Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Hypothetical protein | 0.0137 | 0.8159 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.8899 | 0.8899 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0155 | 1 | 1 |
Leishmania major | cytochrome P450 reductase, putative | 0.0137 | 0.8159 | 0.8159 |
Brugia malayi | FAD binding domain containing protein | 0.0096 | 0.3805 | 0.3805 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0059 | 0 | 0.5 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0155 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0155 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0077 | 0.1841 | 0.5 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0096 | 0.3805 | 0.2407 |
Treponema pallidum | flavodoxin | 0.0059 | 0 | 0.5 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0155 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0077 | 0.1841 | 0.5 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0155 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0155 | 1 | 1 |
Leishmania major | p450 reductase, putative | 0.0155 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0059 | 0 | 0.5 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0155 | 1 | 1 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0155 | 1 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0078 | 0.1964 | 0.0151 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0155 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0059 | 0 | 0.5 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0155 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0059 | 0 | 0.5 |
Chlamydia trachomatis | sulfite reductase | 0.0096 | 0.3805 | 0.5 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0155 | 1 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0155 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0155 | 1 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0155 | 1 | 0.5 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0137 | 0.8159 | 0.5 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0059 | 0 | 0.5 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0137 | 0.8159 | 0.8159 |
Trypanosoma cruzi | p450 reductase, putative | 0.0155 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0155 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0155 | 1 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.8899 | 0.8899 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.8899 | 0.8899 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0096 | 0.3805 | 0.3805 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0155 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0155 | 1 | 1 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0137 | 0.8159 | 0.8159 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0155 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | > 100 ug ml-1 | Compound was tested for brine shrimp (Artemia salina) toxicity measured as the lowest value at which severe inhibition of nauplii movement was observed | ChEMBL. | 10673087 |
Potency (functional) | 3.1623 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 3.5481 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.