Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | fk506 binding protein, putative | 0.0182 | 0.1221 | 0.1238 |
Schistosoma mansoni | immunophilin | 0.1339 | 1 | 1 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 | 0.132 | 0.9863 | 0.9975 |
Trichomonas vaginalis | immunophilin, putative | 0.132 | 0.9863 | 1 |
Echinococcus granulosus | FK506 binding protein 8 38 kDa | 0.0182 | 0.1221 | 0.1221 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.132 | 0.9863 | 1 |
Schistosoma mansoni | immunophilin | 0.1157 | 0.8621 | 0.8621 |
Onchocerca volvulus | 0.0185 | 0.1242 | 1 | |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase FKBP35 | 0.132 | 0.9863 | 1 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.1157 | 0.8621 | 0.8621 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0182 | 0.1221 | 0.1238 |
Schistosoma mansoni | hypothetical protein | 0.0182 | 0.1221 | 0.1221 |
Chlamydia trachomatis | peptidyl-prolyl cis-trans isomerase | 0.0182 | 0.1221 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0182 | 0.1221 | 0.1238 |
Mycobacterium tuberculosis | Probable trigger factor (TF) protein Tig | 0.0182 | 0.1221 | 0.5 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.132 | 0.9863 | 1 |
Trypanosoma brucei | macrophage infectivity potentiator, precursor, putative | 0.0182 | 0.1221 | 0.1238 |
Treponema pallidum | peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) | 0.132 | 0.9863 | 1 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.1339 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.1221 | 0.1238 |
Echinococcus multilocularis | 0.0182 | 0.1221 | 0.1221 | |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.132 | 0.9863 | 1 |
Mycobacterium leprae | PROBABLE TRIGGER FACTOR (TF) PROTEIN TIG | 0.0182 | 0.1221 | 0.5 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.132 | 0.9863 | 1 |
Leishmania major | fk506-binding protein 1-like protein | 0.132 | 0.9863 | 1 |
Wolbachia endosymbiont of Brugia malayi | FKBP-type peptidylprolyl isomerase | 0.0182 | 0.1221 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0182 | 0.1221 | 0.1238 |
Trypanosoma brucei | FKBP-type peptidylprolyl cis-trans isomerase, putative | 0.0182 | 0.1221 | 0.1238 |
Wolbachia endosymbiont of Brugia malayi | FKBP-type peptidylprolyl isomerase | 0.0182 | 0.1221 | 0.5 |
Onchocerca volvulus | 0.0182 | 0.1221 | 0.9829 | |
Echinococcus multilocularis | FK506 binding protein 8, 38 kDa | 0.02 | 0.1358 | 0.1358 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0182 | 0.1221 | 0.1238 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.1157 | 0.8621 | 0.8621 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.132 | 0.9863 | 0.9863 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.1323 | 0.9884 | 1 |
Schistosoma mansoni | immunophilin | 0.1339 | 1 | 1 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative | 0.1339 | 1 | 1 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0182 | 0.1221 | 0.5 |
Leishmania major | FKBP-type peptidyl-prolyl cis-trans isomerase, putative | 0.0182 | 0.1221 | 0.1238 |
Leishmania major | peptidyl-prolyl cis-trans isomerase, putative | 0.0182 | 0.1221 | 0.1238 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.132 | 0.9863 | 1 |
Giardia lamblia | 70 kDa peptidylprolyl isomerase, putative | 0.132 | 0.9863 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0182 | 0.1221 | 0.1238 |
Leishmania major | peptidyl-prolyl cis-trans isomerase, macrophage infectivity potentiator precursor, putative | 0.0182 | 0.1221 | 0.1238 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.0182 | 0.1221 | 0.1238 |
Echinococcus granulosus | FK506 binding protein 2 | 0.0182 | 0.1221 | 0.1221 |
Echinococcus multilocularis | fk506 binding protein | 0.132 | 0.9863 | 0.9863 |
Mycobacterium ulcerans | FK-506 binding protein, peptidyl-prolyl cis-trans isomerase | 0.132 | 0.9863 | 1 |
Schistosoma mansoni | fk506 binding protein | 0.0182 | 0.1221 | 0.1221 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0182 | 0.1221 | 0.5 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-30 | 0.0182 | 0.1221 | 0.1238 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.132 | 0.9863 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1142 | 0.8505 | 0.8624 |
Leishmania major | peptidylprolyl isomerase-like protein | 0.132 | 0.9863 | 1 |
Loa Loa (eye worm) | FKBP5 protein | 0.132 | 0.9863 | 1 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.132 | 0.9863 | 0.9863 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type, putative | 0.1339 | 1 | 1 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0182 | 0.1221 | 0.5 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.132 | 0.9863 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.132 | 0.9863 | 1 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.132 | 0.9863 | 1 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-33 | 0.0182 | 0.1221 | 0.1238 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-13 | 0.0182 | 0.1221 | 0.1238 |
Plasmodium vivax | 70 kDa peptidylprolyl isomerase, putative | 0.132 | 0.9863 | 1 |
Trypanosoma brucei | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.132 | 0.9863 | 1 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.132 | 0.9863 | 1 |
Toxoplasma gondii | peptidyl-prolyl isomerase FKBP12, putative | 0.0182 | 0.1221 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | uM | Compound was evaluated as nitric oxide producing substrate of bovine Endothelial nitric oxide synthase using the Griess assay; NA means Not active | ChEMBL. | 10571154 |
IC50 (binding) | uM | Compound was evaluated as nitric oxide producing substrate of rat Neuronal nitric oxide synthase using the Griess assay; NA means Not active | ChEMBL. | 10571154 |
IC50 (binding) | uM | Compound was evaluated as nitric oxide producing substrate of mouse Inducible nitric oxide synthase using the Griess assay; NA means Not active | ChEMBL. | 10571154 |
IC50 (binding) | 0 uM | Compound was evaluated as nitric oxide producing substrate of mouse Inducible nitric oxide synthase using the Griess assay; NA means Not active | ChEMBL. | 10571154 |
IC50 (binding) | 0 uM | Compound was evaluated as nitric oxide producing substrate of bovine Endothelial nitric oxide synthase using the Griess assay; NA means Not active | ChEMBL. | 10571154 |
IC50 (binding) | 0 uM | Compound was evaluated as nitric oxide producing substrate of rat Neuronal nitric oxide synthase using the Griess assay; NA means Not active | ChEMBL. | 10571154 |
ID50 (functional) | > 500 uM kg-1 | Tested for inhibition of histamine-stimulated gastric acid secretion in the lumen-perfused anesthetized rat expressed as intravenous dose which reduces a near maximal secretion to 50% | ChEMBL. | 6120235 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.