Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | protein patched | 0.0814 | 0.4062 | 0.4007 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0271 | 0.1293 | 0.1212 |
Schistosoma mansoni | survival motor neuron protein | 0.0055 | 0.019 | 0.0099 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0271 | 0.1293 | 0.1212 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.1977 | 1 | 1 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0055 | 0.0188 | 0.0188 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0092 | 0.0092 |
Brugia malayi | hypothetical protein | 0.0187 | 0.0864 | 0.0864 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.1977 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0114 | 0.0492 | 0.0492 |
Onchocerca volvulus | 0.0069 | 0.0262 | 1 | |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0814 | 0.4062 | 0.4007 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.0465 | 0.0465 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0927 | 0.4642 | 0.5 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0814 | 0.4062 | 0.4007 |
Brugia malayi | hypothetical protein | 0.0271 | 0.1293 | 0.1293 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0115 | 0.0493 | 0.0405 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0814 | 0.4062 | 0.4007 |
Schistosoma mansoni | patched 1 | 0.0814 | 0.4062 | 0.4007 |
Brugia malayi | acyl-CoA desaturase | 0.0055 | 0.0188 | 0.0188 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0029 | 0.0055 | 0.5 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0056 | 0.0192 | 0.0101 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0003 | 0.0003 |
Schistosoma mansoni | hypothetical protein | 0.0078 | 0.0307 | 0.0217 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0114 | 0.0492 | 0.0492 |
Schistosoma mansoni | hypothetical protein | 0.0055 | 0.019 | 0.0099 |
Echinococcus multilocularis | protein dispatched 1 | 0.0814 | 0.4062 | 0.4007 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0078 | 0.0307 | 0.0307 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.0492 | 0.0492 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.1977 | 1 | 1 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0814 | 0.4062 | 0.4007 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.0055 | 0.0188 | 1 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.0055 | 0.0188 | 1 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.1977 | 1 | 1 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.1977 | 1 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.1977 | 1 | 1 |
Brugia malayi | CHE-14 protein | 0.0814 | 0.4062 | 0.4062 |
Loa Loa (eye worm) | hypothetical protein | 0.0187 | 0.0864 | 0.0864 |
Onchocerca volvulus | 0.0069 | 0.0262 | 1 | |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0029 | 0.0055 | 0.0055 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0055 | 0.019 | 0.019 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0115 | 0.0493 | 0.0405 |
Brugia malayi | PAS domain containing protein | 0.0056 | 0.0192 | 0.0192 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0814 | 0.4062 | 0.4062 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0927 | 0.4642 | 1 |
Onchocerca volvulus | 0.0055 | 0.019 | 0.499 | |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0069 | 0.0262 | 0.0262 |
Schistosoma mansoni | single-minded | 0.0056 | 0.0192 | 0.0101 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.1977 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0109 | 0.0462 | 0.0462 |
Leishmania major | stearic acid desaturase, putative | 0.0069 | 0.0262 | 0.0262 |
Brugia malayi | bHLH-PAS transcription factor | 0.0041 | 0.0118 | 0.0118 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0029 | 0.0055 | 0.0055 |
Loa Loa (eye worm) | hypothetical protein | 0.0271 | 0.1293 | 0.1293 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.0069 | 0.0262 | 0.0262 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0927 | 0.4642 | 1 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0814 | 0.4062 | 0.4007 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0307 | 0.0307 |
Echinococcus granulosus | single minded 2 | 0.0041 | 0.0118 | 0.0026 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0036 | 0.0092 | 0.0092 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0036 | 0.0092 | 0.0092 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0927 | 0.4642 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0115 | 0.0493 | 0.0493 |
Brugia malayi | hypoxia-induced factor 1 | 0.0173 | 0.079 | 0.079 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.0055 | 0.0188 | 0.0188 |
Echinococcus multilocularis | transfer RNA-Lys | 0.0041 | 0.0118 | 0.0026 |
Leishmania major | fatty-acid desaturase, putative | 0.0069 | 0.0262 | 0.0262 |
Mycobacterium ulcerans | putative regulatory protein | 0.0041 | 0.0118 | 0.0118 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0036 | 0.0092 | 0.0092 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0114 | 0.0492 | 0.0492 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0055 | 0.0055 |
Loa Loa (eye worm) | hypothetical protein | 0.0814 | 0.4062 | 0.4062 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0029 | 0.0055 | 0.0055 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0173 | 0.079 | 0.079 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.003 | 0.006 | 0.006 |
Leishmania major | hypothetical protein, conserved | 0.0029 | 0.0055 | 0.0055 |
Brugia malayi | Cytochrome P450 family protein | 0.003 | 0.006 | 0.006 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0814 | 0.4062 | 0.4007 |
Loa Loa (eye worm) | hypothetical protein | 0.1977 | 1 | 1 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0055 | 0.0188 | 0.0188 |
Brugia malayi | hypothetical protein | 0.0029 | 0.0055 | 0.0055 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.1977 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | uM | Inhibition of EGF-stimulated DNA synthesis in ER 22 (EGF-receptor expressing) cells (Not tested) | ChEMBL. | 8145236 |
IC50 (functional) | uM | Inhibition of EGF-Receptor in ER 22 cell membrane (Not tested) | ChEMBL. | 8145236 |
IC50 (functional) | 0 uM | Inhibition of EGF-Receptor in ER 22 cell membrane (Not tested) | ChEMBL. | 8145236 |
IC50 (functional) | 0 uM | Inhibition of EGF-stimulated DNA synthesis in ER 22 (EGF-receptor expressing) cells (Not tested) | ChEMBL. | 8145236 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.