Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Hepatitis C virus | Hepatitis C virus NS5B RNA-dependent RNA polymerase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | c4b binding protein beta chain | 0.0139 | 0.747 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0127 | 0.6491 | 0.8689 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0127 | 0.6491 | 1 |
Brugia malayi | glutathione reductase | 0.0127 | 0.6491 | 0.6491 |
Onchocerca volvulus | 0.0139 | 0.747 | 0.5 | |
Onchocerca volvulus | 0.0139 | 0.747 | 0.5 | |
Plasmodium falciparum | apical sushi protein | 0.0139 | 0.747 | 1 |
Toxoplasma gondii | rhoptry neck protein RON1 | 0.0139 | 0.747 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0044 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 1 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0044 | 0 | 0.5 |
Onchocerca volvulus | 0.0139 | 0.747 | 0.5 | |
Trichomonas vaginalis | mercuric reductase, putative | 0.0044 | 0 | 0.5 |
Brugia malayi | Sushi domain | 0.0139 | 0.747 | 0.747 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0044 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.747 | 0.2791 |
Echinococcus granulosus | C type lectin domian containing protein | 0.0139 | 0.747 | 1 |
Brugia malayi | hypothetical protein | 0.0139 | 0.747 | 0.747 |
Onchocerca volvulus | 0.0139 | 0.747 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.747 | 0.2791 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.747 | 0.2791 |
Leishmania major | trypanothione reductase | 0.0127 | 0.6491 | 1 |
Brugia malayi | hypothetical protein | 0.0139 | 0.747 | 0.747 |
Brugia malayi | pregnancy-associated plasma protein-A | 0.0139 | 0.747 | 0.747 |
Plasmodium vivax | glutathione reductase, putative | 0.0127 | 0.6491 | 0.8689 |
Plasmodium vivax | apical sushi protein, putative | 0.0139 | 0.747 | 1 |
Onchocerca volvulus | 0.0139 | 0.747 | 0.5 | |
Onchocerca volvulus | 0.0139 | 0.747 | 0.5 | |
Treponema pallidum | NADH oxidase | 0.0044 | 0 | 0.5 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0044 | 0 | 0.5 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0044 | 0 | 0.5 |
Plasmodium falciparum | thioredoxin reductase | 0.0127 | 0.6491 | 0.8689 |
Brugia malayi | hypothetical protein | 0.0139 | 0.747 | 0.747 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0127 | 0.6491 | 0.8689 |
Echinococcus granulosus | c4b binding protein beta chain | 0.0139 | 0.747 | 1 |
Brugia malayi | hypothetical protein | 0.0139 | 0.747 | 0.747 |
Onchocerca volvulus | 0.0139 | 0.747 | 0.5 | |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0127 | 0.6491 | 0.8689 |
Onchocerca volvulus | 0.0139 | 0.747 | 0.5 | |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0044 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0139 | 0.747 | 0.747 |
Echinococcus multilocularis | C type lectin domian containing protein | 0.0139 | 0.747 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0127 | 0.6491 | 1 |
Schistosoma mansoni | c4b-binding protein beta chain | 0.0139 | 0.747 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0044 | 0 | 0.5 |
Onchocerca volvulus | 0.0139 | 0.747 | 0.5 | |
Loa Loa (eye worm) | pregnancy-associated plasma protein-E | 0.0139 | 0.747 | 0.2791 |
Toxoplasma gondii | thioredoxin reductase | 0.0127 | 0.6491 | 0.8689 |
Brugia malayi | hypothetical protein | 0.0139 | 0.747 | 0.747 |
Brugia malayi | hypothetical protein | 0.0139 | 0.747 | 0.747 |
Toxoplasma gondii | rhoptry neck protein RON9 | 0.0139 | 0.747 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.747 | 0.2791 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.8695 | 0.628 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0044 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.747 | 0.2791 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0127 | 0.6491 | 0.8689 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.747 | 0.2791 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0127 | 0.6491 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.747 | 0.2791 |
Onchocerca volvulus | 0.0139 | 0.747 | 0.5 | |
Brugia malayi | Thioredoxin reductase | 0.0127 | 0.6491 | 0.6491 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0044 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.8 uM | Inhibitory activity against Hepatitis C RNA dependent RNA polymerase Nonstructural protein 5B (NS5B polymerase) expressed from baculovirus-infected Sf9 insect cells | ChEMBL. | 12672227 |
IC50 (binding) | = 0.8 uM | Inhibitory activity against Hepatitis C RNA dependent RNA polymerase Nonstructural protein 5B (NS5B polymerase) expressed from baculovirus-infected Sf9 insect cells | ChEMBL. | 12672227 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.