Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0101 | 0 | 0.5 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0203 | 1 | 1 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0203 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0203 | 1 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0203 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0203 | 1 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0203 | 1 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0203 | 1 | 0.5 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0125 | 0.2407 | 0.2407 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0102 | 0.0151 | 0.0151 |
Brugia malayi | FAD binding domain containing protein | 0.0203 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0203 | 1 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0101 | 0 | 0.5 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.018 | 0.7743 | 0.5 |
Trypanosoma cruzi | p450 reductase, putative | 0.0203 | 1 | 0.5 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0203 | 1 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0203 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.018 | 0.7743 | 0.5 |
Chlamydia trachomatis | sulfite reductase | 0.0125 | 0.2407 | 0.5 |
Leishmania major | p450 reductase, putative | 0.0203 | 1 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0203 | 1 | 0.5 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0203 | 1 | 1 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0203 | 1 | 0.5 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0203 | 1 | 1 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0203 | 1 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0203 | 1 | 0.5 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0203 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0203 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 0.5 ug ml-1 | Inhibitory activity against S. pneumoniae UC9912 | ChEMBL. | 10715160 |
MIC (functional) | = 1 ug ml-1 | Inhibitory activity against Methicillin-resistant S. epidermidis UC12084 | ChEMBL. | 10715160 |
MIC (functional) | = 4 ug ml-1 | Inhibitory activity against Methicillin-susceptible S. aureus UC9213 | ChEMBL. | 10715160 |
MIC (functional) | = 4 ug ml-1 | Inhibitory activity against Methicillin-resistant S. aureus UC6685 | ChEMBL. | 10715160 |
MIC (functional) | = 4 ug ml-1 | Inhibitory activity against E. faecalis UC9217 | ChEMBL. | 10715160 |
MIC (functional) | = 8 ug ml-1 | Inhibitory activity against M. catarrhalis UC30610 | ChEMBL. | 10715160 |
MIC (functional) | = 16 ug ml-1 | Inhibitory activity against H. influenzae UC30063 | ChEMBL. | 10715160 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.