Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adrenoceptor alpha 1D | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | amine GPCR | Get druggable targets OG5_128924 | All targets in OG5_128924 |
Schistosoma japonicum | Alpha-1D adrenergic receptor, putative | Get druggable targets OG5_128924 | All targets in OG5_128924 |
Schistosoma japonicum | ko:K04135 adrenergic receptor, alpha 1a, putative | Get druggable targets OG5_128924 | All targets in OG5_128924 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | inositol monophosphatase 1 | 0.0039 | 0.1265 | 0.3892 |
Echinococcus multilocularis | lamin | 0.0027 | 0.0648 | 0.1884 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0039 | 0.1265 | 0.5 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0039 | 0.1265 | 0.5 |
Brugia malayi | hypothetical protein | 0.0075 | 0.3143 | 0.5396 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.1707 | 0.1649 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.0648 | 0.1884 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0039 | 0.1265 | 0.5 |
Schistosoma mansoni | lamin | 0.0027 | 0.0648 | 0.0583 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0039 | 0.1265 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.1707 | 0.5328 |
Echinococcus multilocularis | musashi | 0.0027 | 0.0648 | 0.1884 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.0648 | 0.1112 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.1016 | 0.0953 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0048 | 0.1707 | 0.293 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0069 | 0.0118 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.1832 | 0.3144 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.1707 | 0.1649 |
Schistosoma mansoni | inositol monophosphatase | 0.0039 | 0.1265 | 0.1205 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.0648 | 0.1112 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0016 | 0.0069 | 0.0118 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.1832 | 0.3144 |
Schistosoma mansoni | hypothetical protein | 0.0075 | 0.3143 | 0.3096 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0048 | 0.1707 | 0.293 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0075 | 0.3143 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0075 | 0.3143 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.0127 | 0.5825 | 1 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.1265 | 0.5 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.1265 | 0.5 |
Loa Loa (eye worm) | inositol-1 | 0.0039 | 0.1265 | 0.2172 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0035 | 0.1054 | 0.5 |
Echinococcus granulosus | lamin | 0.0027 | 0.0648 | 0.1884 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0016 | 0.0069 | 0.0118 |
Onchocerca volvulus | Huntingtin homolog | 0.0127 | 0.5825 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0648 | 0.1112 |
Schistosoma mansoni | inositol monophosphatase | 0.0039 | 0.1265 | 0.1205 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.1265 | 0.5 |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 0.0648 | 0.0583 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.5825 | 1 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0035 | 0.1054 | 0.5 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.0648 | 0.1884 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.0648 | 0.1112 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0039 | 0.1265 | 0.3892 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.1707 | 0.5328 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0016 | 0.0069 | 0.0118 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.1707 | 0.1649 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.1832 | 0.3144 |
Schistosoma mansoni | lamin | 0.0027 | 0.0648 | 0.0583 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.1832 | 0.3144 |
Brugia malayi | hypothetical protein | 0.0127 | 0.5825 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.1707 | 0.5328 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.1016 | 0.1743 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0039 | 0.1265 | 0.5 |
Brugia malayi | Inositol-1 | 0.0039 | 0.1265 | 0.2172 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0039 | 0.1265 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0075 | 0.3143 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.1016 | 0.1743 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.0648 | 0.1112 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0622 | 0.1068 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.1265 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.1707 | 0.5328 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.5825 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0075 | 0.3143 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0075 | 0.3143 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0075 | 0.3143 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0075 | 0.3143 | 0.3096 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.0648 | 0.1884 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 24 % | QT interval was determined during cardiovascular test in normotensive male albino Long-Evans rat; delta QT | ChEMBL. | 11300868 |
ED50 (functional) | = 1.18 mg kg-1 | In vivo antinociceptive activity was determined using in rat abdominal irritant test (RAIT) assay | ChEMBL. | 11300868 |
ED50 (functional) | = 2.2 mg kg-1 | In vivo antinociceptive activity was determined using in rat abdominal irritant test (RAIT) assay | ChEMBL. | 11300868 |
Inhibition (functional) | = 100 % | In vivo antinociceptive activity was determined by mouse abdominal irritant test (MAIT) in male pathogen free albino CD-1 mice | ChEMBL. | 11300868 |
Ki (binding) | = 0.78 nM | In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat | ChEMBL. | 11300868 |
Ki (binding) | = 0.78 nM | In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat | ChEMBL. | 11300868 |
Ki (binding) | = 2.1 nM | In vitro binding affinity against alpha-2D adrenergic receptor of male Wistar rat | ChEMBL. | 11300868 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.