Detailed information for compound 300555

Basic information

Technical information
  • TDR Targets ID: 300555
  • Name: 5,7-dichloro-3-(1,3-dihydroxypropan-2-yloxyme thyl)-1H-benzimidazole-2-thione
  • MW: 323.196 | Formula: C11H12Cl2N2O3S
  • H donors: 2 H acceptors: 3 LogP: 1.76 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC(OCn1c(S)nc2c1cc(Cl)cc2Cl)CO
  • InChi: 1S/C11H12Cl2N2O3S/c12-6-1-8(13)10-9(2-6)15(11(19)14-10)5-18-7(3-16)4-17/h1-2,7,16-17H,3-5H2,(H,14,19)
  • InChiKey: KDCFRPZDLDXCBU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5,7-dichloro-3-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]-1H-benzimidazole-2-thione
  • 5,7-dichloro-3-[(2-hydroxy-1-methylol-ethoxy)methyl]-1H-benzimidazole-2-thione
  • 2-[(4,6-Dichloro-2-thiobenzimidazolyl)methoxy]propane-1,3-diol
  • AIDS-057238
  • AIDS057238

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis helicase, putative 0.0007 0.0014 0.0902
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0128 0.0565 0.2924
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0015 0.0052 0.0267
Schistosoma mansoni hypothetical protein 0.0004 0.0002 0.0008
Loa Loa (eye worm) steroid hormone receptor 0.0128 0.0565 0.0582
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.006 0.0258 0.1333
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0159 0.584
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0128 0.0565 0.0582
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0026 0.0132
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0128 0.0565 0.0582
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0128 0.0565 0.2924
Schistosoma mansoni retinoic acid receptor RXR 0.0232 0.1034 0.5355
Echinococcus granulosus cpg binding protein 0.0032 0.0128 0.0661
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative 0.0004 0.0002 0.0099
Loa Loa (eye worm) hypothetical protein 0.0068 0.0291 0.03
Brugia malayi orphan nuclear receptor NR2E1 0.006 0.0258 0.0266
Echinococcus multilocularis netrin receptor unc 5 0.0015 0.0052 0.0267
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0159 0.0824
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0128 0.0565 0.2924
Schistosoma mansoni nuclear receptor 0.006 0.0258 0.1333
Brugia malayi nuclear receptor NHR-88 0.0128 0.0565 0.0582
Echinococcus multilocularis inositol monophosphatase 0.0004 0.0002 0.0008
Loa Loa (eye worm) hypothetical protein 0.0128 0.0565 0.0582
Brugia malayi follicle stimulating hormone receptor 0.0243 0.1086 0.112
Loa Loa (eye worm) hypothetical protein 0.0015 0.0052 0.0054
Schistosoma mansoni inositol monophosphatase 0.0039 0.0159 0.0824
Loa Loa (eye worm) hypothetical protein 0.0068 0.0291 0.03
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative 0.0004 0.0002 0.0099
Brugia malayi nuclear receptor RXR 0.006 0.0258 0.0266
Schistosoma mansoni nuclear hormone receptor 0.006 0.0258 0.1333
Loa Loa (eye worm) hypothetical protein 0.0128 0.0565 0.0582
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0272 1
Schistosoma mansoni cpg binding protein 0.0032 0.0128 0.0661
Mycobacterium ulcerans monophosphatase CysQ 0.0004 0.0002 0.0058
Schistosoma mansoni inositol monophosphatase 0.0039 0.0159 0.0824
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0159 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0128 0.0565 0.0582
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0159 0.584
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0128 0.0565 0.2924
Brugia malayi nuclear receptor NHR-67 0.006 0.0258 0.0266
Brugia malayi Nuclear hormone receptor-like 1 0.0068 0.0291 0.03
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0272 0.141
Echinococcus granulosus nuclear receptor 2DBD gamma 0.006 0.0258 0.1333
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0015 0.0052 0.0267
Schistosoma mansoni pap-inositol-14-phosphatase 0.0004 0.0002 0.0008
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative 0.0004 0.0002 0.0113
Loa Loa (eye worm) hypothetical protein 0.0128 0.0565 0.0582
Brugia malayi Nuclear hormone receptor E75 0.006 0.0258 0.0266
Loa Loa (eye worm) hypothetical protein 0.0128 0.0565 0.0582
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0014 0.0902
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0068 0.0291 0.03
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0014 0.0902
Loa Loa (eye worm) hypothetical protein 0.0068 0.0291 0.03
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0017 0.0089
Schistosoma mansoni hypothetical protein 0.0429 0.1931 1
Loa Loa (eye worm) hypothetical protein 0.0004 0.0002 0.0002
Brugia malayi nuclear receptor RXR 0.0068 0.0291 0.03
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0128 0.0565 0.0582
Onchocerca volvulus Protein ultraspiracle homolog 0.0128 0.0565 0.0563
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0068 0.0291 0.1504
Brugia malayi Inositol monophosphatase family protein 0.0004 0.0002 0.0002
Mycobacterium leprae Probable monophosphatase 0.0004 0.0002 0.0112
Loa Loa (eye worm) hypothetical protein 0.006 0.0258 0.0266
Schistosoma mansoni thyroid hormone receptor 0.0128 0.0565 0.2924
Loa Loa (eye worm) hypothetical protein 0.0128 0.0565 0.0582
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0128 0.0565 0.0582
Echinococcus granulosus nuclear factor of activated T cells 5 0.0077 0.0334 0.1729
Echinococcus multilocularis 3'(2'),5' bisphosphate nucleotidase 1 0.0004 0.0002 0.0008
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0068 0.0291 0.1504
Loa Loa (eye worm) hypothetical protein 0.006 0.0258 0.0266
Loa Loa (eye worm) hypothetical protein 0.006 0.0258 0.0266
Loa Loa (eye worm) hypothetical protein 0.006 0.0258 0.0266
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0128 0.0565 0.2924
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0014 0.0902
Loa Loa (eye worm) hypothetical protein 0.006 0.0258 0.0266
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0014 0.0902
Echinococcus granulosus FTZ F1 alpha 0.0128 0.0565 0.2924
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0128 0.0565 0.0582
Loa Loa (eye worm) hypothetical protein 0.006 0.0258 0.0266
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0077 0.0334 0.1729
Brugia malayi hypothetical protein 0.0068 0.0291 0.03
Loa Loa (eye worm) hypothetical protein 0.2079 0.9419 0.9717
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.0159 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0258 0.0266
Brugia malayi steroid hormone receptor 0.0128 0.0565 0.0582
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0159 1
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0039 0.0159 0.5
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.012 0.0124
Brugia malayi Inositol-1 0.0039 0.0159 0.0164
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0159 1
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0159 0.0824
Brugia malayi CXXC zinc finger family protein 0.003 0.012 0.0124
Loa Loa (eye worm) hypothetical protein 0.0128 0.0565 0.0582
Schistosoma mansoni thyroid hormone receptor 0.0128 0.0565 0.2924
Echinococcus multilocularis Ankyrin 0.0015 0.0052 0.027
Echinococcus multilocularis dnaJ subfamily B 0.0429 0.1931 1
Echinococcus multilocularis FTZ F1 alpha 0.0128 0.0565 0.2924
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0014 0.0902
Schistosoma mansoni zinc finger protein 0.006 0.0258 0.1333
Loa Loa (eye worm) hypothetical protein 0.0015 0.0052 0.0053
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0014 0.0902
Schistosoma mansoni nuclear receptor nhr-48 0.006 0.0258 0.1333
Brugia malayi Nuclear hormone receptor-like 1 0.0128 0.0565 0.0582
Schistosoma mansoni RAR-like nuclear receptor 0.0128 0.0565 0.2924
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0164 0.0727 0.3764
Brugia malayi ecdysone receptor 0.006 0.0258 0.0266
Echinococcus granulosus Ankyrin 0.0015 0.0052 0.027
Echinococcus multilocularis thyroid hormone receptor alpha 0.0128 0.0565 0.2924
Schistosoma mansoni nuclear receptor 0.006 0.0258 0.1333
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0242 0.8896
Schistosoma mansoni hypothetical protein 0.0004 0.0002 0.0008
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.0272 0.141
Onchocerca volvulus 0.006 0.0258 0.0256
Loa Loa (eye worm) hypothetical protein 0.0068 0.0291 0.03
Echinococcus granulosus 3'2'5' bisphosphate nucleotidase 1 0.0004 0.0002 0.0008
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0026 0.0132
Loa Loa (eye worm) hypothetical protein 0.006 0.0258 0.0266
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0128 0.0565 0.2924
Loa Loa (eye worm) hypothetical protein 0.006 0.0258 0.0266
Echinococcus granulosus thyroid hormone receptor alpha 0.006 0.0258 0.1333
Brugia malayi Death domain containing protein 0.0015 0.0052 0.0053
Schistosoma mansoni nuclear hormone receptor 0.0128 0.0565 0.2924
Leishmania major inositol polyphosphate 1-phosphatase, putative 0.0004 0.0002 0.0058
Loa Loa (eye worm) hypothetical protein 0.006 0.0258 0.0266
Loa Loa (eye worm) nuclear receptor nhr-7B 0.2139 0.9693 1
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0015 0.0052 0.0053
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0004 0.0002 0.0113
Trichomonas vaginalis inositol monophosphatase, putative 0.0004 0.0002 0.0113
Schistosoma mansoni steroid hormone receptor ad4bp 0.0128 0.0565 0.2924
Loa Loa (eye worm) nuclear receptor NHR-67 0.006 0.0258 0.0266
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0272 1
Onchocerca volvulus 0.003 0.012 0.0118
Mycobacterium tuberculosis Monophosphatase CysQ 0.0004 0.0002 0.0058
Brugia malayi Nuclear hormone receptor E75 0.006 0.0258 0.0266
Onchocerca volvulus 0.006 0.0258 0.0256
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0128 0.0565 0.2924
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.0159 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0014 0.0902
Chlamydia trachomatis 3'(2'),5'-bisphosphate nucleotidase CysQ 0.0004 0.0002 0.5
Schistosoma mansoni cpg binding protein 0.0032 0.0128 0.0661
Toxoplasma gondii hypothetical protein 0.0004 0.0002 0.0058
Brugia malayi Steroid receptor seven-up type 2 0.0128 0.0565 0.0582
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0035 0.0141 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0258 0.0266
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0128 0.0565 0.2924
Brugia malayi nuclear hormone receptor 0.0128 0.0565 0.0582
Mycobacterium ulcerans monophosphatase CysQ 0.0004 0.0002 0.0058
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.006 0.0258 0.0256
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0159 1
Brugia malayi hypothetical protein 0.006 0.0258 0.0266
Brugia malayi Inositol monophosphatase family protein 0.0004 0.0002 0.0002
Mycobacterium leprae POSSIBLE MONOPHOSPHATASE CYSQ 0.0004 0.0002 0.0112
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0014 0.0902
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0025 0.0026
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0128 0.0565 0.0582
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0014 0.0902
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0128 0.0565 0.0582
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0128 0.0565 0.0582
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.0272 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0128 0.0565 0.0582
Loa Loa (eye worm) hypothetical protein 0.006 0.0258 0.0266
Echinococcus granulosus netrin receptor unc 5 0.0015 0.0052 0.0267
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0128 0.0565 0.0582
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.006 0.0258 0.1333
Brugia malayi nuclear hormone receptor 0.2139 0.9693 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0128 0.0565 0.0582
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0014 0.0902
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0068 0.0291 0.1504
Schistosoma mansoni hypothetical protein 0.0015 0.0052 0.0267
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0128 0.0565 0.2924
Trypanosoma cruzi myo-inositol-1 phosphatase, putative 0.0004 0.0002 0.0099
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0128 0.0565 0.0582
Schistosoma mansoni cpg binding protein 0.003 0.012 0.0621
Brugia malayi nuclear hormone receptor family member odr-7 0.006 0.0258 0.0266
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0015 0.0052 0.027
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0128 0.0565 0.2924
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0128 0.0565 0.2924
Trichomonas vaginalis inositol monophosphatase, putative 0.0004 0.0002 0.0113
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.006 0.0258 0.0256
Brugia malayi hypothetical protein 0.0068 0.0291 0.03
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0026 0.0026
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0273 0.1415
Echinococcus multilocularis Nuclear hormone receptor HR96 0.006 0.0258 0.1333
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0014 0.0902
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0064 0.0272 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.006 0.0258 0.1333
Onchocerca volvulus Bile acid receptor homolog 0.0128 0.0565 0.0563
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0159 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0128 0.0565 0.0582
Echinococcus multilocularis ecdysone induced protein 78C 0.0128 0.0565 0.2924
Loa Loa (eye worm) nuclear hormone receptor 0.006 0.0258 0.0266
Loa Loa (eye worm) hypothetical protein 0.0004 0.0002 0.0002
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0232 0.1034 0.5355
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0128 0.0565 0.0582
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0128 0.0565 0.0582
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0017 0.0089
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0128 0.0565 0.0582
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.0272 0.141
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0128 0.0565 0.0582
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0014 0.0902
Mycobacterium tuberculosis Probable monophosphatase 0.0004 0.0002 0.0058
Echinococcus multilocularis cpg binding protein 0.0032 0.0128 0.0661
Brugia malayi nuclear receptor NHR-88 0.006 0.0258 0.0266
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0091 0.0094
Echinococcus granulosus nuclear receptor nhr 48 0.006 0.0258 0.1333
Brugia malayi tailless protein 0.006 0.0258 0.0266
Loa Loa (eye worm) hypothetical protein 0.0068 0.0291 0.03
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0243 0.1086 0.112
Schistosoma mansoni ankyrin 23/unc44 0.0015 0.0052 0.0267
Mycobacterium ulcerans monophosphatase 0.0004 0.0002 0.0058
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0128 0.0565 0.0582
Brugia malayi conserved hypotetical protein 0.006 0.0258 0.0266
Echinococcus multilocularis nuclear receptor nhr 48 0.006 0.0258 0.1333
Brugia malayi Uncoordinated protein 44 0.0015 0.0052 0.0053
Echinococcus granulosus dnaJ subfamily B 0.0429 0.1931 1
Loa Loa (eye worm) hypothetical protein 0.0128 0.0565 0.0582
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.006 0.0258 0.0266
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0128 0.0565 0.2924
Schistosoma mansoni netrin receptor unc5 0.0015 0.0052 0.0267
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0128 0.0565 0.2924
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0014 0.0902
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0272 1
Onchocerca volvulus 0.0128 0.0565 0.0563
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0128 0.0565 0.2924
Schistosoma mansoni nuclear hormone receptor 0.006 0.0258 0.1333
Leishmania major myo-inositol-1 phosphatase, putative 0.0004 0.0002 0.0058
Schistosoma mansoni coup transcription factor 0.0128 0.0565 0.2924
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0128 0.0565 0.2924
Loa Loa (eye worm) inositol-1 0.0039 0.0159 0.0164
Echinococcus granulosus Nuclear hormone receptor HR96 0.006 0.0258 0.1333
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0017 0.0089
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0128 0.0565 0.2924
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0068 0.0291 0.1504
Trypanosoma brucei inositol polyphosphate 1-phosphatase, putative 0.0004 0.0002 0.0099
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0052 0.0053
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0128 0.0565 0.0582
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.0272 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0014 0.0902
Brugia malayi Cytochrome P450 family protein 0.0024 0.0091 0.0094
Onchocerca volvulus Netrin receptor homolog 0.0015 0.0052 0.005
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0128 0.0565 0.2924
Mycobacterium ulcerans inositol-monophosphatase ImpA 0.0004 0.0002 0.0058
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0004 0.0003 0.0014
Echinococcus granulosus inositol monophosphatase 0.0004 0.0002 0.0008
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.0159 0.584
Schistosoma mansoni myo inositol monophosphatase 0.0004 0.0002 0.0008
Brugia malayi hypothetical protein 0.006 0.0258 0.0266
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0128 0.0565 0.2924
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0141 0.5164
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0017 0.0089
Loa Loa (eye worm) DR-78 0.006 0.0258 0.0266
Echinococcus granulosus ecdysone induced protein 78C 0.0128 0.0565 0.2924
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0014 0.0902
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.006 0.0258 0.1333
Loa Loa (eye worm) hypothetical protein 0.0128 0.0565 0.0582
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0017 0.0089
Echinococcus granulosus Nuclear hormone receptor HR96 0.006 0.0258 0.1333
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0128 0.0565 0.0582
Brugia malayi Nuclear hormone receptor-like 1 0.0068 0.0291 0.03
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0272 0.141
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0014 0.0902
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.006 0.0258 0.1333
Echinococcus multilocularis Nuclear hormone receptor HR96 0.006 0.0258 0.1333
Giardia lamblia Hypothetical protein 0.0004 0.0002 0.5
Brugia malayi ecdysteroid receptor 0.0128 0.0565 0.0582
Echinococcus granulosus death domain containing protein 0.0015 0.0052 0.0267
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0014 0.0902
Loa Loa (eye worm) hypothetical protein 0.006 0.0258 0.0266
Brugia malayi nuclear hormone receptor family member nhr-6 0.006 0.0258 0.0266
Brugia malayi Protein kinase domain containing protein 0.0015 0.0052 0.0053

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 100 uM Antiviral activity against human cytomegalovirus (HCM virus) in plaque assay ChEMBL. 8632412
IC50 (functional) > 100 uM Antiviral activity against herpes simplex virus type 1 (HSV-1) in an ELISA assay ChEMBL. 8632412
IC50 (functional) > 100 uM Visual cytotoxicity of compound on HFF cells at time of HCMV plaque enumeration ChEMBL. 8632412
IC50 (functional) > 100 uM Inhibitory activity of compound against KB cell growth [>-indicates IC50/IC90 was not reached at the noted (highest)concentration tested] ChEMBL. 8632412
IC50 (functional) > 100 uM Visual cytotoxicity of compound on HFF cells at time of HCMV plaque enumeration ChEMBL. 8632412
IC50 (functional) > 100 uM Inhibitory activity of compound against KB cell growth [>-indicates IC50/IC90 was not reached at the noted (highest)concentration tested] ChEMBL. 8632412

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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