TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 310.43 | Formula: C21H26O2
H donors: 1 H acceptors: 2 LogP: 5.87 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: C/C(=C\c1ccc(cc1)C(=O)O)/C=C/C1=C(C)CCCC1(C)C
InChi: 1S/C21H26O2/c1-15(14-17-8-10-18(11-9-17)20(22)23)7-12-19-16(2)6-5-13-21(19,3)4/h7-12,14H,5-6,13H2,1-4H3,(H,22,23)/b12-7+,15-14+
InChiKey: NNTWECUMTLRLCK-SEGNDCOSSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	retinoic acid receptor, gamma	Starlite/ChEMBL	References
Homo sapiens	retinoic acid receptor, alpha	Starlite/ChEMBL	References
Homo sapiens	retinoic acid receptor, beta	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	nuclear receptor nhr-7B	Get druggable targets OG5_131607	All targets in OG5_131607
Brugia malayi	nuclear hormone receptor	Get druggable targets OG5_131607	All targets in OG5_131607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131607	All targets in OG5_131607
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	Get druggable targets OG5_131607	All targets in OG5_131607

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0037	0.0126	0.0121
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0017	0.0014	0.0009
Echinococcus multilocularis	regulator of G protein signaling 7	0.0038	0.0132	0.0127
Loa Loa (eye worm)	glutaminase	0.0273	0.1498	0.1494
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0025	0.0061	0.0135
Echinococcus multilocularis	nuclear receptor nhr 48	0.0017	0.0014	0.0009
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0056	0.0241	0.0236
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0056	0.0241	0.0236
Trypanosoma cruzi	STE group serine/threonine-protein kinase, putative	0.0025	0.0061	0.0135
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0241	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0241	0.0236
Echinococcus granulosus	aryl hydrocarbon receptor	0.0025	0.0058	0.0053
Schistosoma mansoni	nuclear hormone receptor	0.0017	0.0014	0.0009
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0056	0.0241	0.0236
Brugia malayi	Dopamine receptor	0.0056	0.0241	0.0241
Mycobacterium tuberculosis	Probable cytochrome P450 141 Cyp141	0.0022	0.0041	0.0514
Mycobacterium ulcerans	cytochrome P450 51B1 Cyp51B1	0.0022	0.0041	0.0215
Echinococcus multilocularis	somatostatin receptor	0.0056	0.0241	0.0236
Brugia malayi	putative neuropeptide receptor NPR1	0.0056	0.0241	0.0241
Leishmania major	cytochrome p450-like protein	0.0022	0.0041	0.0514
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0056	0.0241	0.0236
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0056	0.0241	0.0241
Echinococcus multilocularis	dro:myosuppressin receptor	0.0056	0.0241	0.0236
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0175	0.017
Echinococcus granulosus	dro:myosuppressin receptor	0.0056	0.0241	0.0236
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0056	0.0241	0.0236
Echinococcus multilocularis	gamma secretase subunit aph 1	0.174	1	1
Brugia malayi	ORL1-like opioid receptor	0.0056	0.0241	0.0241
Loa Loa (eye worm)	cytochrome P450 family protein	0.0031	0.0095	0.0089
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0241	0.0236
Brugia malayi	neuropeptide F receptor	0.0056	0.0241	0.0241
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0026	0.0021
Loa Loa (eye worm)	G-protein coupled receptor	0.0056	0.0241	0.0236
Plasmodium falciparum	ataxin-2 like protein, putative	0.0027	0.0069	0.3354
Onchocerca volvulus		0.0056	0.0241	0.0497
Echinococcus multilocularis	neuropeptide Y receptor	0.0056	0.0241	0.0236
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0287	0.1575	0.157
Loa Loa (eye worm)	glutathione reductase	0.0047	0.0188	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0241	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0126	0.0121
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0037	0.0126	0.0121
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0056	0.0241	0.0236
Mycobacterium ulcerans	cytochrome P450 123A3 Cyp123A3	0.0022	0.0041	0.0215
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0111	0.0106
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0061	0.0351
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0056	0.0241	0.0236
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0056	0.0241	0.0236
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0124	0.0633	0.4188
Echinococcus multilocularis	regulator of G protein signaling 7	0.0038	0.0132	0.0127
Echinococcus granulosus	lamin	0.0026	0.0065	0.006
Schistosoma mansoni	hypothetical protein	0.0056	0.0241	0.0236
Schistosoma mansoni	axis inhibition protein axin	0.0038	0.0132	0.0127
Echinococcus granulosus	tm gpcr rhodopsin	0.0056	0.0241	0.0236
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0061	0.0351
Leishmania major	ATP-dependent phosphofructokinase	0.0109	0.0544	0.8578
Brugia malayi	glutathione reductase	0.0047	0.0188	0.0188
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0054	0.0226	0.0566
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0132	0.0829
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0241	0.0236
Brugia malayi	Cytochrome P450 family protein	0.0031	0.0095	0.0095
Echinococcus granulosus	intermediate filament protein	0.0026	0.0065	0.006
Schistosoma mansoni	hypothetical protein	0.0102	0.0503	0.0498
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0109	0.0544	1
Mycobacterium tuberculosis	Probable reductase	0.0108	0.0539	0.8501
Loa Loa (eye worm)	melatonin receptor type 1A	0.0056	0.0241	0.0236
Echinococcus granulosus	g protein coupled receptor	0.0056	0.0241	0.0236
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0025	0.0058	0.033
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0016	0.0009	0.5
Trypanosoma brucei	trypanothione reductase	0.0047	0.0188	0.0467
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0126	0.0121
Brugia malayi	GnHR receptor homolog	0.0056	0.0241	0.0241
Schistosoma mansoni	amine GPCR	0.0056	0.0241	0.0236
Brugia malayi	Cytochrome P450 family protein	0.0062	0.0275	0.0275
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0175	0.017
Echinococcus multilocularis	musashi	0.0026	0.0065	0.006
Echinococcus granulosus	gamma secretase subunit aph 1	0.174	1	1
Schistosoma mansoni	adenoreceptor	0.0056	0.0241	0.0236
Loa Loa (eye worm)	neuropeptide F receptor	0.0056	0.0241	0.0236
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0037	0.0126	0.0121
Echinococcus granulosus	ecdysone induced protein 78C	0.0037	0.0126	0.0121
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0056	0.0241	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0014	0.0009
Onchocerca volvulus	Protein ultraspiracle homolog	0.0037	0.0126	0.0245
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0126	0.0121
Loa Loa (eye worm)	steroid hormone receptor	0.0037	0.0126	0.0121
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0056	0.0241	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0321	0.1774	0.177
Echinococcus multilocularis	expressed protein	0.0734	0.4168	0.4165
Brugia malayi	hypothetical protein	0.0017	0.0014	0.0014
Echinococcus granulosus	regulator of G protein signaling 3	0.0038	0.0132	0.0127
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0061	0.0351
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0016	0.0009	0.0004
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0108	0.0539	0.8772
Mycobacterium tuberculosis	Possible cytochrome P450 126 Cyp126	0.0022	0.0041	0.0514
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0056	0.0241	0.0236
Echinococcus multilocularis	neuropeptide Y receptor	0.0056	0.0241	0.0236
Mycobacterium tuberculosis	Probable cytochrome P450 137 Cyp137	0.0022	0.0041	0.0514
Trypanosoma brucei	Aph-1 protein, putative	0.0678	0.3844	1
Brugia malayi	6-phosphofructokinase	0.0109	0.0544	0.0544
Brugia malayi	nuclear receptor RXR	0.0019	0.0026	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0014	0.0009
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0056	0.0241	0.0236
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0787	0.4473	0.447
Brugia malayi	nuclear receptor RXR	0.0017	0.0014	0.0014
Echinococcus granulosus	6 phosphofructokinase	0.0109	0.0544	0.0539
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0014	0.0009
Trypanosoma cruzi	PAS-domain containing phosphoglycerate kinase, putative	0.0025	0.0058	0.0128
Echinococcus multilocularis	Protein lozenge	0.0059	0.0254	0.0249
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0026	0.0021
Mycobacterium ulcerans	cytochrome P450 124A1, Cyp124A1	0.0022	0.0041	0.0215
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0132	0.0829
Leishmania major	protein kinase, putative	0.0025	0.0061	0.0832
Echinococcus granulosus	tm gpcr rhodopsin	0.0056	0.0241	0.0236
Echinococcus granulosus	Regulator of G protein signaling 20	0.0038	0.0132	0.0127
Mycobacterium ulcerans	cytochrome P450 144A4 Cyp144A4	0.0022	0.0041	0.0215
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0108	0.0539	0.8501
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0061	0.0351
Schistosoma mansoni	hypothetical protein	0.0034	0.0111	0.0106
Schistosoma mansoni	cellular tumor antigen P53	0.0049	0.0196	0.0191
Onchocerca volvulus		0.0056	0.0241	0.0497
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0037	0.0126	0.0121
Entamoeba histolytica	phosphofructokinase, putative	0.0109	0.0544	1
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0241	0.0236
Mycobacterium ulcerans	hydrolase	0.0025	0.0061	0.0351
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0132	0.0127
Mycobacterium ulcerans	cytochrome P450 136A2 Cyp136A2	0.0022	0.0041	0.0215
Echinococcus multilocularis	orexin receptor type 2	0.0056	0.0241	0.0236
Brugia malayi	ecdysteroid receptor	0.0037	0.0126	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0241	0.0236
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0037	0.0126	0.0121
Schistosoma mansoni	lozenge	0.0059	0.0254	0.0249
Schistosoma mansoni	single-minded	0.0096	0.0468	0.0463
Schistosoma mansoni	neuropeptide receptor	0.0056	0.0241	0.0236
Echinococcus granulosus	g protein coupled receptor	0.0056	0.0241	0.0236
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0061	0.0351
Brugia malayi	PAS domain containing protein	0.0096	0.0468	0.0468
Mycobacterium ulcerans	cytochrome P450 150A6 Cyp150A6	0.0022	0.0041	0.0215
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0241	0.0236
Schistosoma mansoni	6-phosphofructokinase	0.0109	0.0544	0.0539
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0124	0.0633	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.0203	0.0203
Schistosoma mansoni	nuclear receptor	0.0017	0.0014	0.0009
Onchocerca volvulus		0.0056	0.0241	0.0497
Loa Loa (eye worm)	runx1	0.0059	0.0254	0.0249
Brugia malayi	regulator of G-protein signaling rgs-7	0.0038	0.0132	0.0132
Brugia malayi	hypothetical protein	0.0038	0.0132	0.0132
Echinococcus granulosus	single minded 2	0.0071	0.0324	0.0319
Brugia malayi	Serotonin receptor	0.0056	0.0241	0.0241
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0056	0.0241	0.0236
Plasmodium falciparum	flap endonuclease 1	0.0026	0.0065	0.3125
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0014	0.0009
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0056	0.0241	0.0236
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0056	0.0241	0.0236
Mycobacterium leprae	Possible regulatory protein	0.0025	0.0058	0.03
Schistosoma mansoni	lamin	0.0026	0.0065	0.006
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0056	0.0241	0.0236
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0054	0.0226	0.348
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0241	0.0236
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0175	0.017
Onchocerca volvulus		0.0056	0.0241	0.0497
Plasmodium vivax	ataxin-2 like protein, putative	0.0027	0.0069	0.3354
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0038	0.0132	0.0127
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0037	0.0126	0.0126
Brugia malayi	Nuclear hormone receptor E75	0.0017	0.0014	0.0014
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0061	0.0351
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0241	0.0236
Trichomonas vaginalis	guanylate cyclase, putative	0.0025	0.0058	0.033
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0061	0.0351
Schistosoma mansoni	nuclear receptor nhr-48	0.0017	0.0014	0.0009
Brugia malayi	follicle stimulating hormone receptor	0.0287	0.1575	0.1575
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0241	0.0236
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0029	0.0084	0.1406
Echinococcus granulosus	regulator of G protein signaling 7	0.0038	0.0132	0.0127
Schistosoma mansoni	neuropeptide receptor	0.0056	0.0241	0.0236
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.012	0.0609	1
Schistosoma mansoni	opsin-like receptor	0.0056	0.0241	0.0236
Brugia malayi	nuclear receptor NHR-67	0.0017	0.0014	0.0014
Onchocerca volvulus		0.0056	0.0241	0.0497
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0056	0.0241	0.0241
Mycobacterium ulcerans	arylsulfatase, AslA	0.0025	0.0061	0.0351
Schistosoma mansoni	aryl hydrocarbon receptor	0.0096	0.0468	0.0463
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0056	0.0241	0.0236
Toxoplasma gondii	phosphofructokinase PFKII	0.0029	0.0084	0.1206
Echinococcus granulosus	g-protein coupled receptor	0.0056	0.0241	0.0236
Schistosoma mansoni	nuclear receptor	0.0017	0.0014	0.0009
Trichomonas vaginalis	flap endonuclease-1, putative	0.0026	0.0065	0.0376
Echinococcus granulosus	thioredoxin glutathione reductase	0.0047	0.0188	0.0183
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0109	0.0544	0.1395
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0037	0.0126	0.0126
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0111	0.0111
Schistosoma mansoni	hypothetical protein	0.0056	0.0241	0.0236
Mycobacterium tuberculosis	Probable sulfatase	0.0025	0.0061	0.0837
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0014	0.0009
Mycobacterium tuberculosis	Possible hydrolase	0.0025	0.0061	0.0837
Echinococcus multilocularis	neuropeptide receptor	0.0056	0.0241	0.0236
Brugia malayi	nuclear hormone receptor	0.0787	0.4473	0.4473
Brugia malayi	hypothetical protein	0.0038	0.0132	0.0132
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0061	0.0351
Schistosoma mansoni	neuropeptide receptor	0.0056	0.0241	0.0236
Brugia malayi	Dopamine receptor protein 1	0.0056	0.0241	0.0241
Echinococcus granulosus	neuropeptide Y receptor	0.0056	0.0241	0.0236
Schistosoma mansoni	opsin-like receptor	0.0056	0.0241	0.0236
Loa Loa (eye worm)	MH2 domain-containing protein	0.0118	0.0596	0.0591
Schistosoma mansoni	thyroid hormone receptor	0.0037	0.0126	0.0121
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0054	0.0226	0.348
Echinococcus multilocularis	fmrfamide receptor	0.0056	0.0241	0.0236
Leishmania major	PAS-domain containing phosphoglycerate kinase, putative	0.0025	0.0058	0.0787
Onchocerca volvulus		0.0025	0.0058	0.0096
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0056	0.0241	0.0236
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0038	0.0132	0.0127
Brugia malayi	hypothetical protein	0.0525	0.2955	0.2955
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0056	0.0241	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0241	0.0236
Echinococcus granulosus	regulator of G protein signaling 7	0.0038	0.0132	0.0127
Echinococcus multilocularis	axis inhibition protein axin	0.0038	0.0132	0.0127
Mycobacterium ulcerans	putative regulatory protein	0.0071	0.0324	0.2117
Schistosoma mansoni	aldehyde dehydrogenase	0.0124	0.0633	0.0628
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0056	0.0241	0.0236
Trypanosoma brucei	PAB1-binding protein , putative	0.0027	0.0069	0.0157
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0056	0.0241	0.0236
Brugia malayi	AKH receptor	0.0056	0.0241	0.0241
Loa Loa (eye worm)	DR-78	0.0017	0.0014	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0014	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0062	0.0057
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0037	0.0126	0.0121
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0037	0.0126	0.0121
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0056	0.0241	0.0236
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0022	0.0041	0.0084
Loa Loa (eye worm)	CYP4Cod1	0.0031	0.0095	0.0089
Plasmodium vivax	thioredoxin reductase, putative	0.0047	0.0188	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0026	0.0021
Brugia malayi	neuropeptide F receptor	0.0056	0.0241	0.0241
Echinococcus multilocularis	g protein coupled receptor	0.0056	0.0241	0.0236
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0124	0.0633	0.4188
Echinococcus multilocularis	g protein coupled receptor	0.0056	0.0241	0.0236
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0037	0.0126	0.0121
Echinococcus granulosus	mitogen activated protein kinase	0.0054	0.0226	0.0221
Echinococcus multilocularis	transfer RNA-Lys	0.0071	0.0324	0.0319
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0109	0.0544	0.8578
Brugia malayi	Steroid receptor seven-up type 2	0.0037	0.0126	0.0126
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0056	0.0241	0.0241
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0037	0.0126	0.0121
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0054	0.0226	0.0221
Echinococcus granulosus	beta-adrenergic receptor kinase	0.0038	0.0135	0.013
Leishmania major	lanosterol 14-alpha-demethylase, putative	0.0022	0.0041	0.0514
Loa Loa (eye worm)	TYRA-2 protein	0.0056	0.0241	0.0236
Schistosoma mansoni	nuclear hormone receptor	0.0037	0.0126	0.0121
Mycobacterium ulcerans	cytochrome P450 187A4 Cyp187A4	0.0022	0.0041	0.0215
Echinococcus granulosus	rhodopsin orphan GPCR	0.0056	0.0241	0.0236
Schistosoma mansoni	biogenic amine receptor	0.0056	0.0241	0.0236
Echinococcus granulosus	orexin receptor type 2	0.0056	0.0241	0.0236
Schistosoma mansoni	serine/threonine protein kinase	0.0038	0.0135	0.013
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0019	0.0026	0.0021
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.0203	0.0198
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0056	0.0241	0.0236
Trichomonas vaginalis	phosphofructokinase, putative	0.0109	0.0544	0.3592
Brugia malayi	nuclear receptor NHR-88	0.0037	0.0126	0.0126
Mycobacterium tuberculosis	Possible arylsulfatase AtsD (aryl-sulfate sulphohydrolase) (arylsulphatase)	0.0025	0.0061	0.0837
Trichomonas vaginalis	6-phosphofructokinase, putative	0.0029	0.0084	0.0505
Echinococcus granulosus	hypothetical protein	0.0056	0.0241	0.0236
Echinococcus granulosus	rhodopsin orphan GPCR	0.0056	0.0241	0.0236
Trypanosoma cruzi	Aph-1 protein, putative	0.0678	0.3844	1
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0037	0.0126	0.0121
Onchocerca volvulus		0.0468	0.2627	0.5716
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0132	0.0127
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0056	0.0241	0.0241
Brugia malayi	cytochrome P450	0.0022	0.0041	0.0041
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0056	0.0241	0.0236
Mycobacterium ulcerans	sulfatase	0.0025	0.0061	0.0351
Echinococcus granulosus	regulator of G protein signaling 3	0.0038	0.0132	0.0127
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0124	0.0633	0.4188
Plasmodium vivax	6-phosphofructokinase, putative	0.0029	0.0084	0.4201
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0175	0.017
Toxoplasma gondii	cytochrome p450 superfamily protein	0.0022	0.0041	0.0514
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0056	0.0241	0.0236
Brugia malayi	hypothetical protein	0.0468	0.2627	0.2627
Trypanosoma cruzi	STE group serine/threonine-protein kinase, putative	0.0025	0.0061	0.0135
Schistosoma mansoni	lamin	0.0026	0.0065	0.006
Loa Loa (eye worm)	RGS-3 protein	0.0038	0.0132	0.0127
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0056	0.0241	0.0236
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0061	0.0351
Schistosoma mansoni	nuclear hormone receptor	0.0017	0.0014	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0126	0.0121
Trichomonas vaginalis	phosphofructokinase, putative	0.0109	0.0544	0.3592
Toxoplasma gondii	flap structure-specific endonuclease 1, putative	0.0026	0.0065	0.0897
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0056	0.0241	0.0236
Schistosoma mansoni	histamine h1 receptor	0.0056	0.0241	0.0236
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0061	0.0351
Brugia malayi	orphan nuclear receptor NR2E1	0.0017	0.0014	0.0014
Brugia malayi	RE15519p	0.0056	0.0241	0.0241
Echinococcus multilocularis	g-protein coupled receptor	0.0056	0.0241	0.0236
Mycobacterium ulcerans	cytochrome P450 142A3 Cyp142A3	0.0022	0.0041	0.0215
Echinococcus granulosus	neuropeptide s receptor	0.0056	0.0241	0.0236
Mycobacterium ulcerans	cytochrome P450 108B4 Cyp108B4	0.0022	0.0041	0.0215
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0061	0.0351
Brugia malayi	sulfakinin receptor protein	0.0056	0.0241	0.0241
Mycobacterium ulcerans	arylsulfatase AtsD	0.0025	0.0061	0.0351
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0061	0.0351
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0074	0.0341	0.0336
Echinococcus multilocularis	neuropeptide receptor A26	0.0056	0.0241	0.0236
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0175	0.017
Mycobacterium tuberculosis	Probable cytochrome P450 139 Cyp139	0.0022	0.0041	0.0514
Onchocerca volvulus		0.0056	0.0241	0.0497
Loa Loa (eye worm)	cytochrome P450 family protein	0.0031	0.0095	0.0089
Onchocerca volvulus		0.0056	0.0241	0.0497
Echinococcus multilocularis	ecdysone induced protein 78C	0.0037	0.0126	0.0121
Echinococcus granulosus	mitogen activated protein kinase 3	0.0054	0.0226	0.0221
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0084	0.0505
Toxoplasma gondii	6-phosphofructokinase	0.0029	0.0084	0.1206
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0056	0.0241	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0241	0.0236
Loa Loa (eye worm)	flap endonuclease-1	0.0026	0.0065	0.006
Echinococcus granulosus	rhodopsin orphan GPCR	0.0056	0.0241	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0241	0.0236
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.0069	0.0157
Echinococcus granulosus	rhodopsin orphan GPCR	0.0056	0.0241	0.0236
Mycobacterium tuberculosis	Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)	0.0022	0.0041	0.0514
Mycobacterium ulcerans	cytochrome p450 150 cyp150	0.0022	0.0041	0.0215
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0074	0.0341	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0241	0.0236
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0025	0.0058	0.033
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0132	0.0127
Echinococcus multilocularis	regulator of G protein signaling 3	0.0038	0.0132	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0126	0.0121
Mycobacterium tuberculosis	Probable dehydrogenase	0.0108	0.0539	0.8501
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0241	0.0236
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0037	0.0126	0.0126
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0056	0.0241	0.0236
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0017	0.0014	0.0009
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0056	0.0241	0.0236
Loa Loa (eye worm)	6-phosphofructokinase	0.0109	0.0544	0.0539
Loa Loa (eye worm)	aryl Hydrocarbon receptor Associated protein family member	0.0025	0.0058	0.0053
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0054	0.0226	0.348
Loa Loa (eye worm)	phosphofructokinase	0.0109	0.0544	0.0539
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0005	0.0005
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0084	0.0505
Brugia malayi	Thioredoxin reductase	0.0047	0.0188	0.0188
Brugia malayi	nuclear hormone receptor family member odr-7	0.0017	0.0014	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0026	0.0021
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0017	0.0014	0.0009
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0038	0.0135	0.013
Brugia malayi	Cytochrome P450 family protein	0.0031	0.0095	0.0095
Echinococcus granulosus	expressed protein	0.0734	0.4168	0.4165
Trypanosoma cruzi	PAS-domain containing phosphoglycerate kinase, putative	0.0025	0.0058	0.0128
Schistosoma mansoni	z-protein (S1r protein)	0.0038	0.0132	0.0127
Schistosoma mansoni	hypothetical protein	0.0056	0.0241	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0241	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0132	0.0127
Mycobacterium tuberculosis	Probable cytochrome P450 144 Cyp144	0.0022	0.0041	0.0514
Chlamydia trachomatis	two component regulatory system sensor histidine kinase	0.0025	0.0058	0.6526
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0241	0.0236
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0056	0.0241	0.0236
Mycobacterium tuberculosis	Probable cytochrome P450 132 Cyp132	0.0022	0.0041	0.0514
Trypanosoma brucei	cytochrome P450, putative	0.0031	0.0095	0.0223
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0019	0.0026	0.0021
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0037	0.0126	0.0121
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0084	0.0505
Plasmodium falciparum	glutathione reductase	0.0047	0.0188	1
Echinococcus granulosus	cytochrome P450 2K1	0.0022	0.0041	0.0036
Brugia malayi	Cytochrome P450 family protein	0.0022	0.0041	0.0041
Brugia malayi	larval opioid receptor	0.0056	0.0241	0.0241
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0175	0.017
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0061	0.0351
Schistosoma mansoni	RAR-like nuclear receptor	0.0037	0.0126	0.0121
Mycobacterium tuberculosis	Cytochrome P450 121 Cyp121	0.0022	0.0041	0.0514
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0017	0.0014	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0241	0.0236
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0038	0.0132	0.0132
Brugia malayi	conserved hypotetical protein	0.0017	0.0014	0.0014
Brugia malayi	hypothetical protein	0.0017	0.0014	0.0014
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0016	0.0009	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0056	0.0241	0.0236
Giardia lamblia	Flap structure-specific endonuclease	0.0026	0.0065	0.2578
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0126	0.0121
Echinococcus multilocularis	neuropeptides capa receptor	0.0056	0.0241	0.0236
Giardia lamblia	Hypothetical protein	0.0025	0.0061	0.2405
Giardia lamblia	Hypothetical protein	0.0025	0.0061	0.2405
Brugia malayi	hypothetical protein	0.0321	0.1774	0.1774
Brugia malayi	tailless protein	0.0017	0.0014	0.0014
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0017	0.0014	0.0009
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0056	0.0241	0.0236
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0109	0.0544	0.1395
Brugia malayi	hypothetical protein	0.0056	0.0241	0.0241
Brugia malayi	regulator of G-protein signaling egl-10	0.0038	0.0132	0.0132
Plasmodium vivax	flap endonuclease 1, putative	0.0026	0.0065	0.3125
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0175	0.017
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0037	0.0126	0.0121
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0037	0.0126	0.0126
Brugia malayi	MAP kinase sur-1	0.0054	0.0226	0.0226
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0038	0.0132	0.0127
Echinococcus multilocularis	beta adrenergic receptor kinase	0.0038	0.0135	0.013
Mycobacterium tuberculosis	Possible cytochrome P450 135B1 Cyp135B1	0.0022	0.0041	0.0514
Brugia malayi	PXA domain containing protein	0.0038	0.0132	0.0132
Schistosoma mansoni	gamma-secretase subunit aph-1	0.174	1	1
Echinococcus multilocularis	FTZ F1 alpha	0.0037	0.0126	0.0121
Schistosoma mansoni	biogenic amine receptor	0.0056	0.0241	0.0236
Brugia malayi	bHLH-PAS transcription factor	0.0071	0.0324	0.0324
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0016	0.0009	0.0004
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0017	0.0014	0.0009
Loa Loa (eye worm)	6-phosphofructokinase	0.0109	0.0544	0.0539
Loa Loa (eye worm)	hypothetical protein	0.005	0.0203	0.0198
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.012	0.0609	0.9619
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0061	0.0351
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0029	0.0084	1
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0054	0.0226	0.0566
Loa Loa (eye worm)	hypothetical protein	0.0468	0.2627	0.2623
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0108	0.0539	0.8501
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0061	0.0351
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0241	0.0236
Toxoplasma gondii	phosphofructokinase domain-containing protein	0.0029	0.0084	0.1206
Schistosoma mansoni	neuropeptide F-like receptor	0.0056	0.0241	0.0236
Mycobacterium tuberculosis	Probable cytochrome P450 123 Cyp123	0.0022	0.0041	0.0514
Onchocerca volvulus		0.0037	0.0126	0.0245
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0037	0.0126	0.0126
Schistosoma mansoni	cytochrome P450	0.0022	0.0041	0.0036
Echinococcus multilocularis	tumor protein p63	0.0333	0.1844	0.184
Echinococcus granulosus	neuropeptide receptor A26	0.0056	0.0241	0.0236
Echinococcus multilocularis	Aryl hydrocarbon receptor nuclear	0.0025	0.0058	0.0053
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0061	0.0351
Plasmodium falciparum	thioredoxin reductase	0.0047	0.0188	1
Echinococcus granulosus	lamin dm0	0.0026	0.0065	0.006
Echinococcus granulosus	axis inhibition protein axin	0.0038	0.0132	0.0127
Brugia malayi	PXA domain containing protein	0.0038	0.0132	0.0132
Echinococcus multilocularis	regulator of G protein signaling 3	0.0038	0.0132	0.0127
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0056	0.0241	0.0236
Loa Loa (eye worm)	cytochrome P450	0.0022	0.0041	0.0036
Loa Loa (eye worm)	nuclear hormone receptor	0.0017	0.0014	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0241	0.0236
Echinococcus multilocularis	axis inhibition protein axin	0.0038	0.0132	0.0127
Schistosoma mansoni	growth hormone secretagogue receptor	0.0056	0.0241	0.0236
Schistosoma mansoni	neuropeptide f receptor 76f	0.0056	0.0241	0.0236
Schistosoma mansoni	regulator of G protein signaling	0.0038	0.0132	0.0127
Echinococcus granulosus	FTZ F1 alpha	0.0037	0.0126	0.0121
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0054	0.0226	0.0566
Echinococcus granulosus	thyroid hormone receptor alpha	0.0017	0.0014	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0026	0.0021
Entamoeba histolytica	pyrophosphate-dependent phosphofructokinase	0.0029	0.0084	0.0402
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0056	0.0241	0.0497
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0061	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0468	0.2627	0.2623
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0061	0.0056
Brugia malayi	Serotonin receptor	0.0056	0.0241	0.0241
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0037	0.0126	0.0121
Echinococcus granulosus	neuropeptides capa receptor	0.0056	0.0241	0.0236
Schistosoma mansoni	regulator of G protein signaling	0.0038	0.0132	0.0127
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0019	0.0026	0.0021
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0016	0.0009	0.0009
Onchocerca volvulus		0.0056	0.0241	0.0497
Schistosoma mansoni	regulator of G protein signaling	0.0038	0.0132	0.0127
Mycobacterium ulcerans	cytochrome P450 189A7 Cyp189A7	0.0022	0.0041	0.0215
Brugia malayi	G protein-coupled receptor	0.0056	0.0241	0.0241
Echinococcus granulosus	rhodopsin orphan GPCR	0.0056	0.0241	0.0236
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0037	0.0126	0.0121
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0017	0.0014	0.0009
Schistosoma mansoni	serine/threonine protein kinase	0.0038	0.0135	0.013
Schistosoma mansoni	flap endonuclease-1	0.0024	0.005	0.0045
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0037	0.0126	0.0126
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0037	0.0126	0.0121
Echinococcus granulosus	Aryl hydrocarbon receptor nuclear	0.0025	0.0058	0.0053
Echinococcus multilocularis		0.0022	0.0041	0.0036
Mycobacterium ulcerans	6-phosphofructokinase	0.0109	0.0544	0.3592
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0241	0.0236
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0056	0.0241	0.0241
Echinococcus granulosus	sex peptide receptor	0.0056	0.0241	0.0236
Schistosoma mansoni	glutaminase	0.0273	0.1498	0.1494
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0056	0.0241	0.0236
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0124	0.0633	0.0628
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0056	0.0241	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0241	0.0236
Brugia malayi	hypothetical protein	0.0056	0.0241	0.0241
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0108	0.0539	0.8501
Onchocerca volvulus		0.0056	0.0241	0.0497
Echinococcus multilocularis	allatostatin A receptor	0.0056	0.0241	0.0236
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0029	0.0084	0.4201
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0061	0.0351
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0056	0.0241	0.0236
Mycobacterium ulcerans	cytochrome P450 191A3 Cyp191A3	0.0022	0.0041	0.0215
Loa Loa (eye worm)	glutaminase 2	0.0273	0.1498	0.1494
Echinococcus multilocularis	G protein coupled receptor 139	0.0056	0.0241	0.0236
Echinococcus multilocularis	neuropeptide s receptor	0.0056	0.0241	0.0236
Schistosoma mansoni	neuropeptide F-like receptor	0.0056	0.0241	0.0236
Schistosoma mansoni	amine GPCR	0.0056	0.0241	0.0236
Echinococcus granulosus	neuropeptide FF receptor 2	0.0056	0.0241	0.0236
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0038	0.0132	0.0127
Echinococcus granulosus	axis inhibition protein axin	0.0038	0.0132	0.0127
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0058	0.033
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0241	0.0236
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0054	0.0226	0.0566
Echinococcus granulosus	biogenic amine 5HT receptor	0.0056	0.0241	0.0236
Brugia malayi	6-phosphofructokinase	0.0109	0.0544	0.0544
Trypanosoma cruzi	cytochrome p450-like protein, putative	0.0022	0.0041	0.0084
Mycobacterium tuberculosis	Possible cytochrome P450 135A1 Cyp135A1	0.0022	0.0041	0.0514
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0175	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0132	0.0127
Brugia malayi	Nuclear hormone receptor-like 1	0.0019	0.0026	0.0026
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0056	0.0241	0.0236
Leishmania major	flap endonuclease-1 (FEN-1), putative	0.0026	0.0065	0.0897
Leishmania major	protein kinase, putative	0.0025	0.0061	0.0832
Mycobacterium ulcerans	glutaminase	0.0273	0.1498	1
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0056	0.0241	0.0236
Leishmania major	trypanothione reductase	0.0047	0.0188	0.2871
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0241	0.0236
Trypanosoma cruzi	flap endonuclease-1 (FEN-1), putative	0.0026	0.0065	0.0146
Brugia malayi	Melatonin receptor type 1A	0.0056	0.0241	0.0241
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0056	0.0241	0.0236
Mycobacterium ulcerans	cytochrome P450 105Q4 Cyp105Q4	0.0022	0.0041	0.0215
Echinococcus multilocularis	neuropeptide receptor	0.0056	0.0241	0.0236
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0017	0.0014	0.0009
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0056	0.0241	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0241	0.0236
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0019	0.0026	0.0021
Echinococcus granulosus	7tm_1 domain containing protein	0.0056	0.0241	0.0236
Onchocerca volvulus		0.0071	0.0324	0.0679
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0056	0.0241	0.0236
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.0038	0.0135	0.013
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.0065	0.0065
Schistosoma mansoni	regulator of G protein signaling	0.0038	0.0132	0.0127
Mycobacterium ulcerans	cytochrome P450 188A3 Cyp188A3	0.0022	0.0041	0.0215
Onchocerca volvulus		0.0056	0.0241	0.0497
Echinococcus granulosus	neuropeptide receptor	0.0056	0.0241	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0014	0.0009
Echinococcus granulosus	allatostatin A receptor	0.0056	0.0241	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0058	0.0053
Schistosoma mansoni	coup transcription factor	0.0037	0.0126	0.0121
Mycobacterium tuberculosis	Probable cytochrome P450 124 Cyp124	0.0022	0.0041	0.0514
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0056	0.0241	0.0236
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0016	0.0009	0.0004
Onchocerca volvulus		0.0056	0.0241	0.0497
Trichomonas vaginalis	guanylate cyclase, putative	0.0025	0.0058	0.033
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0056	0.0241	0.0236
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0037	0.0126	0.0121
Plasmodium vivax	glutathione reductase, putative	0.0047	0.0188	1
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0061	0.0351
Echinococcus multilocularis	fmrfamide receptor	0.0056	0.0241	0.0236
Schistosoma mansoni	regulator of G protein signaling	0.0038	0.0132	0.0127
Mycobacterium tuberculosis	Probable cytochrome P450 136 Cyp136	0.0022	0.0041	0.0514
Schistosoma mansoni	axis inhibition protein axin	0.0038	0.0132	0.0127
Trypanosoma brucei	protein kinase, putative	0.0054	0.0226	0.0566
Toxoplasma gondii	aldehyde dehydrogenase	0.0124	0.0633	1
Echinococcus granulosus	7TM GPCR rhodopsin	0.0056	0.0241	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0241	0.0236
Schistosoma mansoni	aldehyde dehydrogenase	0.0124	0.0633	0.0628
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0126	0.0121
Echinococcus granulosus	G protein coupled receptor 139	0.0056	0.0241	0.0236
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0061	0.0351
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0241	0.0236
Loa Loa (eye worm)	PXA domain-containing protein	0.0038	0.0132	0.0127
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0037	0.0126	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0241	0.0236
Brugia malayi	hypothetical protein	0.0019	0.0026	0.0026
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0132	0.0829
Trypanosoma brucei	flap endonuclease-1 (FEN-1), putative	0.0026	0.0065	0.0146
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0037	0.0126	0.0126
Leishmania major	cytochrome p450-like protein	0.0022	0.0041	0.0514
Brugia malayi	Flap endonuclease-1	0.0026	0.0065	0.0065
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.0203	0.0203
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0037	0.0126	0.0126
Loa Loa (eye worm)	gamma-secretase subunit aph-1	0.174	1	1
Brugia malayi	glutaminase DH11.1	0.0273	0.1498	0.1498
Mycobacterium ulcerans	cytochrome P450 187A5 Cyp187A5	0.0022	0.0041	0.0215
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0047	0.0188	0.0183
Loa Loa (eye worm)	transcription factor SMAD2	0.0118	0.0596	0.0591
Trichomonas vaginalis	soluble guanylate cyclase gcy, putative	0.0025	0.0058	0.033
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0038	0.0132	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0241	0.0236
Mycobacterium tuberculosis	Probable cytochrome P450 monooxygenase 142 Cyp142	0.0022	0.0041	0.0514
Echinococcus multilocularis	aryl hydrocarbon receptor	0.0025	0.0058	0.0053
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0058	0.033
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0037	0.0126	0.0121
Schistosoma mansoni	amine GPCR	0.0056	0.0241	0.0236
Brugia malayi	Nuclear hormone receptor-like 1	0.0037	0.0126	0.0126
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0037	0.0126	0.0126
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0025	0.0058	0.033
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0241	0.0236
Onchocerca volvulus		0.0056	0.0241	0.0497
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.0065	0.006
Trichomonas vaginalis	CMGC family protein kinase	0.0054	0.0226	0.1457
Schistosoma mansoni	hypothetical protein	0.0022	0.0041	0.0036
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0109	0.0544	0.8857
Mycobacterium tuberculosis	Probable cytochrome P450 125 Cyp125	0.0022	0.0041	0.0514
Brugia malayi	hypothetical protein	0.0056	0.0241	0.0241
Plasmodium falciparum	ataxin-2 like protein, putative	0.0027	0.0069	0.3354
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0241	0.0236
Mycobacterium ulcerans	cytochrome P450 125A7 Cyp125A7	0.0022	0.0041	0.0215
Mycobacterium tuberculosis	Probable cytochrome P450 143 Cyp143	0.0022	0.0041	0.0514
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0037	0.0126	0.0121
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0175	0.017
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0038	0.0132	0.0132
Schistosoma mansoni	6-phosphofructokinase	0.0109	0.0544	0.0539
Loa Loa (eye worm)	hypothetical protein	0.0745	0.423	0.4227
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0061	0.0351
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0037	0.0126	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0126	0.0121
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0029	0.0084	0.4201
Brugia malayi	phosphofructokinase	0.0109	0.0544	0.0544
Onchocerca volvulus	Bile acid receptor homolog	0.0037	0.0126	0.0245
Loa Loa (eye worm)	thioredoxin reductase	0.0047	0.0188	0.0183
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0037	0.0126	0.0121
Schistosoma mansoni	retinoic acid receptor RXR	0.0037	0.0126	0.0121
Echinococcus granulosus	tumor protein p63	0.0333	0.1844	0.184
Brugia malayi	hypothetical protein	0.0056	0.0241	0.0241
Echinococcus granulosus	nuclear receptor nhr 48	0.0017	0.0014	0.0009
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0054	0.0226	0.0221
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0241	0.0236
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0056	0.0241	0.0236
Echinococcus multilocularis	lamin	0.0026	0.0065	0.006
Trichomonas vaginalis	Phosphoglycerol transferase I, putative	0.0025	0.0061	0.0351
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0058	0.033
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0017	0.0014	0.0014
Schistosoma mansoni	intermediate filament proteins	0.0026	0.0065	0.006
Echinococcus granulosus	tm gpcr rhodopsin	0.0056	0.0241	0.0236
Mycobacterium ulcerans	cytochrome P450 143A3 Cyp143A3	0.0022	0.0041	0.0215
Echinococcus granulosus	somatostatin receptor	0.0056	0.0241	0.0236
Trypanosoma cruzi	trypanothione reductase, putative	0.0047	0.0188	0.0467
Giardia lamblia	Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit	0.0029	0.0084	0.3466
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0037	0.0126	0.0121
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0037	0.0126	0.0121
Mycobacterium tuberculosis	Probable cytochrome P450 128 Cyp128	0.0022	0.0041	0.0514
Mycobacterium tuberculosis	Probable cytochrome P450 140 Cyp140	0.0022	0.0041	0.0514
Echinococcus multilocularis	lamin dm0	0.0026	0.0065	0.006
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0056	0.0241	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0241	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0069	0.0064
Mycobacterium ulcerans	cytochrome P450 140A5 Cyp140A5	0.0022	0.0041	0.0215
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.0069	0.0157
Brugia malayi	nuclear hormone receptor	0.0037	0.0126	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0241	0.0236
Echinococcus granulosus	flap endonuclease 1	0.0026	0.0065	0.006
Echinococcus multilocularis	sex peptide receptor	0.0056	0.0241	0.0236
Brugia malayi	MH2 domain containing protein	0.0118	0.0596	0.0596
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0056	0.0241	0.0236
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0132	0.0829
Brugia malayi	nuclear receptor NHR-88	0.0017	0.0014	0.0014
Schistosoma mansoni	amine GPCR	0.0056	0.0241	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0014	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0014	0.0009
Brugia malayi	G-protein coupled receptor	0.0056	0.0241	0.0241
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0241	0.0236
Mycobacterium ulcerans	arylsulfatase AtsD	0.0025	0.0061	0.0351
Trypanosoma brucei	Lanosterol 14-alpha demethylase	0.0022	0.0041	0.0084
Loa Loa (eye worm)	G-protein coupled receptor	0.0056	0.0241	0.0236
Echinococcus granulosus	neuropeptide Y receptor	0.0056	0.0241	0.0236
Echinococcus granulosus	rhodopsin orphan GPCR	0.0056	0.0241	0.0236
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0056	0.0241	0.0236
Brugia malayi	hypothetical protein	0.0056	0.0241	0.0241
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0196	0.0191
Trichomonas vaginalis	CMGC family protein kinase	0.0054	0.0226	0.1457
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0014	0.0009
Brugia malayi	hypothetical protein	0.0056	0.0241	0.0241
Brugia malayi	hypothetical protein	0.0027	0.0069	0.0069
Trichomonas vaginalis	adenylate cyclase, putative	0.0025	0.0058	0.033
Onchocerca volvulus		0.0026	0.0065	0.0111
Echinococcus granulosus	serotonin receptor	0.0056	0.0241	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0132	0.0127
Echinococcus granulosus	g protein coupled receptor	0.0056	0.0241	0.0236
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0037	0.0126	0.0126
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0124	0.0633	1
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0056	0.0241	0.0236
Mycobacterium ulcerans	arylsulfatase AtsB	0.0025	0.0061	0.0351
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0056	0.0241	0.0236
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0806	0.4585	1
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0056	0.0241	0.0236
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0047	0.0188	0.2871
Trypanosoma cruzi	cytochrome P450, putative	0.0031	0.0095	0.0223
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0241	0.0236
Mycobacterium tuberculosis	Probable cytochrome P450 138 Cyp138	0.0022	0.0041	0.0514
Trichomonas vaginalis	phosphofructokinase, putative	0.0109	0.0544	0.3592
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0056	0.0241	0.0497
Echinococcus granulosus	fmrfamide receptor	0.0056	0.0241	0.0236
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0017	0.0014	0.0014
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0037	0.0126	0.0121
Onchocerca volvulus		0.0026	0.0065	0.0111
Trichomonas vaginalis	mucin-desulfating sulfatase, putative	0.0025	0.0061	0.0351
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0084	0.0505
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.0065	0.006
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0241	0.0236
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0031	0.0095	0.0575
Brugia malayi	photoreceptor-specific nuclear receptor	0.0037	0.0126	0.0126
Onchocerca volvulus		0.0056	0.0241	0.0497
Leishmania major	hypothetical protein, conserved	0.0027	0.0069	0.0963
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0054	0.0226	0.0566
Entamoeba histolytica	phosphofructokinase, putative	0.0109	0.0544	1
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0022	0.0041	0.0084
Mycobacterium tuberculosis	Probable cytochrome P450 130 Cyp130	0.0022	0.0041	0.0514
Mycobacterium ulcerans	cytochrome P450 126A3 Cyp126A3	0.0022	0.0041	0.0215
Brugia malayi	hypothetical protein	0.0025	0.0061	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0241	0.0236
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0038	0.0135	0.0135
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0056	0.0241	0.0236
Brugia malayi	hypoxia-induced factor 1	0.0296	0.163	0.163
Trypanosoma cruzi	cytochrome P450, putative	0.0031	0.0095	0.0223
Trichomonas vaginalis	CMGC family protein kinase	0.0054	0.0226	0.1457
Loa Loa (eye worm)	neuropeptide F receptor	0.0056	0.0241	0.0236
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0061	0.0351
Schistosoma mansoni	opsin-like receptor	0.0056	0.0241	0.0236
Entamoeba histolytica	phosphofructokinase, putative	0.0109	0.0544	1
Trichomonas vaginalis	adenylate cyclase, type VII, putative	0.0025	0.0058	0.033
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0037	0.0126	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0241	0.0236
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0084	0.0505
Giardia lamblia	Kinase, CMGC MAPK	0.0054	0.0226	1
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0241	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0241	0.0236
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0056	0.0241	0.0236
Schistosoma mansoni	serine/threonine protein kinase	0.0038	0.0135	0.013
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0056	0.0241	0.0236
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0017	0.0014	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0014	0.0009
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0025	0.0061	0.0135
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0056	0.0241	0.0236
Trichomonas vaginalis	glutaminase, putative	0.0273	0.1498	1
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0017	0.0014	0.0009
Echinococcus multilocularis	flap endonuclease 1	0.0026	0.0065	0.006
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0014	0.0009
Onchocerca volvulus		0.0049	0.0196	0.0399
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0084	0.0505
Schistosoma mansoni	myosin xvIII	0.0056	0.0241	0.0236
Brugia malayi	G protein-coupled receptor F59B2.13	0.0056	0.0241	0.0241
Brugia malayi	hypothetical protein	0.0017	0.0014	0.0014
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0056	0.0241	0.0236
Brugia malayi	Sulfatase family protein	0.0025	0.0061	0.0061
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0132	0.0829
Onchocerca volvulus		0.0056	0.0241	0.0497
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0065	0.006
Trichomonas vaginalis	CMGC family protein kinase	0.0054	0.0226	0.1457
Brugia malayi	A-kinase anchor protein 10, precursor	0.0038	0.0132	0.0132
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0061	0.0351
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0037	0.0126	0.0121
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0037	0.0126	0.0121
Schistosoma mansoni	zinc finger protein	0.0017	0.0014	0.0009
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0037	0.0126	0.0126
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0038	0.0132	0.0829
Echinococcus multilocularis	6 phosphofructokinase	0.0109	0.0544	0.0539
Schistosoma mansoni	serine/threonine protein kinase	0.0054	0.0226	0.0221
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0241	0.0236
Brugia malayi	Nuclear hormone receptor E75	0.0017	0.0014	0.0014
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.012	0.0609	0.9619
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0108	0.0539	0.8501
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0056	0.0241	0.0236
Brugia malayi	hypothetical protein	0.0056	0.0241	0.0241
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0056	0.0241	0.0241
Onchocerca volvulus		0.0056	0.0241	0.0497
Onchocerca volvulus		0.0056	0.0241	0.0497
Mycobacterium tuberculosis	Probable oxidoreductase	0.012	0.0609	0.9619
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0061	0.0351
Echinococcus multilocularis	serotonin receptor	0.0056	0.0241	0.0236
Echinococcus granulosus	neuropeptides capa receptor	0.0056	0.0241	0.0236
Echinococcus multilocularis	serotonin receptor	0.0056	0.0241	0.0236
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0037	0.0126	0.0126
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0056	0.0241	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0769	0.4373	0.437
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0061	0.0351
Loa Loa (eye worm)	cytochrome P450 family protein	0.0062	0.0275	0.0269
Entamoeba histolytica	hypothetical protein	0.0038	0.0132	0.1409
Brugia malayi	hypothetical protein	0.0056	0.0241	0.0241
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0014	0.0009
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0037	0.0126	0.0121
Brugia malayi	Nuclear hormone receptor-like 1	0.0019	0.0026	0.0026
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0038	0.0132	0.0127
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0056	0.0241	0.0236
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0056	0.0241	0.0236
Echinococcus granulosus	rhodopsin orphan GPCR	0.0056	0.0241	0.0236
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0017	0.0014	0.0009
Toxoplasma gondii	thioredoxin reductase	0.0047	0.0188	0.2871
Brugia malayi	hypothetical protein	0.0056	0.0241	0.0241
Brugia malayi	steroid hormone receptor	0.0037	0.0126	0.0126
Loa Loa (eye worm)	hypoxia-induced factor 1	0.0296	0.163	0.1625
Echinococcus multilocularis	neuropeptides capa receptor	0.0056	0.0241	0.0236
Brugia malayi	putative neuropeptide receptor	0.0056	0.0241	0.0241
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0241	0.0236
Onchocerca volvulus		0.0056	0.0241	0.0497
Schistosoma mansoni	hypothetical protein	0.0056	0.0241	0.0236
Brugia malayi	ecdysone receptor	0.0017	0.0014	0.0014
Echinococcus multilocularis	g protein coupled receptor	0.0056	0.0241	0.0236
Schistosoma mansoni	amine GPCR	0.0056	0.0241	0.0236
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0056	0.0241	0.0236
Plasmodium vivax	6-phosphofructokinase, putative	0.0029	0.0084	0.4201
Brugia malayi	intermediate filament protein	0.0026	0.0065	0.0065
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0037	0.0126	0.0121
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0038	0.0132	0.0127
Onchocerca volvulus	GPI ethanolamine phosphate transferase 1 homolog	0.0025	0.0061	0.0103
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0132	0.0829
Schistosoma mansoni	neuropeptide receptor	0.0056	0.0241	0.0236
Trypanosoma cruzi	Aph-1 protein, putative	0.0678	0.3844	1
Brugia malayi	hypothetical protein	0.0056	0.0241	0.0241
Mycobacterium tuberculosis	Possible arylsulfatase AtsA (aryl-sulfate sulphohydrolase) (arylsulphatase)	0.0025	0.0061	0.0837
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0124	0.0633	0.0628
Entamoeba histolytica	hypothetical protein	0.0038	0.0132	0.1409
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0061	0.0351
Brugia malayi	Dopamine receptor protein 2	0.0056	0.0241	0.0241
Mycobacterium ulcerans	cytochrome P450 143A4 Cyp143A4	0.0022	0.0041	0.0215
Toxoplasma gondii	LsmAD domain-containing protein	0.0027	0.0069	0.0963
Echinococcus multilocularis	mitogen activated protein kinase	0.0054	0.0226	0.0221
Entamoeba histolytica	hypothetical protein	0.0038	0.0132	0.1409
Trichomonas vaginalis	phosphofructokinase, putative	0.0109	0.0544	0.3592
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0241	0.0236
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0029	0.0084	1
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0017	0.0014	0.0009
Echinococcus granulosus	neuropeptide receptor	0.0056	0.0241	0.0236
Schistosoma mansoni	thyroid hormone receptor	0.0037	0.0126	0.0121
Echinococcus granulosus	biogenic amine 5HT receptor	0.0056	0.0241	0.0236
Schistosoma mansoni	biogenic amine receptor	0.0056	0.0241	0.0236
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0061	0.0351
Leishmania major	cytochrome p450-like protein	0.0031	0.0095	0.1374
Echinococcus multilocularis	regulator of G protein signaling	0.0038	0.0132	0.0127
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0005	0.0005
Brugia malayi	hypothetical protein	0.0019	0.0026	0.0026
Brugia malayi	G-protein coupled receptor	0.0056	0.0241	0.0241
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0019	0.0026	0.0021
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0056	0.0241	0.0236

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (binding)	= 8 %	Retinoid activity at 10 e-5 M (9Z)- RA against RXR-alpha receptor receptor for gene transcriptional activation in transfected CV-1 cells	ChEMBL.	8410972
Activity (binding)	= 8 %	Retinoid activity at 10 e-5 M (9Z)- RA against RXR-alpha receptor receptor for gene transcriptional activation in transfected CV-1 cells	ChEMBL.	8410972
Activity (binding)	= 55 %	Retinoid activity at 10 e-5 M (E)-RA against Retinoic acid receptor beta for gene transcriptional activation in transfected CV-1 cells	ChEMBL.	8410972
Activity (binding)	= 55 %	Retinoid activity at 10 e-5 M (E)-RA against Retinoic acid receptor beta for gene transcriptional activation in transfected CV-1 cells	ChEMBL.	8410972
Activity (binding)	= 64 %	Retinoid activity at 10 e-5 M (E)-RA against RAR-alpha receptor for gene transcriptional activation in transfected CV-1 cells	ChEMBL.	8410972
Activity (binding)	= 64 %	Retinoid activity at 10 e-5 M (E)-RA against RAR-alpha receptor for gene transcriptional activation in transfected CV-1 cells	ChEMBL.	8410972
Activity (binding)	= 107 %	Retinoid activity at 10 e-5 M (E)-RA against RAR-gamma receptor for gene transcriptional activation in transfected CV-1 cells	ChEMBL.	8410972
Activity (binding)	= 107 %	Retinoid activity at 10 e-5 M (E)-RA against RAR-gamma receptor for gene transcriptional activation in transfected CV-1 cells	ChEMBL.	8410972
EC50 (binding)	= 5 nM	Effective concentration against Retinoic acid receptor beta	ChEMBL.	8410972
EC50 (binding)	= 5 nM	Effective concentration against Retinoic acid receptor beta	ChEMBL.	8410972
EC50 (binding)	= 35 nM	Effective concentration against RAR-gamma receptor	ChEMBL.	8410972
EC50 (binding)	= 35 nM	Effective concentration against RAR-gamma receptor	ChEMBL.	8410972
EC50 (binding)	= 240 nM	Effective concentration against RAR-alpha receptor	ChEMBL.	8410972
EC50 (binding)	= 240 nM	Effective concentration against RAR-alpha receptor	ChEMBL.	8410972
ED50 (functional)	= 0.0000000003	Molarity required to effect reversal of keratinization in 50% of cultures.	ChEMBL.	6208361
ED50 (functional)	= 3 M	ED50 of retinoid required to effect reversal of keratinization	ChEMBL.	6887203
Inhibition (binding)	= 34 %	Inhibition of the induction of ornithine decarboxylase in mouse epidermis by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate(ODC) at dose 1.7 nmol	ChEMBL.	6208361
Inhibition (binding)	= 34 %	Inhibition of the induction of ornithine decarboxylase in mouse epidermis by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate(ODC) at dose 1.7 nmol	ChEMBL.	6208361
Inhibition (binding)	= 62 %	Percent inhibition of induction of ODC(ornithine decarboxylase) by TPA in mouse skin at a dose of 1.7 nmol	ChEMBL.	6195339
Inhibition (functional)	= 62 %	Inhibition of tumor promoter (TPA) -induced mouse epidermal ornithine decarboxylase (ODC) activity at 1.7 nmol dose level	ChEMBL.	7241516
Inhibition (binding)	= 62 %	Percent inhibition of induction of ODC(ornithine decarboxylase) by TPA in mouse skin at a dose of 1.7 nmol	ChEMBL.	6195339
Inhibition (functional)	= 62 %	Inhibition of tumor promoter (TPA) -induced mouse epidermal ornithine decarboxylase (ODC) activity at 1.7 nmol dose level	ChEMBL.	7241516
Inhibition (binding)	= 77 %	Percent inhibition of induction of ODC(ornithine decarboxylase) by TPA in mouse skin at a dose of 17.0 nmol	ChEMBL.	6195339
Inhibition (binding)	= 77 %	Inhibition of the induction of ornithine decarboxylase in mouse epidermis by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate(ODC) at dose 17 nmol	ChEMBL.	6208361
Inhibition (functional)	= 77 %	Inhibition of tumor promoter (TPA) -induced mouse epidermal ornithine decarboxylase (ODC) activity at 17 nmol dose level	ChEMBL.	7241516
Inhibition (binding)	= 77 %	Percent inhibition of induction of ODC(ornithine decarboxylase) by TPA in mouse skin at a dose of 17.0 nmol	ChEMBL.	6195339
Inhibition (binding)	= 77 %	Inhibition of the induction of ornithine decarboxylase in mouse epidermis by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate(ODC) at dose 17 nmol	ChEMBL.	6208361
Inhibition (functional)	= 77 %	Inhibition of tumor promoter (TPA) -induced mouse epidermal ornithine decarboxylase (ODC) activity at 17 nmol dose level	ChEMBL.	7241516
Inhibition (functional)	= 87 %	Inhibition of tumor promoter (TPA) -induced mouse epidermal ornithine decarboxylase (ODC) activity at 170 nmol dose level	ChEMBL.	7241516
Inhibition (functional)	= 87 %	Inhibition of tumor promoter (TPA) -induced mouse epidermal ornithine decarboxylase (ODC) activity at 170 nmol dose level	ChEMBL.	7241516
inhibition of control (functional)	= 62 %	Percent inhibition of the induction of ornithine decarboxylase at 1.7 nmol in mouse dorsal epidermis (ODC assay)	ChEMBL.	6887203
inhibition of control (functional)	= 62 %	Percent inhibition of the induction of ornithine decarboxylase at 1.7 nmol in mouse dorsal epidermis (ODC assay)	ChEMBL.	6887203
inhibition of control (functional)	= 77 %	Percent inhibition of the induction of ornithine decarboxylase at 17 nmol dose in mouse dorsal epidermis (ODC assay)	ChEMBL.	6887203
inhibition of control (functional)	= 77 %	Percent inhibition of the induction of ornithine decarboxylase at 17 nmol dose in mouse dorsal epidermis (ODC assay)	ChEMBL.	6887203
inhibition of control (functional)	= 87 %	Percent inhibition of the induction of ornithine decarboxylase at 170 nmol in mouse dorsal epidermis (ODC assay)	ChEMBL.	6887203
inhibition of control (functional)	= 87 %	Percent inhibition of the induction of ornithine decarboxylase at 170 nmol in mouse dorsal epidermis (ODC assay)	ChEMBL.	6887203
Ratio (functional)	= 1	Relative activity as reciprocal of the ratio of ED50(retinoid)/ED50 (retinoic acid) when control was 3 x 10e-11	ChEMBL.	6195339
Relative activity (functional)	= 2	Relative potency with respect to retinoic acid in hamster tracheal organ culture assay (TOC)	ChEMBL.	6887203

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL284264

Bibliographic References

5 literature references were collected for this gene.

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Detailed information for compound 30345