Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 1 | compound was evaluated for its ability to produce catalepsy activity in rats | ChEMBL. | 6105217 |
Activity (functional) | = 4 | Compound was evaluated for its ability to block conditioned avoidance response (CAR) in rats; Dose administered perorally is 50 mg/kg; 76-99% block | ChEMBL. | 6105217 |
EDmin (functional) | = 25 mg kg-1 | Hypothermia in mice after perorla administration | ChEMBL. | 6105217 |
EDmin (functional) | = 25 mg kg-1 | Hypothermia in mice after perorla administration | ChEMBL. | 6105217 |
LD50 (ADMET) | = 400 mg kg-1 | Lethal dose in mice after perorla administration | ChEMBL. | 6105217 |
LD50 (ADMET) | = 400 mg kg-1 | Lethal dose in mice after perorla administration | ChEMBL. | 6105217 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.