TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 422.601 | Formula: C24H42N2O4
H donors: 3 H acceptors: 2 LogP: 4.79 Rotable bonds: 18
Rule of 5 violations (Lipinski): 1
SMILES: CCCCCCCCC(=O)NCc1ccc(c(c1)OC)OCC(CNC(CC)C)O
InChi: 1S/C24H42N2O4/c1-5-7-8-9-10-11-12-24(28)26-16-20-13-14-22(23(15-20)29-4)30-18-21(27)17-25-19(3)6-2/h13-15,19,21,25,27H,5-12,16-18H2,1-4H3,(H,26,28)
InChiKey: AQGUVFGYLHNNMV-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	DNA topoisomerase II	0.0142	0.1114	0.1059
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0818	0.7882	0.9584
Trypanosoma cruzi	histone deacetylase, putative	0.0056	0.0259	0.0834
Schistosoma mansoni	myosin xvIII	0.0049	0.0187	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0187	0.0127
Trypanosoma cruzi	histone deacetylase 1, putative	0.0198	0.1674	0.6768
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0049	0.0187	0.0127
Echinococcus multilocularis	serotonin receptor	0.0049	0.0187	0.0154
Leishmania major	histone deacetylase, putative	0.0198	0.1674	0.6768
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0049	0.0187	0.0127
Toxoplasma gondii	aminopeptidase n, putative	0.0037	0.0061	0.0248
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0049	0.0187	0.0154
Echinococcus granulosus	histone deacetylase	0.0275	0.2444	0.2921
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0187	0.0127
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0091	0.0602	0.0663
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0049	0.0187	0.0127
Schistosoma mansoni	amine GPCR	0.0049	0.0187	0.0127
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0049	0.0187	0.0154
Plasmodium falciparum	M1-family alanyl aminopeptidase, putative	0.0037	0.0061	0.0248
Mycobacterium tuberculosis	Probable oxidoreductase	0.0121	0.0905	0.2969
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0655	0.0598
Brugia malayi	hypothetical protein	0.0049	0.0187	0.0127
Brugia malayi	DNA gyrase/topoisomerase IV, A subunit family protein	0.0142	0.1114	0.1059
Schistosoma mansoni	hypothetical protein	0.0173	0.1429	0.1377
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0187	0.0127
Schistosoma mansoni	histamine h1 receptor	0.0049	0.0187	0.0127
Echinococcus multilocularis	orexin receptor type 2	0.0049	0.0187	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0187	0.0127
Schistosoma mansoni	histone deacetylase 4 5	0.0275	0.2444	0.2398
Trypanosoma cruzi	mitochondrial DNA topoisomerase II, putative	0.0159	0.1287	0.5146
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0187	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0187	0.0127
Brugia malayi	AKH receptor	0.0049	0.0187	0.0127
Echinococcus granulosus	neuropeptide receptor A26	0.0049	0.0187	0.0154
Leishmania major	histone deacetylase, putative	0.0275	0.2444	1
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0049	0.0187	0.0127
Brugia malayi	histone deacetylase 11	0.0056	0.0259	0.02
Brugia malayi	hypothetical protein	0.0049	0.0187	0.0127
Onchocerca volvulus		0.0049	0.0187	0.2124
Plasmodium vivax	histone deacetylase, putative	0.0275	0.2444	1
Toxoplasma gondii	aminopeptidase N, putative	0.0037	0.0061	0.0248
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0187	0.0127
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0049	0.0187	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0187	0.0127
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.103	1	1
Echinococcus multilocularis	neuropeptide s receptor	0.0049	0.0187	0.0154
Schistosoma mansoni	amine GPCR	0.0049	0.0187	0.0127
Echinococcus granulosus	G protein coupled receptor 139	0.0049	0.0187	0.0154
Trypanosoma cruzi	histone deacetylase, putative	0.0275	0.2444	1
Schistosoma mansoni	amine GPCR	0.0049	0.0187	0.0127
Plasmodium vivax	DNA gyrase subunit B, putative	0.0083	0.0522	0.2136
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0049	0.0187	0.0127
Schistosoma mansoni	neuropeptide F-like receptor	0.0049	0.0187	0.0127
Brugia malayi	hypothetical protein	0.0316	0.286	0.2816
Echinococcus granulosus	7TM GPCR rhodopsin	0.0049	0.0187	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0187	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0187	0.0127
Echinococcus granulosus	somatostatin receptor	0.0049	0.0187	0.0154
Schistosoma mansoni	leukotriene A4 hydrolase (M01 family)	0.0688	0.6578	0.6557
Schistosoma mansoni	neuropeptide receptor	0.0049	0.0187	0.0127
Echinococcus granulosus	rhodopsin orphan GPCR	0.0049	0.0187	0.0154
Onchocerca volvulus	Putative DNA topoisomerase 2, mitochondrial	0.0096	0.0654	1
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0198	0.1674	1
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0187	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0187	0.0127
Brugia malayi	G protein-coupled receptor	0.0049	0.0187	0.0127
Echinococcus granulosus	histone deacetylase 6	0.0275	0.2444	0.2921
Echinococcus granulosus	epidermal growth factor receptor	0.0152	0.1213	0.1412
Brugia malayi	putative neuropeptide receptor NPR1	0.0049	0.0187	0.0127
Brugia malayi	Dopamine receptor	0.0049	0.0187	0.0127
Onchocerca volvulus	DNA topoisomerase 2 homolog	0.0096	0.0654	1
Trichomonas vaginalis	histone deacetylase, putative	0.0198	0.1674	1
Echinococcus granulosus	neuropeptide s receptor	0.0049	0.0187	0.0154
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0049	0.0187	0.0127
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0049	0.0187	0.2124
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0187	0.0127
Onchocerca volvulus		0.0049	0.0187	0.2124
Loa Loa (eye worm)	histone deacetylase 1	0.0198	0.1674	0.1623
Schistosoma mansoni	biogenic amine receptor	0.0049	0.0187	0.0127
Schistosoma mansoni	tyrosine kinase	0.0152	0.1213	0.1159
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0049	0.0187	0.0154
Plasmodium falciparum	histone deacetylase, putative	0.0275	0.2444	1
Brugia malayi	glutathione reductase	0.0048	0.0172	0.0112
Echinococcus granulosus	histone deacetylase 8	0.0056	0.0259	0.0244
Brugia malayi	Furin-like cysteine rich region family protein	0.0227	0.1963	0.1914
Mycobacterium ulcerans	epoxide hydrolase EphA	0.0335	0.305	1
Plasmodium vivax	thioredoxin reductase, putative	0.0048	0.0172	0.0705
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0187	0.0127
Trypanosoma brucei	DNA topoisomerase ii	0.0159	0.1287	0.5146
Echinococcus multilocularis	somatostatin receptor	0.0049	0.0187	0.0154
Brugia malayi	ORL1-like opioid receptor	0.0049	0.0187	0.0127
Brugia malayi	hypothetical protein	0.0049	0.0187	0.0127
Brugia malayi	putative neuropeptide receptor	0.0049	0.0187	0.0127
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0049	0.0187	0.0127
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0852	0.8221	1
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0049	0.0187	0.0154
Leishmania major	histone deacetylase, putative	0.0198	0.1674	0.6768
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0187	0.0127
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0049	0.0187	0.0127
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0048	0.0172	0.0565
Schistosoma mansoni	neuropeptide receptor	0.0049	0.0187	0.0127
Echinococcus multilocularis	allatostatin A receptor	0.0049	0.0187	0.0154
Onchocerca volvulus		0.0049	0.0187	0.2124
Trypanosoma cruzi	histone deacetylase, putative	0.0056	0.0259	0.0834
Echinococcus multilocularis	neuropeptide receptor	0.0049	0.0187	0.0154
Echinococcus granulosus	rhodopsin orphan GPCR	0.0049	0.0187	0.0154
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0049	0.0187	0.0127
Schistosoma mansoni	growth hormone secretagogue receptor	0.0049	0.0187	0.0127
Toxoplasma gondii	ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein	0.0083	0.0522	0.2136
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0049	0.0187	0.0154
Wolbachia endosymbiont of Brugia malayi	DNA gyrase, topoisomerase II, B subunit, GyrB	0.0083	0.0522	1
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0049	0.0187	0.0154
Brugia malayi	larval opioid receptor	0.0049	0.0187	0.0127
Mycobacterium ulcerans	DNA gyrase subunit B	0.0083	0.0522	0.1712
Brugia malayi	sulfakinin receptor protein	0.0049	0.0187	0.0127
Echinococcus granulosus	neuropeptide receptor	0.0049	0.0187	0.0154
Echinococcus granulosus	neuropeptides capa receptor	0.0049	0.0187	0.0154
Echinococcus granulosus	biogenic amine 5HT receptor	0.0049	0.0187	0.0154
Trichomonas vaginalis	histone deacetylase, putative	0.0198	0.1674	1
Brugia malayi	G protein-coupled receptor F59B2.13	0.0049	0.0187	0.0127
Brugia malayi	Protein kinase domain containing protein	0.0194	0.1636	0.1585
Schistosoma mansoni	tyrosine kinase	0.0194	0.1636	0.1585
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0049	0.0187	0.0154
Onchocerca volvulus		0.0049	0.0187	0.2124
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0187	0.0127
Echinococcus granulosus	DNA topoisomerase 2 alpha	0.0142	0.1114	0.129
Brugia malayi	hypothetical protein	0.0049	0.0187	0.0127
Trichomonas vaginalis	histone deacetylase, putative	0.0198	0.1674	1
Echinococcus multilocularis	epidermal growth factor receptor	0.0152	0.1213	0.1412
Schistosoma mansoni	adenoreceptor	0.0049	0.0187	0.0127
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0121	0.0905	0.2969
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0187	0.0127
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0049	0.0187	0.2124
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0187	0.0127
Echinococcus granulosus	rhodopsin orphan GPCR	0.0049	0.0187	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0187	0.0127
Onchocerca volvulus		0.0049	0.0187	0.2124
Brugia malayi	histone deacetylase 3 (HD3)	0.0198	0.1674	0.1623
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0109	0.0784	0.257
Echinococcus granulosus	tm gpcr rhodopsin	0.0049	0.0187	0.0154
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0049	0.0187	0.0127
Schistosoma mansoni	hypothetical protein	0.0049	0.0187	0.0127
Echinococcus multilocularis	DNA topoisomerase 2 alpha	0.0142	0.1114	0.129
Trichomonas vaginalis	histone deacetylase, putative	0.0198	0.1674	1
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0049	0.0187	0.0127
Echinococcus granulosus	tm gpcr rhodopsin	0.0852	0.8221	1
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0187	0.0127
Mycobacterium tuberculosis	Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase)	0.0335	0.305	1
Brugia malayi	Histone deacetylase family protein	0.0275	0.2444	0.2398
Brugia malayi	hypothetical protein	0.0049	0.0187	0.0127
Echinococcus granulosus	hypothetical protein	0.0049	0.0187	0.0154
Schistosoma mansoni	tyrosine kinase	0.0194	0.1636	0.1585
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0187	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0272	0.0213
Loa Loa (eye worm)	G-protein coupled receptor	0.0049	0.0187	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0187	0.0127
Echinococcus multilocularis	histone deacetylase 6	0.0275	0.2444	0.2921
Loa Loa (eye worm)	hypothetical protein	0.0198	0.1674	0.1623
Plasmodium falciparum	DNA gyrase subunit B	0.0083	0.0522	0.2136
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0187	0.0127
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0049	0.0187	0.0127
Toxoplasma gondii	histone deacetylase HDAC4	0.0056	0.0259	0.1061
Echinococcus granulosus	histone deacetylase 6	0.0275	0.2444	0.2921
Onchocerca volvulus		0.0049	0.0187	0.2124
Trypanosoma cruzi	trypanothione reductase, putative	0.0048	0.0172	0.0469
Echinococcus granulosus	rhodopsin orphan GPCR	0.0049	0.0187	0.0154
Trypanosoma cruzi	histone deacetylase, putative	0.0275	0.2444	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0049	0.0187	0.0154
Schistosoma mansoni	hypothetical protein	0.0049	0.0187	0.0127
Echinococcus multilocularis	neuropeptides capa receptor	0.0049	0.0187	0.0154
Echinococcus multilocularis	histone deacetylase 6	0.0275	0.2444	0.2921
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0049	0.0187	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0259	0.02
Echinococcus granulosus	epidermal growth factor receptor	0.0227	0.1963	0.2331
Schistosoma mansoni	histone deacetylase hda2	0.0056	0.0259	0.02
Onchocerca volvulus		0.0049	0.0187	0.2124
Echinococcus granulosus	histone deacetylase 3	0.0198	0.1674	0.1977
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0049	0.0187	0.0127
Trypanosoma brucei	histone deacetylase 2	0.0056	0.0259	0.0834
Onchocerca volvulus		0.0049	0.0187	0.2124
Echinococcus granulosus	geminin	0.0173	0.1429	0.1677
Echinococcus granulosus	thioredoxin glutathione reductase	0.0048	0.0172	0.0137
Trypanosoma brucei	histone deacetylase, putative	0.0275	0.2444	1
Echinococcus multilocularis	neuropeptide receptor	0.0049	0.0187	0.0154
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0049	0.0187	0.0154
Plasmodium falciparum	DNA topoisomerase 2	0.0142	0.1114	0.4556
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0187	0.0127
Loa Loa (eye worm)	TOPoisomerase family member	0.0142	0.1114	0.1059
Echinococcus multilocularis	histone deacetylase	0.0275	0.2444	0.2921
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0187	0.0127
Echinococcus granulosus	g protein coupled receptor	0.0049	0.0187	0.0154
Echinococcus multilocularis	g protein coupled receptor	0.0049	0.0187	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0187	0.0127
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0198	0.1674	1
Echinococcus multilocularis	epidermal growth factor receptor	0.0227	0.1963	0.2331
Schistosoma mansoni	histone deacetylase 4 5	0.0275	0.2444	0.2398
Schistosoma mansoni	histone deacetylase	0.0198	0.1674	0.1623
Schistosoma mansoni	neuropeptide receptor	0.0049	0.0187	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0187	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0187	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0187	0.0127
Echinococcus multilocularis	neuropeptide Y receptor	0.0049	0.0187	0.0154
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0049	0.0187	0.0154
Echinococcus granulosus	g protein coupled receptor	0.0049	0.0187	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0272	0.0213
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0049	0.0187	0.0154
Leishmania major	histone deacetylase, putative	0.0275	0.2444	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0049	0.0187	0.0154
Schistosoma mansoni	hypothetical protein	0.0049	0.0187	0.0127
Trypanosoma cruzi	DNA topoisomerase II, putative	0.0134	0.1037	0.4096
Echinococcus multilocularis	serotonin receptor	0.0049	0.0187	0.0154
Echinococcus granulosus	histone deacetylase 1	0.0198	0.1674	0.1977
Echinococcus granulosus	biogenic amine 5HT receptor	0.0049	0.0187	0.0154
Onchocerca volvulus	Histone deacetylase 10 homolog	0.0056	0.0259	0.3353
Echinococcus multilocularis	G protein coupled receptor 139	0.0049	0.0187	0.0154
Schistosoma mansoni	hypothetical protein	0.0173	0.1429	0.1377
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0091	0.0602	0.0545
Trypanosoma cruzi	mitochondrial DNA topoisomerase II, putative	0.0159	0.1287	0.5146
Plasmodium vivax	histone deacetylase, putative	0.0056	0.0259	0.1061
Echinococcus multilocularis	fmrfamide receptor	0.0049	0.0187	0.0154
Toxoplasma gondii	thioredoxin reductase	0.0048	0.0172	0.0705
Echinococcus multilocularis	histone deacetylase 1	0.0198	0.1674	0.1977
Echinococcus granulosus	fmrfamide receptor	0.0049	0.0187	0.0154
Plasmodium falciparum	histone deacetylase 2	0.0275	0.2444	1
Toxoplasma gondii	aminopeptidase N protein	0.0037	0.0061	0.0248
Schistosoma mansoni	amine GPCR	0.0049	0.0187	0.0127
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0049	0.0187	0.0154
Brugia malayi	GnHR receptor homolog	0.0049	0.0187	0.0127
Echinococcus granulosus	tm gpcr rhodopsin	0.0049	0.0187	0.0154
Leishmania major	mitochondrial DNA topoisomerase II	0.0159	0.1287	0.5146
Loa Loa (eye worm)	histone deacetylase 3	0.0198	0.1674	0.1623
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0655	0.0598
Echinococcus multilocularis	histone deacetylase 8	0.0056	0.0259	0.0244
Echinococcus granulosus	orexin receptor type 2	0.0049	0.0187	0.0154
Loa Loa (eye worm)	hypothetical protein	0.103	1	1
Onchocerca volvulus	DNA topoisomerase 2 homolog	0.0096	0.0654	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0049	0.0187	0.0154
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0049	0.0187	0.0154
Toxoplasma gondii	histone deacetylase HDAC1	0.0275	0.2444	1
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0048	0.0172	0.0137
Trichomonas vaginalis	histone deacetylase, putative	0.0198	0.1674	1
Onchocerca volvulus		0.0049	0.0187	0.2124
Echinococcus granulosus	rhodopsin orphan GPCR	0.0049	0.0187	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0187	0.0127
Echinococcus multilocularis	dro:myosuppressin receptor	0.0049	0.0187	0.0154
Brugia malayi	hypothetical protein	0.0049	0.0187	0.0127
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0049	0.0187	0.0154
Plasmodium vivax	glutathione reductase, putative	0.0048	0.0172	0.0705
Echinococcus multilocularis	g protein coupled receptor	0.0049	0.0187	0.0154
Brugia malayi	follicle stimulating hormone receptor	0.0049	0.0187	0.0127
Onchocerca volvulus		0.0049	0.0187	0.2124
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0194	0.1636	0.193
Loa Loa (eye worm)	hypothetical protein	0.0218	0.188	0.183
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0049	0.0187	0.0127
Toxoplasma gondii	histone deacetylase HDAC2	0.0198	0.1674	0.6848
Echinococcus multilocularis	neuropeptide Y receptor	0.0049	0.0187	0.0154
Schistosoma mansoni	amine GPCR	0.0049	0.0187	0.0127
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0109	0.0784	0.257
Echinococcus granulosus	insulin receptor	0.0194	0.1636	0.193
Loa Loa (eye worm)	neuropeptide F receptor	0.0049	0.0187	0.0127
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0049	0.0187	0.0154
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0049	0.0187	0.0127
Brugia malayi	G-protein coupled receptor	0.0049	0.0187	0.0127
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0198	0.1674	1
Trypanosoma brucei	trypanothione reductase	0.0048	0.0172	0.0469
Loa Loa (eye worm)	histone deacetylase 11	0.0056	0.0259	0.02
Echinococcus granulosus	7tm_1 domain containing protein	0.0049	0.0187	0.0154
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0121	0.0905	1
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0109	0.0784	0.8557
Echinococcus multilocularis	geminin	0.0173	0.1429	0.1677
Schistosoma mansoni	tyrosine kinase	0.015	0.1192	0.1138
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0049	0.0187	0.0154
Echinococcus multilocularis	neuropeptides capa receptor	0.0049	0.0187	0.0154
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0049	0.0187	0.0127
Brugia malayi	Thioredoxin reductase	0.0048	0.0172	0.0112
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0194	0.1636	0.193
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0187	0.0127
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0049	0.0187	0.0154
Loa Loa (eye worm)	leukotriene A4 hydrolase	0.0688	0.6578	0.6557
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0187	0.0127
Trypanosoma cruzi	DNA topoisomerase II, putative	0.0134	0.1037	0.4096
Onchocerca volvulus		0.0049	0.0187	0.2124
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0049	0.0187	0.0127
Echinococcus granulosus	serotonin receptor	0.0049	0.0187	0.0154
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0109	0.0784	0.257
Echinococcus granulosus	neuropeptide receptor	0.0049	0.0187	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0187	0.0127
Plasmodium vivax	M1-family alanyl aminopeptidase, putative	0.0037	0.0061	0.0248
Echinococcus granulosus	allatostatin A receptor	0.0049	0.0187	0.0154
Brugia malayi	neuropeptide F receptor	0.0049	0.0187	0.0127
Brugia malayi	Protein kinase domain containing protein	0.008	0.0491	0.0433
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0049	0.0187	0.0154
Toxoplasma gondii	DNA topoisomerase 2, putative	0.0142	0.1114	0.4556
Brugia malayi	Histone deacetylase 1	0.0198	0.1674	0.1623
Plasmodium falciparum	thioredoxin reductase	0.0048	0.0172	0.0705
Brugia malayi	RE15519p	0.0049	0.0187	0.0127
Plasmodium vivax	M1-family alanyl aminopeptidase, putative	0.0037	0.0061	0.0248
Echinococcus multilocularis	g-protein coupled receptor	0.0049	0.0187	0.0154
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0049	0.0187	0.0154
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0049	0.0187	0.0127
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0049	0.0187	0.0127
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0049	0.0187	0.0127
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0049	0.0187	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0187	0.0127
Trichomonas vaginalis	histone deacetylase, putative	0.0198	0.1674	1
Brugia malayi	neuropeptide F receptor	0.0049	0.0187	0.0127
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0049	0.0187	0.0154
Schistosoma mansoni	tyrosine kinase	0.0152	0.1213	0.1159
Leishmania major	trypanothione reductase	0.0048	0.0172	0.0469
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0049	0.0187	0.0127
Brugia malayi	Serotonin receptor	0.0049	0.0187	0.0127
Schistosoma mansoni	tyrosine kinase	0.0227	0.1963	0.1914
Loa Loa (eye worm)	hypothetical protein	0.0218	0.188	0.183
Chlamydia trachomatis	DNA gyrase subunit B	0.0065	0.0348	0.6674
Schistosoma mansoni	tyrosine kinase	0.015	0.1192	0.1138
Loa Loa (eye worm)	hypothetical protein	0.103	1	1
Entamoeba histolytica	histone deacetylase, putative	0.0198	0.1674	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0091	0.0602	0.0663
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0049	0.0187	0.0154
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0091	0.0602	0.0663
Loa Loa (eye worm)	TYRA-2 protein	0.0049	0.0187	0.0127
Echinococcus multilocularis	neuropeptide receptor A26	0.0049	0.0187	0.0154
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0091	0.0602	0.0545
Echinococcus multilocularis	leukotriene A 4 hydrolase	0.0688	0.6578	0.7987
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0049	0.0187	0.0127
Trypanosoma cruzi	histone deacetylase, putative	0.0275	0.2444	1
Loa Loa (eye worm)	histone deacetylase	0.0275	0.2444	0.2398
Brugia malayi	DNA topoisomerase II, alpha isozyme	0.0142	0.1114	0.1059
Brugia malayi	hypothetical protein	0.0049	0.0187	0.0127
Treponema pallidum	DNA gyrase, subunit B (gyrB)	0.0083	0.0522	1
Brugia malayi	Probable DNA topoisomerase II	0.0142	0.1114	0.1059
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0187	0.0127
Schistosoma mansoni	neuropeptide F-like receptor	0.0049	0.0187	0.0127
Trypanosoma brucei	histone deacetylase 3	0.0275	0.2444	1
Brugia malayi	Melatonin receptor type 1A	0.0049	0.0187	0.0127
Schistosoma mansoni	neuropeptide receptor	0.0049	0.0187	0.0127
Schistosoma mansoni	neuropeptide f receptor 76f	0.0049	0.0187	0.0127
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0049	0.0187	0.0127
Echinococcus granulosus	histone deacetylase 6	0.0275	0.2444	0.2921
Echinococcus granulosus	neuropeptide Y receptor	0.0049	0.0187	0.0154
Echinococcus multilocularis	g protein coupled receptor	0.0049	0.0187	0.0154
Plasmodium vivax	histone deacetylase 2, putative	0.0275	0.2444	1
Echinococcus granulosus	sex peptide receptor	0.0049	0.0187	0.0154
Toxoplasma gondii	histone deacetylase HDAC5	0.0057	0.0262	0.1071
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0187	0.0127
Echinococcus granulosus	dro:myosuppressin receptor	0.0049	0.0187	0.0154
Plasmodium vivax	DNA topoisomerase II, putative	0.0142	0.1114	0.4556
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0049	0.0187	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0187	0.0127
Plasmodium falciparum	glutathione reductase	0.0048	0.0172	0.0705
Giardia lamblia	Histone deacetylase	0.0198	0.1674	1
Loa Loa (eye worm)	thioredoxin reductase	0.0048	0.0172	0.0112
Loa Loa (eye worm)	TK/INSR protein kinase	0.0194	0.1636	0.1585
Echinococcus granulosus	g-protein coupled receptor	0.0049	0.0187	0.0154
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0049	0.0187	0.0154
Schistosoma mansoni	tyrosine kinase	0.015	0.1192	0.1138
Schistosoma mansoni	histone deacetylase 1 2 3	0.0056	0.0259	0.02
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0091	0.0602	0.0545
Trypanosoma cruzi	histone deacetylase 1, putative	0.0198	0.1674	0.6768
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0187	0.0127
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0049	0.0187	0.0127
Schistosoma mansoni	biogenic amine receptor	0.0049	0.0187	0.0127
Onchocerca volvulus		0.0049	0.0187	0.2124
Echinococcus multilocularis	fmrfamide receptor	0.0049	0.0187	0.0154
Loa Loa (eye worm)	histone deacetylase 7A	0.0275	0.2444	0.2398
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0121	0.0905	0.2969
Schistosoma mansoni	opsin-like receptor	0.0049	0.0187	0.0127
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0049	0.0187	0.0154
Trichomonas vaginalis	DNA topoisomerase II, putative	0.0142	0.1114	0.6527
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0049	0.0187	0.0127
Brugia malayi	hypothetical protein	0.0049	0.0187	0.0127
Echinococcus granulosus	neuropeptide FF receptor 2	0.0049	0.0187	0.0154
Loa Loa (eye worm)	neuropeptide F receptor	0.0049	0.0187	0.0127
Brugia malayi	histone deacetylase 1 (HD1)	0.0198	0.1674	0.1623
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0049	0.0187	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0187	0.0127
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0049	0.0187	0.0127
Mycobacterium tuberculosis	Probable reductase	0.0109	0.0784	0.257
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0049	0.0187	0.0127
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0049	0.0187	0.0127
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0049	0.0187	0.0127
Mycobacterium ulcerans	aminopeptidase N PepN	0.0037	0.0061	0.0199
Plasmodium falciparum	histone deacetylase 1	0.0198	0.1674	0.6848
Brugia malayi	Serotonin receptor	0.0049	0.0187	0.0127
Onchocerca volvulus		0.0049	0.0187	0.2124
Entamoeba histolytica	DNA topoisomerase II, putative	0.0142	0.1114	0.6527
Schistosoma mansoni	hypothetical protein	0.0049	0.0187	0.0127
Schistosoma mansoni	opsin-like receptor	0.0049	0.0187	0.0127
Echinococcus granulosus	histone deacetylase 7	0.0275	0.2444	0.2921
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0049	0.0187	0.0127
Mycobacterium tuberculosis	Probable dehydrogenase	0.0109	0.0784	0.257
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0049	0.0187	0.0154
Echinococcus multilocularis		0.0069	0.0382	0.0394
Loa Loa (eye worm)	hypothetical protein	0.0641	0.6107	0.6083
Brugia malayi	hypothetical protein	0.0049	0.0187	0.0127
Echinococcus granulosus	neuropeptide Y receptor	0.0049	0.0187	0.0154
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0109	0.0784	0.257
Plasmodium vivax	histone deacetylase 1, putative	0.0198	0.1674	0.6848
Echinococcus multilocularis	histone deacetylase 7	0.0275	0.2444	0.2921
Leishmania major	DNA topoisomerase ii	0.0134	0.1037	0.4096
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0187	0.0127
Schistosoma mansoni	histone deacetylase	0.0198	0.1674	0.1623
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0091	0.0602	0.0545
Trypanosoma brucei	histone deacetylase 4	0.0275	0.2444	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0091	0.0602	0.0545
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0187	0.0127
Toxoplasma gondii	histone deacetylase HDAC3	0.0198	0.1674	0.6848
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0471	0.0412
Echinococcus multilocularis	histone deacetylase 6	0.0275	0.2444	0.2921
Echinococcus multilocularis	sex peptide receptor	0.0049	0.0187	0.0154
Echinococcus multilocularis	histone deacetylase 3	0.0198	0.1674	0.1977
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0091	0.0602	0.0663
Onchocerca volvulus		0.0049	0.0187	0.2124
Plasmodium falciparum	M1-family alanyl aminopeptidase	0.0037	0.0061	0.0248
Onchocerca volvulus		0.0049	0.0187	0.2124
Mycobacterium ulcerans	aminopeptidase N PepN	0.0037	0.0061	0.0199
Trypanosoma brucei	histone deacetylase 1	0.0198	0.1674	0.6768
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0049	0.0187	0.0127
Mycobacterium tuberculosis	DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase)	0.0083	0.0522	0.1712
Schistosoma mansoni	biogenic amine receptor	0.0049	0.0187	0.0127
Echinococcus granulosus	rhodopsin orphan GPCR	0.0049	0.0187	0.0154
Onchocerca volvulus		0.0049	0.0187	0.2124
Brugia malayi	Histone deacetylase family protein	0.0275	0.2444	0.2398
Loa Loa (eye worm)	melatonin receptor type 1A	0.0049	0.0187	0.0127
Trypanosoma brucei	DNA topoisomerase II alpha, putative	0.0134	0.1037	0.4096
Loa Loa (eye worm)	G-protein coupled receptor	0.0049	0.0187	0.0127
Loa Loa (eye worm)	glutathione reductase	0.0048	0.0172	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0187	0.0127
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0049	0.0187	0.0127
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0049	0.0187	0.0154
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0049	0.0187	0.0127
Echinococcus granulosus	leukotriene A 4 hydrolase	0.0688	0.6578	0.7987
Trypanosoma brucei	DNA topoisomerase II beta, putative	0.0134	0.1037	0.4096
Chlamydia trachomatis	DNA gyrase subunit B	0.0083	0.0522	1
Echinococcus granulosus	neuropeptides capa receptor	0.0049	0.0187	0.0154
Brugia malayi	Dopamine receptor protein 2	0.0049	0.0187	0.0127
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0049	0.0187	0.0154
Schistosoma mansoni	opsin-like receptor	0.0049	0.0187	0.0127
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0152	0.1213	0.1412
Brugia malayi	hypothetical protein	0.0049	0.0187	0.0127
Onchocerca volvulus		0.0049	0.0187	0.2124
Echinococcus granulosus	g protein coupled receptor	0.0049	0.0187	0.0154
Brugia malayi	Dopamine receptor protein 1	0.0049	0.0187	0.0127
Echinococcus granulosus	rhodopsin orphan GPCR	0.0049	0.0187	0.0154
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0227	0.1963	0.1914
Echinococcus multilocularis	insulin receptor	0.0194	0.1636	0.193
Brugia malayi	G-protein coupled receptor	0.0049	0.0187	0.0127
Schistosoma mansoni	histone deacetylase hda2	0.0275	0.2444	0.2398

Activities

Activity type	Activity value	Assay description	Source	Reference
BP (functional)	= -0.88 mmHg	Blood pressure of the urethane-anesthetized normotensive Wistar rat was tested 30 min after inducing the compound on dose of 1.0 mg/kg	ChEMBL.	7908697
BP (functional)	= 1.22 mmHg	Blood pressure of the urethane-anesthetized normotensive Wistar rat was tested 60 min after inducing the compound on dose of 1.0 mg/kg	ChEMBL.	7908697
BP (functional)	= 3.33 mmHg	Blood pressure of the urethane-anesthetized normotensive Wistar rat was tested 15 min after inducing the compound on dose of 1.0 mg/kg	ChEMBL.	7908697
BP (functional)	= 4.11 mmHg	Blood pressure of the urethane-anesthetized normotensive Wistar rat was tested 5 min after inducing the compound on dose of 1.0 mg/kg	ChEMBL.	7908697
BP (functional)	= 4.89 mmHg	Blood pressure of the urethane-anesthetized normotensive Wistar rat was tested 10 min after inducing the compound on dose of 1.0 mg/kg	ChEMBL.	7908697
HR (functional)	= -38.56 beats min-1	Heart rate of the urethane-anesthetized normotensive Wistar rat was tested 5 min after inducing the compound on dose of 1.0 mg/kg	ChEMBL.	7908697
HR (functional)	= -35.44 beats min-1	Heart rate of the urethane-anesthetized normotensive Wistar rat was tested 10 min after inducing the compound on dose of 1.0 mg/kg	ChEMBL.	7908697
HR (functional)	= -32.33 beats min-1	Heart rate of the urethane-anesthetized normotensive Wistar rat was tested 15 min after inducing the compound on dose of 1.0 mg/kg	ChEMBL.	7908697
HR (functional)	= -25.11 beats min-1	Heart rate of the urethane-anesthetized normotensive Wistar rat was tested 30 min after inducing the compound on dose of 1.0 mg/kg	ChEMBL.	7908697
HR (functional)	= -9.56 beats min-1	Heart rate of the urethane-anesthetized normotensive Wistar rat was tested 60 min after inducing the compound on dose of 1.0 mg/kg	ChEMBL.	7908697
pA2 (functional)	= 6.92	Positive chronotropic effect of the compound was evaluated on atrial muscles of the guinea pig	ChEMBL.	7908697
pA2 (functional)	= 7.65	Positive inotropic effect of the compound was evaluated on atrial muscles of the guinea pig	ChEMBL.	7908697

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL173113

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 303239