Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | intermediate filament protein | 0.0026 | 1 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0018 | 0.4151 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.4151 | 0.5 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0014 | 0.1026 | 0.1026 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0026 | 1 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0026 | 1 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0.4151 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0026 | 1 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0026 | 1 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0018 | 0.4151 | 0.5 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0018 | 0.4151 | 0.4151 |
Schistosoma mansoni | lamin | 0.0026 | 1 | 1 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0018 | 0.4151 | 0.4151 |
Echinococcus granulosus | lamin | 0.0026 | 1 | 1 |
Onchocerca volvulus | 0.0026 | 1 | 0.5 | |
Schistosoma mansoni | intermediate filament proteins | 0.0026 | 1 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.4151 | 0.5 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.4151 | 0.5 |
Echinococcus multilocularis | lamin | 0.0026 | 1 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.4151 | 0.5 |
Echinococcus granulosus | intermediate filament protein | 0.0026 | 1 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0018 | 0.4151 | 0.5 |
Toxoplasma gondii | exonuclease III APE | 0.0018 | 0.4151 | 0.5 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0018 | 0.4151 | 0.5 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.4151 | 0.5 |
Schistosoma mansoni | lamin | 0.0026 | 1 | 1 |
Echinococcus multilocularis | musashi | 0.0026 | 1 | 1 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.4151 | 0.5 |
Onchocerca volvulus | 0.0026 | 1 | 0.5 | |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0018 | 0.4151 | 0.5 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0018 | 0.4151 | 0.3482 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0018 | 0.4151 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.9646 | 0.9646 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0018 | 0.4151 | 0.4151 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0.4151 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | ND 0 uM | TNF-alpha production in PBMC by ELISA method. | ChEMBL. | 8568809 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.