Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | growth factor receptor-bound protein | 0.0362 | 0.4968 | 0.7808 |
Schistosoma mansoni | tyrosine kinase | 0.0413 | 0.6363 | 1 |
Brugia malayi | hypothetical protein | 0.0183 | 0.0123 | 0.0194 |
Brugia malayi | SH2 domain containing protein | 0.0183 | 0.0123 | 0.0194 |
Loa Loa (eye worm) | hypothetical protein | 0.0235 | 0.1518 | 0.2386 |
Echinococcus granulosus | arf GAP with SH3 domain ANK repeat and PH | 0.018 | 0.0038 | 0.0038 |
Onchocerca volvulus | 0.0235 | 0.1518 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.0123 | 0.0194 |
Brugia malayi | Protein kinase domain containing protein | 0.0235 | 0.1518 | 0.2386 |
Loa Loa (eye worm) | TK protein kinase | 0.0235 | 0.1518 | 0.2386 |
Schistosoma mansoni | tyrosine kinase | 0.0235 | 0.1518 | 0.2386 |
Brugia malayi | SH2 domain containing protein | 0.0235 | 0.1518 | 0.2386 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0235 | 0.1518 | 0.2386 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0183 | 0.0123 | 0.0123 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0413 | 0.6363 | 0.6363 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.0123 | 0.0194 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0413 | 0.6363 | 0.6363 |
Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.0235 | 0.1518 | 0.1518 |
Echinococcus granulosus | tensin | 0.0183 | 0.0123 | 0.0123 |
Schistosoma mansoni | suppressor of cytokine signaling | 0.0183 | 0.0123 | 0.0194 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0179 | 0 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0413 | 0.6363 | 0.6363 |
Brugia malayi | tRNA modification GTPase TrmE family protein | 0.0183 | 0.0123 | 0.0194 |
Trichomonas vaginalis | neutrophil cytosolic factor 2, neutrophil NADPH oxidase factor, putative | 0.0179 | 0 | 0.5 |
Brugia malayi | Variant SH3 domain containing protein | 0.0183 | 0.0123 | 0.0194 |
Brugia malayi | Variant SH3 domain containing protein | 0.0185 | 0.0161 | 0.0253 |
Echinococcus granulosus | NCK adaptor protein | 0.0362 | 0.4968 | 0.4968 |
Echinococcus granulosus | SH2 motif | 0.0183 | 0.0123 | 0.0123 |
Brugia malayi | SH2 domain containing protein | 0.0183 | 0.0123 | 0.0194 |
Echinococcus multilocularis | suppressor of cytokine signaling 6 | 0.0183 | 0.0123 | 0.0123 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.0235 | 0.1518 | 0.1518 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.0235 | 0.1518 | 0.2386 |
Brugia malayi | SH2 domain containing protein | 0.0183 | 0.0123 | 0.0194 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.0235 | 0.1518 | 0.1518 |
Schistosoma mansoni | adapter molecule crk | 0.0362 | 0.4968 | 0.7808 |
Echinococcus granulosus | growth factor receptor bound protein 2 | 0.0362 | 0.4968 | 0.4968 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.0235 | 0.1518 | 0.1518 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0183 | 0.0123 | 0.0123 |
Schistosoma mansoni | tyrosine kinase | 0.0413 | 0.6363 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0235 | 0.1518 | 0.2386 |
Loa Loa (eye worm) | sex muscle abnormal protein 5 | 0.0362 | 0.4968 | 0.7808 |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.0235 | 0.1518 | 0.1518 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0413 | 0.6363 | 1 |
Onchocerca volvulus | 0.0235 | 0.1518 | 1 | |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0413 | 0.6363 | 0.6363 |
Echinococcus granulosus | suppressor of cytokine signaling 7 | 0.0183 | 0.0123 | 0.0123 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0413 | 0.6363 | 0.6363 |
Echinococcus multilocularis | SH2 motif | 0.0183 | 0.0123 | 0.0123 |
Onchocerca volvulus | Suppressor of cytokine signaling at 36E homolog | 0.0183 | 0.0123 | 0.0812 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0413 | 0.6363 | 1 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0413 | 0.6363 | 0.6363 |
Schistosoma mansoni | tyrosine kinase | 0.0413 | 0.6363 | 1 |
Echinococcus granulosus | SHC transforming protein 3 | 0.0183 | 0.0123 | 0.0123 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0235 | 0.1518 | 0.2386 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.0123 | 0.0194 |
Trypanosoma cruzi | paraflagellar rod protein 5, putative | 0.0179 | 0 | 0.5 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0413 | 0.6363 | 0.6363 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase abl1 | 0.0362 | 0.4968 | 0.7808 |
Onchocerca volvulus | 0.0183 | 0.0123 | 0.0812 | |
Echinococcus multilocularis | tensin | 0.0183 | 0.0123 | 0.0123 |
Echinococcus multilocularis | suppressor of cytokine signaling 7 | 0.0183 | 0.0123 | 0.0123 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0235 | 0.1518 | 0.2386 |
Schistosoma mansoni | chimerin-related rho-gtpase-activating protein | 0.0183 | 0.0123 | 0.0194 |
Schistosoma mansoni | hypothetical protein | 0.0183 | 0.0123 | 0.0194 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0413 | 0.6363 | 0.6363 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0179 | 0 | 0.5 |
Brugia malayi | Tensin | 0.0183 | 0.0123 | 0.0194 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.0123 | 0.0194 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0179 | 0 | 0.5 |
Brugia malayi | SH2 domain containing protein | 0.0235 | 0.1518 | 0.2386 |
Echinococcus granulosus | SH2 domain containing adapter protein F | 0.0183 | 0.0123 | 0.0123 |
Trypanosoma brucei | conserved protein | 0.0179 | 0 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0413 | 0.6363 | 0.6363 |
Brugia malayi | SH2 domain containing protein | 0.0183 | 0.0123 | 0.0194 |
Schistosoma mansoni | tensin | 0.0183 | 0.0123 | 0.0194 |
Schistosoma mansoni | tyrosine kinase | 0.0369 | 0.5155 | 0.8102 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0179 | 0 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0235 | 0.1518 | 0.2386 |
Schistosoma mansoni | SH2A | 0.0183 | 0.0123 | 0.0194 |
Entamoeba histolytica | hypothetical protein | 0.018 | 0.0038 | 0.0247 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0183 | 0.0123 | 0.0123 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0413 | 0.6363 | 0.6363 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0413 | 0.6363 | 0.6363 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0413 | 0.6363 | 0.6363 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0413 | 0.6363 | 0.6363 |
Schistosoma mansoni | development and differentiation-enhancing factor ddef | 0.018 | 0.0038 | 0.0059 |
Loa Loa (eye worm) | SH2 domain-containing protein | 0.0183 | 0.0123 | 0.0194 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0413 | 0.6363 | 0.6363 |
Loa Loa (eye worm) | STAT protein | 0.0183 | 0.0123 | 0.0194 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.0123 | 0.0194 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.0123 | 0.0194 |
Onchocerca volvulus | 0.0235 | 0.1518 | 1 | |
Echinococcus multilocularis | SH2 domain containing protein 7 | 0.0183 | 0.0123 | 0.0123 |
Loa Loa (eye worm) | variant SH3 domain-containing protein | 0.0185 | 0.0161 | 0.0253 |
Echinococcus granulosus | expressed conserved protein | 0.0183 | 0.0123 | 0.0123 |
Echinococcus granulosus | suppressor of cytokine signaling 6 | 0.0183 | 0.0123 | 0.0123 |
Echinococcus granulosus | tyrosine protein kinase Fps85D | 0.0235 | 0.1518 | 0.1518 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0179 | 0 | 0.5 |
Echinococcus granulosus | c src tyrosine kinase | 0.0413 | 0.6363 | 0.6363 |
Onchocerca volvulus | 0.0235 | 0.1518 | 1 | |
Brugia malayi | Protein kinase domain containing protein | 0.0235 | 0.1518 | 0.2386 |
Loa Loa (eye worm) | SH2 domain-containing protein | 0.0183 | 0.0123 | 0.0194 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0235 | 0.1518 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0183 | 0.0123 | 0.0812 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0183 | 0.0123 | 0.0194 |
Schistosoma mansoni | serine/threonine protein kinase | 0.023 | 0.1395 | 0.2192 |
Schistosoma mansoni | hypothetical protein | 0.0183 | 0.0123 | 0.0194 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0235 | 0.1518 | 0.2386 |
Echinococcus granulosus | guanine nucleotide exchange factor VAV2 | 0.0183 | 0.0123 | 0.0123 |
Echinococcus multilocularis | tyrosine protein kinase Fps85D | 0.0235 | 0.1518 | 0.1518 |
Echinococcus multilocularis | 0.0183 | 0.0123 | 0.0123 | |
Brugia malayi | SH2 domain containing protein | 0.0183 | 0.0123 | 0.0194 |
Echinococcus multilocularis | SH2 domain containing adapter protein F | 0.0183 | 0.0123 | 0.0123 |
Schistosoma mansoni | tensin | 0.0183 | 0.0123 | 0.0194 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0179 | 0 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0413 | 0.6363 | 0.6363 |
Echinococcus granulosus | N chimaerin | 0.0183 | 0.0123 | 0.0123 |
Echinococcus multilocularis | tensin | 0.0183 | 0.0123 | 0.0123 |
Echinococcus multilocularis | arf GAP with SH3 domain, ANK repeat and PH | 0.018 | 0.0038 | 0.0038 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.0123 | 0.0194 |
Loa Loa (eye worm) | SRC-1 | 0.0413 | 0.6363 | 1 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.0235 | 0.1518 | 0.1518 |
Schistosoma mansoni | nck2/grb4 | 0.0362 | 0.4968 | 0.7808 |
Echinococcus granulosus | tyrosine kinase | 0.0235 | 0.1518 | 0.1518 |
Schistosoma mansoni | tyrosine kinase | 0.0413 | 0.6363 | 1 |
Schistosoma mansoni | GTPase activating protein | 0.0183 | 0.0123 | 0.0194 |
Echinococcus multilocularis | phosphatidylinositol 3 kinase regulatory subunit | 0.0183 | 0.0123 | 0.0123 |
Brugia malayi | SH2 domain containing protein | 0.0183 | 0.0123 | 0.0194 |
Schistosoma mansoni | tensin-related | 0.0183 | 0.0123 | 0.0194 |
Echinococcus multilocularis | growth factor receptor bound protein 2 | 0.0362 | 0.4968 | 0.4968 |
Echinococcus granulosus | SH2 motif | 0.0183 | 0.0123 | 0.0123 |
Loa Loa (eye worm) | variant SH3 domain-containing protein | 0.0362 | 0.4968 | 0.7808 |
Schistosoma mansoni | chimerin-related rho-gtpase-activating protein | 0.0183 | 0.0123 | 0.0194 |
Echinococcus granulosus | tyrosine kinase | 0.0235 | 0.1518 | 0.1518 |
Schistosoma mansoni | tensin | 0.0183 | 0.0123 | 0.0194 |
Onchocerca volvulus | 0.0183 | 0.0123 | 0.0812 | |
Onchocerca volvulus | 0.0183 | 0.0123 | 0.0812 | |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0235 | 0.1518 | 0.2386 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0179 | 0 | 0.5 |
Brugia malayi | Sex muscle abnormal protein 5 | 0.0362 | 0.4968 | 0.7808 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0183 | 0.0123 | 0.0123 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0413 | 0.6363 | 0.6363 |
Onchocerca volvulus | 0.0183 | 0.0123 | 0.0812 | |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.0123 | 0.0194 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.0123 | 0.0194 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0183 | 0.0123 | 0.0812 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.0123 | 0.0194 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0179 | 0 | 0.5 |
Echinococcus granulosus | signal transduction protein lnk realted | 0.0183 | 0.0123 | 0.0123 |
Brugia malayi | protein-tyrosine kinase | 0.0235 | 0.1518 | 0.2386 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0235 | 0.1518 | 0.2386 |
Brugia malayi | Variant SH3 domain containing protein | 0.0362 | 0.4968 | 0.7808 |
Onchocerca volvulus | Suppressor of cytokine signaling 7 homolog | 0.0183 | 0.0123 | 0.0812 |
Loa Loa (eye worm) | hypothetical protein | 0.0362 | 0.4968 | 0.7808 |
Onchocerca volvulus | 0.0183 | 0.0123 | 0.0812 | |
Brugia malayi | Protein kinase domain containing protein | 0.0235 | 0.1518 | 0.2386 |
Brugia malayi | SH2 domain containing protein | 0.0183 | 0.0123 | 0.0194 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0413 | 0.6363 | 0.6363 |
Entamoeba histolytica | SH2 domain containing protein | 0.0183 | 0.0123 | 0.0812 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0235 | 0.1518 | 0.1518 |
Schistosoma mansoni | shc transforming protein | 0.0183 | 0.0123 | 0.0194 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0362 | 0.4968 | 0.7808 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0235 | 0.1518 | 0.2386 |
Echinococcus multilocularis | signal transduction protein lnk realted | 0.0183 | 0.0123 | 0.0123 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0547 | 1 | 1 |
Echinococcus granulosus | hypothetical protein | 0.0183 | 0.0123 | 0.0123 |
Echinococcus multilocularis | suppressor of cytokine signaling 7 | 0.0183 | 0.0123 | 0.0123 |
Brugia malayi | hypothetical protein | 0.0235 | 0.1518 | 0.2386 |
Onchocerca volvulus | 0.0235 | 0.1518 | 1 | |
Loa Loa (eye worm) | RhoGAP domain-containing protein | 0.0183 | 0.0123 | 0.0194 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0413 | 0.6363 | 0.6363 |
Brugia malayi | Protein kinase domain containing protein | 0.0235 | 0.1518 | 0.2386 |
Brugia malayi | cytokine inducible SH2-containing protein 5 | 0.0183 | 0.0123 | 0.0194 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0413 | 0.6363 | 0.6363 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0235 | 0.1518 | 0.2386 |
Echinococcus multilocularis | N chimaerin | 0.0183 | 0.0123 | 0.0123 |
Echinococcus multilocularis | tyrosine kinase | 0.0235 | 0.1518 | 0.1518 |
Loa Loa (eye worm) | hypothetical protein | 0.0185 | 0.0161 | 0.0253 |
Schistosoma mansoni | vav2 | 0.0185 | 0.0161 | 0.0253 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0183 | 0.0123 | 0.0123 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.0123 | 0.0194 |
Onchocerca volvulus | 0.0183 | 0.0123 | 0.0812 | |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0183 | 0.0123 | 0.0194 |
Schistosoma mansoni | signal transduction protein lnk-related | 0.0183 | 0.0123 | 0.0194 |
Brugia malayi | RhoGAP domain containing protein | 0.0183 | 0.0123 | 0.0194 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.0123 | 0.0194 |
Echinococcus granulosus | tyrosine protein kinase shark | 0.0235 | 0.1518 | 0.1518 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0183 | 0.0123 | 0.0123 |
Echinococcus multilocularis | SHC transforming protein 3 | 0.0183 | 0.0123 | 0.0123 |
Brugia malayi | STAT protein, DNA binding domain containing protein | 0.0183 | 0.0123 | 0.0194 |
Brugia malayi | SRC-1 | 0.0413 | 0.6363 | 1 |
Echinococcus multilocularis | SH2 motif | 0.0183 | 0.0123 | 0.0123 |
Echinococcus granulosus | phosphatidylinositol 3 kinase regulatory subunit | 0.0183 | 0.0123 | 0.0123 |
Echinococcus multilocularis | SH2 motif | 0.0183 | 0.0123 | 0.0123 |
Schistosoma mansoni | protein tyrosine phosphatase n11 (shp2) | 0.0183 | 0.0123 | 0.0194 |
Echinococcus granulosus | SH2 domain containing protein 7 | 0.0183 | 0.0123 | 0.0123 |
Echinococcus multilocularis | NCK adaptor protein | 0.0362 | 0.4968 | 0.4968 |
Trichomonas vaginalis | p67phox protein, putative | 0.0179 | 0 | 0.5 |
Echinococcus granulosus | tensin C1 domain containing phosphatase | 0.0183 | 0.0123 | 0.0123 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0179 | 0 | 0.5 |
Schistosoma mansoni | tyrosine-protein kinase zap-70 | 0.0183 | 0.0123 | 0.0194 |
Echinococcus granulosus | tyrosine protein kinase Srms | 0.0235 | 0.1518 | 0.1518 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.0235 | 0.1518 | 0.1518 |
Brugia malayi | Protein kinase domain containing protein | 0.0235 | 0.1518 | 0.2386 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.0123 | 0.0194 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0179 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0179 | 0 | 0.5 |
Schistosoma mansoni | tensin-related | 0.0183 | 0.0123 | 0.0194 |
Echinococcus multilocularis | guanine nucleotide exchange factor VAV2 | 0.0183 | 0.0123 | 0.0123 |
Onchocerca volvulus | 0.0235 | 0.1518 | 1 | |
Brugia malayi | Variant SH3 domain containing protein | 0.0362 | 0.4968 | 0.7808 |
Loa Loa (eye worm) | cytokine inducible SH2-containing protein 5 | 0.0183 | 0.0123 | 0.0194 |
Loa Loa (eye worm) | SH2 domain-containing protein | 0.0183 | 0.0123 | 0.0194 |
Schistosoma mansoni | suppressor of cytokine signaling | 0.0183 | 0.0123 | 0.0194 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (functional) | = 1.9 ug ml-1 | Cytotoxicity of the compound was evaluated against Hep-2 cells in vitro | ChEMBL. | 11958999 |
CC50 (functional) | = 1.9 ug ml-1 | Cytotoxicity of the compound was evaluated against Hep-2 cells in vitro | ChEMBL. | 11958999 |
MIC (functional) | = 1 ug ml-1 | Minimum inhibitory concentration against Candida albicans | ChEMBL. | 11958999 |
MIC (functional) | = 1 ug ml-1 | Minimum inhibitory concentration against Candida albicans | ChEMBL. | 11958999 |
MIC (functional) | = 4 ug ml-1 | Minimum inhibitory concentration against Candida glabrata | ChEMBL. | 11958999 |
Therapeutic index (functional) | = 1.9 ug ml-1 | Therapeutic index (CC50/MIC) of the compound was determined | ChEMBL. | 11958999 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.