Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | neurogenic locus protein delta | 0.0202 | 0.2077 | 0.3009 |
Onchocerca volvulus | Peroxidasin homolog | 0.0626 | 0.6902 | 1 |
Brugia malayi | EGF-like domain containing protein | 0.0202 | 0.2077 | 0.2978 |
Brugia malayi | EGF-like domain containing protein | 0.0202 | 0.2077 | 0.2978 |
Loa Loa (eye worm) | hypothetical protein | 0.0202 | 0.2077 | 0.3009 |
Mycobacterium tuberculosis | Conserved protein | 0.0042 | 0.0251 | 0.0791 |
Loa Loa (eye worm) | hypothetical protein | 0.0202 | 0.2077 | 0.3009 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0262 | 0.0379 |
Schistosoma mansoni | hypothetical protein | 0.0163 | 0.1633 | 0.2366 |
Onchocerca volvulus | Huntingtin homolog | 0.0285 | 0.3015 | 0.4155 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0023 | 0.003 | 0.0044 |
Giardia lamblia | High cysteine protein | 0.0202 | 0.2077 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0251 | 0.0364 |
Brugia malayi | Importin beta-1 subunit | 0.0035 | 0.0167 | 0.0199 |
Onchocerca volvulus | Dual oxidase homolog | 0.0626 | 0.6902 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0167 | 0.0242 |
Mycobacterium ulcerans | hypothetical protein | 0.0042 | 0.0251 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.0285 | 0.3015 | 0.4155 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0711 | 0.103 |
Schistosoma mansoni | survival motor neuron protein | 0.0111 | 0.104 | 0.1506 |
Mycobacterium leprae | conserved hypothetical protein | 0.0042 | 0.0251 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0251 | 0.0364 |
Mycobacterium ulcerans | beta-lactamase | 0.0042 | 0.0251 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0163 | 0.1633 | 0.1633 |
Loa Loa (eye worm) | hypothetical protein | 0.0202 | 0.2077 | 0.3009 |
Toxoplasma gondii | EGF family domain-containing protein | 0.0202 | 0.2077 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0202 | 0.2077 | 0.3009 |
Loa Loa (eye worm) | hypothetical protein | 0.0626 | 0.6902 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0092 | 0.0825 | 0.1195 |
Entamoeba histolytica | hypothetical protein | 0.0163 | 0.1633 | 1 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0042 | 0.0251 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0092 | 0.0825 | 0.1195 |
Schistosoma mansoni | notch | 0.0202 | 0.2077 | 0.3009 |
Loa Loa (eye worm) | hypothetical protein | 0.0202 | 0.2077 | 0.3009 |
Schistosoma mansoni | hypothetical protein | 0.0202 | 0.2077 | 0.3009 |
Brugia malayi | Animal haem peroxidase family protein | 0.0626 | 0.6902 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0092 | 0.0825 | 0.1195 |
Schistosoma mansoni | ap endonuclease | 0.0023 | 0.003 | 0.0044 |
Schistosoma mansoni | hypothetical protein | 0.0202 | 0.2077 | 0.3009 |
Mycobacterium tuberculosis | Conserved protein | 0.0042 | 0.0251 | 0.0791 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.0397 | 0.0534 |
Loa Loa (eye worm) | hypothetical protein | 0.0202 | 0.2077 | 0.3009 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0042 | 0.0251 | 0.0791 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0026 | 0.0073 | 0.0105 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0042 | 0.0251 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0092 | 0.0825 | 0.0825 |
Entamoeba histolytica | hypothetical protein | 0.0163 | 0.1633 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0262 | 0.0379 |
Brugia malayi | hypothetical protein | 0.0626 | 0.6902 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0626 | 0.6902 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0074 | 0.0613 | 0.0889 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0202 | 0.2077 | 0.2077 |
Loa Loa (eye worm) | hypothetical protein | 0.0202 | 0.2077 | 0.3009 |
Plasmodium vivax | hypothetical protein, conserved | 0.0042 | 0.0251 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0251 | 0.0364 |
Onchocerca volvulus | Putative cubilin | 0.0202 | 0.2077 | 0.2745 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0397 | 0.0576 |
Onchocerca volvulus | 0.0092 | 0.0825 | 0.0862 | |
Echinococcus granulosus | tar DNA binding protein | 0.0074 | 0.0613 | 0.0889 |
Leishmania major | GTP-binding protein, putative | 0.0025 | 0.0063 | 0.1492 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0339 | 0.0491 |
Loa Loa (eye worm) | TAR-binding protein | 0.0074 | 0.0613 | 0.0889 |
Brugia malayi | MH2 domain containing protein | 0.0132 | 0.128 | 0.1818 |
Echinococcus multilocularis | tar DNA binding protein | 0.0074 | 0.0613 | 0.0613 |
Plasmodium falciparum | importin beta, putative | 0.0035 | 0.0167 | 1 |
Brugia malayi | EGF-like domain containing protein | 0.0202 | 0.2077 | 0.2978 |
Echinococcus multilocularis | neurogenic locus notch protein 4 | 0.0202 | 0.2077 | 0.2077 |
Mycobacterium leprae | Probable lipase LipE | 0.0042 | 0.0251 | 0.5 |
Onchocerca volvulus | Slit protein homolog | 0.0202 | 0.2077 | 0.2745 |
Loa Loa (eye worm) | Notch2 | 0.0202 | 0.2077 | 0.3009 |
Schistosoma mansoni | hypothetical protein | 0.0189 | 0.1929 | 0.2795 |
Echinococcus multilocularis | protein jagged 2 | 0.0202 | 0.2077 | 0.2077 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0251 | 0.0364 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0042 | 0.0251 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0626 | 0.6902 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0545 | 0.5979 | 0.8662 |
Echinococcus multilocularis | protein jagged 1 | 0.0202 | 0.2077 | 0.2077 |
Trichomonas vaginalis | ran, putative | 0.0025 | 0.0063 | 0.1492 |
Loa Loa (eye worm) | notch protein | 0.0202 | 0.2077 | 0.3009 |
Echinococcus granulosus | zinc finger protein | 0.0023 | 0.0033 | 0.0048 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0626 | 0.6902 | 1 |
Leishmania major | importin beta-1 subunit, putative | 0.0028 | 0.0093 | 0.2825 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0042 | 0.0251 | 0.0364 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0045 | 0.0281 | 0.0407 |
Brugia malayi | EGF-like domain containing protein | 0.0202 | 0.2077 | 0.2978 |
Echinococcus granulosus | delta-like protein 1 | 0.0202 | 0.2077 | 0.3009 |
Echinococcus multilocularis | fibropellin Ia | 0.0202 | 0.2077 | 0.2077 |
Schistosoma mansoni | lamin | 0.0092 | 0.0825 | 0.1195 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0042 | 0.0251 | 0.0791 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0069 | 0.0565 | 0.0565 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0042 | 0.0251 | 1 |
Brugia malayi | intermediate filament protein | 0.0092 | 0.0825 | 0.1156 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0023 | 0.003 | 0.0044 |
Echinococcus multilocularis | GTP binding nuclear protein Ran | 0.0025 | 0.0063 | 0.0063 |
Loa Loa (eye worm) | hypothetical protein | 0.0626 | 0.6902 | 1 |
Plasmodium vivax | GTP-binding nuclear protein RAN/TC4, putative | 0.0025 | 0.0063 | 0.1492 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0202 | 0.2077 | 0.2077 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0314 | 0.0455 |
Mycobacterium ulcerans | lipase LipD | 0.0042 | 0.0251 | 1 |
Echinococcus multilocularis | slit 2 protein | 0.0202 | 0.2077 | 0.2077 |
Loa Loa (eye worm) | hypothetical protein | 0.0626 | 0.6902 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0045 | 0.0281 | 0.0365 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0251 | 0.0364 |
Loa Loa (eye worm) | hypothetical protein | 0.0285 | 0.3015 | 0.4368 |
Onchocerca volvulus | 0.0111 | 0.104 | 0.1186 | |
Echinococcus granulosus | protein jagged 1 | 0.0202 | 0.2077 | 0.3009 |
Schistosoma mansoni | notch | 0.0202 | 0.2077 | 0.3009 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.0613 | 0.0889 |
Loa Loa (eye worm) | hypothetical protein | 0.0202 | 0.2077 | 0.3009 |
Onchocerca volvulus | Neurogenic locus notch protein homolog | 0.0202 | 0.2077 | 0.2745 |
Schistosoma mansoni | septate junction protein | 0.0202 | 0.2077 | 0.3009 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0042 | 0.0251 | 1 |
Brugia malayi | PHD-finger family protein | 0.0029 | 0.0104 | 0.0107 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.0397 | 0.0576 |
Brugia malayi | Peroxidasin | 0.0626 | 0.6902 | 1 |
Brugia malayi | RNA binding protein | 0.0074 | 0.0613 | 0.0848 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0202 | 0.2077 | 0.2978 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0074 | 0.0613 | 0.0889 |
Loa Loa (eye worm) | hypothetical protein | 0.0626 | 0.6902 | 1 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0042 | 0.0251 | 1 |
Brugia malayi | hypothetical protein | 0.0285 | 0.3015 | 0.4343 |
Schistosoma mansoni | laminin gamma-3 chain | 0.0202 | 0.2077 | 0.3009 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0268 | 0.2821 | 1 |
Trypanosoma brucei | GTP-binding nuclear protein rtb2, putative | 0.0025 | 0.0063 | 0.1492 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0202 | 0.2077 | 0.2077 |
Schistosoma mansoni | ran | 0.0025 | 0.0063 | 0.0092 |
Mycobacterium tuberculosis | Conserved protein | 0.0042 | 0.0251 | 0.0791 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.0613 | 0.0889 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0397 | 0.0397 |
Entamoeba histolytica | Ran family GTPase | 0.0025 | 0.0063 | 0.0205 |
Echinococcus multilocularis | zinc finger protein | 0.0023 | 0.0033 | 0.0033 |
Schistosoma mansoni | hypothetical protein | 0.0202 | 0.2077 | 0.3009 |
Onchocerca volvulus | 0.0202 | 0.2077 | 0.2745 | |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0025 | 0.0063 | 0.1492 |
Onchocerca volvulus | Peroxidase homolog | 0.0626 | 0.6902 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0132 | 0.128 | 0.1854 |
Onchocerca volvulus | Neurogenic locus notch homolog | 0.0202 | 0.2077 | 0.2745 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0049 | 0.0337 | 0.0488 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.0825 | 0.1195 |
Brugia malayi | RNA, U transporter 1 | 0.0098 | 0.0892 | 0.1253 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0069 | 0.0565 | 0.0819 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.0805 | 0.1167 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0028 | 0.0093 | 0.2825 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0282 | 0.0409 |
Brugia malayi | GCC2 and GCC3 family protein | 0.0202 | 0.2077 | 0.2978 |
Onchocerca volvulus | 0.0202 | 0.2077 | 0.2745 | |
Brugia malayi | beta-lactamase | 0.0042 | 0.0251 | 0.0321 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0023 | 0.003 | 0.003 |
Echinococcus granulosus | lamin | 0.0092 | 0.0825 | 0.1195 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0049 | 0.0337 | 0.0446 |
Brugia malayi | Transmembrane cell adhesion receptor mua-3 precursor, putative | 0.0202 | 0.2077 | 0.2978 |
Brugia malayi | Cadherin domain containing protein | 0.0202 | 0.2077 | 0.2978 |
Loa Loa (eye worm) | hypothetical protein | 0.0202 | 0.2077 | 0.3009 |
Onchocerca volvulus | Peroxidasin homolog | 0.0626 | 0.6902 | 1 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0042 | 0.0251 | 0.0791 |
Echinococcus multilocularis | snurportin 1 | 0.0368 | 0.3969 | 0.3969 |
Loa Loa (eye worm) | hypothetical protein | 0.0202 | 0.2077 | 0.3009 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0626 | 0.6902 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0087 | 0.0768 | 0.1073 |
Loa Loa (eye worm) | hypothetical protein | 0.0202 | 0.2077 | 0.3009 |
Schistosoma mansoni | notch | 0.0202 | 0.2077 | 0.3009 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0092 | 0.0825 | 0.1156 |
Echinococcus granulosus | fibropellin Ia | 0.0202 | 0.2077 | 0.3009 |
Loa Loa (eye worm) | hypothetical protein | 0.0202 | 0.2077 | 0.3009 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0202 | 0.2077 | 0.3009 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0042 | 0.0251 | 0.0791 |
Loa Loa (eye worm) | hypothetical protein | 0.0626 | 0.6902 | 1 |
Schistosoma mansoni | slit | 0.0202 | 0.2077 | 0.3009 |
Brugia malayi | Blistered cuticle protein 3 | 0.0626 | 0.6902 | 1 |
Echinococcus multilocularis | peroxidasin | 0.0626 | 0.6902 | 0.6902 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0035 | 0.0167 | 0.0668 |
Loa Loa (eye worm) | hypothetical protein | 0.0626 | 0.6902 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0626 | 0.6902 | 1 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0026 | 0.0073 | 0.0073 |
Brugia malayi | Animal haem peroxidase family protein | 0.0626 | 0.6902 | 1 |
Echinococcus granulosus | protein jagged 2 | 0.0202 | 0.2077 | 0.3009 |
Brugia malayi | Cadherin domain containing protein | 0.0202 | 0.2077 | 0.2978 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0042 | 0.025 | 0.025 |
Loa Loa (eye worm) | hypothetical protein | 0.0545 | 0.5979 | 0.8662 |
Loa Loa (eye worm) | hypothetical protein | 0.0285 | 0.3015 | 0.4368 |
Brugia malayi | Muscle positioning protein 4 | 0.0202 | 0.2077 | 0.2978 |
Brugia malayi | Animal haem peroxidase family protein | 0.0626 | 0.6902 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0023 | 0.003 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0028 | 0.0093 | 0.0389 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0397 | 0.0576 |
Toxoplasma gondii | GTP-binding nuclear protein ran/tc4 | 0.0025 | 0.0063 | 0.0161 |
Loa Loa (eye worm) | hypothetical protein | 0.0626 | 0.6902 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0397 | 0.0397 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0397 | 0.0576 |
Leishmania major | hypothetical protein, conserved | 0.0042 | 0.0251 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0132 | 0.128 | 0.1854 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0545 | 0.5979 | 0.5979 |
Entamoeba histolytica | hypothetical protein | 0.0163 | 0.1633 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0202 | 0.2077 | 0.3009 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0626 | 0.6902 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0042 | 0.0251 | 0.0321 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0025 | 0.0063 | 0.1492 |
Echinococcus granulosus | GTP binding nuclear protein Ran | 0.0025 | 0.0063 | 0.0092 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.0613 | 0.0889 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0028 | 0.0093 | 0.2825 |
Schistosoma mansoni | cell polarity protein | 0.0202 | 0.2077 | 0.3009 |
Echinococcus granulosus | neurogenic locus notch protein 4 | 0.0202 | 0.2077 | 0.3009 |
Loa Loa (eye worm) | hypothetical protein | 0.0202 | 0.2077 | 0.3009 |
Schistosoma mansoni | hypothetical protein | 0.0368 | 0.3969 | 0.5751 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0042 | 0.0251 | 0.0251 |
Onchocerca volvulus | 0.0202 | 0.2077 | 0.2745 | |
Onchocerca volvulus | 0.0626 | 0.6902 | 1 | |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0042 | 0.0251 | 0.0364 |
Echinococcus multilocularis | notch | 0.0202 | 0.2077 | 0.2077 |
Giardia lamblia | GTP-binding nuclear protein RAN/TC4 | 0.0025 | 0.0063 | 0.0161 |
Echinococcus granulosus | lamin dm0 | 0.0092 | 0.0825 | 0.1195 |
Loa Loa (eye worm) | hypothetical protein | 0.0626 | 0.6902 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0042 | 0.025 | 0.0362 |
Loa Loa (eye worm) | hypothetical protein | 0.0202 | 0.2077 | 0.3009 |
Brugia malayi | EGF-like domain containing protein | 0.0202 | 0.2077 | 0.2978 |
Echinococcus granulosus | protein jagged 2 | 0.0202 | 0.2077 | 0.3009 |
Schistosoma mansoni | notch | 0.0202 | 0.2077 | 0.3009 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0251 | 0.0364 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0074 | 0.0613 | 0.0848 |
Brugia malayi | TAR-binding protein | 0.0074 | 0.0613 | 0.0848 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0626 | 0.6902 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0626 | 0.6902 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0042 | 0.0251 | 0.0321 |
Loa Loa (eye worm) | hypothetical protein | 0.0626 | 0.6902 | 1 |
Schistosoma mansoni | lamin | 0.0092 | 0.0825 | 0.1195 |
Loa Loa (eye worm) | hypothetical protein | 0.0202 | 0.2077 | 0.3009 |
Schistosoma mansoni | notch | 0.0202 | 0.2077 | 0.3009 |
Brugia malayi | beta-lactamase family protein | 0.0042 | 0.0251 | 0.0321 |
Onchocerca volvulus | 0.0202 | 0.2077 | 0.2745 | |
Echinococcus granulosus | geminin | 0.0189 | 0.1929 | 0.2795 |
Loa Loa (eye worm) | beta-lactamase | 0.0042 | 0.0251 | 0.0364 |
Echinococcus multilocularis | fat cadherin tumor suppressor | 0.0202 | 0.2077 | 0.2077 |
Loa Loa (eye worm) | hypothetical protein | 0.0202 | 0.2077 | 0.3009 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.0613 | 0.0889 |
Loa Loa (eye worm) | hypothetical protein | 0.0626 | 0.6902 | 1 |
Schistosoma mansoni | Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] | 0.0202 | 0.2077 | 0.3009 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0163 | 0.1633 | 0.2366 |
Schistosoma mansoni | peroxidasin | 0.0626 | 0.6902 | 1 |
Schistosoma mansoni | notch | 0.0202 | 0.2077 | 0.3009 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0045 | 0.0281 | 0.0281 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0021 | 0.0008 | 0.0012 |
Onchocerca volvulus | 0.0626 | 0.6902 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0626 | 0.6902 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0042 | 0.0251 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0042 | 0.0251 | 1 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0042 | 0.0251 | 0.0791 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0042 | 0.0251 | 0.0364 |
Brugia malayi | hypothetical protein | 0.0545 | 0.5979 | 0.8657 |
Echinococcus multilocularis | neural cadherin | 0.0202 | 0.2077 | 0.2077 |
Schistosoma mansoni | hypothetical protein | 0.0202 | 0.2077 | 0.3009 |
Loa Loa (eye worm) | GTP-binding nuclear protein RAN/TC4 | 0.0025 | 0.0063 | 0.0092 |
Echinococcus multilocularis | lamin | 0.0092 | 0.0825 | 0.0825 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0023 | 0.003 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0202 | 0.2077 | 0.3009 |
Loa Loa (eye worm) | hypothetical protein | 0.0202 | 0.2077 | 0.3009 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0368 | 0.3969 | 0.5751 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0397 | 0.0576 |
Onchocerca volvulus | 0.0092 | 0.0825 | 0.0862 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0626 | 0.6902 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0092 | 0.0825 | 0.1195 |
Schistosoma mansoni | zinc finger protein | 0.0023 | 0.0033 | 0.0048 |
Echinococcus multilocularis | musashi | 0.0092 | 0.0825 | 0.0825 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0202 | 0.2077 | 0.2978 |
Schistosoma mansoni | importin beta-1 | 0.0035 | 0.0167 | 0.0242 |
Echinococcus granulosus | neural cadherin | 0.0202 | 0.2077 | 0.3009 |
Schistosoma mansoni | hypothetical protein | 0.0202 | 0.2077 | 0.3009 |
Schistosoma mansoni | hypothetical protein | 0.0202 | 0.2077 | 0.3009 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0163 | 0.1633 | 0.2366 |
Brugia malayi | GTP-binding nuclear protein RAN/TC4 | 0.0025 | 0.0063 | 0.0048 |
Schistosoma mansoni | bromodomain containing protein | 0.0074 | 0.0612 | 0.0887 |
Schistosoma mansoni | ap endonuclease | 0.0023 | 0.003 | 0.0044 |
Onchocerca volvulus | 0.0626 | 0.6902 | 1 | |
Brugia malayi | EGF-like domain containing protein | 0.0202 | 0.2077 | 0.2978 |
Trichomonas vaginalis | importin beta-1, putative | 0.0028 | 0.0093 | 0.2825 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0024 | 0.0047 | 0.0069 |
Loa Loa (eye worm) | hypothetical protein | 0.0202 | 0.2077 | 0.3009 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.0047 | 0.0069 |
Entamoeba histolytica | hypothetical protein | 0.0163 | 0.1633 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0042 | 0.0251 | 0.0364 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0202 | 0.2077 | 0.2077 |
Onchocerca volvulus | Peroxidase homolog | 0.0626 | 0.6902 | 1 |
Echinococcus multilocularis | protein jagged 1 | 0.0202 | 0.2077 | 0.2077 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0042 | 0.0251 | 0.0791 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0281 | 0.0407 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0035 | 0.0167 | 0.0167 |
Echinococcus granulosus | snurportin 1 | 0.0368 | 0.3969 | 0.5751 |
Echinococcus granulosus | notch | 0.0202 | 0.2077 | 0.3009 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0042 | 0.0251 | 1 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0202 | 0.2077 | 0.2978 |
Brugia malayi | EGF-like domain containing protein | 0.0202 | 0.2077 | 0.2978 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0111 | 0.104 | 0.1469 |
Loa Loa (eye worm) | hypothetical protein | 0.0202 | 0.2077 | 0.3009 |
Plasmodium vivax | importin-beta 2, putative | 0.0035 | 0.0167 | 0.6194 |
Loa Loa (eye worm) | hypothetical protein | 0.0202 | 0.2077 | 0.3009 |
Echinococcus granulosus | importin subunit beta 1 | 0.0035 | 0.0167 | 0.0242 |
Schistosoma mansoni | hypothetical protein | 0.0111 | 0.104 | 0.1506 |
Loa Loa (eye worm) | hypothetical protein | 0.0626 | 0.6902 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0202 | 0.2077 | 0.3009 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.0613 | 0.0889 |
Schistosoma mansoni | ran | 0.0025 | 0.0063 | 0.0092 |
Schistosoma mansoni | hypothetical protein | 0.0189 | 0.1929 | 0.2795 |
Echinococcus granulosus | peroxidasin | 0.0626 | 0.6902 | 1 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0035 | 0.0167 | 0.6194 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0397 | 0.0576 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0028 | 0.0093 | 0.2825 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0202 | 0.2077 | 0.3009 |
Onchocerca volvulus | 0.0202 | 0.2077 | 0.2745 | |
Echinococcus granulosus | slit 2 protein | 0.0202 | 0.2077 | 0.3009 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0035 | 0.0167 | 0.6194 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0026 | 0.0073 | 0.0105 |
Brugia malayi | notch-like transmembrane receptor | 0.0202 | 0.2077 | 0.2978 |
Brugia malayi | Delta serrate ligand family protein | 0.0202 | 0.2077 | 0.2978 |
Plasmodium falciparum | GTP-binding nuclear protein RAN/TC4 | 0.0025 | 0.0063 | 0.2408 |
Echinococcus multilocularis | geminin | 0.0189 | 0.1929 | 0.1929 |
Trichomonas vaginalis | esterase, putative | 0.0042 | 0.0251 | 1 |
Echinococcus granulosus | protein jagged 1 | 0.0202 | 0.2077 | 0.3009 |
Schistosoma mansoni | peroxidasin | 0.0626 | 0.6902 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0042 | 0.0251 | 1 |
Brugia malayi | hypothetical protein | 0.0163 | 0.1633 | 0.2332 |
Toxoplasma gondii | ABC1 family protein | 0.0042 | 0.0251 | 0.1078 |
Brugia malayi | Animal haem peroxidase family protein | 0.0626 | 0.6902 | 1 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0042 | 0.0251 | 0.0791 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Delta p (functional) | = -31 % | Antihypertensive activity on spontaneously hypertensive rats when administered orally at a dose 50 mg/kg. | ChEMBL. | 2989524 |
Heart rate (functional) | = 90 beats min-1 | Heart rate after 8 hours of oral administration in renal hypertensive dogs at dose 2 mg/kg | ChEMBL. | 2989524 |
Heart rate (functional) | = 93 beats min-1 | Heart rate after 8 hours of oral administration in renal hypertensive dogs at dose 1 mg/kg | ChEMBL. | 2989524 |
Heart rate (functional) | = 95 beats min-1 | Peak effect after 8 hours on heart rate after 2 day of oral administration in renal hypertensive dogs at dose 0.5 mg/kg | ChEMBL. | 2989524 |
Heart rate (functional) | = 95 beats min-1 | Peak effect after 8 hours on heart rate after 7 days of oral administration in renal hypertensive dogs at dose 0.5 mg/kg | ChEMBL. | 2989524 |
Heart rate (functional) | = 96 beats min-1 | Heart rate after 6 hours of oral administration in renal hypertensive dogs at dose 1 mg/kg | ChEMBL. | 2989524 |
Heart rate (functional) | = 97 beats min-1 | Heart rate after 6 hours of oral administration in renal hypertensive dogs at dose 2 mg/kg | ChEMBL. | 2989524 |
Heart rate (functional) | = 100 beats min-1 | Peak effect after 8 hours on heart rate after 1 days of oral administration in renal hypertensive dogs at dose 0.5 mg/kg | ChEMBL. | 2989524 |
Heart rate (functional) | = 104 beats min-1 | Heart rate after 4 hours of oral administration in renal hypertensive dogs at dose 2 mg/kg | ChEMBL. | 2989524 |
Heart rate (functional) | = 105 beats min-1 | Heart rate after 4 hours of oral administration in renal hypertensive dogs at dose 1 mg/kg | ChEMBL. | 2989524 |
Heart rate (functional) | = 105 beats min-1 | Heart rate after 6 hours of oral administration in renal hypertensive dogs at dose 0.25 mg/kg | ChEMBL. | 2989524 |
Heart rate (functional) | = 105 beats min-1 | Peak effect after 8 hours on heart rate after 3 days of oral administration in renal hypertensive dogs at dose 0.5 mg/kg | ChEMBL. | 2989524 |
Heart rate (functional) | = 107 beats min-1 | Heart rate after 0 hours of oral administration in renal hypertensive dogs at dose 1 mg/kg | ChEMBL. | 2989524 |
Heart rate (functional) | = 107 beats min-1 | Heart rate after 2 hours of oral administration in renal hypertensive dogs at dose 2 mg/kg | ChEMBL. | 2989524 |
Heart rate (functional) | = 108 beats min-1 | Heart rate after 4 hours of oral administration in renal hypertensive dogs at dose 0.25 mg/kg | ChEMBL. | 2989524 |
Heart rate (functional) | = 109 beats min-1 | Heart rate after 2 hours of oral administration in renal hypertensive dogs at dose 1 mg/kg | ChEMBL. | 2989524 |
Heart rate (functional) | = 109 beats min-1 | Heart rate after 8 hours of oral administration in renal hypertensive dogs at dose 0.25 mg/kg | ChEMBL. | 2989524 |
Heart rate (functional) | = 110 beats min-1 | Heart rate after 0 hours of oral administration in renal hypertensive dogs at dose 0.25 mg/kg | ChEMBL. | 2989524 |
Heart rate (functional) | = 110 beats min-1 | Heart rate after 0 hours of oral administration in renal hypertensive dogs at dose 2 mg/kg | ChEMBL. | 2989524 |
Heart rate (functional) | = 112 beats min-1 | Heart rate after 2 hours of oral administration in renal hypertensive dogs at dose 0.25 mg/kg | ChEMBL. | 2989524 |
Ki (binding) | = 14.7 nM | Ability to displace [3H]-prazosin from postsynaptic alpha-1 adrenergic receptor of rat in vitro. | ChEMBL. | 2989524 |
SBP (functional) | = 155 mmHg | Systolic blood pressure after 6 hours of oral administration in renal hypertensive dogs at dose 2 mg/kg | ChEMBL. | 2989524 |
SBP (functional) | = 155 mmHg | Peak effect after 8 hours on systolic blood pressure after 2 days of oral administration in renal hypertensive dogs at dose 0.5 mg/kg | ChEMBL. | 2989524 |
SBP (functional) | = 155 mmHg | Peak effect after 8 hours on systolic blood pressure after 7 days of oral administration in renal hypertensive dogs at dose 0.5 mg/kg | ChEMBL. | 2989524 |
SBP (functional) | = 156 mmHg | Systolic blood pressure after 8 hours of oral administration in renal hypertensive dogs at dose 2 mg/kg | ChEMBL. | 2989524 |
SBP (functional) | = 160 mmHg | Peak effect after 8 hours on systolic blood pressure after 1 day of oral administration in renal hypertensive dogs at dose 0.5 mg/kg | ChEMBL. | 2989524 |
SBP (functional) | = 160 mmHg | Peak effect after 8 hours systolic blood pressure after 3 days of oral administration in renal hypertensive dogs at dose 0.5 mg/kg | ChEMBL. | 2989524 |
SBP (functional) | = 165 mmHg | Systolic blood pressure after 4 hours of oral administration in renal hypertensive dogs at dose 2 mg/kg | ChEMBL. | 2989524 |
SBP (functional) | = 165 mmHg | Systolic blood pressure after 6 hours of oral administration in renal hypertensive dogs at dose 1 mg/kg | ChEMBL. | 2989524 |
SBP (functional) | = 165 mmHg | Systolic blood pressure after 8 hours of oral administration in renal hypertensive dogs at dose 1 mg/kg | ChEMBL. | 2989524 |
SBP (functional) | = 172 mmHg | Systolic blood pressure after 4 hours of oral administration in renal hypertensive dogs at dose 1 mg/kg (mean +/- SE for 3 animals /dose) | ChEMBL. | 2989524 |
SBP (functional) | = 183 mmHg | Systolic blood pressure after 2 hr of oral administration in renal hypertensive dogs at dose 2 mg/kg | ChEMBL. | 2989524 |
SBP (functional) | = 188 mmHg | Systolic blood pressure after 6 hours of oral administration in renal hypertensive dogs at dose 0.25 mg/kg | ChEMBL. | 2989524 |
SBP (functional) | = 190 mmHg | Systolic blood pressure after 8 hours of oral administration in renal hypertensive dogs at dose 0.25 mg/kg | ChEMBL. | 2989524 |
SBP (functional) | = 198 mmHg | Systolic blood pressure after 2 hours of oral administration in renal hypertensive dogs at dose 1 mg/kg | ChEMBL. | 2989524 |
SBP (functional) | = 200 mmHg | Systolic blood pressure after 0 hours of oral administration in renal hypertensive dogs at dose 0.25 mg/kg | ChEMBL. | 2989524 |
SBP (functional) | = 200 mmHg | Systolic blood pressure after 0 hours of oral administration in renal hypertensive dogs at dose 1 mg/kg | ChEMBL. | 2989524 |
SBP (functional) | = 200 mmHg | Systolic blood pressure after 4 hours of oral administration in renal hypertensive dogs at dose 0.25 mg/kg | ChEMBL. | 2989524 |
SBP (functional) | = 202 mmHg | Systolic blood pressure after 2 hours of oral administration in renal hypertensive dogs at dose 0.25 mg/kg | ChEMBL. | 2989524 |
SBP (functional) | = 203 mmHg | Systolic blood pressure after 0 hours of oral administration in renal hypertensive dogs at dose 2 mg/kg | ChEMBL. | 2989524 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.