Detailed information for compound 300748

Basic information

Technical information
  • TDR Targets ID: 300748
  • Name: 4-[2-(2-tert-butyl-4,6-diphenylpyridin-1-ium- 1-yl)ethyl]benzenesulfonamide perchlorate
  • MW: 571.084 | Formula: C29H31ClN2O6S
  • H donors: 1 H acceptors: 6 LogP: 8.6 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: NS(=O)(=O)c1ccc(cc1)CC[n+]1c(cc(cc1C(C)(C)C)c1ccccc1)c1ccccc1.[O-][Cl](=O)(=O)=O
  • InChi: 1S/C29H31N2O2S.ClHO4/c1-29(2,3)28-21-25(23-10-6-4-7-11-23)20-27(24-12-8-5-9-13-24)31(28)19-18-22-14-16-26(17-15-22)34(30,32)33;2-1(3,4)5/h4-17,20-21H,18-19H2,1-3H3,(H2,30,32,33);(H,2,3,4,5)/q+1;/p-1
  • InChiKey: VSDSGLDTMZOJEY-UHFFFAOYSA-M  

Network

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Synonyms

  • 4-[2-(2-tert-butyl-4,6-diphenyl-pyridin-1-ium-1-yl)ethyl]benzenesulfonamide perchlorate
  • 4-[2-(2-tert-butyl-4,6-diphenyl-1-pyridin-1-iumyl)ethyl]benzenesulfonamide perchlorate

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Bos taurus Carbonic anhydrase IV Starlite/ChEMBL References
Homo sapiens carbonic anhydrase IX Starlite/ChEMBL References
Homo sapiens carbonic anhydrase II Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus carbonic anhydrase II Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania major carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma congolense carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma cruzi carbonic anhydrase-like protein, putative Get druggable targets OG5_127628 All targets in OG5_127628
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma cruzi carbonic anhydrase-like protein, putative Get druggable targets OG5_127628 All targets in OG5_127628
Echinococcus multilocularis carbonic anhydrase II Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania braziliensis carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania infantum carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Schistosoma japonicum ko:K01672 carbonic anhydrase [EC4.2.1.1], putative Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma brucei gambiense carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma brucei carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) Get druggable targets OG5_127628 All targets in OG5_127628
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) Get druggable targets OG5_127628 All targets in OG5_127628
Brugia malayi Putative carbonic anhydrase 5 precursor Get druggable targets OG5_127628 All targets in OG5_127628
Loa Loa (eye worm) carbonic anhydrase 3 Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania donovani carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania mexicana carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Brugia malayi Eukaryotic-type carbonic anhydrase family protein Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma congolense carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma japonicum ko:K01672 carbonic anhydrase [EC4.2.1.1], putative Carbonic anhydrase IV   312 aa 253 aa 26.9 %
Brugia malayi Carbonic anhydrase like protein 2 precursor carbonic anhydrase II 260 aa 259 aa 32.0 %
Schistosoma mansoni carbonic anhydrase-related Carbonic anhydrase IV   312 aa 264 aa 24.2 %
Leishmania braziliensis carbonic anhydrase-like protein Carbonic anhydrase IV   312 aa 277 aa 25.6 %
Echinococcus multilocularis carbonic anhydrase Carbonic anhydrase IV   312 aa 259 aa 30.1 %
Brugia malayi Carbonic anhydrase like protein 2 precursor Carbonic anhydrase IV   312 aa 268 aa 24.6 %
Schistosoma mansoni carbonic anhydrase-related Carbonic anhydrase IV   312 aa 265 aa 26.0 %
Leishmania infantum carbonic anhydrase-like protein Carbonic anhydrase IV   312 aa 277 aa 26.7 %
Leishmania mexicana carbonic anhydrase-like protein Carbonic anhydrase IV   312 aa 287 aa 26.8 %
Trypanosoma cruzi carbonic anhydrase-like protein, putative Carbonic anhydrase IV   312 aa 264 aa 25.4 %
Schistosoma japonicum ko:K01672 carbonic anhydrase [EC4.2.1.1], putative Carbonic anhydrase IV   312 aa 322 aa 28.3 %
Onchocerca volvulus Carbonic anhydrase IV   312 aa 252 aa 23.4 %
Echinococcus granulosus carbonic anhydrase Carbonic anhydrase IV   312 aa 304 aa 29.6 %
Loa Loa (eye worm) hypothetical protein Carbonic anhydrase IV   312 aa 268 aa 25.4 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0069 0.0059
Mycobacterium tuberculosis Conserved protein 0.0038 0.0113 0.134
Onchocerca volvulus 0.0008 0.0012 0.0022
Echinococcus granulosus neuropeptide FF receptor 2 0.0008 0.0012 0.0022
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0009 0.0017 0.0029
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0007 0.001 0.0000079012
Schistosoma mansoni bromodomain containing protein 0.0005 0.0001 0.0002
Leishmania major DNA polymerase eta, putative 0.0041 0.0122 0.0118
Toxoplasma gondii sarco/endoplasmic reticulum Ca2+-ATPase 0.0009 0.0015 0.0011
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0008 0.0012 0.0022
Echinococcus granulosus somatostatin receptor 0.0008 0.0012 0.0022
Onchocerca volvulus 0.0038 0.0113 0.0198
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0007 0.001 0.0006
Treponema pallidum cation-transporting ATPase, P-type 0.0009 0.0015 0.8189
Schistosoma mansoni hypothetical protein 0.0008 0.0012 0.0022
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0131 0.0127
Toxoplasma gondii haloacid dehalogenase family hydrolase domain-containing protein 0.0009 0.0015 0.0011
Echinococcus granulosus cpg binding protein 0.0021 0.0057 0.0101
Trypanosoma cruzi DNA damage repair protein, putative 0.0013 0.0028 0.0018
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.0009 0.0015 0.0011
Echinococcus granulosus tm gpcr rhodopsin 0.0008 0.0012 0.0022
Echinococcus multilocularis ecdysone induced protein 78C 0.0009 0.0017 0.0029
Echinococcus multilocularis synaptic glycoprotein sc2 0.1687 0.5672 1
Onchocerca volvulus 0.0008 0.0012 0.0022
Loa Loa (eye worm) beta-lactamase 0.0038 0.0113 0.0113
Mycobacterium ulcerans cation-transporter p-type ATPase B CtpB 0.0009 0.0015 0.0005
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0048 0.0078
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0079 0.0252 0.0243
Loa Loa (eye worm) hypothetical protein 0.0009 0.0015 0.0015
Trypanosoma brucei hypothetical protein, conserved 0.0013 0.0028 0.0024
Onchocerca volvulus 0.0008 0.0012 0.0022
Giardia lamblia NADH oxidase lateral transfer candidate 0.0009 0.0016 0.0005
Trichomonas vaginalis DNA helicase recq1, putative 0.0014 0.0034 0.0033
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0008 0.0012 0.0012
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0009 0.0017 0.0029
Loa Loa (eye worm) kap beta 3 protein 0.0005 0.0004 0.0004
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.297 1 1
Mycobacterium tuberculosis Probable cation transporter P-type ATPase D CtpD 0.0009 0.0015 0.011
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0079 0.0252 0.0249
Loa Loa (eye worm) hypothetical protein 0.0025 0.0069 0.0069
Trypanosoma cruzi copper-transporting ATPase, putative 0.0009 0.0015 0.0005
Brugia malayi AKH receptor 0.0008 0.0012 0.0012
Mycobacterium tuberculosis Probable metal cation transporter P-type ATPase CtpV 0.0009 0.0015 0.011
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase 0.0009 0.0015 0.002
Loa Loa (eye worm) hypothetical protein 0.0027 0.0076 0.0076
Entamoeba histolytica cation-transporting P-typeATPase, putative 0.0009 0.0015 0.0011
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0113 0.134
Schistosoma mansoni steroid hormone receptor ad4bp 0.0009 0.0017 0.0029
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0007 0.0008 0.0008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0009 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Brugia malayi AMP-binding enzyme family protein 0.0007 0.001 0.001
Onchocerca volvulus 0.0007 0.001 0.0017
Toxoplasma gondii P-type ATPase4, putative 0.0009 0.0015 0.0011
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0013 0.0028 0.0024
Onchocerca volvulus 0.0008 0.0012 0.0022
Trypanosoma brucei DNA polymerase eta, putative 0.0041 0.0122 0.0118
Onchocerca volvulus 0.0008 0.0012 0.0022
Schistosoma mansoni opsin-like receptor 0.0008 0.0012 0.0022
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0113 0.134
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0009 0.0017 0.0017
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0064 0.0202 0.0356
Echinococcus granulosus orexin receptor type 2 0.0008 0.0012 0.0022
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0009 0.0016 0.0006
Trichomonas vaginalis cation-transporting ATPase fungi, putative 0.0009 0.0015 0.0014
Echinococcus multilocularis allatostatin A receptor 0.0008 0.0012 0.0022
Trichomonas vaginalis ran, putative 0.0021 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0008 0.0012 0.0022
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0005 0.0001 0.000000000019982
Loa Loa (eye worm) hypothetical protein 0.0009 0.0015 0.0015
Echinococcus multilocularis neuropeptide s receptor 0.0513 0.1714 0.3022
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0074 0.0125
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0008 0.0012 0.0012
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0008 0.0012 0.0022
Echinococcus granulosus snurportin 1 0.0309 0.1028 0.1813
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0006 0.0006 0.0011
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0241 0.0799 1
Onchocerca volvulus 0.0008 0.0012 0.0022
Plasmodium falciparum carbonic anhydrase 0.0101 0.0325 0.0566
Echinococcus granulosus cation transporting ATPase 13A1 0.0009 0.0015 0.0027
Echinococcus multilocularis carbonic anhydrase 0.0101 0.0325 0.0572
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.1687 0.5672 0.5672
Brugia malayi hypothetical protein 0.0008 0.0012 0.0012
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0044 0.048
Mycobacterium tuberculosis Probable metal cation transporter ATPase P-type CtpE 0.0009 0.0015 0.011
Brugia malayi polk-prov protein 0.0013 0.0028 0.0028
Mycobacterium ulcerans inositol-monophosphatase ImpA 0.0008 0.0013 0.0003
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0008 0.0012 0.0012
Entamoeba histolytica plasma membrane calcium-transporting ATPase 1, putative 0.0009 0.0015 0.0011
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0009 0.0015 0.0005
Entamoeba histolytica phospholipid-transporting P-type ATPase, putative 0.0009 0.0015 0.0011
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0009 0.0017 0.0029
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0008 0.0012 0.0022
Loa Loa (eye worm) histone methyltransferase 0.0006 0.0006 0.0006
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0009 0.0016 0.0006
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0012 0.0022
Giardia lamblia Phospholipid-transporting ATPase IA, putative 0.0009 0.0015 0.0003
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0043 0.0129 0.0228
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0009 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Echinococcus granulosus sex peptide receptor 0.0008 0.0012 0.0022
Loa Loa (eye worm) E1-E2 ATPase 0.0009 0.0015 0.0015
Loa Loa (eye worm) neuropeptide F receptor 0.0008 0.0012 0.0012
Echinococcus granulosus rhodopsin orphan GPCR 0.0008 0.0012 0.0022
Loa Loa (eye worm) CXXC zinc finger family protein 0.002 0.0053 0.0053
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0015 0.0027
Mycobacterium ulcerans hypothetical protein 0.297 1 1
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0113 0.0112
Loa Loa (eye worm) hypothetical protein 0.0009 0.0017 0.0017
Brugia malayi Calcitonin receptor-like protein seb-1 0.0085 0.0273 0.0273
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0009 0.0016 0.0022
Schistosoma mansoni eyes absent homolog 0.0092 0.0297 0.0523
Brugia malayi Na,K-ATPase alpha subunit 0.0009 0.0015 0.0015
Leishmania major importin beta-1 subunit, putative 0.0023 0.0064 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.1687 0.5672 0.5672
Brugia malayi Steroid receptor seven-up type 2 0.0009 0.0017 0.0017
Echinococcus granulosus g-protein coupled receptor 0.0008 0.0012 0.0022
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0009 0.0016 0.0006
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0014 0.0034 0.0053
Schistosoma mansoni carbonic anhydrase-related 0.0101 0.0325 0.0572
Trypanosoma cruzi trypanothione reductase, putative 0.0009 0.0016 0.0006
Trypanosoma brucei vacuolar-type Ca2+-ATPase, putative 0.0009 0.0015 0.0011
Echinococcus granulosus G protein coupled receptor 139 0.0008 0.0012 0.0022
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0041 0.0122 0.0121
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0008 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0113 0.4786
Brugia malayi Tachykinin-like peptides receptor 99D 0.0008 0.0012 0.0012
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0007 0.001 0.0017
Entamoeba histolytica hypothetical protein 0.0023 0.0064 0.0061
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0005 0.0001 0.0002
Brugia malayi Serotonin receptor 0.0008 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0009 0.0015 0.0015
Echinococcus granulosus carbonic anhydrase 0.0101 0.0325 0.0572
Loa Loa (eye worm) hypothetical protein 0.0019 0.0048 0.0048
Echinococcus multilocularis 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal 0.1687 0.5672 1
Schistosoma mansoni biogenic amine receptor 0.0008 0.0012 0.0022
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0113 0.0198
Mycobacterium leprae Probable lipase LipE 0.0038 0.0113 0.4786
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0009 0.0017 0.0029
Echinococcus multilocularis inositol monophosphatase 1 0.0079 0.0252 0.0445
Echinococcus granulosus mixed lineage leukemia protein mll 0.0005 0.0002 0.0004
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.1687 0.5672 0.5668
Loa Loa (eye worm) hypothetical protein 0.0038 0.0113 0.0113
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Echinococcus multilocularis phospholipid transporting ATPase VA 0.0009 0.0015 0.0027
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Brugia malayi hypothetical protein 0.0005 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0009 0.0016 0.0013
Leishmania major DNA polymerase kappa, putative 0.0041 0.0122 0.0118
Schistosoma mansoni biogenic amine receptor 0.0008 0.0012 0.0022
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0044 0.048
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative 0.0008 0.0013 0.001
Plasmodium vivax glutathione reductase, putative 0.0027 0.0075 0.0125
Trichomonas vaginalis inositol monophosphatase, putative 0.0008 0.0013 0.0013
Schistosoma mansoni histamine h1 receptor 0.0008 0.0012 0.0022
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.001 0.0043
Mycobacterium ulcerans monophosphatase 0.0008 0.0013 0.0003
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0008 0.0012 0.0022
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0113 0.0112
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0009 0.0016 0.0006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0009 0.0017 0.0017
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0214 0.0708 0.0708
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0131 0.013
Echinococcus granulosus hypothetical protein 0.0008 0.0012 0.0022
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0008 0.0012 0.0022
Trypanosoma cruzi proton motive ATPase 1, putative 0.0009 0.0015 0.0005
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0113 0.0103
Schistosoma mansoni hypothetical protein 0.0027 0.0076 0.0135
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0027 0.0076 0.0076
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0079 0.0252 0.0249
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0009 0.0015 0.0011
Echinococcus multilocularis carbonic anhydrase II 0.0214 0.0708 0.1248
Echinococcus multilocularis carbonic anhydrase 0.0101 0.0325 0.0572
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0009 0.0017 0.0017
Trypanosoma brucei trypanothione reductase 0.0027 0.0075 0.0071
Leishmania major P-type H -ATPase, putative 0.0009 0.0015 0.0011
Echinococcus multilocularis importin 5 0.0005 0.0004 0.0007
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0012 0.0022
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0041 0.0122 0.0215
Schistosoma mansoni synaptic glycoprotein sc2 related 0.1687 0.5672 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Echinococcus multilocularis neuropeptide FF receptor 2 0.0008 0.0012 0.0022
Echinococcus granulosus neuropeptide s receptor 0.0513 0.1714 0.3022
Loa Loa (eye worm) hypothetical protein 0.0157 0.0514 0.0514
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0069 0.0069
Mycobacterium ulcerans cation transporter p-type ATPase a CtpA 0.0009 0.0015 0.0005
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0005 0.0001 0.000000000019982
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0085 0.0273 0.0273
Schistosoma mansoni amine GPCR 0.0008 0.0012 0.0022
Brugia malayi Probable cation-transporting ATPase C10C6.6 in chromosome IV 0.0009 0.0015 0.0015
Onchocerca volvulus Inositol monophosphatase 3 homolog 0.0008 0.0013 0.0023
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0064 0.0202 0.0356
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.1687 0.5672 0.5671
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0064 0.0202 0.0202
Loa Loa (eye worm) RecQ helicase 0.0014 0.0034 0.0034
Trypanosoma cruzi P-type H+-ATPase, putative 0.0009 0.0015 0.0005
Schistosoma mansoni cation-transporting atpase worm 0.0009 0.0015 0.0027
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0122 0.0118
Trypanosoma brucei copper-transporting ATPase-like protein, putative 0.0009 0.0015 0.0011
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0014 0.0034 0.0059
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0074 0.0065
Echinococcus multilocularis inositol monophosphatase 0.0008 0.0013 0.0023
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0025 0.0044
Schistosoma mansoni neuropeptide receptor 0.0008 0.0012 0.0022
Trichomonas vaginalis cation-transporting ATPase, putative 0.0009 0.0015 0.0014
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0009 0.0016 0.0006
Mycobacterium tuberculosis Conserved protein 0.0038 0.0113 0.134
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0007 0.001 0.001
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0113 0.0103
Schistosoma mansoni myosin xvIII 0.0008 0.0012 0.0022
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0034 0.003
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0027 0.0076 0.0135
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0015 0.0027
Trypanosoma brucei hypothetical protein, conserved 0.0013 0.0028 0.0024
Trypanosoma cruzi copper-transporting ATPase-like protein, putative 0.0009 0.0015 0.0005
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0069 0.0059
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0214 0.0708 0.0708
Loa Loa (eye worm) melatonin receptor type 1A 0.0008 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Mycobacterium ulcerans metal cation transporter p-type ATPase a 0.0009 0.0015 0.0005
Onchocerca volvulus 0.0038 0.0113 0.0198
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0007 0.001 0.0011
Trypanosoma brucei thymidine kinase 0.0244 0.0807 0.0804
Echinococcus multilocularis neuropeptide receptor 0.0008 0.0012 0.0022
Trypanosoma cruzi phospholipid-transporting ATPase-like protein, putative 0.0009 0.0015 0.0005
Entamoeba histolytica recQ family helicase, putative 0.0014 0.0034 0.003
Echinococcus multilocularis fmrfamide receptor 0.0008 0.0012 0.0022
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0069 0.0065
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0007 0.001 0.0006
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0008 0.0012 0.0022
Schistosoma mansoni acetyl-CoA synthetase 0.0007 0.001 0.0017
Leishmania major proton motive ATPase, putative 0.0009 0.0015 0.0011
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0007 0.001 0.0006
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0009 0.0015 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0009 0.0017 0.0017
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0064 0.0064
Echinococcus granulosus carbonic anhydrase 0.0101 0.0325 0.0572
Onchocerca volvulus 0.0008 0.0012 0.0022
Mycobacterium tuberculosis Probable oxidoreductase 0.0067 0.0212 0.2599
Leishmania major thymidine kinase, putative 0.0244 0.0807 0.0804
Echinococcus multilocularis copper transporting ATPase 1 0.0009 0.0015 0.0027
Echinococcus granulosus allatostatin A receptor 0.0008 0.0012 0.0022
Loa Loa (eye worm) importin-beta domain-containing protein 0.0005 0.0004 0.0004
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0009 0.0016 0.0029
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0069 0.0065
Schistosoma mansoni hypothetical protein 0.0008 0.0012 0.0022
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0309 0.1028 0.1028
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0008 0.0012 0.0022
Schistosoma mansoni phosphoserine phosphatase 0.0009 0.0015 0.0027
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0009 0.0015 0.0027
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0009 0.0016 0.0876
Echinococcus multilocularis neuropeptides capa receptor 0.0008 0.0012 0.0022
Plasmodium falciparum polyprenol reductase, putative 0.1687 0.5672 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0009 0.0017 0.0017
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0008 0.0012 0.0022
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0008 0.0012 0.0022
Schistosoma mansoni importin-beta 2 0.0005 0.0004 0.0007
Trypanosoma brucei cation-transporting ATPase, putative 0.0009 0.0015 0.0011
Onchocerca volvulus 0.0038 0.0113 0.0198
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0044 0.048
Brugia malayi E1-E2 ATPase family protein 0.0009 0.0015 0.0015
Loa Loa (eye worm) G-protein coupled receptor 0.0008 0.0012 0.0012
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0074 0.0125
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0008 0.0012 0.0012
Leishmania major hypothetical protein, conserved 0.0038 0.0113 0.0109
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0057 0.0053
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0057 0.0057
Brugia malayi Nuclear hormone receptor-like 1 0.0009 0.0017 0.0017
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0009 0.0017 0.0017
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0057 0.0053
Echinococcus granulosus dro:myosuppressin receptor 0.0008 0.0012 0.0022
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0005 0.0002 0.0003
Plasmodium falciparum thioredoxin reductase 0.0027 0.0075 0.0125
Echinococcus granulosus biogenic amine 5HT receptor 0.0008 0.0012 0.0022
Echinococcus multilocularis cation transporting atpase worm 0.0009 0.0015 0.0027
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0008 0.0012 0.0012
Echinococcus granulosus importin subunit beta 1 0.0029 0.0083 0.0146
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0101 0.0325 0.0325
Plasmodium falciparum glutathione reductase 0.0009 0.0016 0.0022
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0079 0.0252 0.0249
Entamoeba histolytica thymidine kinase, putative 0.0244 0.0807 0.0804
Mycobacterium leprae PROBABLE CATION-TRANSPORTER P-TYPE ATPASE B CTPB 0.0009 0.0015 0.0246
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0009 0.0015 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0009 0.0017 0.0017
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0009 0.0017 0.0029
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0214 0.0708 0.0708
Brugia malayi hypothetical protein 0.0008 0.0012 0.0012
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0009 0.0017 0.0029
Schistosoma mansoni DNA helicase recq1 0.0014 0.0034 0.0059
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0079 0.0252 0.0252
Echinococcus granulosus tachykinin peptides receptor 99D 0.0008 0.0012 0.0022
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0057 0.0047
Mycobacterium leprae Probable metal cation-transporting P-type ATPase C CtpC 0.0009 0.0015 0.0246
Brugia malayi nuclear receptor RXR 0.0005 0.0002 0.0002
Leishmania major DNA polymerase kappa, putative 0.0013 0.0028 0.0024
Loa Loa (eye worm) hypothetical protein 0.0029 0.0083 0.0083
Onchocerca volvulus 0.0008 0.0012 0.0022
Schistosoma mansoni myo inositol monophosphatase 0.0008 0.0013 0.0023
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.001 0.001
Trypanosoma brucei DNA damage repair protein, putative 0.0013 0.0028 0.0024
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0006 0.0006 0.0011
Brugia malayi putative neuropeptide receptor NPR1 0.0008 0.0012 0.0012
Brugia malayi GnHR receptor homolog 0.0008 0.0012 0.0012
Echinococcus granulosus ecdysone induced protein 78C 0.0009 0.0017 0.0029
Echinococcus granulosus rhodopsin orphan GPCR 0.0008 0.0012 0.0022
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.008 0.0076
Loa Loa (eye worm) hypothetical protein 0.0009 0.0017 0.0017
Leishmania major calcium-translocating P-type ATPase 0.0009 0.0015 0.0011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0012 0.0022
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0005 0.0002 0.0002
Trypanosoma brucei unspecified product 0.0028 0.008 0.0076
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0009 0.0015 0.0015
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0005 0.0002 0.0003
Leishmania major carbonic anhydrase-like protein 0.0214 0.0708 0.0704
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0007 0.001 0.0043
Echinococcus granulosus neuropeptide receptor 0.0008 0.0012 0.0022
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0122 0.0118
Brugia malayi hypothetical protein 0.0009 0.0015 0.0015
Echinococcus granulosus g protein coupled receptor 0.0008 0.0012 0.0022
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0008 0.0012 0.0022
Echinococcus multilocularis neuropeptide receptor A26 0.0513 0.1714 0.3022
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0007 0.001 0.0043
Echinococcus multilocularis fmrfamide receptor 0.0008 0.0012 0.0022
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0083 0.0146
Toxoplasma gondii histone lysine methyltransferase SET1 0.0042 0.0126 0.0123
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0079 0.0252 0.0252
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0064 0.0064
Echinococcus multilocularis muscleblind protein 1 0.0157 0.0514 0.0905
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0007 0.001 0.0006
Mycobacterium ulcerans metal cation transporter p-type ATPase, CtpV 0.0009 0.0015 0.0005
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0008 0.0012 0.0022
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0007 0.001 0.0006
Entamoeba histolytica calcium-transporting P-type ATPase, putative 0.0009 0.0015 0.0011
Onchocerca volvulus Neuropeptide F receptor homolog 0.0008 0.0012 0.0022
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.008 0.0076
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0012 0.0022
Brugia malayi ImpB/MucB/SamB family protein 0.0041 0.0122 0.0122
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0009 0.0016 0.0029
Mycobacterium ulcerans monophosphatase CysQ 0.0008 0.0013 0.0003
Trypanosoma cruzi cation-transporting ATPase, putative 0.0009 0.0015 0.0005
Echinococcus multilocularis neuropeptide Y receptor 0.0008 0.0012 0.0022
Brugia malayi hypothetical protein 0.0026 0.0074 0.0074
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0041 0.0122 0.0118
Loa Loa (eye worm) hypothetical protein 0.0026 0.0074 0.0074
Schistosoma mansoni neuropeptide receptor 0.0008 0.0012 0.0022
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0064 0.0202 0.0356
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0069 0.0065
Loa Loa (eye worm) hypothetical protein 0.0009 0.0017 0.0017
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0101 0.0325 0.0325
Loa Loa (eye worm) hypothetical protein 0.0038 0.0113 0.0113
Echinococcus granulosus copper transporting ATPase 1 0.0009 0.0015 0.0027
Schistosoma mansoni inositol monophosphatase 0.0079 0.0252 0.0445
Brugia malayi Inositol-1 0.0079 0.0252 0.0252
Trypanosoma cruzi P-type H+-ATPase, putative 0.0009 0.0015 0.0005
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0009 0.0016 0.0022
Mycobacterium ulcerans cation transporter p-type ATPase D CtpD 0.0009 0.0015 0.0005
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0041 0.0122 0.1459
Brugia malayi sulfakinin receptor protein 0.0008 0.0012 0.0012
Brugia malayi hypothetical protein 0.0008 0.0012 0.0012
Trichomonas vaginalis cation-transporting ATPase, putative 0.0009 0.0015 0.0014
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0113 0.134
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0074 0.0071
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0009 0.0015 0.0014
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0017 0.0029
Brugia malayi CXXC zinc finger family protein 0.002 0.0053 0.0053
Schistosoma mansoni carbonic anhydrase-related 0.0101 0.0325 0.0572
Echinococcus granulosus bloom syndrome protein 0.0014 0.0034 0.0059
Mycobacterium tuberculosis Cation transporter P-type ATPase a CtpA 0.0009 0.0015 0.011
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Leishmania major inositol polyphosphate 1-phosphatase, putative 0.0008 0.0013 0.001
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0034 0.003
Schistosoma mansoni hypothetical protein 0.0008 0.0013 0.0023
Echinococcus granulosus carbonic anhydrase II 0.0214 0.0708 0.1248
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0009 0.0017 0.0017
Echinococcus granulosus phospholipid transporting ATPase IIB 0.0009 0.0015 0.0027
Onchocerca volvulus 0.0009 0.0017 0.0029
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0005 0.0002 0.0003
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0017 0.0029
Schistosoma mansoni opsin-like receptor 0.0008 0.0012 0.0022
Echinococcus multilocularis rhodopsin orphan GPCR 0.0008 0.0012 0.0022
Trypanosoma cruzi copper-transporting ATPase-like protein, putative 0.0009 0.0015 0.0005
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative 0.0008 0.0013 0.001
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0069 0.0791
Entamoeba histolytica hypothetical protein 0.1687 0.5672 0.5671
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0061 0.019 0.8374
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0122 0.0112
Brugia malayi G protein-coupled receptor F59B2.13 0.0008 0.0012 0.0012
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0122 0.0112
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.1687 0.5672 0.5672
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0008 0.0012 0.0022
Mycobacterium tuberculosis Monophosphatase CysQ 0.0008 0.0013 0.0086
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0025 0.0044
Echinococcus multilocularis g protein coupled receptor 0.0008 0.0012 0.0022
Loa Loa (eye worm) hypothetical protein 0.297 1 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0008 0.0012 0.0012
Echinococcus granulosus muscleblind protein 0.0157 0.0514 0.0905
Onchocerca volvulus 0.0008 0.0012 0.0022
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0122 0.0112
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0009 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0092 0.0297 0.0297
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0008 0.0012 0.0022
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0074 0.0071
Loa Loa (eye worm) carbonic anhydrase 3 0.0214 0.0708 0.0708
Schistosoma mansoni neuropeptide F-like receptor 0.0008 0.0012 0.0022
Trichomonas vaginalis hypothetical protein 0.0005 0.0004 0.0003
Schistosoma mansoni hypothetical protein 0.0058 0.0182 0.0321
Schistosoma mansoni carbonic anhydrase-related 0.0101 0.0325 0.0572
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.001 0.0009
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0008 0.0012 0.0022
Brugia malayi steroid hormone receptor 0.0009 0.0017 0.0017
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.1687 0.5672 0.5672
Brugia malayi G-protein coupled receptor 0.0008 0.0012 0.0012
Echinococcus granulosus neuropeptide receptor A26 0.0513 0.1714 0.3022
Schistosoma mansoni hypothetical protein 0.0008 0.0012 0.0022
Echinococcus multilocularis orexin receptor type 2 0.0008 0.0012 0.0022
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0113 0.0112
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0028 0.0024
Schistosoma mansoni importin beta-1 0.0029 0.0083 0.0146
Loa Loa (eye worm) hypothetical protein 0.0092 0.0297 0.0297
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0008 0.0012 0.0022
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0009 0.0017 0.0017
Chlamydia trachomatis metal transport ATPase 0.0009 0.0015 0.0544
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Toxoplasma gondii calcium-translocating P-type ATPase, PMCA-type protein 0.0009 0.0015 0.0011
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0007 0.001 0.001
Trypanosoma cruzi myo-inositol-1 phosphatase, putative 0.0008 0.0013 0.0003
Echinococcus granulosus cation transporting ATPase 13A3 0.0009 0.0015 0.0027
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0069 0.276
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0122 0.0112
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0009 0.0017 0.0017
Entamoeba histolytica recQ family DNA helicase 0.0007 0.001 0.0006
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0008 0.0012 0.0022
Toxoplasma gondii hypothetical protein 0.0008 0.0013 0.001
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0009 0.0017 0.0029
Trypanosoma cruzi thymidine kinase, putative 0.0244 0.0807 0.0798
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0005 0.0001 0.000000000019982
Brugia malayi F/Y-rich N-terminus family protein 0.0006 0.0006 0.0006
Schistosoma mansoni hypothetical protein 0.0008 0.0012 0.0022
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Entamoeba histolytica Ran family GTPase 0.0021 0.0057 0.0053
Plasmodium falciparum copper-transporting ATPase 0.0009 0.0015 0.002
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0009 0.0017 0.0029
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0071 0.0224 0.2752
Trypanosoma cruzi DNA damage repair protein, putative 0.0013 0.0028 0.0018
Brugia malayi Dopamine receptor 0.0008 0.0012 0.0012
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0008 0.0012 0.0022
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0009 0.0017 0.0017
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0028 0.0018
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.001 0.001
Trichomonas vaginalis cation-transporting ATPase, putative 0.0009 0.0015 0.0014
Schistosoma mansoni adenoreceptor 0.0008 0.0012 0.0022
Echinococcus granulosus tm gpcr rhodopsin 0.0008 0.0012 0.0022
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0009 0.0016 0.0029
Echinococcus granulosus FTZ F1 alpha 0.0009 0.0017 0.0029
Schistosoma mansoni hypothetical protein 0.0027 0.0076 0.0135
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0214 0.0708 0.1248
Loa Loa (eye worm) hypothetical protein 0.0019 0.0048 0.0048
Toxoplasma gondii hypothetical protein 0.0101 0.0325 0.0321
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0007 0.001 0.0043
Leishmania major GTP-binding protein, putative 0.0021 0.0057 0.0053
Toxoplasma gondii phospholipid-translocating P-type ATPase, flippase subfamily protein 0.0009 0.0015 0.0011
Loa Loa (eye worm) hypothetical protein 0.0009 0.0017 0.0017
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0005 0.0001 0.000000000019982
Mycobacterium ulcerans metal cation-transporting p-type ATPase CtpC 0.0009 0.0015 0.0005
Brugia malayi AMP-binding enzyme family protein 0.0007 0.001 0.001
Giardia lamblia Copper-transporting P-type ATPase 0.0009 0.0015 0.0003
Echinococcus granulosus rhodopsin orphan GPCR 0.0008 0.0012 0.0022
Loa Loa (eye worm) hypothetical protein 0.0013 0.0028 0.0028
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0074 0.0065
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Echinococcus granulosus rhodopsin orphan GPCR 0.0008 0.0012 0.0022
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0009 0.0017 0.0029
Trypanosoma brucei DNA damage repair protein, putative 0.0013 0.0028 0.0024
Brugia malayi latrophilin 2 splice variant baaae 0.0058 0.0182 0.0182
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0002 0.0002
Brugia malayi Dopamine receptor protein 2 0.0008 0.0012 0.0012
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0007 0.0009 0.0005
Schistosoma mansoni terminal deoxycytidyl transferase 0.0041 0.0122 0.0215
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0067 0.0212 0.2599
Loa Loa (eye worm) hypothetical protein 0.0009 0.0017 0.0017
Entamoeba histolytica steroid 5-alpha reductase, putative 0.297 1 1
Brugia malayi Melatonin receptor type 1A 0.0008 0.0012 0.0012
Schistosoma mansoni type V p-type atpase isoform 0.0009 0.0015 0.0027
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0009 0.0017 0.0029
Echinococcus granulosus dna polymerase eta 0.0041 0.0122 0.0215
Giardia lamblia DINP protein human, muc B family 0.0041 0.0122 0.0192
Leishmania major acetyl-CoA synthetase, putative 0.0007 0.001 0.0006
Brugia malayi kap beta 3 protein 0.0005 0.0004 0.0004
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0122 0.0112
Loa Loa (eye worm) hypothetical protein 0.0025 0.0069 0.0069
Echinococcus granulosus tm gpcr rhodopsin 0.0008 0.0012 0.0022
Leishmania major copper-transporting ATPase-like protein, putative 0.0009 0.0015 0.0011
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0061 0.019 0.2311
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.0009 0.0015 0.0015
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0008 0.0013 0.0013
Echinococcus multilocularis thyroid hormone receptor alpha 0.0009 0.0017 0.0029
Mycobacterium leprae POSSIBLE MONOPHOSPHATASE CYSQ 0.0008 0.0013 0.0158
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0013 0.0028 0.0024
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0113 0.0112
Loa Loa (eye worm) thioredoxin reductase 0.0027 0.0075 0.0075
Schistosoma mansoni amine GPCR 0.0008 0.0012 0.0022
Echinococcus multilocularis thioredoxin glutathione reductase 0.0027 0.0076 0.0134
Onchocerca volvulus 0.0008 0.0012 0.0022
Echinococcus multilocularis neuropeptide Y receptor 0.0008 0.0012 0.0022
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0027 0.0076 0.0135
Loa Loa (eye worm) hypothetical protein 0.0038 0.0113 0.0113
Onchocerca volvulus 0.0007 0.001 0.0017
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein 0.297 1 1
Toxoplasma gondii haloacid dehalogenase family hydrolase domain-containing protein 0.0009 0.0015 0.0011
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0061 0.019 0.2311
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0009 0.0017 0.0017
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0122 0.0118
Trichomonas vaginalis glutathione reductase, putative 0.0009 0.0016 0.0016
Plasmodium vivax polyprenol reductase, putative 0.1687 0.5672 1
Brugia malayi beta-lactamase family protein 0.0038 0.0113 0.0113
Entamoeba histolytica phospholipid-transporting P-type ATPase, putative 0.0009 0.0015 0.0011
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0009 0.0017 0.0029
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Schistosoma mansoni retinoic acid receptor RXR 0.0009 0.0017 0.0029
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0101 0.0325 0.0325
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0067 0.0212 0.2599
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0048 0.0523
Brugia malayi Serotonin receptor 0.0008 0.0012 0.0012
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0101 0.0325 0.0325
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0069 0.0059
Leishmania major DNA damage repair protein, putative 0.0013 0.0028 0.0024
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0113 0.0113
Schistosoma mansoni growth hormone secretagogue receptor 0.0008 0.0012 0.0022
Loa Loa (eye worm) neuropeptide F receptor 0.0008 0.0012 0.0012
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0122 0.0112
Onchocerca volvulus 0.0008 0.0012 0.0022
Loa Loa (eye worm) G-protein coupled receptor 0.0008 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0079 0.0252 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0182 0.0182
Brugia malayi G-protein coupled receptor 0.0008 0.0012 0.0012
Brugia malayi hypothetical protein 0.0008 0.0012 0.0012
Schistosoma mansoni amine GPCR 0.0008 0.0012 0.0022
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0009 0.0017 0.0017
Schistosoma mansoni ATPase 0.0009 0.0015 0.0027
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0008 0.0012 0.0022
Trichomonas vaginalis cation-transporting ATPase, putative 0.0009 0.0015 0.0014
Echinococcus granulosus fmrfamide receptor 0.0008 0.0012 0.0022
Brugia malayi Importin beta-1 subunit 0.0029 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Echinococcus multilocularis GPCR, family 2 0.0027 0.0076 0.0135
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0028 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0009 0.0017 0.0017
Echinococcus granulosus rhodopsin orphan GPCR 0.0008 0.0012 0.0022
Echinococcus granulosus neuropeptide Y receptor 0.0008 0.0012 0.0022
Echinococcus multilocularis dro:myosuppressin receptor 0.0008 0.0012 0.0022
Loa Loa (eye worm) hypothetical protein 0.0085 0.0273 0.0273
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0009 0.0017 0.0029
Schistosoma mansoni thyroid hormone receptor 0.0009 0.0017 0.0029
Trypanosoma cruzi DNA polymerase eta, putative 0.0041 0.0122 0.0112
Schistosoma mansoni synaptic glycoprotein sc2 related 0.1687 0.5672 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0005 0.0001 0.000000000019982
Echinococcus granulosus biogenic amine 5HT receptor 0.0008 0.0012 0.0022
Plasmodium falciparum glutathione reductase 0.0027 0.0075 0.0125
Loa Loa (eye worm) hypothetical protein 0.0014 0.0034 0.0034
Trichomonas vaginalis esterase, putative 0.0038 0.0113 0.0112
Echinococcus multilocularis rhodopsin orphan GPCR 0.0008 0.0012 0.0022
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.0009 0.0015 0.0015
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0012 0.0022
Echinococcus multilocularis transportin 1 0.0005 0.0004 0.0007
Brugia malayi Synaptic glycoprotein SC2 0.1687 0.5672 0.5672
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0009 0.0016 0.0006
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0008 0.0012 0.0022
Mycobacterium ulcerans cation-transporter ATPase I CtpI 0.0009 0.0015 0.0005
Echinococcus multilocularis dna polymerase eta 0.0041 0.0122 0.0215
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0027 0.0076 0.0135
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 0.297 1 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0009 0.0016 0.0013
Echinococcus multilocularis phospholipid transporting ATPase IIB 0.0009 0.0015 0.0027
Giardia lamblia DNA damage repair protein 0.0013 0.0028 0.0026
Echinococcus multilocularis 3'(2'),5' bisphosphate nucleotidase 1 0.0008 0.0013 0.0023
Mycobacterium leprae Probable monophosphatase 0.0008 0.0013 0.0158
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0027 0.0076 0.0135
Onchocerca volvulus 0.0008 0.0012 0.0022
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0009 0.0015 0.0005
Mycobacterium tuberculosis Conserved protein 0.0038 0.0113 0.134
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0005 0.0001 0.000000000019982
Brugia malayi AMP-binding enzyme family protein 0.0007 0.001 0.001
Mycobacterium tuberculosis Probable dehydrogenase 0.0061 0.019 0.2311
Loa Loa (eye worm) hypothetical protein 0.0038 0.0113 0.0113
Trypanosoma brucei unspecified product 0.0041 0.0122 0.0118
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0061 0.019 0.2311
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0034 0.0034
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0079 0.0252 0.0243
Echinococcus multilocularis g-protein coupled receptor 0.0008 0.0012 0.0022
Echinococcus granulosus neuropeptides capa receptor 0.0008 0.0012 0.0022
Echinococcus granulosus transportin 1 0.0005 0.0004 0.0007
Brugia malayi Thioredoxin reductase 0.0027 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Trypanosoma brucei carbonic anhydrase-like protein 0.0214 0.0708 0.0704
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.297 1 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Mycobacterium tuberculosis Probable monophosphatase 0.0008 0.0013 0.0086
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0007 0.001 0.0043
Plasmodium vivax calcium-transporting ATPase, putative 0.0009 0.0015 0.002
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0079 0.0252 0.0243
Echinococcus multilocularis bloom syndrome protein 0.0014 0.0034 0.0059
Echinococcus granulosus 3 oxo 5 alpha steroid 4 dehydrogenase C terminal 0.1687 0.5672 1
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Trypanosoma brucei vacuolar-type Ca2+-ATPase 1 0.0009 0.0015 0.0011
Trypanosoma cruzi Calcium ATPase SERCA-like 0.0009 0.0015 0.0005
Onchocerca volvulus 0.0008 0.0012 0.0022
Brugia malayi ImpB/MucB/SamB family protein 0.0041 0.0122 0.0122
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0113 0.0109
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0005 0.0001 0.0001
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0009 0.0015 0.0027
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0012 0.0022
Onchocerca volvulus 0.0007 0.001 0.0017
Echinococcus granulosus rhodopsin orphan GPCR 0.0008 0.0012 0.0022
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0009 0.0016 0.0013
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0009 0.0015 0.0014
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0069 0.0059
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0113 0.0192
Schistosoma mansoni hypothetical protein 0.0027 0.0076 0.0135
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0027 0.0075 0.0863
Mycobacterium ulcerans lipase LipD 0.0038 0.0113 0.0103
Loa Loa (eye worm) hypothetical protein 0.0005 0.0001 0.0001
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0007 0.001 0.0011
Brugia malayi putative neuropeptide receptor 0.0008 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Brugia malayi neuropeptide F receptor 0.0008 0.0012 0.0012
Plasmodium falciparum DNA repair protein REV1, putative 0.0013 0.0028 0.0042
Brugia malayi Muscleblind-like protein 0.0157 0.0514 0.0514
Echinococcus granulosus serotonin receptor 0.0008 0.0012 0.0022
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0113 0.0198
Loa Loa (eye worm) TYRA-2 protein 0.0008 0.0012 0.0012
Echinococcus multilocularis cpg binding protein 0.0021 0.0057 0.0101
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Brugia malayi ORL1-like opioid receptor 0.0008 0.0012 0.0012
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0005 0.0002 0.0003
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0008 0.0012 0.0022
Brugia malayi PHD-finger family protein 0.0005 0.0001 0.0001
Brugia malayi hypothetical protein 0.0008 0.0012 0.0012
Onchocerca volvulus 0.0008 0.0012 0.0022
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0009 0.0015 0.0027
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.001 0.0043
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0009 0.0016 0.0006
Echinococcus granulosus thioredoxin glutathione reductase 0.0027 0.0076 0.0134
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0041 0.0122 0.0215
Schistosoma mansoni amine GPCR 0.0008 0.0012 0.0022
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0007 0.001 0.0043
Echinococcus granulosus 3'2'5' bisphosphate nucleotidase 1 0.0008 0.0013 0.0023
Schistosoma mansoni cpg binding protein 0.0021 0.0057 0.0101
Schistosoma mansoni zinc finger protein 0.0005 0.0001 0.0002
Trichomonas vaginalis ATPase, class VI, type 11C, putative 0.0009 0.0015 0.0014
Echinococcus granulosus translational activator gcn1 0.0005 0.0004 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0009 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Schistosoma mansoni copper ABC transporter ATPase 0.0009 0.0015 0.0027
Loa Loa (eye worm) hypothetical protein 0.0019 0.0048 0.0048
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0057 0.0101
Schistosoma mansoni ran 0.0021 0.0057 0.0101
Schistosoma mansoni cation-transporting atpase worm 0.0009 0.0015 0.0027
Toxoplasma gondii P-type ATPase PMA1 0.0009 0.0015 0.0011
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0122 0.0118
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0015 0.0027
Trypanosoma brucei P-type H+-ATPase, putative 0.0009 0.0015 0.0011
Echinococcus granulosus dna polymerase kappa 0.0041 0.0122 0.0215
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0048 0.0078
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0064 0.0055
Schistosoma mansoni opsin-like receptor 0.0008 0.0012 0.0022
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.0007 0.0009 0.0009
Brugia malayi RNA, U transporter 1 0.0082 0.0263 0.0263
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0122 0.0118
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1666 0.5601 0.9875
Plasmodium vivax copper-transporting ATPase, putative 0.0009 0.0015 0.002
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0008 0.0012 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0009 0.0017 0.0017
Brugia malayi hypothetical protein 0.0008 0.0012 0.0012
Echinococcus multilocularis dna polymerase kappa 0.0041 0.0122 0.0215
Leishmania major hypothetical protein, conserved 0.0026 0.0074 0.0071
Echinococcus granulosus inositol monophosphatase 0.0008 0.0013 0.0023
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0069 0.0059
Echinococcus multilocularis neuropeptides capa receptor 0.0008 0.0012 0.0022
Echinococcus multilocularis carbonic anhydrase 0.0101 0.0325 0.0572
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0101 0.0325 0.0325
Onchocerca volvulus Bile acid receptor homolog 0.0009 0.0017 0.0029
Mycobacterium ulcerans hypothetical protein 0.0038 0.0113 0.0103
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0028 0.0018
Loa Loa (eye worm) glutathione reductase 0.0027 0.0075 0.0075
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0122 0.0118
Echinococcus multilocularis somatostatin receptor 0.0008 0.0012 0.0022
Schistosoma mansoni hypothetical protein 0.0138 0.045 0.0794
Echinococcus granulosus neuropeptide receptor 0.0008 0.0012 0.0022
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0008 0.0012 0.0022
Giardia lamblia Thymidine kinase 0.0244 0.0807 0.1403
Brugia malayi acetyltransferase, GNAT family protein 0.0147 0.0479 0.0479
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0009 0.0015 0.0027
Echinococcus multilocularis serotonin receptor 0.0008 0.0012 0.0022
Echinococcus granulosus phospholipid transporting ATPase VA 0.0009 0.0015 0.0027
Onchocerca volvulus 0.002 0.0053 0.0094
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.297 1 1
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0214 0.0708 0.0699
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0009 0.0016 0.0022
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0014 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0007 0.001 0.001
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0044 0.048
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0069 0.0065
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.0009 0.0015 0.0015
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0015 0.0027
Schistosoma mansoni inositol monophosphatase 0.0079 0.0252 0.0445
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0113 0.134
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.008 0.0076
Loa Loa (eye worm) hypothetical protein 0.0038 0.0113 0.0113
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0017 0.0029
Loa Loa (eye worm) latrophilin receptor protein 2 0.0027 0.0076 0.0076
Schistosoma mansoni cpg binding protein 0.002 0.0053 0.0094
Brugia malayi Inositol monophosphatase family protein 0.0008 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0157 0.0514 0.0514
Echinococcus multilocularis g protein coupled receptor 0.0008 0.0012 0.0022
Brugia malayi hypothetical protein 0.0017 0.0043 0.0043
Echinococcus multilocularis cation transporting ATPase 13A3 0.0009 0.0015 0.0027
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0069 0.0065
Mycobacterium ulcerans beta-lactamase 0.0038 0.0113 0.0103
Brugia malayi beta-lactamase 0.0038 0.0113 0.0113
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0061 0.019 0.2311
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0008 0.0012 0.0022
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0048 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0008 0.0012 0.0022
Echinococcus multilocularis g protein coupled receptor 0.0008 0.0012 0.0022
Echinococcus multilocularis sex peptide receptor 0.0008 0.0012 0.0022
Loa Loa (eye worm) hypothetical protein 0.0101 0.0325 0.0325
Entamoeba histolytica trans-2,3-enoyl-CoA reductase, putative 0.1687 0.5672 0.5671
Brugia malayi RE15519p 0.0008 0.0012 0.0012
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0015 0.0027
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0122 0.0118
Brugia malayi hypothetical protein 0.0008 0.0012 0.0012
Plasmodium vivax acetyl-CoA synthetase, putative 0.0007 0.001 0.0011
Echinococcus granulosus g protein coupled receptor 0.0008 0.0012 0.0022
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0131 0.0127
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0009 0.0015 0.0014
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0008 0.0012 0.0012
Toxoplasma gondii ABC1 family protein 0.0038 0.0113 0.0109
Schistosoma mansoni ran 0.0021 0.0057 0.0101
Brugia malayi nuclear receptor NHR-88 0.0009 0.0017 0.0017
Mycobacterium leprae PROBABLE CATION-TRANSPORTER ATPASE I CTPI 0.0009 0.0015 0.0246
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0057 0.0078
Mycobacterium ulcerans hypothetical protein 0.0025 0.0069 0.0059
Giardia lamblia Sgs1 DNA helicase, putative 0.0014 0.0034 0.0036
Toxoplasma gondii thioredoxin reductase 0.0027 0.0075 0.0071
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0008 0.0012 0.0022
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.297 1 1
Brugia malayi nuclear hormone receptor 0.0009 0.0017 0.0017
Brugia malayi hypothetical protein 0.0008 0.0012 0.0012
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0009 0.0016 0.0006
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0012 0.0022
Schistosoma mansoni RAR-like nuclear receptor 0.0009 0.0017 0.0029
Brugia malayi larval opioid receptor 0.0008 0.0012 0.0012
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0057 0.0094
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0009 0.0015 0.0014
Trichomonas vaginalis DNA polymerase eta, putative 0.0041 0.0122 0.0121
Trichomonas vaginalis cation-transporting ATPase, putative 0.0009 0.0015 0.0014
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0008 0.0012 0.0022
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0009 0.0015 0.0003
Echinococcus multilocularis rhodopsin orphan GPCR 0.0008 0.0012 0.0022
Loa Loa (eye worm) hypothetical protein 0.0019 0.0048 0.0048
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0067 0.0212 0.9436
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Plasmodium falciparum 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.1687 0.5672 1
Treponema pallidum NADH oxidase 0.0009 0.0016 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.0325 0.0325
Schistosoma mansoni neuropeptide f receptor 76f 0.0008 0.0012 0.0022
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0009 0.0016 0.0013
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0012 0.0025 0.0044
Leishmania major myo-inositol-1 phosphatase, putative 0.0008 0.0013 0.001
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0071 0.0224 1
Onchocerca volvulus 0.0008 0.0012 0.0022
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0012 0.0022
Loa Loa (eye worm) hypothetical protein 0.0038 0.0113 0.0113
Echinococcus multilocularis rhodopsin orphan GPCR 0.0008 0.0012 0.0022
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0012 0.0022
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Schistosoma mansoni biogenic amine (5HT) receptor 0.0008 0.0012 0.0022
Echinococcus multilocularis muscleblind protein 0.0157 0.0514 0.0905
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0009 0.0015 0.0011
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0008 0.0012 0.0022
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0009 0.0017 0.0029
Loa Loa (eye worm) hypothetical protein 0.1687 0.5672 0.5672
Plasmodium vivax P-type ATPase4, putative 0.0009 0.0015 0.002
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0009 0.0015 0.0027
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0083 0.0079
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0083 0.0079
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Schistosoma mansoni DNA polymerase eta 0.0041 0.0122 0.0215
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0007 0.001 0.0006
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0009 0.0015 0.0015
Giardia lamblia Synaptic glycoprotein SC2 0.1687 0.5672 1
Leishmania major DNA polymerase eta, putative 0.0013 0.0028 0.0024
Brugia malayi potential phospholipid-transporting ATPase IIB, putative 0.0009 0.0015 0.0015
Trypanosoma brucei P-type H+-ATPase, putative 0.0009 0.0015 0.0011
Trypanosoma brucei vacuolar-type Ca2+-ATPase 2 0.0009 0.0015 0.0011
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0009 0.0016 0.0013
Schistosoma mansoni hypothetical protein 0.0008 0.0013 0.0023
Plasmodium vivax 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.1687 0.5672 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0007 0.001 0.001
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0064 0.0202 0.0356
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0041 0.0122 0.0215
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0009 0.0017 0.0029
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0015 0.0027
Echinococcus multilocularis translational activator gcn1 0.0005 0.0004 0.0007
Brugia malayi beta-lactamase family protein 0.0038 0.0113 0.0113
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0064 0.0202 0.0356
Schistosoma mansoni ATPase 0.0009 0.0015 0.0027
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0122 0.0118
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0008 0.0012 0.0022
Trypanosoma brucei RNA helicase, putative 0.0138 0.045 0.0447
Trypanosoma cruzi thymidine kinase, putative 0.0244 0.0807 0.0798
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0064 0.0202 0.0202
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.001 0.0043
Entamoeba histolytica 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein 0.1687 0.5672 0.5671
Loa Loa (eye worm) steroid hormone receptor 0.0009 0.0017 0.0017
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0009 0.0016 0.0006
Loa Loa (eye worm) inositol-1 0.0079 0.0252 0.0252
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0009 0.0016 0.0013
Trichomonas vaginalis phospholipid-transporting ATPase, putative 0.0009 0.0015 0.0014
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0017 0.0029
Trichomonas vaginalis thymidine kinase, putative 0.0244 0.0807 0.0807
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0113 0.134
Trypanosoma brucei inositol polyphosphate 1-phosphatase, putative 0.0008 0.0013 0.001
Brugia malayi hypothetical protein 0.0008 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0019 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Treponema pallidum hypothetical protein 0.0009 0.0015 0.8189
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0057 0.0047
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.297 1 1
Echinococcus granulosus g protein coupled receptor 0.0008 0.0012 0.0022
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0008 0.0012 0.0022
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0113 0.0113
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0002 0.0002
Trichomonas vaginalis thymidine kinase, putative 0.0244 0.0807 0.0807
Loa Loa (eye worm) hypothetical protein 0.1687 0.5672 0.5672
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0009 0.0016 0.0013
Entamoeba histolytica deoxycytidyl transferase, putative 0.0041 0.0122 0.0118
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0008 0.0012 0.0022
Echinococcus granulosus histone acetyltransferase KAT2B 0.0142 0.0465 0.0821
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0064 0.0202 0.0356
Schistosoma mansoni cation-transporting ATPase 0.0009 0.0015 0.0027
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0131 0.0224
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Schistosoma mansoni alpha-1 adrenergic receptor 0.0008 0.0012 0.0022
Loa Loa (eye worm) hypothetical protein 0.0007 0.001 0.001
Schistosoma mansoni blooms syndrome DNA helicase 0.0007 0.001 0.0017
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0113 0.0103
Echinococcus multilocularis snurportin 1 0.0309 0.1028 0.1813
Schistosoma mansoni amine GPCR 0.0008 0.0012 0.0022
Schistosoma mansoni DNA polymerase IV / kappa 0.0013 0.0028 0.0049
Echinococcus granulosus synaptic glycoprotein sc2 0.1687 0.5672 1
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0009 0.0015 0.0027
Trypanosoma brucei chrX additional, unordered contigs 0.0013 0.0028 0.0024
Brugia malayi Inositol monophosphatase family protein 0.0008 0.0013 0.0013
Schistosoma mansoni bromodomain containing protein 0.0005 0.0001 0.0002
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0008 0.0012 0.0012
Onchocerca volvulus 0.0025 0.0069 0.0122
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.001 0.0009
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0113 0.0103
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0147 0.0479 0.0845
Mycobacterium ulcerans hypothetical protein 0.0013 0.0028 0.0018
Schistosoma mansoni thyroid hormone receptor 0.0009 0.0017 0.0029
Brugia malayi Bromodomain containing protein 0.0005 0.0001 0.0001
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0005 0.0001 0.000000000019982
Toxoplasma gondii heavy metal translocating P-type ATPase subfamily protein 0.0009 0.0015 0.0011
Plasmodium vivax cation transporting ATPase, putative 0.0009 0.0015 0.002
Echinococcus granulosus zinc finger protein 0.0005 0.0001 0.0002
Echinococcus multilocularis G-protein coupled receptor, putative 0.0008 0.0012 0.0022
Echinococcus granulosus cation transporting atpase worm 0.0009 0.0015 0.0027
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0005 0.0002 0.0004
Entamoeba histolytica phospholipid-transporting P-type ATPase, putative 0.0009 0.0015 0.0011
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0069 0.0059
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Echinococcus granulosus rhodopsin orphan GPCR 0.0008 0.0012 0.0022
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0079 0.0252 0.0249
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.001 0.0043
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0113 0.0198
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0014 0.0034 0.0059
Echinococcus granulosus 7TM GPCR rhodopsin 0.0008 0.0012 0.0022
Brugia malayi Bloom's syndrome protein homolog 0.0014 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative 0.0008 0.0013 0.001
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0005 0.0001 0.0002
Brugia malayi hypothetical protein 0.0005 0.0002 0.0002
Mycobacterium tuberculosis Conserved hypothetical protein 0.0041 0.0122 0.1459
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0113 0.134
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0122 0.0118
Plasmodium falciparum importin beta, putative 0.0029 0.0083 0.014
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0131 0.023
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0009 0.0015 0.0011
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0009 0.0015 0.0011
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0048 0.0038
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0009 0.0016 0.0006
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0064 0.0202 0.0356
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0009 0.0017 0.0017
Toxoplasma gondii NADPH-glutathione reductase 0.0009 0.0016 0.0013
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0041 0.0122 0.0122
Plasmodium vivax importin-beta 2, putative 0.0029 0.0083 0.014
Trichomonas vaginalis conserved hypothetical protein 0.1687 0.5672 0.5672
Brugia malayi G protein-coupled receptor 0.0008 0.0012 0.0012
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0113 0.134
Schistosoma mansoni blooms syndrome DNA helicase 0.0007 0.0009 0.0016
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.1687 0.5672 0.5672
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative 0.0008 0.0013 0.0013
Echinococcus multilocularis rhodopsin orphan GPCR 0.0008 0.0012 0.0022
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0007 0.001 0.0043
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0007 0.001 0.0000079012
Loa Loa (eye worm) hypothetical protein 0.0009 0.0017 0.0017
Mycobacterium tuberculosis Possible metal cation transporting P-type ATPase CtpH 0.0009 0.0015 0.011
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0009 0.0017 0.0029
Onchocerca volvulus Protein ultraspiracle homolog 0.0009 0.0017 0.0029
Onchocerca volvulus 0.0008 0.0012 0.0022
Schistosoma mansoni hypothetical protein 0.0101 0.0325 0.0572
Toxoplasma gondii cation-transporting atpase family protein 0.0009 0.0015 0.0011
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0017 0.0029
Schistosoma mansoni biogenic amine receptor 0.0008 0.0012 0.0022
Trypanosoma cruzi trypanothione reductase, putative 0.0027 0.0075 0.0065
Loa Loa (eye worm) calcium ATPase 0.0009 0.0015 0.0015
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0085 0.0273 0.0273
Echinococcus multilocularis serotonin receptor 0.0008 0.0012 0.0022
Echinococcus granulosus GPCR family 2 0.0027 0.0076 0.0135
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Brugia malayi hypothetical protein 0.0008 0.0012 0.0012
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0014 0.0034 0.0053
Echinococcus granulosus neuropeptide Y receptor 0.0008 0.0012 0.0022
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0101 0.0325 0.0325
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0118 0.0202
Schistosoma mansoni hypothetical protein 0.0309 0.1028 0.1813
Echinococcus multilocularis G protein coupled receptor 139 0.0008 0.0012 0.0022
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0041 0.0122 0.0122
Trichomonas vaginalis inositol monophosphatase, putative 0.0079 0.0252 0.0252
Mycobacterium ulcerans metal cation transporter ATPase p-type CtpE 0.0009 0.0015 0.0005
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0009 0.0016 0.0006
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0034 0.0024
Echinococcus granulosus 7tm_1 domain containing protein 0.0008 0.0012 0.0022
Schistosoma mansoni carbonic anhydrase 0.0101 0.0325 0.0572
Echinococcus multilocularis cation transporting ATPase 13A1 0.0009 0.0015 0.0027
Mycobacterium ulcerans metal cation-transporting p-type ATPase F, CtpF 0.0009 0.0015 0.0005
Brugia malayi AMP-binding enzyme family protein 0.0007 0.001 0.001
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0005 0.0002 0.0004
Schistosoma mansoni neuropeptide receptor 0.0008 0.0012 0.0022
Loa Loa (eye worm) hypothetical protein 0.0009 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0007 0.001 0.001
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0113 0.0112
Echinococcus multilocularis rhodopsin orphan GPCR 0.0008 0.0012 0.0022
Trypanosoma cruzi copper-transporting ATPase-like protein, putative 0.0009 0.0015 0.0005
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Loa Loa (eye worm) acetyltransferase 0.0147 0.0479 0.0479
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0113 0.0198
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative 0.0008 0.0013 0.0003
Schistosoma mansoni neuropeptide F-like receptor 0.0008 0.0012 0.0022
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0083 0.0079
Entamoeba histolytica recQ family helicase, putative 0.0007 0.0009 0.0005
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0034 0.003
Echinococcus granulosus alpha 1A adrenergic receptor 0.0008 0.0012 0.0022
Onchocerca volvulus 0.0008 0.0012 0.0022
Trichomonas vaginalis ATPase, class I, type 8B, putative 0.0009 0.0015 0.0014
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0057 0.0101
Schistosoma mansoni biogenic amine (5HT) receptor 0.0008 0.0012 0.0022
Brugia malayi ecdysteroid receptor 0.0009 0.0017 0.0017
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0009 0.0016 0.0124
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0007 0.0008 0.0008
Schistosoma mansoni hypothetical protein 0.0027 0.0076 0.0135
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0118 0.0115
Echinococcus granulosus carbonic anhydrase 0.0101 0.0325 0.0572
Trichomonas vaginalis inositol monophosphatase, putative 0.0008 0.0013 0.0013
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0005 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0025 0.0069 0.0069
Echinococcus multilocularis rhodopsin orphan GPCR 0.0008 0.0012 0.0022
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0014 0.0034 0.0059
Onchocerca volvulus 0.1687 0.5672 1
Toxoplasma gondii phospholipid-translocating P-type ATPase, flippase subfamily protein 0.0009 0.0015 0.0011
Mycobacterium ulcerans monophosphatase CysQ 0.0008 0.0013 0.0003
Echinococcus multilocularis FTZ F1 alpha 0.0009 0.0017 0.0029
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0064 0.0064
Plasmodium falciparum thioredoxin reductase 0.0009 0.0016 0.0022
Trichomonas vaginalis DNA helicase recq, putative 0.0014 0.0034 0.0033
Brugia malayi Dopamine receptor protein 1 0.0008 0.0012 0.0012
Schistosoma mansoni cation-transporting atpase 13a1 (G-box binding protein) 0.0009 0.0015 0.0027
Schistosoma mansoni pap-inositol-14-phosphatase 0.0008 0.0013 0.0023
Echinococcus multilocularis neuropeptide receptor 0.0008 0.0012 0.0022
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0009 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0009 0.0017 0.0017
Trichomonas vaginalis DNA helicase recq, putative 0.0014 0.0034 0.0033
Trichomonas vaginalis thymidine kinase, putative 0.0244 0.0807 0.0807
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Leishmania major trypanothione reductase 0.0027 0.0075 0.0071
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0101 0.0325 0.0325
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0008 0.0012 0.0012
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0005 0.0001 0.000000000019982
Loa Loa (eye worm) hypothetical protein 0.0008 0.0013 0.0013
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0147 0.0479 0.0845
Brugia malayi follicle stimulating hormone receptor 0.0008 0.0012 0.0012
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0009 0.0016 0.0022
Loa Loa (eye worm) oxidoreductase 0.0007 0.001 0.001
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0214 0.0708 0.1248
Schistosoma mansoni atpase class VI type 11c 0.0009 0.0015 0.0027
Echinococcus granulosus neuropeptides capa receptor 0.0008 0.0012 0.0022
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0009 0.0015 0.0011
Brugia malayi Latrophilin receptor protein 2 0.0027 0.0076 0.0076
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0009 0.0016 0.0013
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0118 0.0186
Brugia malayi hypothetical protein 0.0092 0.0297 0.0297
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0007 0.001 0.0043
Trypanosoma cruzi DNA polymerase eta, putative 0.0013 0.0028 0.0018
Leishmania major acetyl-CoA synthetase, putative 0.0007 0.001 0.0006
Schistosoma mansoni neuropeptide receptor 0.0008 0.0012 0.0022
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0034 0.003
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0008 0.0012 0.0022
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0122 0.0118
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0069 0.276
Echinococcus granulosus importin 5 0.0005 0.0004 0.0007
Leishmania major P-type H -ATPase, putative 0.0009 0.0015 0.0011
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0005 0.0002 0.0004
Onchocerca volvulus 0.0009 0.0015 0.0027
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0069 0.0059
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0014 0.0034 0.0059
Trypanosoma brucei unspecified product 0.0028 0.008 0.0076
Trichomonas vaginalis mercuric reductase, putative 0.0009 0.0016 0.0016
Mycobacterium tuberculosis Probable reductase 0.0061 0.019 0.2311
Brugia malayi glutathione reductase 0.0027 0.0075 0.0075
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0034 0.0034
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0008 0.0012 0.0022
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0214 0.0708 0.0699
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0007 0.001 0.0017
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0008 0.0012 0.0022
Echinococcus multilocularis zinc finger protein 0.0005 0.0001 0.0002
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0009 0.0017 0.0029
Toxoplasma gondii propionate-CoA ligase 0.0007 0.001 0.0006
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0013 0.0028 0.0024
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0008 0.0012 0.0012
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0057 0.0057
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0007 0.001 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0122 0.0118
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0009 0.0016 0.0013
Echinococcus multilocularis rhodopsin orphan GPCR 0.0008 0.0012 0.0022
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0074 0.0125
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0009 0.0016 0.0016
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0122 0.0118
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.1687 0.5672 0.5671
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0069 0.0791
Brugia malayi neuropeptide F receptor 0.0008 0.0012 0.0012
Onchocerca volvulus 0.0007 0.001 0.0017
Brugia malayi E1-E2 ATPase family protein 0.0009 0.0015 0.0015
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0131 0.013
Plasmodium vivax DNA repair protein REV1, putative 0.0013 0.0028 0.0042
Echinococcus granulosus peptide allatostatin:somatostatin 0.0008 0.0012 0.0022
Schistosoma mansoni coup transcription factor 0.0009 0.0017 0.0029
Loa Loa (eye worm) hypothetical protein 0.0009 0.0017 0.0017
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.1687 0.5672 0.5671
Schistosoma mansoni cpg binding protein 0.0021 0.0057 0.0101
Schistosoma mansoni DNA helicase recq5 0.0014 0.0034 0.0059
Plasmodium vivax thioredoxin reductase, putative 0.0027 0.0075 0.0125
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0057 0.0094
Echinococcus granulosus inositol monophosphatase 1 0.0079 0.0252 0.0445
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0122 0.0118
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.0012
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0069 0.0065
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.297 1 1

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 275 nM Inhibitory activity against human carbonic anhydrase II ChEMBL. 15012984
Ki (binding) = 275 nM Inhibitory activity against human carbonic anhydrase II ChEMBL. 15012984
Ki (binding) > 500 nM Inhibitory activity against human carbonic anhydrase IX ChEMBL. 15012984
Ki (binding) > 500 nM Inhibitory activity against human carbonic anhydrase IX ChEMBL. 15012984
Ki (binding) = 1000 nM Inhibitory activity of the compound against carbonic anhydrase IV from bovine lung microsomes ChEMBL. 15012984
Ki (binding) = 1000 nM Inhibitory activity of the compound against carbonic anhydrase IV from bovine lung microsomes ChEMBL. 15012984
Ki (binding) = 92 uM Inhibitory activity against human carbonic anhydrase I ChEMBL. 15012984
Ki (binding) = 92 uM Inhibitory activity against human carbonic anhydrase I ChEMBL. 15012984

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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