Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Change in weight (functional) | = 6.6 % | Compound was tested for the effect on the survival time of the mice bearing P388 leukemia at dose 120 mg/kg | ChEMBL. | 3941417 |
Change in weight (functional) | = 6.6 % | Compound was tested for the effect on the survival time of the mice bearing P388 leukemia at dose 120 mg/kg | ChEMBL. | 3941417 |
Change in weight (functional) | = 8.4 % | Compound was tested for the effect on the survival time of the mice bearing P388 leukemia at dose 100 mg/kg | ChEMBL. | 3941417 |
Change in weight (functional) | = 8.4 % | Compound was tested for the effect on the survival time of the mice bearing P388 leukemia at dose 100 mg/kg | ChEMBL. | 3941417 |
Change in weight (functional) | = 15.1 % | Compound was tested for the effect on the survival time of the mice bearing P388 leukemia at dose 60 mg/kg | ChEMBL. | 3941417 |
Change in weight (functional) | = 15.1 % | Compound was tested for the effect on the survival time of the mice bearing P388 leukemia at dose 60 mg/kg | ChEMBL. | 3941417 |
T/C (functional) | = 72 | Compound was tested for the effect on the survival time of the mice bearing P388 leukemia at dose 60 mg/kg; ratio of survival time of treated and control | ChEMBL. | 3941417 |
T/C (functional) | = 101 | Compound was tested for the effect on the survival time of the mice bearing P388 leukemia at dose 120 mg/kg; ratio of survival time of treated and control | ChEMBL. | 3941417 |
T/C (functional) | = 103 | Compound was tested for the effect on the survival time of the mice bearing P388 leukemia at dose 100 mg/kg; ratio of survival time of treated and control | ChEMBL. | 3941417 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.