Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | pyridine nucleotide-disulphide oxidoreductase, putative | 0.0057 | 0.0643 | 0.0374 |
Schistosoma mansoni | dihydrofolate reductase | 0.0079 | 0.1023 | 0.0762 |
Entamoeba histolytica | pyridine nucleotide-disulfide oxidoreductase family protein | 0.0057 | 0.0643 | 1 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0048 | 0.0503 | 0.0227 |
Schistosoma mansoni | glutamate synthase | 0.0057 | 0.0643 | 0.0371 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0213 | 0.3266 | 0.31 |
Trypanosoma brucei | pyridine nucleotide-disulphide oxidoreductase, putative | 0.0057 | 0.0643 | 0.0643 |
Trypanosoma brucei | NADH dehydrogenase | 0.0057 | 0.0643 | 0.0643 |
Plasmodium falciparum | glutathione reductase | 0.0616 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0033 | 0.0241 | 0.0473 |
Schistosoma mansoni | survival motor neuron protein | 0.0047 | 0.0483 | 0.0206 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0213 | 0.3266 | 0.2803 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0213 | 0.3266 | 1 |
Trypanosoma brucei | phosphatidylinositol 4-kinase, putative | 0.0044 | 0.0429 | 0.0429 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.0213 | 0.3266 | 0.2803 |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.3557 | 0.3268 |
Trichomonas vaginalis | disulfide oxidoreductase, putative | 0.0057 | 0.0643 | 0.1739 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0079 | 0.1023 | 0.145 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0213 | 0.3266 | 0.3073 |
Echinococcus granulosus | dihydrofolate reductase | 0.0079 | 0.1023 | 0.0762 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0079 | 0.1023 | 0.0406 |
Entamoeba histolytica | FKBP-rapamycin associated protein (FRAP), putative | 0.0044 | 0.0429 | 0.4061 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0643 | 0.0224 |
Leishmania major | hypothetical protein, conserved | 0.0057 | 0.0643 | 0.0374 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0033 | 0.0241 | 0.0473 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0213 | 0.3266 | 0.3073 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor1 | 0.0044 | 0.0429 | 0.0154 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0213 | 0.3266 | 0.3073 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0213 | 0.3266 | 0.3073 |
Trypanosoma cruzi | NADH dehydrogenase, putative | 0.0057 | 0.0643 | 0.0374 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0079 | 0.1023 | 0.0621 |
Echinococcus granulosus | pyridine nucleotide disulfide oxidoreductase | 0.0057 | 0.0643 | 0.0371 |
Echinococcus multilocularis | tumor protein p63 | 0.033 | 0.5213 | 0.5074 |
Leishmania major | trypanothione reductase | 0.0616 | 1 | 1 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase family protein | 0.0057 | 0.0643 | 0.0371 |
Trypanosoma cruzi | 2,4-dienoyl-coa reductase-like protein, putative | 0.0057 | 0.0643 | 0.0374 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0616 | 1 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0616 | 1 | 1 |
Onchocerca volvulus | 0.0057 | 0.0643 | 1 | |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0213 | 0.3266 | 0.3073 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0616 | 1 | 1 |
Trypanosoma brucei | 2,4-dienoyl-coa reductase-like protein | 0.0057 | 0.0643 | 0.0643 |
Giardia lamblia | Thioredoxin reductase | 0.0057 | 0.0643 | 0.0754 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0213 | 0.3266 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0213 | 0.3266 | 0.2803 |
Toxoplasma gondii | thioredoxin reductase | 0.0616 | 1 | 1 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0213 | 0.3266 | 0.3266 |
Toxoplasma gondii | pyridine nucleotide-disulfide oxidoreductase domain-containing protein | 0.0057 | 0.0643 | 0.0412 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0213 | 0.3266 | 1 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0213 | 0.3266 | 0.31 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0213 | 0.3266 | 0.3266 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.0213 | 0.3266 | 0.2803 |
Schistosoma mansoni | sulfide quinone reductase | 0.0057 | 0.0643 | 0.0371 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0483 | 0.0206 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0026 | 0.0134 | 0.0135 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0079 | 0.1023 | 0.0762 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0213 | 0.3266 | 0.307 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0213 | 0.3266 | 1 |
Trypanosoma cruzi | NADH dehydrogenase, putative | 0.0057 | 0.0643 | 0.0374 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0503 | 0.0077 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0024 | 0.0091 | 0.0002 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0035 | 0.0279 | 0.0592 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0026 | 0.0129 | 0.0121 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0079 | 0.1023 | 0.0765 |
Trichomonas vaginalis | disulfide oxidoreductase, putative | 0.0057 | 0.0643 | 0.1739 |
Trypanosoma brucei | phosphatidylinositol 3-kinase tor, putative | 0.0021 | 0.0042 | 0.0042 |
Leishmania major | hypothetical protein, conserved | 0.0057 | 0.0643 | 0.0374 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0213 | 0.3266 | 0.307 |
Schistosoma mansoni | glutamate synthase | 0.0057 | 0.0643 | 0.0371 |
Schistosoma mansoni | sulfide quinone reductase | 0.0057 | 0.0643 | 0.0371 |
Echinococcus multilocularis | sulfide:quinone oxidoreductase | 0.0057 | 0.0643 | 0.0371 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0213 | 0.3266 | 0.3266 |
Treponema pallidum | NADH oxidase | 0.0213 | 0.3266 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0213 | 0.3266 | 1 |
Toxoplasma gondii | non-proton pumping type-II NADH dehydrogenase I | 0.0057 | 0.0643 | 0.0412 |
Leishmania major | 2,4-dienoyl-coa reductase-like protein | 0.0057 | 0.0643 | 0.0374 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0026 | 0.0129 | 0.0121 |
Entamoeba histolytica | glutamate synthase beta subunit, putative | 0.0057 | 0.0643 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 0.0079 | 0.1023 | 0.0762 |
Leishmania major | target of rapamycin (TOR) kinase 2, putative | 0.0044 | 0.0429 | 0.0154 |
Trypanosoma brucei | pyridine nucleotide-disulphide oxidoreductase, putative | 0.0057 | 0.0643 | 0.0643 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0057 | 0.0643 | 0.1739 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0079 | 0.1023 | 0.1023 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0079 | 0.1023 | 0.0765 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0616 | 1 | 1 |
Echinococcus granulosus | glutamate synthase | 0.0057 | 0.0643 | 0.0371 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0037 | 0.0322 | 0.0727 |
Mycobacterium tuberculosis | Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot | 0.0213 | 0.3266 | 0.2803 |
Entamoeba histolytica | disulphide oxidoreductase, putative | 0.0057 | 0.0643 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0079 | 0.1023 | 0.0802 |
Trichomonas vaginalis | dihydrolipoamide dehydrogenase, putative | 0.0057 | 0.0643 | 0.1739 |
Brugia malayi | hypothetical protein | 0.0231 | 0.3557 | 0.3369 |
Trichomonas vaginalis | glutamate synthase, putative | 0.0057 | 0.0643 | 0.1739 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0057 | 0.0643 | 0.0374 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor2 | 0.0044 | 0.0429 | 0.0154 |
Trypanosoma cruzi | 2,4-dienoyl-coa reductase fadh1, putative | 0.0057 | 0.0643 | 0.0374 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0029 | 0.0187 | 0.0304 |
Plasmodium vivax | glutathione reductase, putative | 0.0616 | 1 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0616 | 1 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0616 | 1 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0616 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0033 | 0.0241 | 0.0473 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0028 | 0.0172 | 0.0254 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0044 | 0.0429 | 0.1065 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0213 | 0.3266 | 0.2803 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0213 | 0.3266 | 1 |
Schistosoma mansoni | disulfide oxidoreductase | 0.0057 | 0.0643 | 0.0371 |
Trypanosoma brucei | NADPH:adrenodoxin oxidoreductase, mitochondrial, putative | 0.0057 | 0.0643 | 0.0643 |
Plasmodium falciparum | thioredoxin reductase | 0.0213 | 0.3266 | 0.2803 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0033 | 0.0241 | 0.0473 |
Schistosoma mansoni | hypothetical protein | 0.0057 | 0.0643 | 0.0371 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0057 | 0.0643 | 0.0643 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0057 | 0.0643 | 0.0371 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0213 | 0.3266 | 0.3073 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0213 | 0.3266 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0213 | 0.3266 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0213 | 0.3266 | 1 |
Trypanosoma cruzi | pyridine nucleotide-disulphide oxidoreductase, putative | 0.0057 | 0.0643 | 0.0374 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0213 | 0.3266 | 0.3073 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0026 | 0.0134 | 0.0135 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0057 | 0.0643 | 1 |
Echinococcus granulosus | tumor protein p63 | 0.033 | 0.5213 | 0.5074 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0033 | 0.0241 | 0.0473 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0024 | 0.0091 | 0.0002 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase family protein | 0.0057 | 0.0643 | 0.0371 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0033 | 0.0241 | 0.0473 |
Entamoeba histolytica | glutamate synthase beta subunit, putative | 0.0057 | 0.0643 | 1 |
Toxoplasma gondii | pyridine nucleotide-disulfide oxidoreductase domain-containing protein | 0.0057 | 0.0643 | 0.0412 |
Leishmania major | NADH dehydrogenase, putative | 0.0057 | 0.0643 | 0.0374 |
Toxoplasma gondii | selenide, water dikinase | 0.0057 | 0.0643 | 0.0412 |
Toxoplasma gondii | NADH dehydrogenase (NDH2-II) | 0.0057 | 0.0643 | 0.0412 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0213 | 0.3266 | 0.2803 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm)-related | 0.0044 | 0.0429 | 0.0151 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0079 | 0.1023 | 0.145 |
Trypanosoma cruzi | NADPH:adrenodoxin oxidoreductase, mitochondrial, putative | 0.0057 | 0.0643 | 0.0374 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0079 | 0.1023 | 0.145 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0213 | 0.3266 | 0.3073 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0057 | 0.0643 | 0.1739 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0213 | 0.3266 | 0.307 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0213 | 0.3266 | 0.3073 |
Echinococcus multilocularis | glutamate synthase | 0.0057 | 0.0643 | 0.0371 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0035 | 0.0279 | 0.0592 |
Entamoeba histolytica | NAD(FAD)-dependent dehydrogenase, putative | 0.0057 | 0.0643 | 1 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0157 | 0.2318 | 0.2095 |
Trichomonas vaginalis | disulfide oxidoreductase, putative | 0.0057 | 0.0643 | 0.1739 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0024 | 0.0091 | 0.0002 |
Echinococcus multilocularis | FKBP12 rapamycin complex associated protein | 0.0044 | 0.0429 | 0.0151 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0044 | 0.0429 | 0.1065 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0044 | 0.0429 | 0.1065 |
Loa Loa (eye worm) | glutathione reductase | 0.0616 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0035 | 0.0279 | 0.0592 |
Giardia lamblia | Glycerol-3-phosphate dehydrogenase | 0.0057 | 0.0643 | 0.0754 |
Toxoplasma gondii | pyridine nucleotide-disulfide oxidoreductase domain-containing protein | 0.0057 | 0.0643 | 0.0412 |
Trichomonas vaginalis | disulfide oxidoreductase, putative | 0.0057 | 0.0643 | 0.1739 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0213 | 0.3266 | 0.3073 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0213 | 0.3266 | 0.3073 |
Echinococcus granulosus | sulfide:quinone oxidoreductase | 0.0057 | 0.0643 | 0.0371 |
Trichomonas vaginalis | apoptosis inducing factor, putative | 0.0057 | 0.0643 | 0.1739 |
Leishmania major | 2,4-dienoyl-coa reductase fadh1, putative | 0.0057 | 0.0643 | 0.0374 |
Entamoeba histolytica | phosphatidylinositol3-kinaseTor2, putative | 0.0044 | 0.0429 | 0.4061 |
Echinococcus multilocularis | pyridine nucleotide disulfide oxidoreductase | 0.0057 | 0.0643 | 0.0371 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0057 | 0.0643 | 0.1739 |
Trichomonas vaginalis | glutamate synthase, putative | 0.0057 | 0.0643 | 0.1739 |
Trichomonas vaginalis | disulfide oxidoreductase, putative | 0.0057 | 0.0643 | 0.1739 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0057 | 0.0643 | 0.0371 |
Entamoeba histolytica | thioredoxin reductase, putative | 0.0057 | 0.0643 | 1 |
Loa Loa (eye worm) | programmed cell death 8 | 0.0057 | 0.0643 | 0.0224 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0157 | 0.2318 | 0.2095 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0231 | 0.3557 | 0.3369 |
Onchocerca volvulus | 0.0048 | 0.0503 | 0.1248 | |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0079 | 0.1023 | 0.0406 |
Echinococcus granulosus | FKBP12 rapamycin complex associated protein | 0.0044 | 0.0429 | 0.0151 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0231 | 0.3557 | 0.3369 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0035 | 0.0279 | 0.0592 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0079 | 0.1023 | 0.0406 |
Brugia malayi | glutamate synthase | 0.0057 | 0.0643 | 0.0371 |
Brugia malayi | Dihydrofolate reductase | 0.0079 | 0.1023 | 0.0762 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0616 | 1 | 1 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0213 | 0.3266 | 0.307 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0057 | 0.0643 | 0.0374 |
Echinococcus granulosus | apoptosis inducing factor 1 mitochondrial | 0.0057 | 0.0643 | 0.0371 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.0213 | 0.3266 | 0.2803 |
Trypanosoma brucei | Phosphatidylinositol 3-kinase tor1 | 0.0044 | 0.0429 | 0.0429 |
Echinococcus multilocularis | apoptosis inducing factor 1 mitochondrial | 0.0057 | 0.0643 | 0.0371 |
Leishmania major | hypothetical protein, conserved | 0.0057 | 0.0643 | 0.0374 |
Trichomonas vaginalis | disulfide oxidoreductase, putative | 0.0057 | 0.0643 | 0.1739 |
Loa Loa (eye worm) | pyridine nucleotide-disufhide oxidoreductase | 0.0057 | 0.0643 | 0.0224 |
Schistosoma mansoni | glutamate synthase | 0.0057 | 0.0643 | 0.0371 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0213 | 0.3266 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0026 | 0.0134 | 0.0135 |
Echinococcus multilocularis | NADPH:adrenodoxin oxidoreductase | 0.0057 | 0.0643 | 0.0371 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0057 | 0.0643 | 0.0371 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0213 | 0.3266 | 0.3073 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0057 | 0.0643 | 0.0371 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0213 | 0.3266 | 0.3073 |
Trypanosoma brucei | target of rapamycin kinase 3, putative | 0.0035 | 0.0279 | 0.0279 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.0213 | 0.3266 | 0.2803 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0024 | 0.0091 | 0.0002 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0035 | 0.0279 | 0.0592 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0033 | 0.0241 | 0.0473 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0044 | 0.0429 | 0.0151 |
Echinococcus granulosus | NADPH:adrenodoxin oxidoreductase | 0.0057 | 0.0643 | 0.0371 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0616 | 1 | 1 |
Giardia lamblia | Glutamate synthase | 0.0057 | 0.0643 | 0.0754 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0047 | 0.0483 | 0.0206 |
Brugia malayi | NADPH:adrenodoxin oxidoreductase, mitochondrial precursor | 0.0057 | 0.0643 | 0.0371 |
Leishmania major | target of rapamycin (TOR) kinase 1, putative | 0.0044 | 0.0429 | 0.0154 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0213 | 0.3266 | 0.3266 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Dissociation rate constant (binding) | = 1.4 s-1 | Dissociation rate constant of compound for wild type E. coli dihydrofolate reductase | ChEMBL. | 1495020 |
Dissociation rate constant (binding) | = 3.6 s-1 | Dissociation rate constant of compound for mutant T46S E. coli dihydrofolate reductase | ChEMBL. | 1495020 |
Dissociation rate constant (binding) | = 12.2 s-1 | Dissociation rate constant of compound for mutant T46A E. coli dihydrofolate reductase | ChEMBL. | 1495020 |
Dissociation rate constant (binding) | = 14 s-1 | Dissociation rate constant of compound for mutant T46N E. coli dihydrofolate reductase | ChEMBL. | 1495020 |
Kd (binding) | = 0.06 uM | Thermodynamic Dissociation Constant for compound-Phe31-dihydrofolate reductase (DHFR) complex at pH 7 | ChEMBL. | 3275776 |
Kd (binding) | = 0.3 uM | Thermodynamic Dissociation Constant for compound-Tyr31-dihydrofolate reductase (DHFR) complex at pH 7 | ChEMBL. | 3275776 |
Kd (binding) | = 0.3 uM | Thermodynamic Dissociation Constant for compound-Val31-dihydrofolate reductase (DHFR) complex at pH 7 | ChEMBL. | 3275776 |
Km (binding) | = 4.2 uM | Apparent kinetic constant of substrate activity for Hog liver Folyl-polyglutamate synthase | ChEMBL. | 1895294 |
Km (binding) | = 8 uM | The apparent Km of compound as a substrate for partially purified mouse liver Folyl-polyglutamate synthase | ChEMBL. | 2918520 |
Km app (binding) | = 7.1 M | Activity(apparent Km ) of the compound was evaluated in vitro by purified mouse liver folate polyglutamate synthetase (FPGS) . | ChEMBL. | 4009615 |
Rate of hydride transfer (binding) | 0 s-1 | Rate of hydride transfer (E-N) of compound for mutant T46S E. coli dihydrofolate reductase; ND=no data | ChEMBL. | 1495020 |
Rate of hydride transfer (binding) | 0 s-1 | Rate of hydride transfer (E-N) of compound for mutant T46A E. coli dihydrofolate reductase; ND=no data | ChEMBL. | 1495020 |
Rate of hydride transfer (binding) | = 2.4 s-1 | Rate of hydride transfer (E-N) of compound for wild type E. coli dihydrofolate reductase | ChEMBL. | 1495020 |
Rate of hydride transfer (binding) | = 10 s-1 | Rate of hydride transfer (E-NH) of compound for mutant T46S E. coli dihydrofolate reductase | ChEMBL. | 1495020 |
Rate of hydride transfer (binding) | = 12 s-1 | Rate of hydride transfer (E-NH) of compound for wild type E. coli dihydrofolate reductase | ChEMBL. | 1495020 |
Rate of hydride transfer (binding) | = 13 s-1 | Rate of hydride transfer (E-N) of compound for mutant T46N E. coli dihydrofolate reductase | ChEMBL. | 1495020 |
Rate of hydride transfer (binding) | = 18 s-1 | Rate of hydride transfer (E-NH) of compound for mutant T46N E. coli dihydrofolate reductase | ChEMBL. | 1495020 |
Rate of hydride transfer (binding) | = 52 s-1 | Rate of hydride transfer (E-NH) of compound for mutant T46A E. coli dihydrofolate reductase | ChEMBL. | 1495020 |
Ratio (binding) | = 32.1 | It is the ratio of apparent kinetic constant to that of relative maximum velocity | ChEMBL. | 1895294 |
Relative Km (binding) | = 0.051 | Activity(relative Km ) of the compound was evaluated in vitro by purified mouse liver folate polyglutamate synthetase (FPGS) . | ChEMBL. | 4009615 |
Relative Vmax (binding) | = 1.31 | Activity(relative Vmax) of the compound was evaluated in vitro by purified mouse liver folate polyglutamate synthetase (FPGS) . | ChEMBL. | 4009615 |
Vmax (binding) | = 135 % | Relative maximum velocity of substrate activity for Hog liver Folyl-polyglutamate synthase (relative to control of 50 microM aminopterin) | ChEMBL. | 1895294 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
9 literature references were collected for this gene.