TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 481.03 | Formula: C27H33ClN4O2
H donors: 0 H acceptors: 3 LogP: 2.79 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc2c(c1)CCc1c(C2N2CCN(CC2)C(=O)CC2CCCN(C2)C(=O)C)nccc1
InChi: 1S/C27H33ClN4O2/c1-19(33)32-11-3-4-20(18-32)16-25(34)30-12-14-31(15-13-30)27-24-9-8-23(28)17-22(24)7-6-21-5-2-10-29-26(21)27/h2,5,8-10,17,20,27H,3-4,6-7,11-16,18H2,1H3
InChiKey: NACLMRMBLJHXKV-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	farnesyltransferase, CAAX box, alpha	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128459	All targets in OG5_128459
Theileria parva	hypothetical protein	Get druggable targets OG5_128459	All targets in OG5_128459
Toxoplasma gondii	hypothetical protein	Get druggable targets OG5_128459	All targets in OG5_128459
Echinococcus granulosus	protein farnesyltransferase alpha subunit	Get druggable targets OG5_128459	All targets in OG5_128459
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Cryptosporidium hominis	farnesyltransferase	Get druggable targets OG5_128459	All targets in OG5_128459
Schistosoma japonicum	ko:K05954 farnesyltransferase, CAAX box, alpha [EC:2.5.1.58 2.5.1.59], putative	Get druggable targets OG5_128459	All targets in OG5_128459
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	Get druggable targets OG5_128459	All targets in OG5_128459
Cryptosporidium parvum	farnesyltransferase	Get druggable targets OG5_128459	All targets in OG5_128459
Giardia lamblia	Rab geranylgeranyltransferase	Get druggable targets OG5_128459	All targets in OG5_128459
Candida albicans	alpha subunit shared by C terminal CaaX Geranylgeranyltransferase I (Ram2p+Cdc43p) and farnesyltransferase (Ram2p+Ram1p)	Get druggable targets OG5_128459	All targets in OG5_128459
Plasmodium berghei	protein farnesyltransferase subunit alpha, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	Get druggable targets OG5_128459	All targets in OG5_128459
Plasmodium knowlesi	protein farnesyltransferase subunit alpha, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Plasmodium falciparum	protein farnesyltransferase subunit alpha	Get druggable targets OG5_128459	All targets in OG5_128459
Neospora caninum	hypothetical protein	Get druggable targets OG5_128459	All targets in OG5_128459
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Echinococcus multilocularis	protein farnesyltransferase alpha subunit	Get druggable targets OG5_128459	All targets in OG5_128459
Candida albicans	alpha subunit shared by C terminal CaaX Geranylgeranyltransferase I (Ram2p+Cdc43p) and farnesyltransferase (Ram2p+Ram1p)	Get druggable targets OG5_128459	All targets in OG5_128459
Entamoeba histolytica	protein farnesyltransferase alpha subunit, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Schistosoma mansoni	protein farnesyltransferase alpha subunit	Get druggable targets OG5_128459	All targets in OG5_128459
Plasmodium vivax	prenyltransferase alpha subunit, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Babesia bovis	protein prenyltransferase alpha subunit repeat domain containing protein	Get druggable targets OG5_128459	All targets in OG5_128459

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	0.0193	0.2916	1
Entamoeba histolytica	protein farnesyltransferase alpha subunit, putative	0.0193	0.2916	1
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0608	0.1208
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0018	0.0031	0.0061
Echinococcus granulosus	glycoprotein Antigen 5	0.0061	0.0733	0.1457
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0031	0.0061
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0051	0.058	1
Echinococcus multilocularis	baculoviral IAP repeat containing protein	0.0096	0.1323	0.1323
Onchocerca volvulus		0.0061	0.0733	0.1004
Schistosoma mansoni	slit	0.0053	0.0608	0.1208
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0019	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0019	0.0039
Onchocerca volvulus	Pyruvate kinase homolog	0.0051	0.058	0.0683
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0087	0.1166	1
Schistosoma mansoni	caspase-7 (C14 family)	0.0031	0.0253	0.0503
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.0061	0.0733	0.1457
Brugia malayi	GCC2 and GCC3 family protein	0.0053	0.0608	0.1208
Loa Loa (eye worm)	MH2 domain-containing protein	0.0073	0.0932	0.1851
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0028	0.0194	0.0385
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0061	0.0733	0.1457
Entamoeba histolytica	Rab geranylgeranyltransferase alpha subunit, putative	0.005	0.056	0.1488
Brugia malayi	Delta serrate ligand family protein	0.0053	0.0608	0.1208
Entamoeba histolytica	heat shock transcription factor, putative	0.0076	0.0991	0.3043
Trypanosoma brucei	protein farnesyltransferase alpha subunit, putative	0.005	0.056	0.9655
Loa Loa (eye worm)	Notch2	0.0053	0.0608	0.1208
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0022	0.0094	0.1617
Plasmodium vivax	pyruvate kinase, putative	0.0051	0.058	0.1989
Schistosoma mansoni	cercarial elastase (S01 family)	0.0061	0.0733	0.1457
Onchocerca volvulus		0.0053	0.0608	0.0742
Brugia malayi	Pyruvate kinase, muscle isozyme	0.0051	0.058	0.1152
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0982	0.195
Entamoeba histolytica	pyruvate kinase, putative	0.0036	0.0324	0.0636
Brugia malayi	Animal haem peroxidase family protein	0.0321	0.5033	1
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.0061	0.0733	0.0733
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0061	0.0733	0.1457
Echinococcus multilocularis	lamin	0.0037	0.0347	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0608	0.1208
Echinococcus multilocularis	protein prenyltransferase alpha subunit	0.005	0.056	0.056
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0022	0.0094	0.0094
Schistosoma mansoni	hypothetical protein	0.0053	0.0608	0.1208
Trypanosoma brucei	pyruvate kinase 1, putative	0.0051	0.058	1
Brugia malayi	Animal haem peroxidase family protein	0.0321	0.5033	1
Schistosoma mansoni	protein farnesyltransferase alpha subunit	0.0193	0.2916	0.5793
Entamoeba histolytica	heat shock transcription factor, putative	0.0076	0.0991	0.3043
Echinococcus multilocularis	inhibitor of apoptosis protein	0.0096	0.1323	0.1323
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0608	0.1208
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0178	0.2664	0.909
Echinococcus multilocularis	geminin	0.0233	0.3578	0.3578
Schistosoma mansoni	hypothetical protein	0.0031	0.0251	0.0499
Echinococcus granulosus	apoptotic protease activating factor 1	0.0031	0.0253	0.0503
Schistosoma mansoni	hypothetical protein	0.0053	0.0608	0.1208
Brugia malayi	Calcium binding EGF domain containing protein	0.0053	0.0608	0.1208
Plasmodium vivax	pyruvate kinase 2, putative	0.0026	0.0169	0.0579
Onchocerca volvulus	Peroxidase homolog	0.0321	0.5033	1
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	0.0143	0.2091	0.7021
Loa Loa (eye worm)	hypothetical protein	0.004	0.0391	0.0776
Loa Loa (eye worm)	pyruvate kinase	0.0051	0.058	0.1152
Brugia malayi	isocitrate dehydrogenase	0.0022	0.0094	0.0186
Trypanosoma cruzi	protein farnesyltransferase alpha subunit, putative	0.005	0.056	0.9655
Loa Loa (eye worm)	hypothetical protein	0.0321	0.5033	1
Echinococcus granulosus	enteropeptidase	0.0061	0.0733	0.1457
Echinococcus granulosus	pyruvate kinase	0.0051	0.058	0.1152
Echinococcus multilocularis	expressed conserved protein	0.0071	0.0906	0.0906
Brugia malayi	Peroxidasin	0.0321	0.5033	1
Onchocerca volvulus		0.0053	0.0608	0.0742
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0733	0.1457
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0022	0.0094	0.1617
Brugia malayi	Trypsin family protein	0.0061	0.0733	0.1457
Schistosoma mansoni	hypothetical protein	0.0053	0.0608	0.1208
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0022	0.0094	0.0186
Giardia lamblia	Pyruvate kinase	0.0051	0.058	0.1496
Schistosoma mansoni	intermediate filament proteins	0.0037	0.0347	0.069
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0608	0.1208
Toxoplasma gondii	isocitrate dehydrogenase	0.0022	0.0094	0.0448
Echinococcus multilocularis	neural cadherin	0.0053	0.0608	0.0608
Trypanosoma cruzi	protein farnesyltransferase alpha subunit, putative	0.005	0.056	0.9655
Schistosoma mansoni	lamin	0.0037	0.0347	0.069
Schistosoma mansoni	rotamase	0.0026	0.0158	0.0314
Echinococcus multilocularis	protein patched	0.0032	0.027	0.027
Brugia malayi	Cadherin domain containing protein	0.0053	0.0608	0.1208
Loa Loa (eye worm)	hypothetical protein	0.0321	0.5033	1
Echinococcus multilocularis	pyruvate kinase	0.0026	0.0169	0.0169
Echinococcus granulosus	protein jagged 1	0.0053	0.0608	0.1208
Loa Loa (eye worm)	hypothetical protein	0.0321	0.5033	1
Echinococcus multilocularis	apoptotic protease activating factor 1	0.0031	0.0253	0.0253
Trypanosoma cruzi	hypothetical protein, conserved	0.005	0.056	0.9655
Loa Loa (eye worm)	hypothetical protein	0.0032	0.027	0.0537
Brugia malayi	Inhibitor of Apoptosis domain containing protein	0.0096	0.1323	0.2628
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0022	0.0094	0.0322
Loa Loa (eye worm)	hypothetical protein	0.0193	0.2916	0.5793
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0028	0.0194	0.0194
Treponema pallidum	fructose-bisphosphate aldolase	0.0178	0.2664	0.5
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0608	0.1208
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.0061	0.0733	0.0733
Echinococcus multilocularis	slit 2 protein	0.0053	0.0608	0.0608
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0178	0.2664	0.909
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0608	0.1208
Loa Loa (eye worm)	hypothetical protein	0.0321	0.5033	1
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0077	0.1001	0.1989
Echinococcus multilocularis	protein jagged 1	0.0053	0.0608	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0253	0.0503
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0025	0.0148	0.2557
Brugia malayi	Cell death protein 3 precursor	0.0031	0.0253	0.0503
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0018	0.0031	0.0031
Onchocerca volvulus		0.0061	0.0733	0.1004
Trypanosoma brucei	Protein prenyltransferase alpha subunit repeat, putative	0.005	0.056	0.9655
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0608	0.1208
Echinococcus multilocularis	sterol regulatory element binding protein	0.0032	0.027	0.027
Schistosoma mansoni	hypothetical protein	0.0031	0.0251	0.0499
Onchocerca volvulus	Peroxidasin homolog	0.0321	0.5033	1
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	0.0193	0.2916	0.5793
Brugia malayi	EGF-like domain containing protein	0.0053	0.0608	0.1208
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0061	0.0733	0.1457
Echinococcus granulosus	lamin dm0	0.0037	0.0347	0.069
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0022	0.0094	0.0094
Plasmodium falciparum	pyruvate kinase 2	0.0026	0.0169	0.0579
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0061	0.0733	0.1457
Toxoplasma gondii	hypothetical protein	0.005	0.056	0.2678
Giardia lamblia	High cysteine protein	0.0053	0.0608	0.1599
Brugia malayi	EGF-like domain containing protein	0.0053	0.0608	0.1208
Trypanosoma cruzi	hypothetical protein, conserved	0.005	0.056	0.9655
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0733	0.1457
Onchocerca volvulus	Chorion peroxidase homolog	0.0321	0.5033	1
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0608	0.1208
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.0061	0.0733	0.1457
Echinococcus granulosus	protein jagged 2	0.0053	0.0608	0.1208
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0733	0.1457
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0028	0.0194	0.0194
Echinococcus multilocularis	neurogenic locus protein delta	0.0053	0.0608	0.0608
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0178	0.2664	0.909
Echinococcus multilocularis	geranylgeranyl transferase type 2 subunit alpha	0.005	0.056	0.056
Schistosoma mansoni	hypothetical protein	0.0031	0.0253	0.0503
Echinococcus granulosus	pyruvate kinase	0.0026	0.0169	0.0336
Brugia malayi	notch-like transmembrane receptor	0.0053	0.0608	0.1208
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0608	0.1208
Mycobacterium ulcerans	hypothetical protein	0.0061	0.0733	0.2617
Brugia malayi	hypothetical protein	0.0061	0.0733	0.1457
Loa Loa (eye worm)	hypothetical protein	0.0051	0.058	0.1152
Brugia malayi	Intermediate filament tail domain containing protein	0.0037	0.0347	0.069
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0032	0.027	0.0537
Echinococcus granulosus	lamin	0.0037	0.0347	0.069
Toxoplasma gondii	hypothetical protein	0.0143	0.2091	1
Trypanosoma cruzi	Protein prenyltransferase alpha subunit repeat, putative	0.005	0.056	0.9655
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0087	0.1166	1
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0991	0.1968
Echinococcus multilocularis	neurogenic locus protein delta	0.0053	0.0608	0.0608
Echinococcus multilocularis	pyruvate kinase	0.0051	0.058	0.058
Loa Loa (eye worm)	transcription factor SMAD2	0.0073	0.0932	0.1851
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0193	0.2916	1
Brugia malayi	hypothetical protein	0.0031	0.0253	0.0503
Brugia malayi	cytoplasmic intermediate filament protein	0.002	0.0063	0.0125
Echinococcus multilocularis	enteropeptidase	0.0061	0.0733	0.0733
Schistosoma mansoni	notch	0.0053	0.0608	0.1208
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0051	0.058	1
Giardia lamblia	Fructose-bisphosphate aldolase	0.0178	0.2664	0.9083
Leishmania major	peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative	0.0025	0.0148	0.2557
Schistosoma mansoni	hypothetical protein	0.0233	0.3578	0.7109
Schistosoma mansoni	pyruvate kinase	0.0051	0.058	0.1152
Loa Loa (eye worm)	hypothetical protein	0.0321	0.5033	1
Trichomonas vaginalis	pyruvate kinase, putative	0.0051	0.058	0.156
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.006	0.0727	0.0727
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0178	0.2664	0.909
Onchocerca volvulus	Putative cubilin	0.0053	0.0608	0.0742
Loa Loa (eye worm)	trypsin family protein	0.0061	0.0733	0.1457
Schistosoma mansoni	cercarial elastase (S01 family)	0.0061	0.0733	0.1457
Loa Loa (eye worm)	hypothetical protein	0.0321	0.5033	1
Loa Loa (eye worm)	hypothetical protein	0.0321	0.5033	1
Brugia malayi	Animal haem peroxidase family protein	0.0321	0.5033	1
Echinococcus multilocularis	transmembrane protease serine 3	0.0061	0.0733	0.0733
Schistosoma mansoni	hypothetical protein	0.0233	0.3578	0.7109
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0053	0.0608	0.1208
Onchocerca volvulus	Neurogenic locus notch protein homolog	0.0053	0.0608	0.0742
Echinococcus granulosus	protein prenyltransferase alpha subunit	0.005	0.056	0.1113
Brugia malayi	CHE-14 protein	0.0032	0.027	0.0537
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.0158	0.0036
Brugia malayi	Muscle positioning protein 4	0.0053	0.0608	0.1208
Echinococcus granulosus	caspase 2	0.0031	0.0253	0.0503
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0608	0.1208
Schistosoma mansoni	hypothetical protein	0.0053	0.0608	0.1208
Echinococcus multilocularis	peroxidasin	0.0321	0.5033	0.5033
Onchocerca volvulus		0.0037	0.0347	0.0196
Schistosoma mansoni	hypothetical protein	0.0053	0.0608	0.1208
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.006	0.0727	0.1445
Echinococcus granulosus	delta-like protein 1	0.0053	0.0608	0.1208
Echinococcus granulosus	neurogenic locus protein delta	0.0053	0.0608	0.1208
Echinococcus granulosus	Protein patched homolog 1	0.0032	0.027	0.0537
Schistosoma mansoni	cercarial elastase (S01 family)	0.0061	0.0733	0.1457
Leishmania major	protein farnesyltransferase alpha subunit, putative	0.005	0.056	0.9655
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0022	0.0094	0.0322
Echinococcus granulosus	protein jagged 1	0.0053	0.0608	0.1208
Schistosoma mansoni	patched 1	0.0032	0.027	0.0537
Brugia malayi	Inhibitor of Apoptosis domain containing protein	0.0096	0.1323	0.2628
Echinococcus multilocularis	neurogenic locus notch protein	0.0053	0.0608	0.0608
Echinococcus granulosus	protein farnesyltransferase alpha subunit	0.0193	0.2916	0.5793
Toxoplasma gondii	EGF family domain-containing protein	0.0053	0.0608	0.2908
Loa Loa (eye worm)	animal heme peroxidase	0.0321	0.5033	1
Echinococcus granulosus	fibropellin Ia	0.0053	0.0608	0.1208
Echinococcus granulosus	expressed conserved protein	0.0071	0.0906	0.18
Echinococcus multilocularis	protein dispatched 1	0.0037	0.0346	0.0346
Echinococcus granulosus	sterol regulatory element binding protein	0.0032	0.027	0.0537
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0022	0.0094	0.1617
Schistosoma mansoni	cercarial elastase (S01 family)	0.0061	0.0733	0.1457
Echinococcus multilocularis	musashi	0.0037	0.0347	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0096	0.1323	0.2628
Brugia malayi	MH2 domain containing protein	0.0073	0.0932	0.1851
Echinococcus multilocularis	fibropellin Ia	0.0053	0.0608	0.0608
Brugia malayi	EGF-like domain containing protein	0.0053	0.0608	0.1208
Schistosoma mansoni	notch	0.0053	0.0608	0.1208
Schistosoma mansoni	peroxidasin	0.0321	0.5033	1
Brugia malayi	Trypsin family protein	0.0061	0.0733	0.1457
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0028	0.0194	0.0385
Plasmodium falciparum	pyruvate kinase	0.0051	0.058	0.1989
Brugia malayi	HSF-type DNA-binding domain containing protein	0.0076	0.0991	0.1968
Schistosoma mansoni	peroxidasin	0.0321	0.5033	1
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0022	0.0094	0.1617
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0608	0.1208
Echinococcus multilocularis	lysine specific demethylase 5A	0.006	0.0727	0.0727
Toxoplasma gondii	pyruvate kinase PyKII	0.0026	0.0169	0.0808
Brugia malayi	Pyruvate kinase, M2 isozyme	0.0051	0.058	0.1152
Echinococcus granulosus	notch	0.0053	0.0608	0.1208
Echinococcus multilocularis	pyruvate kinase	0.004	0.0402	0.0402
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0178	0.2664	0.909
Schistosoma mansoni	jumonji/arid domain-containing protein	0.006	0.0727	0.1445
Onchocerca volvulus	Neurogenic locus notch homolog	0.0053	0.0608	0.0742
Echinococcus granulosus	pyruvate kinase	0.0026	0.0169	0.0336
Onchocerca volvulus		0.0061	0.0733	0.1004
Schistosoma mansoni	hypothetical protein	0.0096	0.1323	0.2628
Onchocerca volvulus		0.0053	0.0608	0.0742
Echinococcus multilocularis	lamin dm0	0.0037	0.0347	0.0347
Echinococcus multilocularis	caspase 2	0.0031	0.0253	0.0253
Echinococcus granulosus	Mastin	0.0061	0.0733	0.1457
Loa Loa (eye worm)	Pin1-type peptidyl-prolyl cis-trans isomerase	0.0026	0.0158	0.0314
Loa Loa (eye worm)	animal heme peroxidase	0.0321	0.5033	1
Echinococcus multilocularis	pyruvate kinase	0.0051	0.058	0.058
Echinococcus multilocularis	isocitrate dehydrogenase	0.0022	0.0094	0.0094
Echinococcus multilocularis	protein farnesyltransferase alpha subunit	0.0193	0.2916	0.2916
Echinococcus granulosus	geranylgeranyl transferase type 2 subunit alpha	0.005	0.056	0.1113
Brugia malayi	Isocitrate dehydrogenase	0.0022	0.0094	0.0186
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0022	0.0094	0.0094
Brugia malayi	EGF-like domain containing protein	0.0053	0.0608	0.1208
Brugia malayi	Animal haem peroxidase family protein	0.0321	0.5033	1
Onchocerca volvulus	Slit protein homolog	0.0053	0.0608	0.0742
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0087	0.1166	1
Giardia lamblia	Rab geranylgeranyltransferase	0.005	0.056	0.1424
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0028	0.0194	0.0385
Echinococcus granulosus	neural cadherin	0.0053	0.0608	0.1208
Onchocerca volvulus	Deterin homolog	0.0096	0.1323	0.2238
Onchocerca volvulus	Heat shock factor protein 2 homolog	0.0076	0.0991	0.1542
Schistosoma mansoni	hypothetical protein	0.0053	0.0608	0.1208
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0028	0.0194	0.0385
Echinococcus granulosus	geminin	0.0233	0.3578	0.7109
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0178	0.2664	0.909
Echinococcus granulosus	pyruvate kinase	0.0026	0.0169	0.0336
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0178	0.2664	0.909
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0022	0.0094	0.0186
Echinococcus multilocularis	protein jagged 1	0.0053	0.0608	0.0608
Brugia malayi	Calcium binding EGF domain containing protein	0.0053	0.0608	0.1208
Schistosoma mansoni	inhibitor of apoptosis (iap) domain family member	0.0096	0.1323	0.2628
Brugia malayi	Blistered cuticle protein 3	0.0321	0.5033	1
Echinococcus granulosus	inhibitor of apoptosis protein	0.0096	0.1323	0.2628
Echinococcus granulosus	intermediate filament protein	0.0037	0.0347	0.069
Onchocerca volvulus		0.0053	0.0608	0.0742
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase/rotamase, putative	0.0025	0.0148	0.2557
Brugia malayi	Trypsin family protein	0.0061	0.0733	0.1457
Giardia lamblia	Rab geranylgeranyltransferase	0.0193	0.2916	1
Echinococcus multilocularis	neurogenic locus notch protein 4	0.0053	0.0608	0.0608
Schistosoma mansoni	hypothetical protein	0.0031	0.0251	0.0499
Schistosoma mansoni	hypothetical protein	0.0053	0.0608	0.1208
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0336	0.0667
Plasmodium falciparum	protein farnesyltransferase subunit alpha	0.0193	0.2916	1
Brugia malayi	Trypsin-like protease protein 5	0.0061	0.0733	0.1457
Echinococcus multilocularis	protein jagged 2	0.0053	0.0608	0.0608
Loa Loa (eye worm)	intermediate filament protein	0.0037	0.0347	0.069
Loa Loa (eye worm)	jmjC domain-containing protein	0.006	0.0727	0.1445
Loa Loa (eye worm)	hypothetical protein	0.0321	0.5033	1
Chlamydia trachomatis	pyruvate kinase	0.0051	0.058	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.027	0.0441
Echinococcus multilocularis	pyruvate kinase	0.0026	0.0169	0.0169
Schistosoma mansoni	jumonji domain containing protein	0.006	0.0727	0.1445
Echinococcus multilocularis	notch	0.0053	0.0608	0.0608
Echinococcus multilocularis	Niemann Pick C1 protein	0.0076	0.0982	0.0982
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0022	0.0094	0.1617
Trichomonas vaginalis	pyruvate kinase, putative	0.0051	0.058	0.156
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0028	0.0194	0.0385
Schistosoma mansoni	hypothetical protein	0.0061	0.0733	0.1457
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0028	0.0194	0.0385
Echinococcus granulosus	slit 2 protein	0.0053	0.0608	0.1208
Loa Loa (eye worm)	hypothetical protein	0.0321	0.5033	1
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0076	0.0982	0.3011
Loa Loa (eye worm)	notch protein	0.0053	0.0608	0.1208
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0061	0.0733	0.1457
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0037	0.0347	0.069
Brugia malayi	Calcium binding EGF domain containing protein	0.0053	0.0608	0.1208
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.0193	0.2916	0.5793
Schistosoma mansoni	cercarial elastase (S01 family)	0.0061	0.0733	0.1457
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0061	0.0733	0.1457
Leishmania major	pyruvate kinase	0.0051	0.058	1
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.0053	0.0608	0.1208
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0193	0.2916	1
Loa Loa (eye worm)	hypothetical protein	0.0321	0.5033	1
Loa Loa (eye worm)	hypothetical protein	0.0321	0.5033	1
Echinococcus granulosus	expressed protein	0.0026	0.0158	0.0314
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0347	0.069
Schistosoma mansoni	cell polarity protein	0.0053	0.0608	0.1208
Schistosoma mansoni	cercarial elastase (S01 family)	0.0061	0.0733	0.1457
Echinococcus granulosus	neurogenic locus notch protein 4	0.0053	0.0608	0.1208
Loa Loa (eye worm)	hypothetical protein	0.0321	0.5033	1
Brugia malayi	EGF-like domain containing protein	0.0053	0.0608	0.1208
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0028	0.0194	0.0385
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0022	0.0094	0.0094
Loa Loa (eye worm)	animal heme peroxidase	0.0321	0.5033	1
Schistosoma mansoni	notch	0.0053	0.0608	0.1208
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	0.005	0.056	0.1113
Trypanosoma brucei	Protein prenyltransferase alpha subunit repeat, putative	0.005	0.056	0.9655
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0062	0.0753	0.1497
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0608	0.1208
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0733	0.1457
Toxoplasma gondii	pyruvate kinase PyK1	0.0051	0.058	0.2773
Schistosoma mansoni	cercarial elastase (S01 family)	0.0061	0.0733	0.1457
Trypanosoma brucei	pyruvate kinase 1	0.0051	0.058	1
Schistosoma mansoni	notch	0.0053	0.0608	0.1208
Echinococcus granulosus	neurogenic locus notch protein	0.0053	0.0608	0.1208
Echinococcus multilocularis	fat cadherin tumor suppressor	0.0053	0.0608	0.0608
Echinococcus granulosus	pyruvate kinase	0.0051	0.058	0.1152
Schistosoma mansoni	lamin	0.0037	0.0347	0.069
Schistosoma mansoni	hypothetical protein	0.0061	0.0733	0.1457
Schistosoma mansoni	cercarial elastase (S01 family)	0.0061	0.0733	0.1457
Onchocerca volvulus	Peroxidasin homolog	0.0321	0.5033	1
Onchocerca volvulus		0.0061	0.0733	0.1004
Echinococcus multilocularis	pyruvate kinase	0.0026	0.0169	0.0169
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0022	0.0094	0.0186
Mycobacterium tuberculosis	Probable pyruvate kinase PykA	0.0051	0.058	0.4535
Loa Loa (eye worm)	hypothetical protein	0.0321	0.5033	1
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0608	0.1208
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0733	0.1457
Onchocerca volvulus	Pyruvate kinase homolog	0.0051	0.058	0.0683
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0178	0.2664	0.909
Schistosoma mansoni	hypothetical protein	0.0031	0.0251	0.0499
Schistosoma mansoni	pyruvate kinase	0.0026	0.0169	0.0336
Echinococcus multilocularis	Niemann Pick C1 protein	0.0108	0.1517	0.1517
Onchocerca volvulus		0.0061	0.0733	0.1004
Echinococcus granulosus	neurogenic locus notch protein	0.0053	0.0608	0.1208
Schistosoma mansoni	jumonji/arid domain-containing protein	0.006	0.0727	0.1445
Onchocerca volvulus		0.005	0.056	0.0642
Onchocerca volvulus		0.0061	0.0733	0.1004
Onchocerca volvulus		0.0321	0.5033	1
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0608	0.1208
Plasmodium vivax	protein prenyltransferase alpha subunit, putative	0.005	0.056	0.1921
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0608	0.1208
Schistosoma mansoni	septate junction protein	0.0053	0.0608	0.1208
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0608	0.1208
Echinococcus granulosus	protein jagged 2	0.0053	0.0608	0.1208
Onchocerca volvulus	Peroxidase homolog	0.0321	0.5033	1
Brugia malayi	EGF-like domain containing protein	0.0053	0.0608	0.1208
Trichomonas vaginalis	rotamase, putative	0.0026	0.0158	0.0036
Toxoplasma gondii	peptidylprolyl isomerase	0.0025	0.0148	0.0709
Brugia malayi	Niemann-Pick C1 protein precursor	0.0076	0.0982	0.195
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0178	0.2664	0.909
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0608	0.1208
Brugia malayi	jmjC domain containing protein	0.006	0.0727	0.1445
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0253	0.0503
Brugia malayi	intermediate filament protein	0.0037	0.0347	0.069
Brugia malayi	Animal haem peroxidase family protein	0.0321	0.5033	1
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0061	0.0733	0.1457
Brugia malayi	jmjC domain containing protein	0.006	0.0727	0.1445
Schistosoma mansoni	notch	0.0053	0.0608	0.1208
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0608	0.1208
Schistosoma mansoni	pyruvate kinase	0.0051	0.058	0.1152
Echinococcus granulosus	lysine specific demethylase 5A	0.006	0.0727	0.1445
Echinococcus multilocularis	expressed protein	0.0026	0.0158	0.0158
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0608	0.1208
Loa Loa (eye worm)	pyruvate kinase	0.0051	0.058	0.1152
Schistosoma mansoni	cercarial elastase (S01 family)	0.0061	0.0733	0.1457
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0178	0.2664	0.909
Echinococcus granulosus	baculoviral IAP repeat containing protein	0.0096	0.1323	0.2628
Leishmania major	pyruvate kinase	0.0051	0.058	1
Onchocerca volvulus		0.0096	0.1323	0.2238
Loa Loa (eye worm)	pyruvate kinase-PB	0.0036	0.0324	0.0645
Plasmodium falciparum	geranylgeranyl transferase type-2 subunit alpha, putative	0.005	0.056	0.1921
Onchocerca volvulus	Dual oxidase homolog	0.0321	0.5033	1
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0733	0.1457
Echinococcus granulosus	transmembrane protease serine 3	0.0061	0.0733	0.1457
Echinococcus granulosus	peroxidasin	0.0321	0.5033	1
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.0061	0.0733	0.1457
Onchocerca volvulus		0.0321	0.5033	1
Echinococcus multilocularis	glycoprotein Antigen 5	0.0061	0.0733	0.0733
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0608	0.1208
Schistosoma mansoni	laminin gamma-3 chain	0.0053	0.0608	0.1208
Toxoplasma gondii	isocitrate dehydrogenase	0.0022	0.0094	0.0448
Onchocerca volvulus		0.0037	0.0347	0.0196
Loa Loa (eye worm)	hypothetical protein	0.0096	0.1323	0.2628
Onchocerca volvulus	Pyruvate kinase homolog	0.0051	0.058	0.0683
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0324	0.0645
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0733	0.1457
Brugia malayi	Trypsin family protein	0.0061	0.0733	0.1457
Echinococcus multilocularis	neurogenic locus notch protein	0.0053	0.0608	0.0608
Echinococcus granulosus	Niemann Pick C1 protein	0.0076	0.0982	0.195
Entamoeba histolytica	heat shock transcription factor, putative	0.0076	0.0991	0.3043
Schistosoma mansoni	cercarial elastase (S01 family)	0.0061	0.0733	0.1457
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.005	0.056	0.1113
Loa Loa (eye worm)	pyruvate kinase	0.0051	0.058	0.1152
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.005	0.056	0.1488
Loa Loa (eye worm)	hypothetical protein	0.0321	0.5033	1
Schistosoma mansoni	notch	0.0053	0.0608	0.1208
Trypanosoma brucei	hypothetical protein, conserved	0.005	0.056	0.9655
Brugia malayi	Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1	0.0026	0.0158	0.0314
Brugia malayi	Cadherin domain containing protein	0.0053	0.0608	0.1208
Loa Loa (eye worm)	animal heme peroxidase	0.0321	0.5033	1
Echinococcus granulosus	Niemann Pick C1 protein	0.0108	0.1517	0.3013
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0608	0.1208
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0061	0.0733	0.1457
Plasmodium vivax	prenyltransferase alpha subunit, putative	0.0193	0.2916	1
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0608	0.1208
Loa Loa (eye worm)	blistered cuticle protein 3	0.0321	0.5033	1
Brugia malayi	EGF-like domain containing protein	0.0053	0.0608	0.1208
Echinococcus multilocularis	Mastin	0.0061	0.0733	0.0733
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.002	0.0063	0.0125
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0025	0.0148	0.2557
Schistosoma mansoni	cercarial elastase (S01 family)	0.0061	0.0733	0.1457
Onchocerca volvulus		0.0053	0.0608	0.0742
Schistosoma mansoni	inhibitor of apoptosis protein	0.0096	0.1323	0.2628
Onchocerca volvulus		0.0321	0.5033	1
Brugia malayi	hypothetical protein	0.0321	0.5033	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 3.1 uM	In vitro inhibition of farnesyltransferase farnesylation of the H-ras oncogene	ChEMBL.	9526562
IC50 (binding)	= 3.1 uM	In vitro inhibition of farnesyltransferase farnesylation of the H-ras oncogene	ChEMBL.	9526562

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 10504924

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 302481