Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0048 | 0.0048 | 0.2026 |
Echinococcus multilocularis | geminin | 0.0178 | 0.0563 | 0.1427 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0096 | 0.0238 | 0.0571 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0998 | 0.3818 | 1 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.2555 | 1 | 1 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0096 | 0.0238 | 0.0571 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0048 | 0.0048 | 0.0048 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0998 | 0.3818 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0048 | 0.0048 | 0.0027 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0048 | 0.0048 | 0.0048 |
Echinococcus granulosus | expressed conserved protein | 0.009 | 0.0215 | 0.0511 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0096 | 0.0238 | 0.0504 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0097 | 0.0244 | 0.0229 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.2555 | 1 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0048 | 0.0048 | 0.0048 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.2555 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0021 | 0.0883 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0048 | 0.0033 |
Mycobacterium ulcerans | hypothetical protein | 0.0048 | 0.0048 | 0.0048 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0048 | 0.0048 | 0.0048 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.0048 | 0.0072 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0788 | 0.2988 | 0.7812 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0048 | 0.202 |
Schistosoma mansoni | patched 1 | 0.0041 | 0.0021 | 0.0006 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0048 | 0.202 |
Schistosoma mansoni | hypothetical protein | 0.0178 | 0.0563 | 0.0548 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.2555 | 1 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.0048 | 0.0072 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.0048 | 0.0072 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0048 | 0.0048 | 0.0027 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0048 | 0.0033 |
Schistosoma mansoni | hypothetical protein | 0.0178 | 0.0563 | 0.0548 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0048 | 0.0048 | 0.0048 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0238 | 1 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.2555 | 1 | 1 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0998 | 0.3818 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0058 | 0.2425 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0137 | 0.0401 | 0.1001 |
Leishmania major | dihydroorotate dehydrogenase | 0.2555 | 1 | 1 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0998 | 0.3818 | 0.3805 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0998 | 0.3818 | 1 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0041 | 0.0021 | 0.0883 |
Onchocerca volvulus | 0.0048 | 0.0048 | 0.5 | |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0096 | 0.0238 | 0.0217 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0048 | 0.0033 |
Echinococcus multilocularis | protein dispatched 1 | 0.0047 | 0.0044 | 0.0061 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.2555 | 1 | 1 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.2555 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0048 | 0.202 |
Echinococcus multilocularis | expressed conserved protein | 0.009 | 0.0215 | 0.0511 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0998 | 0.3818 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0998 | 0.3818 | 1 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.2555 | 1 | 1 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.2555 | 1 | 0.5 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.2555 | 1 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0048 | 0.0048 | 0.0048 |
Brugia malayi | AMP-binding enzyme family protein | 0.0048 | 0.0048 | 0.0027 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0048 | 0.0048 | 0.0048 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.2555 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.0048 | 0.0072 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0036 | 0 | 0.5 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0998 | 0.3818 | 1 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0048 | 0.0048 | 0.0048 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0998 | 0.3818 | 1 |
Echinococcus granulosus | geminin | 0.0178 | 0.0563 | 0.1427 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.2555 | 1 | 1 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0998 | 0.3818 | 1 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.2555 | 1 | 1 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0998 | 0.3818 | 1 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0137 | 0.0401 | 0.1001 |
Brugia malayi | AMP-binding enzyme family protein | 0.0048 | 0.0048 | 0.0027 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0048 | 0.0048 | 0.0048 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0998 | 0.3818 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC25 (functional) | = 24 uM | The compound was evaluated for the inhibition of Na+-dependent [3H]-taurocholate uptake into ileal brush border membrane vesicles in rabbit, by 25% | ChEMBL. | 8151614 |
IC50 (functional) | = 48 uM | The compound was evaluated for the inhibition of Na+-dependent [3H]-taurocholate uptake into ileal brush border membrane vesicles in rabbit, by 50% | ChEMBL. | 8151614 |
IC75 (functional) | = 84 uM | The compound was evaluated for the inhibition of Na+-dependent [3H]-taurocholate uptake into ileal brush border membrane vesicles in rabbit, by 75% | ChEMBL. | 8151614 |
Inhibition (functional) | = 51 % | The compound was evaluated for the percentage inhibition of ileal taurocholate transport, in anesthetized wistar rats at 12 min | ChEMBL. | 8151614 |
Inhibition (functional) | = 54 % | The compound was evaluated for the percentage inhibition of ileal taurocholate transport, in anesthetized wistar rats at 60 min | ChEMBL. | 8151614 |
Inhibition (functional) | = 59 % | The compound was evaluated for the percentage inhibition of ileal taurocholate transport, in anesthetized wistar rats at 30 min | ChEMBL. | 8151614 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.