Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | 0.0353 | 0.1353 | 0.1353 |
Echinococcus multilocularis | neuroligin | 0.0353 | 0.1353 | 0.1353 |
Brugia malayi | Carboxylesterase family protein | 0.0353 | 0.1353 | 0.1353 |
Brugia malayi | Carboxylesterase family protein | 0.0353 | 0.1353 | 0.1353 |
Loa Loa (eye worm) | carboxylesterase | 0.0353 | 0.1353 | 0.1353 |
Onchocerca volvulus | 0.0353 | 0.1353 | 1 | |
Brugia malayi | Carboxylesterase family protein | 0.2091 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0353 | 0.1353 | 0.1353 |
Loa Loa (eye worm) | carboxylesterase | 0.0353 | 0.1353 | 0.1353 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0353 | 0.1353 | 0.5 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0353 | 0.1353 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0353 | 0.1353 | 0.1353 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0353 | 0.1353 | 0.1353 |
Onchocerca volvulus | 0.0353 | 0.1353 | 1 | |
Echinococcus granulosus | BC026374 protein S09 family | 0.0353 | 0.1353 | 0.1353 |
Loa Loa (eye worm) | hypothetical protein | 0.0353 | 0.1353 | 0.1353 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0353 | 0.1353 | 0.1353 |
Onchocerca volvulus | 0.0353 | 0.1353 | 1 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0353 | 0.1353 | 0.5 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0353 | 0.1353 | 0.1353 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0353 | 0.1353 | 0.5 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0868 | 0.3913 | 0.3913 |
Loa Loa (eye worm) | hypothetical protein | 0.0353 | 0.1353 | 0.1353 |
Loa Loa (eye worm) | hypothetical protein | 0.0353 | 0.1353 | 0.1353 |
Schistosoma mansoni | acetylcholinesterase | 0.0353 | 0.1353 | 0.1353 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0353 | 0.1353 | 0.1353 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0128 | 0.023 | 0.023 |
Loa Loa (eye worm) | hypothetical protein | 0.0353 | 0.1353 | 0.1353 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0353 | 0.1353 | 0.1353 |
Echinococcus multilocularis | carboxylesterase 5A | 0.2091 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.2091 | 1 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0128 | 0.023 | 0.023 |
Loa Loa (eye worm) | hypothetical protein | 0.2091 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0353 | 0.1353 | 0.1353 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.2091 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.2091 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.2091 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0353 | 0.1353 | 0.1353 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0353 | 0.1353 | 0.5 |
Echinococcus granulosus | neuroligin | 0.0353 | 0.1353 | 0.1353 |
Loa Loa (eye worm) | hypothetical protein | 0.0353 | 0.1353 | 0.1353 |
Echinococcus granulosus | acetylcholinesterase | 0.2091 | 1 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0128 | 0.023 | 0.023 |
Schistosoma mansoni | gliotactin | 0.0353 | 0.1353 | 0.1353 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0353 | 0.1353 | 0.1353 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.2091 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0353 | 0.1353 | 0.1353 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0353 | 0.1353 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.2091 | 1 | 1 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0353 | 0.1353 | 0.1353 |
Echinococcus multilocularis | acetylcholinesterase | 0.2091 | 1 | 1 |
Onchocerca volvulus | 0.0353 | 0.1353 | 1 | |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0353 | 0.1353 | 0.1353 |
Loa Loa (eye worm) | hypothetical protein | 0.2091 | 1 | 1 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0353 | 0.1353 | 0.1353 |
Onchocerca volvulus | 0.0353 | 0.1353 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (ADMET) | = 74.2 uM | Inhibition of MAMC O-dealkylation mediated by human Cytochrome P450 2D6 expressed in human lymphoblastoid cell line | ChEMBL. | 12502361 |
IC50 (ADMET) | = 74.2 uM | Inhibition of MAMC O-dealkylation mediated by human Cytochrome P450 2D6 expressed in human lymphoblastoid cell line | ChEMBL. | 12502361 |
IC50 (ADMET) | = 307 uM | Inhibition of MAMC O-dealkylation mediated by rat Cytochrome P450 2D2 expressed in Saccharomyces cerivisiae | ChEMBL. | 12502361 |
IC50 (ADMET) | = 307 uM | Inhibition of MAMC O-dealkylation mediated by rat Cytochrome P450 2D2 expressed in Saccharomyces cerivisiae | ChEMBL. | 12502361 |
IC50 (ADMET) | = 329 uM | Inhibition of MAMC O-dealkylation mediated by rat Cytochrome P450 2D1 expressed in Saccharomyces cerivisiae | ChEMBL. | 12502361 |
IC50 (ADMET) | = 329 uM | Inhibition of MAMC O-dealkylation mediated by rat Cytochrome P450 2D1 expressed in Saccharomyces cerivisiae | ChEMBL. | 12502361 |
IC50 (ADMET) | = 862 uM | Inhibition of MAMC O-dealkylation mediated by rat Cytochrome P450 2D3 expressed in Saccharomyces cerivisiae | ChEMBL. | 12502361 |
IC50 (ADMET) | = 862 uM | Inhibition of MAMC O-dealkylation mediated by rat Cytochrome P450 2D3 expressed in Saccharomyces cerivisiae | ChEMBL. | 12502361 |
IC50 (ADMET) | = 1178 uM | Inhibition of MAMC O-dealkylation mediated by rat Cytochrome P450 2D4 expressed in Saccharomyces cerivisiae | ChEMBL. | 12502361 |
IC50 (ADMET) | = 1178 uM | Inhibition of MAMC O-dealkylation mediated by rat Cytochrome P450 2D4 expressed in Saccharomyces cerivisiae | ChEMBL. | 12502361 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.