Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thymidylate synthetase | Starlite/ChEMBL | References |
Escherichia coli | thymidylate synthetase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | thymidylate synthase | 0.0389 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0389 | 0.5 | 0.5 | |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0389 | 0.5 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0389 | 0.5 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.0389 | 0.5 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0389 | 0.5 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0389 | 0.5 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 0.0389 | 0.5 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0389 | 0.5 | 0.5 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0389 | 0.5 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.0389 | 0.5 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0389 | 0.5 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0389 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0389 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 10 uM | Compound was tested for the the inhibition of mouse L1210 leukemia cell growth | ChEMBL. | 1548676 |
IC50 (functional) | > 10 uM | Compound was tested for the the inhibition of human CCRF-CEM leukemia cell growth | ChEMBL. | 1548676 |
IC50 (functional) | > 10 uM | Compound was tested for the the inhibition of thymidine kinase deficient human adenocarcinoma GC3M(-) cell growth | ChEMBL. | 1548676 |
IC50 (functional) | > 10 uM | Compound was tested for the the inhibition of mouse L1210 leukemia cell growth | ChEMBL. | 1548676 |
IC50 (functional) | > 10 uM | Compound was tested for the the inhibition of human CCRF-CEM leukemia cell growth | ChEMBL. | 1548676 |
Ki (binding) | > 3 uM | Inhibition of Escherichia coli Thymidylate synthase (TS) | ChEMBL. | 1548676 |
Ki (binding) | > 3 uM | Inhibition of Escherichia coli Thymidylate synthase (TS) | ChEMBL. | 1548676 |
Ki (binding) | = 4.2 uM | Inhibition of human Thymidylate synthase (TS) | ChEMBL. | 1548676 |
Ki (binding) | = 4.2 uM | Inhibition of human Thymidylate synthase (TS) | ChEMBL. | 1548676 |
Kii (binding) | > 3 uM | Inhibition of Escherichia coli Thymidylate synthase (TS) | ChEMBL. | 1548676 |
Kii (binding) | > 3 uM | Inhibition of Escherichia coli Thymidylate synthase (TS) | ChEMBL. | 1548676 |
Kii (binding) | = 8.1 uM | Inhibition of human Thymidylate synthase (TS) | ChEMBL. | 1548676 |
Kii (binding) | = 8.1 uM | Inhibition of human Thymidylate synthase (TS) | ChEMBL. | 1548676 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 1548676 | |
Mus musculus | ChEMBL23 | 1548676 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.