Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0814 | 0.4062 | 0.4007 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0814 | 0.4062 | 0.4007 |
Echinococcus multilocularis | transfer RNA-Lys | 0.0041 | 0.0118 | 0.0026 |
Onchocerca volvulus | 0.0055 | 0.019 | 0.499 | |
Echinococcus granulosus | Protein patched homolog 1 | 0.0814 | 0.4062 | 0.4007 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0036 | 0.0092 | 0.0092 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.1977 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0003 | 0.0003 |
Brugia malayi | Cytochrome P450 family protein | 0.003 | 0.006 | 0.006 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0115 | 0.0493 | 0.0493 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0069 | 0.0262 | 0.0262 |
Echinococcus multilocularis | protein patched | 0.0814 | 0.4062 | 0.4007 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0114 | 0.0492 | 0.0492 |
Echinococcus granulosus | single minded 2 | 0.0041 | 0.0118 | 0.0026 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0814 | 0.4062 | 0.4062 |
Brugia malayi | hypothetical protein | 0.0187 | 0.0864 | 0.0864 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0029 | 0.0055 | 0.0055 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.003 | 0.006 | 0.006 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0114 | 0.0492 | 0.0492 |
Echinococcus multilocularis | protein dispatched 1 | 0.0814 | 0.4062 | 0.4007 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.1977 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1977 | 1 | 1 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.1977 | 1 | 1 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.1977 | 1 | 1 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.1977 | 1 | 1 |
Brugia malayi | acyl-CoA desaturase | 0.0055 | 0.0188 | 0.0188 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0173 | 0.079 | 0.079 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0029 | 0.0055 | 0.0055 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0036 | 0.0092 | 0.0092 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0055 | 0.0055 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0056 | 0.0192 | 0.0101 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.0055 | 0.0188 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0927 | 0.4642 | 1 |
Leishmania major | fatty-acid desaturase, putative | 0.0069 | 0.0262 | 0.0262 |
Onchocerca volvulus | 0.0069 | 0.0262 | 1 | |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0115 | 0.0493 | 0.0405 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0029 | 0.0055 | 0.0055 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.0055 | 0.0188 | 0.0188 |
Schistosoma mansoni | patched 1 | 0.0814 | 0.4062 | 0.4007 |
Brugia malayi | hypothetical protein | 0.0271 | 0.1293 | 0.1293 |
Schistosoma mansoni | hypothetical protein | 0.0055 | 0.019 | 0.0099 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0814 | 0.4062 | 0.4007 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0036 | 0.0092 | 0.0092 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0092 | 0.0092 |
Leishmania major | stearic acid desaturase, putative | 0.0069 | 0.0262 | 0.0262 |
Schistosoma mansoni | survival motor neuron protein | 0.0055 | 0.019 | 0.0099 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0814 | 0.4062 | 0.4007 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0114 | 0.0492 | 0.0492 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0271 | 0.1293 | 0.1212 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0055 | 0.0188 | 0.0188 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.0465 | 0.0465 |
Onchocerca volvulus | 0.0069 | 0.0262 | 1 | |
Leishmania major | hypothetical protein, conserved | 0.0029 | 0.0055 | 0.0055 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0115 | 0.0493 | 0.0405 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0927 | 0.4642 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0187 | 0.0864 | 0.0864 |
Loa Loa (eye worm) | hypothetical protein | 0.0814 | 0.4062 | 0.4062 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.0069 | 0.0262 | 0.0262 |
Brugia malayi | bHLH-PAS transcription factor | 0.0041 | 0.0118 | 0.0118 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.1977 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0109 | 0.0462 | 0.0462 |
Brugia malayi | PAS domain containing protein | 0.0056 | 0.0192 | 0.0192 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.0055 | 0.0188 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.0492 | 0.0492 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0055 | 0.0188 | 0.0188 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0307 | 0.0307 |
Schistosoma mansoni | single-minded | 0.0056 | 0.0192 | 0.0101 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.1977 | 1 | 1 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0814 | 0.4062 | 0.4007 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0029 | 0.0055 | 0.5 |
Mycobacterium ulcerans | putative regulatory protein | 0.0041 | 0.0118 | 0.0118 |
Brugia malayi | CHE-14 protein | 0.0814 | 0.4062 | 0.4062 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0271 | 0.1293 | 0.1212 |
Brugia malayi | hypothetical protein | 0.0029 | 0.0055 | 0.0055 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0927 | 0.4642 | 0.5 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.1977 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0271 | 0.1293 | 0.1293 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0927 | 0.4642 | 1 |
Brugia malayi | hypoxia-induced factor 1 | 0.0173 | 0.079 | 0.079 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0055 | 0.019 | 0.019 |
Schistosoma mansoni | hypothetical protein | 0.0078 | 0.0307 | 0.0217 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0078 | 0.0307 | 0.0307 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | 0 uM | Inhibition of EGF-Receptor in ER 22 cell membrane (Not tested) | ChEMBL. | 8145236 |
IC50 (functional) | 0 uM | Inhibition of EGF-stimulated DNA synthesis in ER 22 (EGF-receptor expressing) cells (Not tested) | ChEMBL. | 8145236 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.