Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | carboxylesterase 5A | 0.1097 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.1097 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.1097 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.1097 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1097 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.1097 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.1097 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1097 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.1097 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.1097 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1097 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1097 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 1.9 mg kg-1 | Analgesic activity tested by phenylquinone induced writhing test in mice | ChEMBL. | 3086559 |
ED50 (functional) | = 1.9 mg kg-1 | Analgesic activity tested by phenylquinone induced writhing test in mice | ChEMBL. | 3086559 |
ID50 (binding) | = 2 ug ml-1 | Ability to inhibit prostaglandin synthetase ([3H]-PGE2 synthesis) from [3H]-arachidonic acid in bovine seminal vesicles | ChEMBL. | 3086559 |
ID50 (binding) | = 2 ug ml-1 | Ability to inhibit prostaglandin synthetase ([3H]-PGE2 synthesis) from [3H]-arachidonic acid in bovine seminal vesicles | ChEMBL. | 3086559 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.