Detailed information for compound 30362

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 333.379 | Formula: C18H23NO5
  • H donors: 1 H acceptors: 4 LogP: 2.57 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)C1Cc2c(N1C(=O)[C@@H](C[C@H](C(=O)O)C)C)cccc2
  • InChi: 1S/C18H23NO5/c1-4-24-18(23)15-10-13-7-5-6-8-14(13)19(15)16(20)11(2)9-12(3)17(21)22/h5-8,11-12,15H,4,9-10H2,1-3H3,(H,21,22)/t11-,12-,15?/m1/s1
  • InChiKey: FYGXHTCBEFEFEV-IQQIRFCMSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Giardia lamblia hypothetical protein 0.007 0.0281 0.0929
Brugia malayi hypothetical protein 0.0035 0.0091 0.0026
Loa Loa (eye worm) hypothetical protein 0.0048 0.0164 0.0214
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0281 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.007 0.0281 1
Plasmodium vivax phosphodiesterase gamma, putative 0.007 0.0281 1
Echinococcus granulosus tar DNA binding protein 0.0061 0.0235 0.0491
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.007 0.0281 1
Trypanosoma brucei cAMP-specific phosphodiesterase 0.007 0.0281 1
Leishmania major hypothetical protein, conserved 0.007 0.0281 1
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0523 0.2748 0.9082
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.007 0.0281 1
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0281 1
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0281 1
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.007 0.0281 0.065
Entamoeba histolytica hypothetical protein 0.0035 0.0091 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.007 0.0281 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.047 0.0456
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.007 0.0281 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0281 1
Echinococcus multilocularis tar DNA binding protein 0.0061 0.0235 0.0491
Echinococcus multilocularis geminin 0.0164 0.0794 0.2396
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0281 0.0929
Leishmania major hypothetical protein, conserved 0.007 0.0281 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0281 1
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.007 0.0281 0.0682
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0505 0.2645 0.6589
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.007 0.0281 0.0682
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0574 0.3026 1
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.007 0.0281 0.0682
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0235 0.0524
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.015 0.0203
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0281 0.0929
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.007 0.0281 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.007 0.0281 1
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0281 1
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0091 0.0034
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0505 0.2645 0.8704
Brugia malayi Angiotensin-converting enzyme family protein 0.0749 0.3973 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.007 0.0281 1
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.007 0.0281 1
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0235 0.0524
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0281 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0281 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0281 0.0929
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0505 0.2645 0.8704
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.007 0.0281 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.047 0.0456
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.007 0.0281 0.0682
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.007 0.0281 0.065
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.007 0.0281 0.065
Trypanosoma brucei cAMP-specific phosphodiesterase 0.007 0.0281 1
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.007 0.0281 0.0682
Leishmania major cAMP-specific phosphodiesterase, putative 0.007 0.0281 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.007 0.0281 0.0516
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0574 0.3026 1
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.0235 0.0396
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0164 0.0214
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.007 0.0281 1
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.007 0.0281 1
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.007 0.0281 1
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0235 0.0524
Schistosoma mansoni hypothetical protein 0.0164 0.0794 0.2422
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0281 1
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.007 0.0281 0.065
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.007 0.0281 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.007 0.0281 1
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1857 1 0.5
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0281 0.0929
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0281 1
Entamoeba histolytica hypothetical protein 0.0035 0.0091 1
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.007 0.0281 1
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0235 0.0524
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.007 0.0281 0.0516
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.0533 0.0095
Echinococcus granulosus geminin 0.0164 0.0794 0.2396
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.0533 0.0546
Loa Loa (eye worm) PDE1B protein 0.007 0.0281 0.0516
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0164 0.0214
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0281 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.007 0.0281 0.0516
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.015 0.0203
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.007 0.0281 1
Loa Loa (eye worm) TAR-binding protein 0.0061 0.0235 0.0396
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0574 0.3026 1
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0235 0.0524
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.007 0.0281 1
Loa Loa (eye worm) hypothetical protein 0.007 0.0281 0.0516
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0505 0.2645 0.6589
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.007 0.0281 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.047 0.0456
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0281 0.0929
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.007 0.0281 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0281 0.0929
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.007 0.0281 0.065
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0281 1
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.007 0.0281 1
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.007 0.0281 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.007 0.0281 0.0682
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0281 0.0929
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.007 0.0281 1
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0018 0 0.0017
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0281 0.0929
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.1333 0.7153 1
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0749 0.3973 1
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0574 0.3026 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0281 0.0929
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0281 1
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.007 0.0281 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0281 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0574 0.3026 1
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.007 0.0281 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0281 0.0929
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.007 0.0281 0.0682
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.007 0.0281 0.065
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.007 0.0281 0.065
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.053 0.1155
Schistosoma mansoni hypothetical protein 0.0164 0.0794 0.2422
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.007 0.0281 1
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.1333 0.7153 1
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0523 0.2748 0.3409
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.007 0.0281 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0281 1
Giardia lamblia Hypothetical protein 0.007 0.0281 0.0929
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0281 1
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.007 0.0281 1
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.007 0.0281 0.065
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0281 0.0929
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.0533 0.0546
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0281 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.007 0.0281 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.007 0.0281 1
Loa Loa (eye worm) glutathione reductase 0.0046 0.015 0.0179
Plasmodium falciparum phosphodiesterase gamma, putative 0.007 0.0281 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.007 0.0281 1
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0281 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.007 0.0281 1
Brugia malayi MH2 domain containing protein 0.0116 0.053 0.1155
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0281 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0281 0.0929
Toxoplasma gondii thioredoxin reductase 0.0046 0.015 0.0495
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.053 0.1155
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.007 0.0281 1
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.007 0.0281 0.065
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.007 0.0281 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0164 0.0214
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.0235 0.0396
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0018 0 0.0017
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.007 0.0281 1
Mycobacterium tuberculosis Probable reductase 0.0105 0.047 0.0456
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.047 0.0456
Entamoeba histolytica hypothetical protein 0.0035 0.0091 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0574 0.3026 1
Brugia malayi RNA binding protein 0.0061 0.0235 0.0396
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0281 0.0929
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1857 1 0.5
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.007 0.0281 0.0516
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0281 0.0929
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.007 0.0281 0.0516
Loa Loa (eye worm) hypothetical protein 0.007 0.0281 0.0516
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.007 0.0281 0.0682
Brugia malayi TAR-binding protein 0.0061 0.0235 0.0396
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0281 1
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.007 0.0281 1
Trichomonas vaginalis MYB, putative 0.0018 0 0.0017
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.047 0.0456
Brugia malayi glutathione reductase 0.0046 0.015 0.0179
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.0533 0.0546
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.007 0.0281 1
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0574 0.3026 1
Loa Loa (eye worm) hypothetical protein 0.0574 0.3026 0.7566
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1857 1 1
Plasmodium falciparum phosphodiesterase delta, putative 0.007 0.0281 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.007 0.0281 0.0516
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.007 0.0281 0.0682
Plasmodium falciparum cGMP-specific phosphodiesterase 0.007 0.0281 1
Loa Loa (eye worm) RNA binding protein 0.0061 0.0235 0.0396
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0281 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0281 0.0929
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.007 0.0281 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.007 0.0281 0.0682
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.007 0.0281 0.065
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0281 1
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.007 0.0281 0.065
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.007 0.0281 0.0516
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.007 0.0281 1
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.007 0.0281 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.007 0.0281 1
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0281 1
Plasmodium falciparum cGMP-specific phosphodiesterase 0.007 0.0281 1
Brugia malayi Thioredoxin reductase 0.0046 0.015 0.0179
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0281 1
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.015 0.0179
Schistosoma mansoni hypothetical protein 0.0035 0.0091 0.0034
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.007 0.0281 0.065
Loa Loa (eye worm) hypothetical protein 0.007 0.0281 0.0516
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0281 0.0929
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0281 1
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.007 0.0281 1
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0281 1
Entamoeba histolytica hypothetical protein 0.0035 0.0091 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0281 0.0929
Trypanosoma brucei hypothetical protein, conserved 0.007 0.0281 1
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0281 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.007 0.0281 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 28000 nM In vitro inhibition of angiotensin I converting enzyme (ACE) ChEMBL. 6310113
IC50 (binding) = 28000 nM In vitro inhibition of angiotensin I converting enzyme (ACE) ChEMBL. 6310113
Inhibition (functional) = 16 % Invivo percent inhibition of angiotensin I pressor response 15 min after 0.3mg/kg, iv administration in spontaneously hypertensive rat (SHR) ChEMBL. 6310113

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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