Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0261 | 0.3225 | 0.5 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.0669 | 1 | 0.5 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0261 | 0.3225 | 1 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0261 | 0.3225 | 0.5 |
Leishmania major | dihydroorotate dehydrogenase | 0.0669 | 1 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.0669 | 1 | 1 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0105 | 0.0629 | 1 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.0669 | 1 | 1 |
Brugia malayi | Matrixin family protein | 0.0115 | 0.0786 | 0.0786 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0669 | 1 | 1 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0261 | 0.3225 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0669 | 1 | 1 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0261 | 0.3225 | 0.3225 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0261 | 0.3225 | 1 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0261 | 0.3225 | 1 |
Onchocerca volvulus | Matrilysin homolog | 0.0105 | 0.0629 | 1 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.0669 | 1 | 0.5 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0261 | 0.3225 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0261 | 0.3225 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0261 | 0.3225 | 0.5 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.0669 | 1 | 0.5 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.0669 | 1 | 0.5 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0669 | 1 | 0.5 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0669 | 1 | 1 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.0669 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0261 | 0.3225 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.0669 | 1 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.0115 | 0.0786 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0261 | 0.3225 | 0.5 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.0669 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 15 % | Percent remaining enzyme activity (RA) in human gelatinase B (matrix metalloproteinase-9) | ChEMBL. | 11958997 |
Inhibition (binding) | = 15 % | Percent remaining enzyme activity (RA) in human gelatinase B (matrix metalloproteinase-9) | ChEMBL. | 11958997 |
Inhibition (binding) | = 26 % | Percent remaining enzyme activity (RA) in catalytic domains of the membrane type MT1-MMP (matrix metalloproteinase-14) | ChEMBL. | 11958997 |
Inhibition (binding) | = 26 % | Percent remaining enzyme activity (RA) in catalytic domains of the membrane type MT1-MMP (matrix metalloproteinase-14) | ChEMBL. | 11958997 |
Inhibition (binding) | = 47 % | Percent remaining enzyme activity (RA) in neutrophil collagenase (matrix metalloproteinase-8) | ChEMBL. | 11958997 |
Inhibition (binding) | = 47 % | Percent remaining enzyme activity (RA) in neutrophil collagenase (matrix metalloproteinase-8) | ChEMBL. | 11958997 |
Ki (binding) | = 8.2 uM | Inhibitory activity against human gelatinase B (matrix metalloproteinase-9) | ChEMBL. | 11958997 |
Ki (binding) | = 8.2 uM | Inhibitory activity against human gelatinase B (matrix metalloproteinase-9) | ChEMBL. | 11958997 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.