Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Cavia porcellus | Neurokinin 2 receptor | Starlite/ChEMBL | References |
Cavia porcellus | Neurokinin 1 receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K04224 tachykinin receptor 3, putative | Get druggable targets OG5_137770 | All targets in OG5_137770 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0242 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0242 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0242 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0242 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0242 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0242 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0242 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0242 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0242 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0242 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0242 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0242 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0242 | 0.5 | 0.5 | |
Onchocerca volvulus | 0.0242 | 0.5 | 0.5 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0242 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0242 | 0.5 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0242 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0242 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0242 | 0.5 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.0242 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0242 | 0.5 | 0.5 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0242 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0242 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0242 | 0.5 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0242 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0242 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0242 | 0.5 | 0.5 |
Brugia malayi | Peroxidasin | 0.0242 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0242 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0242 | 0.5 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0242 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0242 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0242 | 0.5 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0242 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0242 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0242 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0242 | 0.5 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.0242 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0242 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 65 ng ml-1 | Inhibitory activity against Neurokinin 1 (NK1) receptor from guinea pig lung | ChEMBL. | 10206553 |
IC50 (binding) | = 65 ng ml-1 | Inhibitory activity against Neurokinin 1 (NK1) receptor from guinea pig lung | ChEMBL. | 10206553 |
IC50 (binding) | = 170 ng ml-1 | Inhibitory activity against Neurokinin 2 (NK2) receptor from guinea pig ileum | ChEMBL. | 10206553 |
IC50 (binding) | = 170 ng ml-1 | Inhibitory activity against Neurokinin 2 (NK2) receptor from guinea pig ileum | ChEMBL. | 10206553 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.