Detailed information for compound 300651

Basic information

Technical information
  • TDR Targets ID: 300651
  • Name: 2-(3-methyloxiran-2-yl)quinoline
  • MW: 185.222 | Formula: C12H11NO
  • H donors: 0 H acceptors: 1 LogP: 2.12 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1OC1c1ccc2c(n1)cccc2
  • InChi: 1S/C12H11NO/c1-8-12(14-8)11-7-6-9-4-2-3-5-10(9)13-11/h2-8,12H,1H3
  • InChiKey: IDMQYPZJYBLBCF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(3-methyl-2-oxiranyl)quinoline

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi photoreceptor-specific nuclear receptor 0.0127 0.0174 0.0336
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0127 0.0174 0.0336
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0127 0.0174 0.0132
Brugia malayi Ets-domain containing protein 0.0074 0.0088 0.012
Schistosoma mansoni rotamase 0.0075 0.009 0.0047
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0017 0.0255
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.006 0.0066 0.0064
Brugia malayi Fli-1 protein 0.0224 0.0329 0.0728
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.006 0.0066 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0043 0.1069
Brugia malayi Nuclear hormone receptor E75 0.006 0.0066 0.0064
Brugia malayi nuclear receptor NHR-67 0.006 0.0066 0.0064
Schistosoma mansoni tar DNA-binding protein 0.0062 0.007 0.0027
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0127 0.0174 0.0141
Loa Loa (eye worm) hypothetical protein 0.0221 0.0325 0.074
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0127 0.0174 0.0336
Schistosoma mansoni neuropeptide receptor 0.0121 0.0164 0.0121
Brugia malayi TAR-binding protein 0.0062 0.007 0.0074
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0074 0.0088 0.0144
Loa Loa (eye worm) hypothetical protein 0.006 0.0066 0.0088
Echinococcus multilocularis ecdysone induced protein 78C 0.0127 0.0174 0.0141
Loa Loa (eye worm) nuclear receptor NHR-67 0.006 0.0066 0.0088
Brugia malayi beta-lactamase 0.0221 0.0325 0.0718
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0036 0.0028 0.0681
Brugia malayi nuclear hormone receptor 0.2512 0.401 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.0077 0.0117
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0127 0.0174 0.0132
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0067 0.0077 0.0044
Schistosoma mansoni nuclear receptor 0.006 0.0066 0.0023
Plasmodium vivax hypothetical protein, conserved 0.0221 0.0325 0.5
Loa Loa (eye worm) hypothetical protein 0.0127 0.0174 0.0359
Schistosoma mansoni gabp alpha 0.0074 0.0088 0.0045
Loa Loa (eye worm) hypothetical protein 0.006 0.0066 0.0088
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0013 0.0135
Loa Loa (eye worm) phosphatidylinositol 3 0.0046 0.0043 0.003
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0075 0.009 0.0125
Brugia malayi Nuclear hormone receptor-like 1 0.0067 0.0077 0.0093
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0028 0.0594
Brugia malayi orphan nuclear receptor NR2E1 0.006 0.0066 0.0064
Echinococcus multilocularis G protein coupled receptor 139 0.0121 0.0164 0.0131
Loa Loa (eye worm) hypothetical protein 0.0127 0.0174 0.0359
Echinococcus granulosus nuclear receptor 2DBD gamma 0.006 0.0066 0.0033
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0127 0.0174 0.0132
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.258 0.4118 1
Brugia malayi nuclear hormone receptor 0.0127 0.0174 0.0336
Brugia malayi nuclear receptor RXR 0.0067 0.0077 0.0093
Schistosoma mansoni RAR-like nuclear receptor 0.0127 0.0174 0.0132
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0127 0.0174 0.0336
Echinococcus granulosus tumor protein p63 0.0688 0.1076 0.1046
Loa Loa (eye worm) hypothetical protein 0.0221 0.0325 0.074
Loa Loa (eye worm) hypothetical protein 0.004 0.0033 0.0006
Echinococcus multilocularis thyroid hormone receptor alpha 0.0127 0.0174 0.0141
Onchocerca volvulus Bile acid receptor homolog 0.0127 0.0174 0.0266
Loa Loa (eye worm) hypothetical protein 0.0101 0.0131 0.0253
Echinococcus granulosus thyroid hormone receptor alpha 0.006 0.0066 0.0033
Loa Loa (eye worm) fli-1 protein 0.0224 0.0329 0.075
Mycobacterium leprae conserved hypothetical protein 0.0221 0.0325 0.5
Trichomonas vaginalis rotamase, putative 0.0075 0.009 0.2563
Loa Loa (eye worm) hypothetical protein 0.006 0.0066 0.0088
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.006 0.0066 0.0033
Brugia malayi tailless protein 0.006 0.0066 0.0064
Brugia malayi Intermediate filament tail domain containing protein 0.0082 0.0102 0.0155
Brugia malayi nuclear receptor NHR-88 0.006 0.0066 0.0064
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.006 0.0066 0.0033
Loa Loa (eye worm) hypothetical protein 0.006 0.0066 0.0088
Onchocerca volvulus 0.0082 0.0102 0.0089
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0127 0.0174 0.0336
Schistosoma mansoni microtubule-associated protein tau 0.6237 1 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0127 0.0174 0.0336
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0127 0.0174 0.0359
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0028 0.0594
Echinococcus granulosus beta LACTamase domain containing family member 0.0221 0.0325 0.0293
Brugia malayi hypothetical protein 0.0067 0.0077 0.0093
Trypanosoma cruzi hypothetical protein, conserved 0.0221 0.0325 1
Echinococcus multilocularis neuropeptide receptor 0.0121 0.0164 0.0131
Loa Loa (eye worm) nuclear receptor nhr-7B 0.2512 0.401 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0127 0.0174 0.0359
Brugia malayi Ets-domain containing protein 0.0074 0.0088 0.012
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0067 0.0077 0.0035
Echinococcus granulosus GA binding protein alpha chain 0.0074 0.0088 0.0055
Loa Loa (eye worm) hypothetical protein 0.006 0.0066 0.0088
Loa Loa (eye worm) TAR-binding protein 0.0062 0.007 0.0097
Mycobacterium ulcerans lipase LipD 0.0221 0.0325 0.5
Loa Loa (eye worm) DR-78 0.006 0.0066 0.0088
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0024 0.0475
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0073 0.0087 0.2684
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0127 0.0174 0.0141
Loa Loa (eye worm) intermediate filament protein 0.0082 0.0102 0.0178
Leishmania major hypothetical protein, conserved 0.0221 0.0325 1
Trichomonas vaginalis conserved hypothetical protein 0.0075 0.009 0.2563
Schistosoma mansoni tar DNA-binding protein 0.0062 0.007 0.0027
Schistosoma mansoni ets-related 0.0224 0.0329 0.0288
Loa Loa (eye worm) hypothetical protein 0.0081 0.0099 0.0172
Schistosoma mansoni thyroid hormone receptor 0.0127 0.0174 0.0132
Mycobacterium leprae Probable lipase LipE 0.0221 0.0325 0.5
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0127 0.0174 0.0141
Brugia malayi beta-lactamase family protein 0.0221 0.0325 0.0718
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.0166 0.034
Trypanosoma brucei hypothetical protein, conserved 0.0221 0.0325 1
Loa Loa (eye worm) hypothetical protein 0.0127 0.0174 0.0359
Echinococcus granulosus neuropeptide receptor 0.0121 0.0164 0.0131
Brugia malayi Steroid receptor seven-up type 2 0.0127 0.0174 0.0336
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0046 0.0043 0.1149
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0024 0.0475
Echinococcus granulosus nuclear receptor nhr 48 0.006 0.0066 0.0033
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0009 0.0002
Toxoplasma gondii target of rapamycin (TOR), putative 0.0034 0.0024 0.056
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.006 0.0066 0.0033
Schistosoma mansoni lamin 0.0082 0.0102 0.0059
Loa Loa (eye worm) hypothetical protein 0.0127 0.0174 0.0359
Schistosoma mansoni nuclear hormone receptor 0.006 0.0066 0.0023
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.006 0.0066 0.0033
Loa Loa (eye worm) hypothetical protein 0.0063 0.0071 0.01
Loa Loa (eye worm) hypothetical protein 0.006 0.0066 0.0088
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0073 0.0087 1
Onchocerca volvulus 0.0221 0.0325 0.064
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0127 0.0174 0.0359
Schistosoma mansoni nuclear hormone receptor 0.006 0.0066 0.0023
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.006 0.0066 0.0023
Schistosoma mansoni nuclear hormone receptor 0.0127 0.0174 0.0132
Onchocerca volvulus 0.0082 0.0102 0.0089
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0127 0.0174 0.0336
Schistosoma mansoni tar DNA-binding protein 0.0062 0.007 0.0027
Brugia malayi ecdysteroid receptor 0.0127 0.0174 0.0336
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0073 0.0087 0.2541
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0046 0.0043 0.1318
Schistosoma mansoni lamin 0.0082 0.0102 0.0059
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0127 0.0174 0.0336
Loa Loa (eye worm) hypothetical protein 0.0221 0.0325 0.074
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0082 0.0102 0.0178
Loa Loa (eye worm) hypothetical protein 0.0127 0.0174 0.0359
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0046 0.0043 0.1318
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0043 0.1069
Toxoplasma gondii ABC1 family protein 0.0221 0.0325 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0127 0.0174 0.0141
Loa Loa (eye worm) hypothetical protein 0.0067 0.0077 0.0117
Brugia malayi MH2 domain containing protein 0.0122 0.0166 0.0317
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0221 0.0325 0.0718
Echinococcus granulosus FTZ F1 alpha 0.0127 0.0174 0.0141
Schistosoma mansoni cellular tumor antigen P53 0.0101 0.0131 0.0089
Echinococcus multilocularis beta LACTamase domain containing family member 0.0221 0.0325 0.0293
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0028 0.0594
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0127 0.0174 0.0359
Loa Loa (eye worm) hypothetical protein 0.0127 0.0174 0.0359
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0127 0.0174 0.0359
Loa Loa (eye worm) hypothetical protein 0.0221 0.0325 0.074
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0067 0.0077 0.0044
Echinococcus granulosus lamin dm0 0.0082 0.0102 0.0069
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0009 0.0002
Loa Loa (eye worm) RNA binding protein 0.0062 0.007 0.0097
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0046 0.0043 0.1149
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0036 0.0028 0.0859
Trichomonas vaginalis esterase, putative 0.0221 0.0325 1
Loa Loa (eye worm) hypothetical protein 0.0127 0.0174 0.0359
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0127 0.0174 0.0141
Schistosoma mansoni coup transcription factor 0.0127 0.0174 0.0132
Mycobacterium ulcerans esterase/lipase LipP 0.0221 0.0325 0.5
Loa Loa (eye worm) hypothetical protein 0.0221 0.0325 0.074
Onchocerca volvulus 0.0127 0.0174 0.0266
Echinococcus multilocularis Nuclear hormone receptor HR96 0.006 0.0066 0.0033
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0127 0.0174 0.0336
Brugia malayi steroid hormone receptor 0.0127 0.0174 0.0336
Loa Loa (eye worm) hypothetical protein 0.006 0.0066 0.0088
Brugia malayi conserved hypotetical protein 0.006 0.0066 0.0064
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0046 0.0043 0.1149
Loa Loa (eye worm) hypothetical protein 0.0067 0.0077 0.0117
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0023 0.0006 0.0191
Brugia malayi nuclear receptor RXR 0.006 0.0066 0.0064
Wolbachia endosymbiont of Brugia malayi parvulin-like peptidyl-prolyl isomerase, PPID 0.0023 0.0006 0.5
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0221 0.0325 0.074
Schistosoma mansoni thyroid hormone receptor 0.0127 0.0174 0.0132
Echinococcus granulosus lamin 0.0082 0.0102 0.0069
Toxoplasma gondii peptidylprolyl isomerase 0.0073 0.0087 0.2541
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0127 0.0174 0.0359
Echinococcus multilocularis lamin 0.0082 0.0102 0.0069
Echinococcus multilocularis nuclear receptor nhr 48 0.006 0.0066 0.0033
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0127 0.0174 0.0141
Schistosoma mansoni steroid hormone receptor ad4bp 0.0127 0.0174 0.0132
Brugia malayi Nuclear hormone receptor E75 0.006 0.0066 0.0064
Giardia lamblia GTOR 0.0046 0.0043 0.5
Trypanosoma cruzi target of rapamycin kinase 3 0.0036 0.0028 0.0681
Echinococcus multilocularis microtubule associated protein 2 0.6237 1 1
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0022 0.0004 0.013
Loa Loa (eye worm) nuclear hormone receptor 0.006 0.0066 0.0088
Brugia malayi intermediate filament protein 0.0082 0.0102 0.0155
Onchocerca volvulus 0.0101 0.0131 0.0162
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.007 0.0097
Loa Loa (eye worm) hypothetical protein 0.006 0.0066 0.0088
Brugia malayi beta-lactamase family protein 0.0221 0.0325 0.0718
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0019 0.0305
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0013 0.0135
Onchocerca volvulus 0.0221 0.0325 0.064
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0073 0.0087 0.2541
Schistosoma mansoni retinoic acid receptor RXR 0.0127 0.0174 0.0132
Schistosoma mansoni tar DNA-binding protein 0.0062 0.007 0.0027
Brugia malayi hypothetical protein 0.006 0.0066 0.0064
Echinococcus granulosus Nuclear hormone receptor HR96 0.006 0.0066 0.0033
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0127 0.0174 0.0336
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0075 0.009 0.0149
Onchocerca volvulus 0.0221 0.0325 0.064
Schistosoma mansoni tar DNA-binding protein 0.0062 0.007 0.0027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0009 0.0002
Trichomonas vaginalis D-aminoacylase, putative 0.0221 0.0325 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0127 0.0174 0.0141
Schistosoma mansoni nuclear receptor nhr-48 0.006 0.0066 0.0023
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0067 0.0077 0.0035
Loa Loa (eye worm) hypothetical protein 0.006 0.0066 0.0088
Brugia malayi nuclear receptor NHR-88 0.0127 0.0174 0.0336
Loa Loa (eye worm) beta-lactamase 0.0221 0.0325 0.074
Loa Loa (eye worm) hypothetical protein 0.006 0.0066 0.0088
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0073 0.0087 0.2541
Brugia malayi Nuclear hormone receptor-like 1 0.0067 0.0077 0.0093
Loa Loa (eye worm) hypothetical protein 0.006 0.0066 0.0088
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0127 0.0174 0.0132
Echinococcus granulosus tar DNA binding protein 0.0062 0.007 0.0036
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0127 0.0174 0.0141
Schistosoma mansoni intermediate filament proteins 0.0082 0.0102 0.0059
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0024 0.0475
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0127 0.0174 0.0141
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.007 0.0074
Loa Loa (eye worm) steroid hormone receptor 0.0127 0.0174 0.0359
Trichomonas vaginalis penicillin-binding protein, putative 0.0221 0.0325 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.0077 0.0117
Trichomonas vaginalis D-aminoacylase, putative 0.0221 0.0325 1
Echinococcus multilocularis FTZ F1 alpha 0.0127 0.0174 0.0141
Brugia malayi RNA binding protein 0.0062 0.007 0.0074
Echinococcus multilocularis tumor protein p63 0.0688 0.1076 0.1046
Echinococcus granulosus expressed protein 0.0075 0.009 0.0057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0024 0.0475
Mycobacterium ulcerans beta-lactamase 0.0221 0.0325 0.5
Brugia malayi nuclear hormone receptor family member nhr-6 0.006 0.0066 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0127 0.0174 0.0336
Trichomonas vaginalis rotamase, putative 0.0073 0.0087 0.2474
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0013 0.0135
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0127 0.0174 0.0141
Brugia malayi nuclear hormone receptor family member odr-7 0.006 0.0066 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0127 0.0174 0.0336
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0046 0.0043 0.001
Echinococcus multilocularis tar DNA binding protein 0.0062 0.007 0.0036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0024 0.0475
Loa Loa (eye worm) hypothetical protein 0.0067 0.0077 0.0117
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0127 0.0174 0.0336
Onchocerca volvulus Protein ultraspiracle homolog 0.0127 0.0174 0.0266
Echinococcus granulosus Nuclear hormone receptor HR96 0.006 0.0066 0.0033
Echinococcus granulosus intermediate filament protein 0.0082 0.0102 0.0069
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0013 0.0122
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0127 0.0174 0.0141
Trichomonas vaginalis penicillin-binding protein, putative 0.0221 0.0325 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0032 0.073
Echinococcus multilocularis expressed protein 0.0075 0.009 0.0057
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0127 0.0174 0.0359
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0127 0.0174 0.0132
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0221 0.0325 0.0284
Brugia malayi Nuclear hormone receptor-like 1 0.0127 0.0174 0.0336
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0044 0.004 0.0024
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0221 0.0325 0.5
Loa Loa (eye worm) hypothetical protein 0.0082 0.0102 0.0178
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0028 0.0594
Schistosoma mansoni zinc finger protein 0.006 0.0066 0.0023
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0046 0.0043 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0013 0.0122
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0028 0.0594
Brugia malayi ecdysone receptor 0.006 0.0066 0.0064
Echinococcus multilocularis GA binding protein alpha chain 0.0074 0.0088 0.0055
Loa Loa (eye worm) hypothetical protein 0.2453 0.3914 0.9758
Echinococcus multilocularis Nuclear hormone receptor HR96 0.006 0.0066 0.0033
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0046 0.0043 0.1149
Echinococcus multilocularis lamin dm0 0.0082 0.0102 0.0069
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0043 0.1069
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.0166 0.034
Mycobacterium ulcerans hypothetical protein 0.0221 0.0325 0.5
Loa Loa (eye worm) hypothetical protein 0.006 0.0066 0.0088
Echinococcus multilocularis musashi 0.0082 0.0102 0.0069
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0127 0.0174 0.0141
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0009 0.0002
Trypanosoma cruzi hypothetical protein, conserved 0.0221 0.0325 1
Loa Loa (eye worm) hypothetical protein 0.0221 0.0325 0.074
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0221 0.0325 0.0284
Loa Loa (eye worm) hypothetical protein 0.006 0.0066 0.0088
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0024 0.0475
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0067 0.0077 0.0117
Loa Loa (eye worm) hypothetical protein 0.0127 0.0174 0.0359
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0024 0.0475
Echinococcus granulosus ecdysone induced protein 78C 0.0127 0.0174 0.0141
Brugia malayi hypothetical protein 0.0067 0.0077 0.0093
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0046 0.0043 0.0006
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0127 0.0174 0.0132
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0127 0.0174 0.0336
Trichomonas vaginalis D-aminoacylase, putative 0.0221 0.0325 1
Schistosoma mansoni nuclear receptor 0.006 0.0066 0.0023
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0127 0.0174 0.0141
Mycobacterium tuberculosis Possible penicillin-binding protein 0.1414 0.2243 1
Brugia malayi hypothetical protein 0.006 0.0066 0.0064

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 0 % Inhibitory activity against human T-lymphotropic virus type 1 (HTLV-1) infected HUT-102 cells at 10 microM. ChEMBL. 12617915

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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