Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | coagulation factor X | Starlite/ChEMBL | References |
Homo sapiens | protease, serine, 1 (trypsin 1) | Starlite/ChEMBL | References |
Homo sapiens | plasminogen | Starlite/ChEMBL | References |
Homo sapiens | coagulation factor II (thrombin) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Trypsin family protein | protease, serine, 1 (trypsin 1) | 247 aa | 287 aa | 21.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | calcium channel | 0.0198 | 1 | 1 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0198 | 1 | 1 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0198 | 1 | 1 |
Schistosoma mansoni | high voltage-activated calcium channel Cav1 | 0.0198 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.8854 | 1 |
Onchocerca volvulus | 0.013 | 0.498 | 1 | |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0198 | 1 | 1 |
Brugia malayi | Trypsin family protein | 0.0126 | 0.4735 | 0.4735 |
Trypanosoma cruzi | Voltage-dependent calcium channel subunit, putative | 0.0121 | 0.4313 | 0.4872 |
Loa Loa (eye worm) | hypothetical protein | 0.0126 | 0.4735 | 0.4433 |
Onchocerca volvulus | 0.0106 | 0.3269 | 0.6144 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0069 | 0.0543 | 0.0614 |
Echinococcus granulosus | voltage dependent calcium channel | 0.0198 | 1 | 1 |
Schistosoma mansoni | voltage-gated cation channel | 0.0198 | 1 | 1 |
Echinococcus granulosus | voltage dependent L type calcium channel subunit|voltage dependent calcium channel | 0.0198 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0126 | 0.4735 | 0.4433 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0183 | 0.8854 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.8854 | 1 |
Echinococcus multilocularis | sodium channel protein | 0.0084 | 0.164 | 0.116 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0062 | 0 | 0.5 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0198 | 1 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.013 | 0.498 | 0.4692 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0198 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0069 | 0.0543 | 0.0543 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.8854 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0126 | 0.4735 | 0.4433 |
Brugia malayi | thymidylate synthase | 0.013 | 0.498 | 0.498 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.013 | 0.498 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.8854 | 1 |
Brugia malayi | Kringle domain containing protein | 0.0069 | 0.0543 | 0.0543 |
Loa Loa (eye worm) | hypothetical protein | 0.0198 | 1 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.013 | 0.498 | 1 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 | 0.0198 | 1 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.013 | 0.498 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0126 | 0.4735 | 0.4433 |
Schistosoma mansoni | high voltage-activated calcium channel Cav2A | 0.0198 | 1 | 1 |
Echinococcus granulosus | voltage gated sodium channel Nav1 alpha subunit | 0.0084 | 0.164 | 0.116 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0198 | 1 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.013 | 0.498 | 0.4692 |
Echinococcus granulosus | thymidylate synthase | 0.013 | 0.498 | 0.4692 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.8854 | 1 |
Onchocerca volvulus | 0.0126 | 0.4735 | 0.9448 | |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu | 0.0198 | 1 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.013 | 0.498 | 0.4692 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 6.2 nM | Concentration required for the in vitro inhibitory activity against human enzyme, thrombin cleavage of the chromogenic substrate | ChEMBL. | 10206557 |
IC50 (binding) | = 6.2 nM | Concentration required for the in vitro inhibitory activity against human enzyme, thrombin cleavage of the chromogenic substrate | ChEMBL. | 10206557 |
IC50 (binding) | = 791 nM | Concentration required for the in vitro inhibitory activity against human enzyme, trypsin cleavage of the chromogenic substrate | ChEMBL. | 10206557 |
IC50 (binding) | = 791 nM | Concentration required for the in vitro inhibitory activity against human enzyme, trypsin cleavage of the chromogenic substrate | ChEMBL. | 10206557 |
IC50 (binding) | = 2500 nM | Concentration required for the in vitro inhibitory activity against human enzyme, Factor Xa cleavage of the chromogenic substrate | ChEMBL. | 10206557 |
IC50 (binding) | > 2500 nM | Concentration required for the in vitro inhibitory activity against human enzyme, Plasmin cleavage of the chromogenic substrate | ChEMBL. | 10206557 |
IC50 (binding) | = 2500 nM | Concentration required for the in vitro inhibitory activity against human enzyme, Factor Xa cleavage of the chromogenic substrate | ChEMBL. | 10206557 |
IC50 (binding) | > 2500 nM | Concentration required for the in vitro inhibitory activity against human enzyme, Plasmin cleavage of the chromogenic substrate | ChEMBL. | 10206557 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.