TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 375.464 | Formula: C23H25N3O2
H donors: 2 H acceptors: 0 LogP: 4.1 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: C/N=C(\Nc1ccc(c(c1)OCCc1ccccc1)OCc1ccccc1)/N
InChi: 1S/C23H25N3O2/c1-25-23(24)26-20-12-13-21(28-17-19-10-6-3-7-11-19)22(16-20)27-15-14-18-8-4-2-5-9-18/h2-13,16H,14-15,17H2,1H3,(H3,24,25,26)
InChiKey: GECOAQNIUKBYLB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	oxidoreductase-protein, putative	0.0037	0.0157	0.0277
Echinococcus multilocularis	methionine synthase reductase	0.0201	0.3297	0.3297
Toxoplasma gondii	NADPH-glutathione reductase	0.0109	0.1526	0.2803
Brugia malayi	Intermediate filament tail domain containing protein	0.0032	0.0061	0.0107
Leishmania major	cytochrome-b5 reductase, putative	0.0037	0.0157	0.0277
Loa Loa (eye worm)	flavodoxin family protein	0.0125	0.1833	0.3226
Echinococcus granulosus	neuropeptide receptor A26	0.0552	1	1
Echinococcus granulosus	intermediate filament protein	0.0032	0.0061	0.0061
Brugia malayi	flavodoxin family protein	0.0326	0.5682	1
Loa Loa (eye worm)	FAD binding domain-containing protein	0.0326	0.5682	1
Schistosoma mansoni	diflavin oxidoreductase	0.0162	0.2541	0.4473
Trichomonas vaginalis	glutathione reductase, putative	0.0109	0.1526	0.2685
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0109	0.1526	0.1526
Schistosoma mansoni	cytochrome P450 reductase	0.0326	0.5682	1
Schistosoma mansoni	intermediate filament proteins	0.0032	0.0061	0.0107
Leishmania major	NADH-dependent fumarate reductase, putative	0.0037	0.0157	0.0277
Schistosoma mansoni	cytochrome B5	0.0037	0.0157	0.0277
Trypanosoma cruzi	cytochrome P450 reductase, putative	0.0326	0.5682	1
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0109	0.1526	0.2685
Mycobacterium tuberculosis	Hypothetical oxidoreductase	0.0037	0.0157	0.0289
Leishmania major	NADH-cytochrome b5 reductase, putative	0.0037	0.0157	0.0277
Leishmania major	hypothetical protein, conserved	0.0125	0.1833	0.3226
Loa Loa (eye worm)	FAD binding domain-containing protein	0.0201	0.3297	0.5804
Onchocerca volvulus		0.0037	0.0157	1
Schistosoma mansoni	lamin	0.0032	0.0061	0.0107
Echinococcus granulosus	cytochrome b5 reductase 4	0.0037	0.0157	0.0157
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0109	0.1526	0.2685
Giardia lamblia	Nitric oxide synthase, inducible	0.0289	0.4973	1
Echinococcus multilocularis	lamin	0.0032	0.0061	0.0061
Brugia malayi	intermediate filament protein	0.0032	0.0061	0.0107
Schistosoma mansoni	5-methyl tetrahydrofolate-homocysteine methyltransferase reductase	0.0201	0.3297	0.5804
Trypanosoma cruzi	cytochrome-b5 reductase, putative	0.0037	0.0157	0.0277
Mycobacterium ulcerans	formate dehydrogenase H FdhF	0.0326	0.5682	1
Echinococcus multilocularis	NADPH cytochrome P450 reductase	0.0326	0.5682	0.5682
Leishmania major	oxidoreductase-like protein	0.0037	0.0157	0.0277
Leishmania major	NADH-cytochrome b5 reductase, putative	0.0037	0.0157	0.0277
Trypanosoma brucei	NADPH--cytochrome P450 reductase, putative	0.0326	0.5682	1
Entamoeba histolytica	type A flavoprotein, putative	0.0125	0.1833	1
Trichomonas vaginalis	NADPH cytochrome P450, putative	0.0125	0.1833	0.3226
Plasmodium falciparum	glutathione reductase	0.0314	0.5442	0.9579
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0061	0.0107
Entamoeba histolytica	type A flavoprotein, putative	0.0125	0.1833	1
Mycobacterium ulcerans	oxygenase	0.0037	0.0157	0.0277
Onchocerca volvulus		0.0032	0.0061	0.3868
Trypanosoma cruzi	NADPH-dependent FMN/FAD containing oxidoreductase, putative	0.0326	0.5682	1
Trypanosoma cruzi	NADH-dependent fumarate reductase, putative	0.0037	0.0157	0.0277
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0109	0.1526	0.2685
Mycobacterium tuberculosis	Probable oxidoreductase	0.0109	0.1526	0.2803
Trichomonas vaginalis	sulfite reductase, putative	0.0326	0.5682	1
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0109	0.1526	0.2685
Leishmania major	p450 reductase, putative	0.0326	0.5682	1
Leishmania major	cytochrome P450 reductase, putative	0.0289	0.4973	0.8753
Trypanosoma cruzi	p450 reductase, putative	0.0326	0.5682	1
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0109	0.1526	0.2685
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0109	0.1526	0.2685
Entamoeba histolytica	type A flavoprotein, putative	0.0125	0.1833	1
Plasmodium vivax	flavodoxin domain containing protein	0.0289	0.4973	0.8753
Trypanosoma cruzi	NADPH--cytochrome P450 reductase, putative	0.0125	0.1833	0.3226
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0109	0.1526	0.2803
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0109	0.1526	0.2685
Treponema pallidum	flavodoxin	0.0125	0.1833	1
Giardia lamblia	Hypothetical protein	0.0289	0.4973	1
Trypanosoma brucei	NADH-cytochrome b5 reductase, putative	0.0037	0.0157	0.0277
Plasmodium falciparum	ferredoxin--NADP reductase	0.0037	0.0157	0.0277
Trypanosoma cruzi	NADH-dependent fumarate reductase, putative	0.0037	0.0157	0.0277
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0032	0.0061	0.0107
Brugia malayi	FAD binding domain containing protein	0.0201	0.3297	0.5804
Trypanosoma brucei	NADPH--cytochrome P450 reductase, putative	0.0326	0.5682	1
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0109	0.1526	0.3068
Brugia malayi	glutathione reductase	0.0314	0.5442	0.9579
Trypanosoma cruzi	reductase, putative	0.0037	0.0157	0.0277
Mycobacterium tuberculosis	Probable monooxygenase	0.0037	0.0157	0.0289
Trypanosoma cruzi	NADH-cytochrome b5 reductase, putative	0.0037	0.0157	0.0277
Trypanosoma cruzi	Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative	0.0125	0.1833	0.3226
Trypanosoma cruzi	NADH-cytochrome b5 reductase, putative	0.0037	0.0157	0.0277
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0109	0.1526	0.2803
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0109	0.1526	0.2685
Leishmania major	nitrate reductase, putative	0.0037	0.0157	0.0277
Echinococcus multilocularis	cytochrome b5 reductase 4	0.0037	0.0157	0.0157
Chlamydia trachomatis	Na(+)-translocating NADH-quinone reductase subunit F	0.0037	0.0157	0.0477
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0109	0.1526	0.1526
Plasmodium falciparum	thioredoxin reductase	0.0109	0.1526	0.2685
Plasmodium vivax	oxidoreductase NAD-binding domain containing protein	0.0037	0.0157	0.0277
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.008	0.0974	0.1715
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0109	0.1526	0.2685
Echinococcus multilocularis	musashi	0.0032	0.0061	0.0061
Schistosoma mansoni	NADPH flavin oxidoreductase	0.0164	0.2589	0.4557
Echinococcus granulosus	lamin	0.0032	0.0061	0.0061
Trypanosoma cruzi	NADH-cytochrome b5 reductase, putative	0.0037	0.0157	0.0277
Trichomonas vaginalis	NADPH cytochrome P450, putative	0.0125	0.1833	0.3226
Trypanosoma cruzi	nitrate reductase, putative	0.0037	0.0157	0.0277
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0109	0.1526	0.2685
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0109	0.1526	0.2685
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0109	0.1526	0.4627
Echinococcus granulosus	thioredoxin glutathione reductase	0.0314	0.5442	0.5442
Mycobacterium tuberculosis	Probable oxidoreductase	0.0037	0.0157	0.0289
Giardia lamblia	Flavohemoprotein lateral transfer candidate	0.0037	0.0157	0.0316
Trypanosoma brucei	trypanothione reductase	0.0314	0.5442	0.9579
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0109	0.1526	0.2685
Mycobacterium ulcerans	monooxygenase	0.0037	0.0157	0.0277
Brugia malayi	diaphorase	0.0037	0.0157	0.0277
Plasmodium falciparum	S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative	0.0125	0.1833	0.3226
Brugia malayi	FAD binding domain containing protein	0.0326	0.5682	1
Trichomonas vaginalis	mercuric reductase, putative	0.0109	0.1526	0.2685
Schistosoma mansoni	lamin	0.0032	0.0061	0.0107
Toxoplasma gondii	flavodoxin domain-containing protein	0.0162	0.2541	0.467
Chlamydia trachomatis	sulfite reductase	0.0201	0.3297	1
Trypanosoma cruzi	NADH-cytochrome b5 reductase, putative	0.0037	0.0157	0.0277
Trypanosoma cruzi	cytochrome P450 reductase, putative	0.0326	0.5682	1
Toxoplasma gondii	NADH-cytochrome b5 reductase 1, putative	0.0037	0.0157	0.0289
Trypanosoma cruzi	Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative	0.0125	0.1833	0.3226
Trypanosoma cruzi	p450 reductase, putative	0.0037	0.0157	0.0277
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0109	0.1526	0.2685
Trypanosoma cruzi	NADH-dependent fumarate reductase, putative	0.0037	0.0157	0.0277
Echinococcus granulosus	NADPH cytochrome P450 reductase	0.0326	0.5682	0.5682
Trypanosoma cruzi	trypanothione reductase, putative	0.0314	0.5442	0.9579
Trypanosoma brucei	NADH-cytochrome b5 reductase, putative	0.0037	0.0157	0.0277
Echinococcus multilocularis	NADPH dependent diflavin oxidoreductase 1	0.0326	0.5682	0.5682
Trypanosoma brucei	NADH-cytochrome b5 reductase, putative	0.0037	0.0157	0.0277
Echinococcus granulosus	NADPH dependent diflavin oxidoreductase 1	0.0326	0.5682	0.5682
Brugia malayi	Thioredoxin reductase	0.0314	0.5442	0.9579
Trypanosoma brucei	NADH-dependent fumarate reductase, putative	0.0037	0.0157	0.0277
Trypanosoma cruzi	NADH-cytochrome b5 reductase, putative	0.0037	0.0157	0.0277
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.0037	0.0157	0.0277
Trypanosoma cruzi	NADH-cytochrome b5 reductase, putative	0.0037	0.0157	0.0277
Trypanosoma brucei	NADH-cytochrome b5 reductase, putative	0.0037	0.0157	0.0277
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0109	0.1526	0.2685
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0109	0.1526	0.2685
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0109	0.1526	0.2685
Loa Loa (eye worm)	thioredoxin reductase	0.0314	0.5442	0.9579
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.008	0.0974	0.1715
Loa Loa (eye worm)	diaphorase	0.0037	0.0157	0.0277
Trypanosoma brucei	NADH-dependent fumarate reductase	0.0037	0.0157	0.0277
Mycobacterium ulcerans	flavodoxin reductase Hmp	0.0037	0.0157	0.0277
Mycobacterium tuberculosis	Possible electron transfer protein FdxB	0.0037	0.0157	0.0289
Plasmodium vivax	hypothetical protein, conserved	0.0125	0.1833	0.3226
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0109	0.1526	0.2685
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0109	0.1526	0.2685
Trichomonas vaginalis	NADPH cytochrome P450, putative	0.0125	0.1833	0.3226
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0109	0.1526	0.2685
Trypanosoma brucei	NADPH-cytochrome p450 reductase, putative	0.0326	0.5682	1
Toxoplasma gondii	thioredoxin reductase	0.0314	0.5442	1
Echinococcus granulosus	lamin dm0	0.0032	0.0061	0.0061
Trypanosoma cruzi	cytochrome-b5 reductase, putative	0.0037	0.0157	0.0277
Trichomonas vaginalis	NADPH fad oxidoreductase, putative	0.0289	0.4973	0.8753
Plasmodium falciparum	NADH-cytochrome b5 reductase, putative	0.0037	0.0157	0.0277
Plasmodium vivax	thioredoxin reductase, putative	0.0314	0.5442	0.9579
Plasmodium vivax	NADPH-cytochrome p450 reductase, putative	0.0326	0.5682	1
Leishmania major	NADPH-cytochrome p450 reductase-like protein	0.0326	0.5682	1
Loa Loa (eye worm)	intermediate filament protein	0.0032	0.0061	0.0107
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0109	0.1526	0.2803
Leishmania major	NADH-dependent fumarate reductase-like protein	0.0037	0.0157	0.0277
Trypanosoma brucei	S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative	0.0125	0.1833	0.3226
Trypanosoma cruzi	NADH-dependent fumarate reductase, putative	0.0037	0.0157	0.0277
Toxoplasma gondii	ferredoxin NADP+ oxidoreductase FNR	0.0037	0.0157	0.0289
Echinococcus multilocularis	neuropeptide s receptor	0.0552	1	1
Mycobacterium tuberculosis	Possible oxygenase	0.0037	0.0157	0.0289
Trypanosoma brucei	NADH-cytochrome b5 reductase-like protein	0.0037	0.0157	0.0277
Entamoeba histolytica	type A flavoprotein, putative	0.0125	0.1833	1
Toxoplasma gondii	flavodoxin domain-containing protein	0.0162	0.2541	0.467
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0109	0.1526	0.2685
Plasmodium falciparum	glutathione reductase	0.0109	0.1526	0.2685
Leishmania major	NADH-cytochrome b5 reductase, putative	0.0037	0.0157	0.0277
Trypanosoma brucei	NADH-cytochrome b5 reductase, putative	0.0037	0.0157	0.0277
Plasmodium vivax	ferredoxin--NADP reductase, putative	0.0037	0.0157	0.0277
Leishmania major	reductase, putative	0.0037	0.0157	0.0277
Trypanosoma brucei	NADPH-dependent diflavin oxidoreductase 1	0.0326	0.5682	1
Echinococcus granulosus	NADH cytochrome b5 reductase 3	0.0037	0.0157	0.0157
Plasmodium falciparum	thioredoxin reductase	0.0314	0.5442	0.9579
Trypanosoma cruzi	NADH-dependent fumarate reductase, putative	0.0037	0.0157	0.0277
Plasmodium vivax	glutathione reductase, putative	0.0314	0.5442	0.9579
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0109	0.1526	0.2685
Trypanosoma brucei	NADH-dependent fumarate reductase	0.0037	0.0157	0.0277
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0109	0.1526	0.2685
Trypanosoma cruzi	NADH-dependent fumarate reductase, putative	0.0037	0.0157	0.0277
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0314	0.5442	0.5442
Treponema pallidum	NADH oxidase	0.0109	0.1526	0.8324
Entamoeba histolytica	type A flavoprotein, putative	0.0125	0.1833	1
Brugia malayi	flavodoxin family protein	0.0125	0.1833	0.3226
Echinococcus multilocularis	lamin dm0	0.0032	0.0061	0.0061
Plasmodium falciparum	NADPH--cytochrome P450 reductase, putative	0.0125	0.1833	0.3226
Trichomonas vaginalis	NADPH cytochrome P450, putative	0.0125	0.1833	0.3226
Mycobacterium ulcerans	oxidoreductase	0.0037	0.0157	0.0277
Mycobacterium ulcerans	flavodoxin oxidoreductase	0.0037	0.0157	0.0277
Mycobacterium ulcerans	electron transfer protein FdxB	0.0037	0.0157	0.0277
Trypanosoma brucei	nitrate reductase, putative	0.0037	0.0157	0.0277
Trypanosoma brucei	NADH-cytochrome b5 reductase, putative	0.0037	0.0157	0.0277
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0109	0.1526	1
Leishmania major	cytochrome-b5 reductase, putative	0.0037	0.0157	0.0277
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0109	0.1526	0.2803
Loa Loa (eye worm)	hypothetical protein	0.0031	0.005	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0326	0.5682	1
Brugia malayi	Cytochrome b5-like Heme/Steroid binding domain containing protein	0.0037	0.0157	0.0277
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0109	0.1526	1
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0109	0.1526	0.2685
Schistosoma mansoni	NADH-cytochrome B5 reductase	0.0037	0.0157	0.0277
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0314	0.5442	1
Trypanosoma brucei	oxidoreductase-protein, putative	0.0037	0.0157	0.0277
Loa Loa (eye worm)	glutathione reductase	0.0314	0.5442	0.9579
Echinococcus multilocularis	NADH cytochrome b5 reductase 3	0.0037	0.0157	0.0157
Plasmodium falciparum	nitric oxide synthase, putative	0.0326	0.5682	1
Leishmania major	trypanothione reductase	0.0314	0.5442	0.9579
Onchocerca volvulus		0.0032	0.0061	0.3868
Treponema pallidum	ferredoxin-NADP(+) reductase subunit alpha	0.0037	0.0157	0.0858
Echinococcus multilocularis	neuropeptide receptor A26	0.0552	1	1
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0109	0.1526	1
Trypanosoma brucei	NADH-dependent fumarate reductase, putative	0.0037	0.0157	0.0277
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0109	0.1526	0.2685
Echinococcus granulosus	cytochrome b5 reductase 4	0.0037	0.0157	0.0157
Echinococcus granulosus	methionine synthase reductase	0.0201	0.3297	0.3297
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0109	0.1526	0.2685
Trypanosoma cruzi	trypanothione reductase, putative	0.0109	0.1526	0.2685
Loa Loa (eye worm)	cytochrome b5 reductase 4	0.0037	0.0157	0.0277

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (binding)	< 20 %	Tested in vitro for the inhibition against C5a anaphylatoxin chemotactic receptor assayed on human monocyte cell line U937; Inactive at 30 microM	ChEMBL.	No reference
Inhibition (binding)	< 20 %	Tested in vitro for the inhibition against C5a anaphylatoxin chemotactic receptor assayed on human monocyte cell line U937; Inactive at 30 microM	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

No literature references available for this target.

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Detailed information for compound 301629