Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | immunophilin, putative | 0.1565 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0741 | 0.207 | 0.207 |
Onchocerca volvulus | 0.0741 | 0.207 | 0.5 | |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.135 | 0.7928 | 0.7387 |
Loa Loa (eye worm) | FKBP5 protein | 0.1565 | 1 | 1 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative | 0.1565 | 1 | 0.5 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.1565 | 1 | 1 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.1565 | 1 | 1 |
Trypanosoma brucei | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.1565 | 1 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0741 | 0.207 | 0.207 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.1565 | 1 | 1 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.1565 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0741 | 0.207 | 0.207 |
Onchocerca volvulus | 0.0741 | 0.207 | 0.5 | |
Onchocerca volvulus | Peroxidase homolog | 0.0741 | 0.207 | 0.5 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.1565 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0741 | 0.207 | 0.207 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.1565 | 1 | 0.5 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.1565 | 1 | 0.5 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.1565 | 1 | 0.5 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.1565 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0741 | 0.207 | 0.207 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.1565 | 1 | 0.5 |
Treponema pallidum | peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) | 0.1565 | 1 | 0.5 |
Plasmodium vivax | 70 kDa peptidylprolyl isomerase, putative | 0.1565 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0741 | 0.207 | 0.207 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0741 | 0.207 | 0.207 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0741 | 0.207 | 0.207 |
Loa Loa (eye worm) | hypothetical protein | 0.0741 | 0.207 | 0.207 |
Loa Loa (eye worm) | hypothetical protein | 0.0741 | 0.207 | 0.207 |
Loa Loa (eye worm) | hypothetical protein | 0.0741 | 0.207 | 0.207 |
Leishmania major | peptidylprolyl isomerase-like protein | 0.1565 | 1 | 0.5 |
Leishmania major | fk506-binding protein 1-like protein | 0.1565 | 1 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0741 | 0.207 | 0.207 |
Schistosoma mansoni | immunophilin | 0.135 | 0.7928 | 0.7387 |
Giardia lamblia | 70 kDa peptidylprolyl isomerase, putative | 0.1565 | 1 | 0.5 |
Brugia malayi | Angiotensin-converting enzyme family protein | 0.0749 | 0.2145 | 0.2145 |
Schistosoma mansoni | immunophilin | 0.1565 | 1 | 1 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.1565 | 1 | 0.5 |
Echinococcus multilocularis | fk506 binding protein | 0.1565 | 1 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0741 | 0.207 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0741 | 0.207 | 0.207 |
Onchocerca volvulus | 0.0741 | 0.207 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0741 | 0.207 | 0.207 |
Onchocerca volvulus | Peroxidasin homolog | 0.0741 | 0.207 | 0.5 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.1565 | 1 | 0.5 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.1565 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0741 | 0.207 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0741 | 0.207 | 0.207 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0741 | 0.207 | 0.207 |
Mycobacterium ulcerans | FK-506 binding protein, peptidyl-prolyl cis-trans isomerase | 0.1565 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0741 | 0.207 | 0.207 |
Brugia malayi | Animal haem peroxidase family protein | 0.0741 | 0.207 | 0.207 |
Brugia malayi | Animal haem peroxidase family protein | 0.0741 | 0.207 | 0.207 |
Brugia malayi | hypothetical protein | 0.0741 | 0.207 | 0.207 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0741 | 0.207 | 0.207 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.135 | 0.7928 | 0.7387 |
Loa Loa (eye worm) | hypothetical protein | 0.0741 | 0.207 | 0.207 |
Schistosoma mansoni | immunophilin | 0.1565 | 1 | 1 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type, putative | 0.1565 | 1 | 0.5 |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | 0.0749 | 0.2145 | 0.2145 |
Loa Loa (eye worm) | hypothetical protein | 0.0741 | 0.207 | 0.207 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0741 | 0.207 | 0.5 |
Brugia malayi | Peroxidasin | 0.0741 | 0.207 | 0.207 |
Brugia malayi | Animal haem peroxidase family protein | 0.0741 | 0.207 | 0.207 |
Onchocerca volvulus | Peroxidase homolog | 0.0741 | 0.207 | 0.5 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.1565 | 1 | 0.5 |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase FKBP35 | 0.1565 | 1 | 0.5 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.1565 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0741 | 0.207 | 0.207 |
Loa Loa (eye worm) | hypothetical protein | 0.135 | 0.7928 | 0.7928 |
Loa Loa (eye worm) | hypothetical protein | 0.0741 | 0.207 | 0.207 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Delta blood pressure (functional) | = 48 mM | Compound was tested for bradykinin potentiation at 0.1 ug/kg dose | ChEMBL. | 2832605 |
Delta blood pressure (functional) | = 48 mM | Compound was tested for bradykinin potentiation at 0.1 ug/kg dose | ChEMBL. | 2832605 |
ID50 (binding) | = 0.16 ug kg-1 | In vitro inhibition of Angiotensin I converting enzyme relative to captopril(=1) | ChEMBL. | 2832605 |
ID50 (binding) | = 0.16 ug kg-1 | In vitro inhibition of Angiotensin I converting enzyme relative to captopril(=1) | ChEMBL. | 2832605 |
ID50 (binding) | = 253 ug kg-1 | In vivo inhibition of Angiotensin I converting enzyme in anaesthatized rats | ChEMBL. | 2832605 |
ID50 (binding) | = 253 ug kg-1 | In vivo inhibition of Angiotensin I converting enzyme in anaesthatized rats | ChEMBL. | 2832605 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.