Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0255 | 0.5 | 0.5 |
Brugia malayi | Peroxidasin | 0.0255 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0255 | 0.5 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0255 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0255 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0255 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0255 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0255 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0255 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0255 | 0.5 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0255 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0255 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0255 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0255 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0255 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0255 | 0.5 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0255 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0255 | 0.5 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.0255 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0255 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0255 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0255 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0255 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0255 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0255 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0255 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0255 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0255 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0255 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0255 | 0.5 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0255 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0255 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0255 | 0.5 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.0255 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0255 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0255 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0255 | 0.5 | 0.5 | |
Onchocerca volvulus | 0.0255 | 0.5 | 0.5 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0255 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
LD50 (ADMET) | > 1000 mg kg-1 | Lethal dose of the compound is determined in mice (po) | ChEMBL. | No reference |
LD50 (ADMET) | > 1000 mg kg-1 | Lethal dose of the compound is determined in mice (po) | ChEMBL. | No reference |
Reduction (functional) | = 22 % | Compound is evaluated for antiinflammatory activity using carrageenin-induced paw edema method in rat at a dose 200 mg/kg po after 1 hr | ChEMBL. | No reference |
Reduction (functional) | = 30 % | Compound is evaluated for antiinflammatory activity using carrageenin-induced paw edema method in rat at a dose 200 mg/kg po after 2 hr | ChEMBL. | No reference |
Reduction (functional) | = 30 % | Compound is evaluated for antiinflammatory activity using carrageenin-induced paw edema method in rat at a dose 200 mg/kg po after 3h | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.