Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | animal heme peroxidase | 0.024 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.024 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.024 | 0.5 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.024 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.024 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.024 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.024 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.024 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.024 | 0.5 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.024 | 0.5 | 0.5 |
Brugia malayi | Peroxidasin | 0.024 | 0.5 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.024 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.024 | 0.5 | 0.5 |
Onchocerca volvulus | 0.024 | 0.5 | 0.5 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.024 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.024 | 0.5 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.024 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.024 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.024 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.024 | 0.5 | 0.5 |
Onchocerca volvulus | 0.024 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.024 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.024 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.024 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.024 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.024 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.024 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.024 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.024 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.024 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.024 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.024 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.024 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.024 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.024 | 0.5 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.024 | 0.5 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.024 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.024 | 0.5 | 0.5 |
Onchocerca volvulus | 0.024 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Oral activity (functional) | = 1.7 | Compound was tested for diuretic activity in dogs at 5 mg/kg dose after intravenous administration measured as microequivalent of K+/minute (Control/Drug treated) | ChEMBL. | 7277395 |
Oral activity (functional) | = 1.7 | Compound was tested for diuretic activity in dogs at 5 mg/kg dose after oral administration measured as microequivalent of K+/minute | ChEMBL. | 7277395 |
Oral activity (functional) | = 2.1 | Compound was tested for diuretic activity in dogs at 5 mg/kg dose after intravenous administration measured as microequivalent of Na+/minute (Control/Drug treated) | ChEMBL. | 7277395 |
Oral activity (functional) | = 2.1 | Compound was tested for diuretic activity in dogs at 5 mg/kg dose after oral administration measured as microequivalent of Na+/minute | ChEMBL. | 7277395 |
Oral activity (functional) | = 3 | Compound was tested for diuretic activity in dogs at 5 mg/kg dose after intravenous administration measured as microequivalent of Cl-/minute (Control/Drug treated) | ChEMBL. | 7277395 |
Oral activity (functional) | = 3 | Compound was tested for diuretic activity in dogs at 5 mg/kg dose after oral administration measured as microequivalent of Cl-/minute | ChEMBL. | 7277395 |
Oral activity (functional) | = 7 | Natriuretic activity in rats at 3 mg/kg of dosage; mequiv of Na | ChEMBL. | 7277395 |
Oral activity (functional) | = 9 | Natriuretic activity in rats at 9 mg/kg of dosage; mequiv of Na | ChEMBL. | 7277395 |
Oral activity (functional) | = 11 | Natriuretic activity in rats at 27 mg/kg of dosage; mequiv of Na | ChEMBL. | 7277395 |
Oral activity (functional) | = 25 | Natriuretic activity in rats at 81 mg/kg of dosage; mequiv of Na | ChEMBL. | 7277395 |
Urine volume (functional) | = 229 ml min-1 | Diuretic activity in dogs following 5 mg/kg i.v. administration. | ChEMBL. | 7277395 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.