Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Staphylococcus aureus | Dihydrofolate reductase | Starlite/ChEMBL | References |
Escherichia coli | Dihydrofolate reductase | Starlite/ChEMBL | References |
Plasmodium berghei | bifunctional dihydrofolate reductase-thymidylate synthase, putative | Starlite/ChEMBL | References |
Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcuslactis) | Dihydrofolate reductase | Starlite/ChEMBL | References |
Neisseria gonorrhoeae | Dihydrofolate reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | dihydrofolate reductase | 0.0963 | 1 | 1 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0265 | 0.2254 | 0.1621 |
Brugia malayi | Dihydrofolate reductase | 0.0963 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0579 | 0.5748 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0963 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0963 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0963 | 1 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0963 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0963 | 1 | 1 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0265 | 0.2254 | 0.1621 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0062 | 0 | 0.5 |
Echinococcus multilocularis | serotonin receptor | 0.0265 | 0.2254 | 0.1621 |
Echinococcus granulosus | dihydrofolate reductase | 0.0963 | 1 | 1 |
Brugia malayi | thymidylate synthase | 0.013 | 0.0755 | 0.0755 |
Loa Loa (eye worm) | hypothetical protein | 0.0265 | 0.2254 | 0.1621 |
Loa Loa (eye worm) | hypothetical protein | 0.0265 | 0.2254 | 0.1621 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0579 | 0.5748 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.013 | 0.0755 | 0.0755 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0579 | 0.5748 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0963 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0579 | 0.5748 | 0.5 |
Onchocerca volvulus | 0.013 | 0.0755 | 0.5 | |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0579 | 0.5748 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0579 | 0.5748 | 1 |
Echinococcus multilocularis | serotonin receptor | 0.0265 | 0.2254 | 0.1621 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
I50 (binding) | = 4.4 M | In vitro inhibition of E. coli dihydrofolate reductase. | ChEMBL. | 2754716 |
I50 (binding) | = 6 M | In vitro inhibition of dihydrofolate reductase enzymes in Neisseria gonorrhoeae | ChEMBL. | 2754716 |
I50 (binding) | = 2100 M | In vitro inhibition of rat liver dihydrofolate reductase. | ChEMBL. | 2754716 |
I50 (binding) | = 200000000 M | Inhibitory activity against dihydrofolate reductase (DHFR) of Plasmodium berghei | ChEMBL. | 3100802 |
I50 (binding) | = 440000000 M | Inhibitory activity against dihydrofolate reductase (DHFR) from Escherichia coli | ChEMBL. | 3100802 |
I50 (binding) | = 600000000 M | Inhibitory activity against dihydrofolate reductase (DHFR) of Neisseria gonorrhoea | ChEMBL. | 3100802 |
I50 (binding) | = 210000000000 M | Inhibitory activity against dihydrofolate reductase (DHFR) from rat liver | ChEMBL. | 3100802 |
IC50 (binding) | = 0.00000002 M | Inhibitory activity against dihydrofolate reductase (DHFR) of Plasmodium berghei | ChEMBL. | 3100802 |
IC50 (binding) | = 0.000000044 M | In vitro inhibition of E. coli dihydrofolate reductase. | ChEMBL. | 2754716 |
IC50 (binding) | = 0.000000044 M | Inhibitory activity against dihydrofolate reductase (DHFR) from Escherichia coli | ChEMBL. | 3100802 |
IC50 (binding) | = 0.00000006 M | In vitro inhibition of dihydrofolate reductase enzymes in Neisseria gonorrhoeae | ChEMBL. | 2754716 |
IC50 (binding) | = 0.00000006 M | Inhibitory activity against dihydrofolate reductase (DHFR) of Neisseria gonorrhoea | ChEMBL. | 3100802 |
IC50 (binding) | = 0.000021 M | In vitro inhibition of rat liver dihydrofolate reductase. | ChEMBL. | 2754716 |
IC50 (binding) | = 0.000021 M | Inhibitory activity against dihydrofolate reductase (DHFR) from rat liver | ChEMBL. | 3100802 |
Ki (binding) | = 3.2 nM | Antibacterial activity against Staphylococcus aureus | ChEMBL. | 2754716 |
Ki (binding) | = 3.2 nM | Antibacterial activity against Staphylococcus aureus | ChEMBL. | 2754716 |
MIC (functional) | = 1 ug ml-1 | Inhibition of growth of Staphylococcus aureus (CN491) measured as MIC compound/MIC Trimethoprim | ChEMBL. | 3121854 |
MIC (functional) | = 1 ug ml-1 | Inhibition of growth of Mycobacterium smegmatis (S3254) measured as MIC compound/MIC Trimethoprim | ChEMBL. | 3121854 |
MIC (functional) | = 1 ug ml-1 | Inhibition of growth of serratia marcescens (CN2398) measured as MIC compound/MIC Trimethoprim | ChEMBL. | 3121854 |
MIC (functional) | = 10 ug ml-1 | Inhibition of growth of Vibrio cholera (ATCC14035) measured as MIC compound/MIC Trimethoprim | ChEMBL. | 3121854 |
MIC (functional) | = 30 ug ml-1 | Inhibition of growth of Escherichia coli (CN314) measured as MIC compound/MIC Trimethoprim | ChEMBL. | 3121854 |
MIC (functional) | = 30 ug ml-1 | Inhibition of growth of Klebsiella pneumoniae (CN3632) measured as MIC compound/MIC Trimethoprim | ChEMBL. | 3121854 |
MIC (functional) | = 30 ug ml-1 | Inhibition of growth of Proteus vulgaris (CN329) measured as MIC compound/MIC Trimethoprim | ChEMBL. | 3121854 |
MIC (functional) | = 30 ug ml-1 | Inhibition of growth of Escherichia coli (CN314) measured as MIC compound/MIC Trimethoprim | ChEMBL. | 3121854 |
MIC (functional) | = 100 ug ml-1 | Inhibition of growth of Salmonella typhi (CN512) measured as MIC compound/MIC Trimethoprim | ChEMBL. | 3121854 |
MIC (functional) | = 100 ug ml-1 | Inhibition of growth of Shigella flexneri (CN6007) measured as MIC compound/MIC Trimethoprim | ChEMBL. | 3121854 |
MIC (functional) | = 100 ug ml-1 | Inhibition of growth of Enterobacter aerogenes(2200/186) measured as MICcompound/MIC Trimethoprim | ChEMBL. | 3121854 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.