Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0305 | 1 | 1 |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0154 | 0.4402 | 0.4402 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0305 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0305 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0305 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0155 | 0.4458 | 0.2046 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0155 | 0.4458 | 0.4458 |
Schistosoma mansoni | diflavin oxidoreductase | 0.0151 | 0.4316 | 0.4316 |
Plasmodium falciparum | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.0117 | 0.3033 | 0.3033 |
Mycobacterium tuberculosis | Hypothetical oxidoreductase | 0.0035 | 0 | 0.5 |
Brugia malayi | MAP kinase sur-1 | 0.0155 | 0.4458 | 0.4458 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0155 | 0.4458 | 0.5114 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0305 | 1 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0305 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0155 | 0.4458 | 0.4458 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0271 | 0.8717 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0189 | 0.5684 | 0.5684 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0305 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0155 | 0.4458 | 0.4458 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0305 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0155 | 0.4458 | 0.4458 |
Leishmania major | rac serine-threonine kinase, putative,protein kinase, putative | 0.0088 | 0.1958 | 0.1958 |
Mycobacterium tuberculosis | Probable monooxygenase | 0.0035 | 0 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0151 | 0.4316 | 0.968 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0305 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0117 | 0.3033 | 0.3033 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0305 | 1 | 1 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0271 | 0.8717 | 0.8159 |
Mycobacterium tuberculosis | Possible oxygenase | 0.0035 | 0 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0305 | 1 | 1 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0155 | 0.4458 | 0.4458 |
Trypanosoma cruzi | p450 reductase, putative | 0.0305 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0155 | 0.4458 | 0.2046 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0117 | 0.3033 | 0.5 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0305 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0117 | 0.3033 | 0.5 |
Leishmania major | cytochrome P450 reductase, putative | 0.0271 | 0.8717 | 0.8717 |
Chlamydia trachomatis | sulfite reductase | 0.0189 | 0.5684 | 1 |
Brugia malayi | ribosomal protein S6 kinase alpha 3 | 0.0088 | 0.1958 | 0.1958 |
Giardia lamblia | Hypothetical protein | 0.0271 | 0.8717 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0117 | 0.3033 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.0189 | 0.5684 | 0.5684 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0117 | 0.3033 | 0.5 |
Echinococcus multilocularis | ribosomal protein S6 kinase alpha 3 | 0.0102 | 0.2487 | 0.2487 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0155 | 0.4458 | 0.4458 |
Loa Loa (eye worm) | hypothetical protein | 0.0305 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0117 | 0.3033 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0102 | 0.2487 | 0.2487 |
Loa Loa (eye worm) | flavodoxin family protein | 0.0117 | 0.3033 | 0.3033 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.0102 | 0.2487 | 0.2487 |
Brugia malayi | FAD binding domain containing protein | 0.0305 | 1 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0305 | 1 | 1 |
Trypanosoma brucei | protein kinase, putative | 0.0155 | 0.4458 | 0.4458 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0305 | 1 | 1 |
Treponema pallidum | flavodoxin | 0.0117 | 0.3033 | 1 |
Brugia malayi | flavodoxin family protein | 0.0117 | 0.3033 | 0.3033 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0155 | 0.4458 | 0.4458 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0305 | 1 | 1 |
Trypanosoma cruzi | NADPH--cytochrome P450 reductase, putative | 0.0117 | 0.3033 | 0.3033 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0151 | 0.4316 | 0.968 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.0117 | 0.3033 | 0.3033 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0155 | 0.4458 | 0.4458 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0155 | 0.4458 | 0.2046 |
Plasmodium vivax | hypothetical protein, conserved | 0.0117 | 0.3033 | 0.3033 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0305 | 1 | 1 |
Echinococcus granulosus | methionine synthase reductase | 0.0189 | 0.5684 | 0.5684 |
Trypanosoma brucei | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.0117 | 0.3033 | 0.3033 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0155 | 0.4458 | 0.4458 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0155 | 0.4458 | 0.4458 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0305 | 1 | 1 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0271 | 0.8717 | 0.8717 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0155 | 0.4458 | 1 |
Mycobacterium tuberculosis | Possible electron transfer protein FdxB | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0189 | 0.5684 | 0.5684 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.0117 | 0.3033 | 0.3033 |
Giardia lamblia | Kinase, AGC AKT | 0.0088 | 0.1958 | 0.2246 |
Leishmania major | p450 reductase, putative | 0.0305 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0155 | 0.4458 | 0.2046 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0155 | 0.4458 | 0.4458 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0035 | 0 | 0.5 |
Echinococcus multilocularis | methionine synthase reductase | 0.0189 | 0.5684 | 0.5684 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0305 | 1 | 1 |
Echinococcus granulosus | ribosomal protein S6 kinase alpha 3 | 0.0102 | 0.2487 | 0.2487 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0155 | 0.4458 | 0.4458 |
Plasmodium falciparum | NADPH--cytochrome P450 reductase, putative | 0.0117 | 0.3033 | 0.3033 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0155 | 0.4458 | 0.4458 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Taste class (functional) | = 0 | Evaluated for the quality of taste by acting at receptor site | ChEMBL. | 3712380 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.