.0136	0.3744	0.3744
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0033	0.0525	0.0525
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0031	0.0466	0.0466
Echinococcus granulosus	geminin	0.0176	0.5028	0.5028
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0016	0.0001	0.0001
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0033	0.0525	0.0694
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0025	0.0283	0.287
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0873	0.0873
Brugia malayi	Steroid receptor seven-up type 2	0.0033	0.0525	0.0694
Schistosoma mansoni	hypothetical protein	0.0334	1	1
Plasmodium falciparum	endoplasmin, putative	0.0035	0.0572	0.1106
Schistosoma mansoni	heat shock protein	0.0032	0.048	0.048
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0033	0.0525	0.0525
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0841	0.0841
Toxoplasma gondii	heat shock protein 75, putative	0.0032	0.048	0.0928
Leishmania major	4-coumarate:coa ligase-like protein	0.0043	0.0841	0.855
Brugia malayi	Importin beta-1 subunit	0.0031	0.0469	0.062
Wolbachia endosymbiont of Brugia malayi	heat shock protein 90	0.0045	0.0891	0.5
Onchocerca volvulus		0.0037	0.0662	0.0256
Plasmodium vivax	heat shock protein 90, putative	0.0032	0.048	0.0928
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0023	0.0209	0.0403
Brugia malayi	nuclear hormone receptor	0.0033	0.0525	0.0694
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0033	0.0525	0.0525
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0136	0.3744	0.3744
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0662	0.0662
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0498	0.0498
Schistosoma mansoni	tar DNA-binding protein	0.0136	0.3744	0.3744
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0043	0.0841	0.8721
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0044	0.0873	0.1155
Echinococcus multilocularis	endoplasmin	0.0045	0.0891	0.0891
Trypanosoma brucei	heat shock protein, putative	0.0048	0.0983	1
Echinococcus granulosus	heat shock protein 75 kDa mitochondrial	0.0032	0.048	0.048
Trypanosoma brucei	heat shock protein, putative	0.0048	0.0983	1
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0001	0.0001
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0043	0.0841	0.816
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0662	0.0615
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0032	0.0504	0.0504
Brugia malayi	steroid hormone receptor	0.0033	0.0525	0.0694
Treponema pallidum	heat shock protein 90	0.0045	0.0891	0.5
Brugia malayi	Helix-loop-helix DNA-binding domain containing protein	0.0112	0.3015	0.3987
Mycobacterium ulcerans	esterase/lipase LipP	0.0037	0.0662	0.4175
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0873	0.0873
Mycobacterium ulcerans	lipase LipD	0.0037	0.0662	0.4175
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0033	0.0525	0.0694
Echinococcus granulosus	tar DNA binding protein	0.0136	0.3744	0.3744
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0662	0.673
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0525	0.0525
Echinococcus granulosus	ecdysone induced protein 78C	0.0033	0.0525	0.0525
Trypanosoma brucei	importin beta-1 subunit, putative	0.0031	0.0469	0.4767

Activities

Activity type	Activity value	Assay description	Source	Reference
Reduction (functional)	= 40 %	Maximum percentage reduction in mean arterial blood pressure in metacorticoid (DOCA) hypertensive rats at a standard oral dose of 100 mg/kg	ChEMBL.	3361579

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 386318

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 300158