Detailed information for compound 301605

Basic information

Technical information
  • TDR Targets ID: 301605
  • Name: 4-amino-5-fluoro-3,4-dihydro-1H-pyrimidin-2-o ne
  • MW: 131.108 | Formula: C4H6FN3O
  • H donors: 3 H acceptors: 1 LogP: -1.62 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1NC=C(C(N1)N)F
  • InChi: 1S/C4H6FN3O/c5-2-1-7-4(9)8-3(2)6/h1,3H,6H2,(H2,7,8,9)
  • InChiKey: SGJHJTLXTSZBRW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-azanyl-5-fluoro-3,4-dihydro-1H-pyrimidin-2-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.0222 0.0042
Echinococcus multilocularis neuropeptide FF receptor 2 0.007 0.0222 0.0042
Loa Loa (eye worm) hypothetical protein 0.1709 1 1
Loa Loa (eye worm) hypothetical protein 0.007 0.0222 0.0222
Brugia malayi RE15519p 0.007 0.0222 0.0222
Loa Loa (eye worm) hypothetical protein 0.007 0.0222 0.0222
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.0222 0.0222
Loa Loa (eye worm) hypothetical protein 0.007 0.0222 0.0222
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0091 0.0091
Echinococcus multilocularis G protein coupled receptor 139 0.007 0.0222 0.0042
Loa Loa (eye worm) hypothetical protein 0.007 0.0222 0.0222
Loa Loa (eye worm) hypothetical protein 0.1709 1 1
Loa Loa (eye worm) hypothetical protein 0.0289 0.1526 0.1526
Echinococcus granulosus rhodopsin orphan GPCR 0.007 0.0222 0.0042
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.007 0.0222 0.0042
Loa Loa (eye worm) hypothetical protein 0.007 0.0222 0.0222
Echinococcus granulosus carboxylesterase 5A 0.1709 1 1
Brugia malayi neuropeptide F receptor 0.007 0.0222 0.0222
Schistosoma mansoni BC026374 protein (S09 family) 0.0289 0.1526 0.1526
Echinococcus multilocularis neuropeptide receptor 0.007 0.0222 0.0042
Brugia malayi sulfakinin receptor protein 0.007 0.0222 0.0222
Brugia malayi hypothetical protein 0.007 0.0222 0.0222
Brugia malayi G-protein coupled receptor 0.007 0.0222 0.0222
Loa Loa (eye worm) hypothetical protein 0.007 0.0222 0.0222
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.007 0.0222 0.0222
Brugia malayi larval opioid receptor 0.007 0.0222 0.0222
Brugia malayi G protein-coupled receptor F59B2.13 0.007 0.0222 0.0222
Loa Loa (eye worm) hypothetical protein 0.007 0.0222 0.0222
Loa Loa (eye worm) hypothetical protein 0.007 0.0222 0.0222
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.1709 1 1
Loa Loa (eye worm) hypothetical protein 0.007 0.0222 0.0222
Echinococcus multilocularis neuropeptide s receptor 0.007 0.0222 0.0042
Schistosoma mansoni opsin-like receptor 0.007 0.0222 0.0222
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0289 0.1526 0.1526
Schistosoma mansoni amine GPCR 0.007 0.0222 0.0222
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.0222 0.0042
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.0222 0.0042
Echinococcus granulosus neuropeptides capa receptor 0.007 0.0222 0.0042
Echinococcus multilocularis somatostatin receptor 0.007 0.0222 0.0042
Echinococcus granulosus rhodopsin orphan GPCR 0.007 0.0222 0.0042
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.0222 0.0042
Echinococcus granulosus serotonin receptor 0.007 0.0222 0.0042
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.007 0.0222 0.0042
Brugia malayi AKH receptor 0.007 0.0222 0.0222
Brugia malayi Tachykinin-like peptides receptor 99D 0.007 0.0222 0.0222
Echinococcus multilocularis acetylcholinesterase 0.1709 1 1
Schistosoma mansoni neuroligin 3 (S09 family) 0.0289 0.1526 0.1526
Schistosoma mansoni neuropeptide F-like receptor 0.007 0.0222 0.0222
Loa Loa (eye worm) hypothetical protein 0.007 0.0222 0.0222
Brugia malayi ORL1-like opioid receptor 0.007 0.0222 0.0222
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.007 0.0222 0.0042
Schistosoma mansoni biogenic amine receptor 0.007 0.0222 0.0222
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.0222 0.0042
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.007 0.0222 0.0042
Echinococcus granulosus biogenic amine 5HT receptor 0.007 0.0222 0.0042
Loa Loa (eye worm) melatonin receptor type 1A 0.007 0.0222 0.0222
Echinococcus granulosus dro:myosuppressin receptor 0.007 0.0222 0.0042
Schistosoma mansoni hypothetical protein 0.007 0.0222 0.0222
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0289 0.1526 0.5
Loa Loa (eye worm) carboxylesterase 0.1709 1 1
Brugia malayi Serotonin receptor 0.007 0.0222 0.0222
Brugia malayi hypothetical protein 0.007 0.0222 0.0222
Echinococcus multilocularis serotonin receptor 0.007 0.0222 0.0042
Schistosoma mansoni neuropeptide F-like receptor 0.007 0.0222 0.0222
Echinococcus multilocularis serotonin receptor 0.007 0.0222 0.0042
Loa Loa (eye worm) hypothetical protein 0.007 0.0222 0.0222
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0289 0.1526 0.1371
Echinococcus granulosus neuropeptide receptor A26 0.007 0.0222 0.0042
Brugia malayi putative neuropeptide receptor 0.007 0.0222 0.0222
Schistosoma mansoni hypothetical protein 0.007 0.0222 0.0222
Schistosoma mansoni neuropeptide receptor 0.007 0.0222 0.0222
Schistosoma mansoni adenoreceptor 0.007 0.0222 0.0222
Echinococcus multilocularis fmrfamide receptor 0.007 0.0222 0.0042
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.007 0.0222 0.0042
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.007 0.0222 0.0222
Brugia malayi Dopamine receptor 0.007 0.0222 0.0222
Brugia malayi hypothetical protein 0.007 0.0222 0.0222
Schistosoma mansoni neuropeptide receptor 0.007 0.0222 0.0222
Echinococcus granulosus rhodopsin orphan GPCR 0.007 0.0222 0.0042
Echinococcus granulosus para nitrobenzyl esterase 0.0289 0.1526 0.1371
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.007 0.0222 0.0222
Brugia malayi hypothetical protein 0.007 0.0222 0.0222
Brugia malayi Dopamine receptor protein 1 0.007 0.0222 0.0222
Loa Loa (eye worm) hypothetical protein 0.007 0.0222 0.0222
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.0222 0.0042
Echinococcus multilocularis g protein coupled receptor 0.007 0.0222 0.0042
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.007 0.0222 0.0222
Schistosoma mansoni myosin xvIII 0.007 0.0222 0.0222
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.007 0.0222 0.0222
Echinococcus granulosus neuropeptide receptor 0.007 0.0222 0.0042
Loa Loa (eye worm) hypothetical protein 0.007 0.0222 0.0222
Echinococcus multilocularis neuropeptide receptor 0.007 0.0222 0.0042
Echinococcus multilocularis BC026374 protein (S09 family) 0.0289 0.1526 0.1371
Echinococcus multilocularis g protein coupled receptor 0.007 0.0222 0.0042
Loa Loa (eye worm) hypothetical protein 0.007 0.0222 0.0222
Loa Loa (eye worm) G-protein coupled receptor 0.007 0.0222 0.0222
Echinococcus granulosus rhodopsin orphan GPCR 0.007 0.0222 0.0042
Echinococcus granulosus g protein coupled receptor 0.007 0.0222 0.0042
Onchocerca volvulus 0.0289 0.1526 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.0222 0.0222
Echinococcus multilocularis orexin receptor type 2 0.007 0.0222 0.0042
Loa Loa (eye worm) hypothetical protein 0.007 0.0222 0.0222
Loa Loa (eye worm) carboxylesterase 0.0289 0.1526 0.1526
Loa Loa (eye worm) hypothetical protein 0.0289 0.1526 0.1526
Loa Loa (eye worm) carboxylesterase 0.0289 0.1526 0.1526
Echinococcus multilocularis g protein coupled receptor 0.007 0.0222 0.0042
Onchocerca volvulus 0.0289 0.1526 1
Schistosoma mansoni mucolipin 0.0063 0.018 0.018
Echinococcus multilocularis sex peptide receptor 0.007 0.0222 0.0042
Loa Loa (eye worm) hypothetical protein 0.007 0.0222 0.0222
Echinococcus multilocularis allatostatin A receptor 0.007 0.0222 0.0042
Echinococcus granulosus acetylcholinesterase 0.1709 1 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.007 0.0222 0.0042
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.0222 0.0222
Echinococcus granulosus rhodopsin orphan GPCR 0.007 0.0222 0.0042
Schistosoma mansoni neuropeptide receptor 0.007 0.0222 0.0222
Echinococcus multilocularis neuroligin 0.0289 0.1526 0.1371
Brugia malayi hypothetical protein 0.007 0.0222 0.0222
Loa Loa (eye worm) hypothetical protein 0.007 0.0222 0.0222
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.0222 0.0222
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.007 0.0222 0.0222
Onchocerca volvulus 0.0289 0.1526 1
Echinococcus multilocularis dro:myosuppressin receptor 0.007 0.0222 0.0042
Schistosoma mansoni alpha-1 adrenergic receptor 0.007 0.0222 0.0222
Brugia malayi Carboxylesterase family protein 0.1709 1 1
Echinococcus multilocularis neuropeptides capa receptor 0.007 0.0222 0.0042
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.007 0.0222 0.0042
Echinococcus multilocularis fmrfamide receptor 0.007 0.0222 0.0042
Schistosoma mansoni acetylcholinesterase 0.0289 0.1526 0.1526
Loa Loa (eye worm) hypothetical protein 0.0289 0.1526 0.1526
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.007 0.0222 0.0042
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0289 0.1526 0.5
Brugia malayi hypothetical protein 0.0289 0.1526 0.1526
Loa Loa (eye worm) hypothetical protein 0.007 0.0222 0.0222
Echinococcus multilocularis tachykinin peptides receptor 99D 0.007 0.0222 0.0042
Echinococcus multilocularis G-protein coupled receptor, putative 0.007 0.0222 0.0042
Echinococcus granulosus rhodopsin orphan GPCR 0.007 0.0222 0.0042
Echinococcus granulosus biogenic amine 5HT receptor 0.007 0.0222 0.0042
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.0222 0.0222
Schistosoma mansoni opsin-like receptor 0.007 0.0222 0.0222
Brugia malayi follicle stimulating hormone receptor 0.007 0.0222 0.0222
Loa Loa (eye worm) hypothetical protein 0.007 0.0222 0.0222
Schistosoma mansoni biogenic amine (5HT) receptor 0.007 0.0222 0.0222
Brugia malayi gonadotropin-releasing hormone receptor 2 0.007 0.0222 0.0222
Loa Loa (eye worm) hypothetical protein 0.007 0.0222 0.0222
Schistosoma mansoni mucolipin 0.0058 0.0148 0.0148
Schistosoma mansoni hypothetical protein 0.0164 0.0782 0.0782
Echinococcus granulosus neuropeptides capa receptor 0.007 0.0222 0.0042
Echinococcus multilocularis neuropeptide receptor A26 0.007 0.0222 0.0042
Echinococcus granulosus peptide allatostatin:somatostatin 0.007 0.0222 0.0042
Schistosoma mansoni neuropeptide receptor 0.007 0.0222 0.0222
Echinococcus multilocularis acetylcholinesterase 0.1709 1 1
Brugia malayi Melatonin receptor type 1A 0.007 0.0222 0.0222
Echinococcus multilocularis g-protein coupled receptor 0.007 0.0222 0.0042
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.007 0.0222 0.0222
Echinococcus granulosus g protein coupled receptor 0.007 0.0222 0.0042
Loa Loa (eye worm) TYRA-2 protein 0.007 0.0222 0.0222
Brugia malayi Coelomocyte uptake defective protein 5 0.0063 0.018 0.018
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0289 0.1526 0.1526
Echinococcus granulosus BC026374 protein S09 family 0.0289 0.1526 0.1371
Schistosoma mansoni biogenic amine (dopamine) receptor 0.007 0.0222 0.0222
Echinococcus granulosus 7tm_1 domain containing protein 0.007 0.0222 0.0042
Brugia malayi hypothetical protein 0.007 0.0222 0.0222
Schistosoma mansoni neuropeptide f receptor 76f 0.007 0.0222 0.0222
Loa Loa (eye worm) hypothetical protein 0.007 0.0222 0.0222
Loa Loa (eye worm) hypothetical protein 0.007 0.0222 0.0222
Echinococcus multilocularis neuropeptide Y receptor 0.007 0.0222 0.0042
Onchocerca volvulus 0.0289 0.1526 1
Schistosoma mansoni biogenic amine receptor 0.007 0.0222 0.0222
Brugia malayi hypothetical protein 0.007 0.0222 0.0222
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.0222 0.0042
Loa Loa (eye worm) hypothetical protein 0.0289 0.1526 0.1526
Echinococcus granulosus neuropeptide s receptor 0.007 0.0222 0.0042
Brugia malayi hypothetical protein 0.007 0.0222 0.0222
Schistosoma mansoni growth hormone secretagogue receptor 0.007 0.0222 0.0222
Echinococcus granulosus geminin 0.0164 0.0782 0.0613
Brugia malayi G protein-coupled receptor 0.007 0.0222 0.0222
Loa Loa (eye worm) hypothetical protein 0.0289 0.1526 0.1526
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.007 0.0222 0.0042
Schistosoma mansoni amine GPCR 0.007 0.0222 0.0222
Schistosoma mansoni peptide (allatostatin)-like receptor 0.007 0.0222 0.0222
Echinococcus granulosus rhodopsin orphan GPCR 0.007 0.0222 0.0042
Loa Loa (eye worm) hypothetical protein 0.007 0.0222 0.0222
Brugia malayi putative neuropeptide receptor NPR1 0.007 0.0222 0.0222
Echinococcus granulosus allatostatin A receptor 0.007 0.0222 0.0042
Loa Loa (eye worm) hypothetical protein 0.007 0.0222 0.0222
Loa Loa (eye worm) hypothetical protein 0.007 0.0222 0.0222
Schistosoma mansoni amine GPCR 0.007 0.0222 0.0222
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.007 0.0222 0.0222
Schistosoma mansoni amine GPCR 0.007 0.0222 0.0222
Loa Loa (eye worm) hypothetical protein 0.007 0.0222 0.0222
Loa Loa (eye worm) hypothetical protein 0.007 0.0222 0.0222
Loa Loa (eye worm) hypothetical protein 0.007 0.0222 0.0222
Echinococcus granulosus neuroligin 0.0289 0.1526 0.1371
Schistosoma mansoni biogenic amine receptor 0.007 0.0222 0.0222
Brugia malayi hypothetical protein 0.007 0.0222 0.0222
Schistosoma mansoni amine GPCR 0.007 0.0222 0.0222
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.007 0.0222 0.0222
Echinococcus granulosus thyrotropin releasing hormone receptor 0.007 0.0222 0.0042
Loa Loa (eye worm) mucolipin 1 0.0063 0.018 0.018
Loa Loa (eye worm) hypothetical protein 0.007 0.0222 0.0222
Loa Loa (eye worm) neuropeptide F receptor 0.007 0.0222 0.0222
Schistosoma mansoni gliotactin 0.0289 0.1526 0.1526
Loa Loa (eye worm) hypothetical protein 0.007 0.0222 0.0222
Brugia malayi Carboxylesterase family protein 0.0289 0.1526 0.1526
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0785 0.4488 0.4387
Brugia malayi Carboxylesterase family protein 0.0289 0.1526 0.1526
Brugia malayi neuropeptide F receptor 0.007 0.0222 0.0222
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.0222 0.0042
Echinococcus multilocularis neuropeptides capa receptor 0.007 0.0222 0.0042
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0091 0.0091
Echinococcus granulosus tachykinin peptides receptor 99D 0.007 0.0222 0.0042
Echinococcus granulosus tm gpcr rhodopsin 0.007 0.0222 0.0042
Echinococcus granulosus tm gpcr rhodopsin 0.007 0.0222 0.0042
Schistosoma mansoni hypothetical protein 0.007 0.0222 0.0222
Echinococcus granulosus 7TM GPCR rhodopsin 0.007 0.0222 0.0042
Echinococcus granulosus orexin receptor type 2 0.007 0.0222 0.0042
Loa Loa (eye worm) hypothetical protein 0.0048 0.0091 0.0091
Loa Loa (eye worm) follicle stimulating hormone receptor 0.007 0.0222 0.0222
Schistosoma mansoni biogenic amine (dopamine) receptor 0.007 0.0222 0.0222
Loa Loa (eye worm) hypothetical protein 0.007 0.0222 0.0222
Trichomonas vaginalis spcc417.12 protein, putative 0.0289 0.1526 0.5
Echinococcus granulosus g-protein coupled receptor 0.007 0.0222 0.0042
Loa Loa (eye worm) G-protein coupled receptor 0.007 0.0222 0.0222
Echinococcus granulosus neuropeptide Y receptor 0.007 0.0222 0.0042
Echinococcus granulosus hypothetical protein 0.007 0.0222 0.0042
Schistosoma mansoni histamine h1 receptor 0.007 0.0222 0.0222
Schistosoma mansoni biogenic amine (5HT) receptor 0.007 0.0222 0.0222
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.007 0.0222 0.0042
Echinococcus multilocularis carboxylesterase 5A 0.1709 1 1
Brugia malayi G-protein coupled receptor 0.007 0.0222 0.0222
Loa Loa (eye worm) hypothetical protein 0.007 0.0222 0.0222
Echinococcus granulosus alpha 1A adrenergic receptor 0.007 0.0222 0.0042
Echinococcus granulosus neuropeptide FF receptor 2 0.007 0.0222 0.0042
Echinococcus multilocularis neuropeptide Y receptor 0.007 0.0222 0.0042
Onchocerca volvulus 0.0289 0.1526 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.007 0.0222 0.0222
Mycobacterium tuberculosis Carboxylesterase LipT 0.0289 0.1526 0.5
Echinococcus granulosus g protein coupled receptor 0.007 0.0222 0.0042
Loa Loa (eye worm) hypothetical protein 0.007 0.0222 0.0222
Loa Loa (eye worm) hypothetical protein 0.007 0.0222 0.0222
Brugia malayi Carboxylesterase family protein 0.0289 0.1526 0.1526
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0289 0.1526 0.1371
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.007 0.0222 0.0042
Brugia malayi Serotonin receptor 0.007 0.0222 0.0222
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.0222 0.0222
Echinococcus multilocularis geminin 0.0164 0.0782 0.0613
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0091 0.0091
Echinococcus granulosus neuropeptide Y receptor 0.007 0.0222 0.0042
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.007 0.0222 0.0222
Schistosoma mansoni opsin-like receptor 0.007 0.0222 0.0222
Loa Loa (eye worm) hypothetical protein 0.007 0.0222 0.0222
Loa Loa (eye worm) hypothetical protein 0.007 0.0222 0.0222
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.007 0.0222 0.0042
Brugia malayi Serotonin/octopamine receptor family protein 7 0.007 0.0222 0.0222
Mycobacterium ulcerans carboxylesterase, LipT 0.0289 0.1526 0.5
Echinococcus granulosus tm gpcr rhodopsin 0.007 0.0222 0.0042
Loa Loa (eye worm) acetylcholinesterase 1 0.1709 1 1
Loa Loa (eye worm) hypothetical protein 0.007 0.0222 0.0222
Loa Loa (eye worm) hypothetical protein 0.007 0.0222 0.0222
Schistosoma mansoni hypothetical protein 0.007 0.0222 0.0222
Loa Loa (eye worm) hypothetical protein 0.0289 0.1526 0.1526
Loa Loa (eye worm) hypothetical protein 0.007 0.0222 0.0222
Echinococcus multilocularis para nitrobenzyl esterase 0.0289 0.1526 0.1371
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.0222 0.0222
Loa Loa (eye worm) hypothetical protein 0.007 0.0222 0.0222
Echinococcus multilocularis alpha 1A adrenergic receptor 0.007 0.0222 0.0042
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.007 0.0222 0.0222
Echinococcus granulosus acetylcholinesterase 0.1709 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.0222 0.0222
Brugia malayi Carboxylesterase family protein 0.0289 0.1526 0.1526
Echinococcus granulosus fmrfamide receptor 0.007 0.0222 0.0042
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.007 0.0222 0.0042
Loa Loa (eye worm) hypothetical protein 0.007 0.0222 0.0222
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.0222 0.0222
Brugia malayi hypothetical protein 0.007 0.0222 0.0222
Schistosoma mansoni hypothetical protein 0.0164 0.0782 0.0782
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.007 0.0222 0.0222
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.007 0.0222 0.0222
Echinococcus granulosus somatostatin receptor 0.007 0.0222 0.0042
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.007 0.0222 0.0042
Echinococcus granulosus G protein coupled receptor 139 0.007 0.0222 0.0042
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.007 0.0222 0.0222
Loa Loa (eye worm) hypothetical protein 0.007 0.0222 0.0222
Loa Loa (eye worm) hypothetical protein 0.007 0.0222 0.0222
Brugia malayi Dopamine receptor protein 2 0.007 0.0222 0.0222
Loa Loa (eye worm) hypothetical protein 0.0289 0.1526 0.1526
Loa Loa (eye worm) hypothetical protein 0.007 0.0222 0.0222
Echinococcus granulosus neuropeptide receptor 0.007 0.0222 0.0042
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.007 0.0222 0.0042
Loa Loa (eye worm) hypothetical protein 0.007 0.0222 0.0222
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.007 0.0222 0.0222
Echinococcus granulosus sex peptide receptor 0.007 0.0222 0.0042
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0289 0.1526 0.1526
Loa Loa (eye worm) neuropeptide F receptor 0.007 0.0222 0.0222
Echinococcus multilocularis biogenic amine (5HT) receptor 0.007 0.0222 0.0042
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.007 0.0222 0.0042
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0289 0.1526 0.5
Schistosoma mansoni biogenic amine (dopamine) receptor 0.007 0.0222 0.0222
Brugia malayi GnHR receptor homolog 0.007 0.0222 0.0222

Activities

Activity type Activity value Assay description Source Reference
MIC (ADMET) = 0.04 ug ml-1 Toxicity of the compound against S. cerevisiae Z1-2D at a pH of 5.0 ChEMBL. 6995613
MIC (ADMET) = 0.08 ug ml-1 Toxicity of the compound against S. cerevisiae ATCC 9763 at a pH of 5.0 ChEMBL. 6995613
MIC (ADMET) = 0.32 ug ml-1 Toxicity of the compound against S. cerevisiae ATCC 9763 at a pH of 7.2 ChEMBL. 6995613
MIC (ADMET) = 0.63 ug ml-1 Toxicity of the compound against Candida albicans WD 18-4 at a pH of 5.0 ChEMBL. 6995613
MIC (ADMET) = 0.63 ug ml-1 Toxicity of the compound against Candida albicans WD 18-4 at a pH of 5.0 ChEMBL. 6995613
MIC (ADMET) = 1.25 ug ml-1 Toxicity of the compound against Candida albicans WD 18-4 at a pH of 7.2 ChEMBL. 6995613
MIC (ADMET) = 1.25 ug ml-1 Toxicity of the compound against Candida albicans WD I-V at a pH of 7.2 ChEMBL. 6995613
MIC (ADMET) = 1.25 ug ml-1 Toxicity of the compound against Candida albicans IV at a pH of 5.0 ChEMBL. 6995613
MIC (ADMET) = 1.25 ug ml-1 Toxicity of the compound against Candida albicans WD 18-4 at a pH of 7.2 ChEMBL. 6995613
MIC (ADMET) = 1.25 ug ml-1 Toxicity of the compound against Candida albicans WD I-V at a pH of 7.2 ChEMBL. 6995613
MIC (ADMET) = 1.25 ug ml-1 Toxicity of the compound against Candida albicans IV at a pH of 5.0 ChEMBL. 6995613
MIC (ADMET) = 2.5 ug ml-1 Toxicity of the compound against Candida krusei I-T at a pH of 5.0 ChEMBL. 6995613
MIC (ADMET) = 10 ug ml-1 Toxicity of the compound against Candida krusei I-T at a pH of 7.2 ChEMBL. 6995613

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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