Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | ATP binding cassette subfamily B (MDR:TAP) | 0.0022 | 0.0113 | 0.0113 |
Entamoeba histolytica | P-glyco protein 6, putative | 0.0022 | 0.0113 | 1 |
Giardia lamblia | MRP-like ABC transporter | 0.0007 | 0 | 0.5 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.0022 | 0.0113 | 0.0238 |
Echinococcus multilocularis | ATP binding cassette subfamily B (MDR:TAP) | 0.0022 | 0.0113 | 0.0113 |
Schistosoma mansoni | multidrug resistance protein | 0.0022 | 0.0113 | 0.0113 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.1321 | 1 | 1 |
Giardia lamblia | Multidrug resistance-associated protein 1 | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.1321 | 1 | 1 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.0022 | 0.0113 | 0.0238 |
Entamoeba histolytica | P-glycoprotein-1 | 0.0022 | 0.0113 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.1321 | 1 | 1 |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.0022 | 0.0113 | 0.0238 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1321 | 1 | 1 |
Plasmodium vivax | multidrug resistance protein 1, putative | 0.0022 | 0.0113 | 0.0113 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.0022 | 0.0113 | 0.0238 |
Schistosoma mansoni | multidrug resistance protein | 0.0022 | 0.0113 | 0.0113 |
Echinococcus multilocularis | kinesin protein KIF20A | 0.0768 | 0.5796 | 0.5796 |
Echinococcus granulosus | multidrug resistance protein 1 | 0.0015 | 0.0063 | 0.0063 |
Echinococcus granulosus | thymidylate synthase | 0.1321 | 1 | 1 |
Echinococcus multilocularis | multidrug resistance protein 1 | 0.0022 | 0.0113 | 0.0113 |
Echinococcus granulosus | ATP binding cassette subfamily B MDR:TAP | 0.0022 | 0.0113 | 0.0113 |
Trichomonas vaginalis | abcb9, putative | 0.0022 | 0.0113 | 0.0238 |
Trichomonas vaginalis | abcb9, putative | 0.0022 | 0.0113 | 0.0238 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.0022 | 0.0113 | 0.0238 |
Chlamydia trachomatis | ABC transporter ATP binding protein/permease | 0.0022 | 0.0113 | 0.5 |
Echinococcus multilocularis | multidrug resistance protein 1 | 0.0022 | 0.0113 | 0.0113 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.0022 | 0.0113 | 0.0238 |
Echinococcus granulosus | ATP binding cassette subfamily B MDR:TAP | 0.0022 | 0.0113 | 0.0113 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1321 | 1 | 1 |
Trichomonas vaginalis | ABC transporter, putative | 0.0022 | 0.0113 | 0.0238 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0113 | 0.0113 |
Trichomonas vaginalis | ABC transporter, putative | 0.0022 | 0.0113 | 0.0238 |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.0022 | 0.0113 | 0.0238 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1321 | 1 | 1 |
Toxoplasma gondii | ABC transporter transmembrane region domain-containing protein | 0.0022 | 0.0113 | 0.0113 |
Echinococcus multilocularis | ATP binding cassette subfamily B (MDR:TAP) | 0.0022 | 0.0113 | 0.0113 |
Echinococcus granulosus | 5'partial|ATP binding cassette sub family B | 0.0021 | 0.0111 | 0.0111 |
Loa Loa (eye worm) | multidrug resistance protein 3 | 0.0022 | 0.0113 | 0.0113 |
Entamoeba histolytica | P-glycoprotein-5 | 0.0022 | 0.0113 | 1 |
Trichomonas vaginalis | ABC transporter, putative | 0.0022 | 0.0113 | 0.0238 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.0022 | 0.0113 | 0.0238 |
Schistosoma mansoni | multidrug resistance protein | 0.0022 | 0.0113 | 0.0113 |
Echinococcus granulosus | multidrug resistance protein 1 | 0.0022 | 0.0113 | 0.0113 |
Echinococcus multilocularis | kinesin protein KIF20A | 0.0768 | 0.5796 | 0.5796 |
Plasmodium falciparum | multidrug resistance protein 1 | 0.0022 | 0.0113 | 0.0113 |
Loa Loa (eye worm) | ATP-binding cassette sub-family B member 2 | 0.0022 | 0.0113 | 0.0113 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.0022 | 0.0113 | 0.0238 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.0022 | 0.0113 | 0.0238 |
Leishmania major | ATP-binding cassette protein subfamily B, member 2, putative | 0.0022 | 0.0113 | 0.0113 |
Echinococcus multilocularis | multidrug resistance protein 1 | 0.0015 | 0.0063 | 0.0063 |
Mycobacterium tuberculosis | Probable transmembrane multidrug efflux pump | 0.0022 | 0.0113 | 0.0113 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.0022 | 0.0113 | 0.0238 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.0022 | 0.0113 | 0.0238 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0628 | 0.473 | 0.473 |
Echinococcus multilocularis | ATP binding cassette subfamily B (MDR:TAP) | 0.0022 | 0.0113 | 0.0113 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.0022 | 0.0113 | 0.0238 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.0022 | 0.0113 | 0.0238 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0113 | 0.0113 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1321 | 1 | 1 |
Trichomonas vaginalis | ABC transporter, half transporter, putative | 0.0022 | 0.0113 | 0.0238 |
Echinococcus granulosus | ATP binding cassette subfamily B MDR:TAP | 0.0022 | 0.0113 | 0.0113 |
Giardia lamblia | Multidrug resistance-associated protein 1 | 0.0007 | 0 | 0.5 |
Entamoeba histolytica | P-glycoprotein-2 | 0.0022 | 0.0113 | 1 |
Echinococcus granulosus | multidrug resistance protein 1 | 0.0015 | 0.0063 | 0.0063 |
Brugia malayi | multidrug resistance protein 3 | 0.0022 | 0.0113 | 0.0113 |
Echinococcus granulosus | ATP binding cassette subfamily B MDR:TAP | 0.0022 | 0.0113 | 0.0113 |
Trichomonas vaginalis | abcb9, putative | 0.0022 | 0.0113 | 0.0238 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.0022 | 0.0113 | 0.0238 |
Entamoeba histolytica | P-glycoprotein 5, putative | 0.0022 | 0.0113 | 1 |
Entamoeba histolytica | P-glycoprotein-2, putative | 0.0022 | 0.0113 | 1 |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.0022 | 0.0113 | 0.0238 |
Mycobacterium ulcerans | thymidylate synthase | 0.1321 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1321 | 1 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.1321 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1321 | 1 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.1321 | 1 | 1 |
Trichomonas vaginalis | ABC transporter, half transporter, putative | 0.0022 | 0.0113 | 0.0238 |
Brugia malayi | hypothetical protein | 0.0628 | 0.473 | 0.473 |
Echinococcus multilocularis | ATP binding cassette sub family B | 0.0021 | 0.0111 | 0.0111 |
Brugia malayi | ABC transporter family protein | 0.0022 | 0.0113 | 0.0113 |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.0015 | 0.0063 | 0.0134 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0111 | 0.0111 |
Entamoeba histolytica | P-glycoprotein-2 | 0.0022 | 0.0113 | 1 |
Wolbachia endosymbiont of Brugia malayi | ABC-type protease secretion system, ATPase and permease component, AprD | 0.0007 | 0 | 0.5 |
Giardia lamblia | ABC transporter, putative | 0.0007 | 0 | 0.5 |
Trichomonas vaginalis | taga, putative | 0.0022 | 0.0113 | 0.0238 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.0022 | 0.0113 | 0.0238 |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.0022 | 0.0113 | 0.0238 |
Wolbachia endosymbiont of Brugia malayi | ABC-type multidrug transport system, ATPase and permease component | 0.0007 | 0 | 0.5 |
Schistosoma mansoni | smdr2 | 0.0022 | 0.0113 | 0.0113 |
Echinococcus multilocularis | ATP binding cassette subfamily B (MDR:TAP) | 0.0022 | 0.0113 | 0.0113 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.0022 | 0.0113 | 0.0238 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0628 | 0.473 | 1 |
Trichomonas vaginalis | ABC transporter, putative | 0.0022 | 0.0113 | 0.0238 |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.0022 | 0.0113 | 0.0238 |
Toxoplasma gondii | ATP-binding cassette transporter ABC.B1 | 0.0022 | 0.0113 | 0.0113 |
Onchocerca volvulus | 0.1321 | 1 | 1 | |
Leishmania major | p-glycoprotein | 0.0022 | 0.0113 | 0.0113 |
Echinococcus granulosus | multidrug resistance protein 1 | 0.0022 | 0.0113 | 0.0113 |
Echinococcus granulosus | kinesin protein KIF20A | 0.0768 | 0.5796 | 0.5796 |
Echinococcus granulosus | multidrug resistance protein 1 | 0.0022 | 0.0113 | 0.0113 |
Echinococcus granulosus | kinesin protein KIF20A | 0.0768 | 0.5796 | 0.5796 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0628 | 0.473 | 0.473 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC25 (functional) | > 100 ug ml-1 | Cytotoxic concentration against uninfected CEM cells | ChEMBL. | 9548818 |
CC25 (functional) | > 100 ug ml-1 | Cytotoxic concentration against uninfected CEM cells | ChEMBL. | 9548818 |
CC50 (functional) | = 260 ug ml-1 | Cytotoxic concentration to uninfected vero cells | ChEMBL. | 9548818 |
IC50 (functional) | > 100 ug ml-1 | Inhibitory activity against 1RF strain of HIV-1 by plaque reduction assay in CEM cells | ChEMBL. | 9548818 |
IC50 (functional) | > 100 ug ml-1 | Inhibitory activity against 1RF strain of HIV-1 by plaque reduction assay in CEM cells | ChEMBL. | 9548818 |
IC50 (functional) | > 500 ug ml-1 | Inhibition of Tomioka strain of herpes simplex virus( Tomioka strain of HSV-1) by quantitative CPE reduction assay in vero cells | ChEMBL. | 9548818 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.